CDC25A | ENSG00000164045 | NCBI 993

Details for: CDC25A

Gene ID: 993

Symbol: CDC25A

Ensembl ID: ENSG00000164045

Description: cell division cycle 25A

Associated with

Activation of atr in response to replication stress
(R-HSA-176187)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cyclin a/b1/b2 associated events during g2/m transition
(R-HSA-69273)
Cyclin a:cdk2-associated events at s phase entry
(R-HSA-69656)
Cyclin e associated events during g1/s transition
(R-HSA-69202)
Defective intrinsic pathway for apoptosis
(R-HSA-9734009)
Deregulated cdk5 triggers multiple neurodegenerative pathways in alzheimer's disease models
(R-HSA-8862803)
Deubiquitination
(R-HSA-5688426)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
G0 and early g1
(R-HSA-1538133)
G1/s-specific transcription
(R-HSA-69205)
G1/s dna damage checkpoints
(R-HSA-69615)
G1/s transition
(R-HSA-69206)
G2/m checkpoints
(R-HSA-69481)
G2/m transition
(R-HSA-69275)
Metabolism of proteins
(R-HSA-392499)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Mitotic g2-g2/m phases
(R-HSA-453274)
Neurodegenerative diseases
(R-HSA-8863678)
P53-independent dna damage response
(R-HSA-69610)
P53-independent g1/s dna damage checkpoint
(R-HSA-69613)
Polo-like kinase mediated events
(R-HSA-156711)
Post-translational protein modification
(R-HSA-597592)
S phase
(R-HSA-69242)
Transcription of e2f targets under negative control by dream complex
(R-HSA-1362277)
Ub-specific processing proteases
(R-HSA-5689880)
Ubiquitin mediated degradation of phosphorylated cdc25a
(R-HSA-69601)
Cell division
(GO:0051301)
Cell population proliferation
(GO:0008283)
Cellular response to uv
(GO:0034644)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
G1/s transition of mitotic cell cycle
(GO:0000082)
G2/m transition of mitotic cell cycle
(GO:0000086)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Phosphoprotein phosphatase activity
(GO:0004721)
Positive regulation of dna replication
(GO:0045740)
Positive regulation of g2/mi transition of meiotic cell cycle
(GO:0110032)
Positive regulation of g2/m transition of mitotic cell cycle
(GO:0010971)
Protein-folding chaperone binding
(GO:0051087)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Protein tyrosine phosphatase activity
(GO:0004725)
Regulation of cyclin-dependent protein serine/threonine kinase activity
(GO:0000079)
Response to radiation
(GO:0009314)

Other Information

Proteins

M-phase inducer phosphatase 1

Genular Protein ID: 566855348

Symbol: MPIP1_HUMAN

Name: M-phase inducer phosphatase 1

UniProtKB Accession Codes:

P30304 Q8IZH5 Q96IL3 Q9H2F2

Database IDs:

Citations:

PubMed ID: 1836978

Title: Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins.

PubMed ID: 1836978

DOI: 10.1016/0092-8674(91)90294-9

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11139144

Title: Alternative splicing in the regulatory region of the human phosphatases CDC25A and CDC25C.

PubMed ID: 11139144

DOI: 10.1078/0171-9335-00115

PubMed ID: 11298456

Title: The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis.

PubMed ID: 11298456

DOI: 10.1038/35071124

PubMed ID: 12234927

Title: Dual mode of degradation of Cdc25 A phosphatase.

PubMed ID: 12234927

DOI: 10.1093/emboj/cdf491

PubMed ID: 12399544

Title: Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints.

PubMed ID: 12399544

DOI: 10.1073/pnas.182557299

PubMed ID: 12676583

Title: Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A.

PubMed ID: 12676583

DOI: 10.1016/s1535-6108(03)00048-5

PubMed ID: 14681206

Title: SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase.

PubMed ID: 14681206

DOI: 10.1101/gad.1157503

PubMed ID: 12676925

Title: Chk1 mediates S and G2 arrests through Cdc25A degradation in response to DNA-damaging agents.

PubMed ID: 12676925

DOI: 10.1074/jbc.m300229200

PubMed ID: 12759351

Title: Phosphorylation at serine 75 is required for UV-mediated degradation of human Cdc25A phosphatase at the S-phase checkpoint.

PubMed ID: 12759351

DOI: 10.1074/jbc.m302704200

PubMed ID: 14559997

Title: Chk1 kinase negatively regulates mitotic function of Cdc25A phosphatase through 14-3-3 binding.

PubMed ID: 14559997

DOI: 10.1128/mcb.23.21.7488-7497.2003

PubMed ID: 16356754

Title: The oncogenic serine/threonine kinase Pim-1 directly phosphorylates and activates the G2/M specific phosphatase Cdc25C.

PubMed ID: 16356754

DOI: 10.1016/j.biocel.2005.10.010

PubMed ID: 19734889

Title: NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint.

PubMed ID: 19734889

DOI: 10.1038/ncb1969

PubMed ID: 20090422

Title: NEK11: linking CHK1 and CDC25A in DNA damage checkpoint signaling.

PubMed ID: 20090422

DOI: 10.4161/cc.9.3.10513

PubMed ID: 20228808

Title: Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A.

PubMed ID: 20228808

DOI: 10.1038/ncb2041

PubMed ID: 21376736

Title: Absence of polo-like kinase 3 in mice stabilizes Cdc25A after DNA damage but is not sufficient to produce tumors.

PubMed ID: 21376736

DOI: 10.1016/j.mrfmmm.2011.02.006

PubMed ID: 22843495

Title: Hsp90 stabilizes Cdc25A and counteracts heat shock-mediated Cdc25A degradation and cell-cycle attenuation in pancreatic carcinoma cells.

PubMed ID: 22843495

DOI: 10.1093/hmg/dds303

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 9604936

Title: Crystal structure of the catalytic domain of the human cell cycle control phosphatase, Cdc25A.

PubMed ID: 9604936

DOI: 10.1016/s0092-8674(00)81190-3

Sequence Information:

Length: 524
Mass: 59087
Checksum: B2F6B792D4E6122B
Sequence:

MELGPEPPHR RRLLFACSPP PASQPVVKAL FGASAAGGLS PVTNLTVTMD QLQGLGSDYE 
QPLEVKNNSN LQRMGSSEST DSGFCLDSPG PLDSKENLEN PMRRIHSLPQ KLLGCSPALK 
RSHSDSLDHD IFQLIDPDEN KENEAFEFKK PVRPVSRGCL HSHGLQEGKD LFTQRQNSAP 
ARMLSSNERD SSEPGNFIPL FTPQSPVTAT LSDEDDGFVD LLDGENLKNE EETPSCMASL 
WTAPLVMRTT NLDNRCKLFD SPSLCSSSTR SVLKRPERSQ EESPPGSTKR RKSMSGASPK 
ESTNPEKAHE TLHQSLSLAS SPKGTIENIL DNDPRDLIGD FSKGYLFHTV AGKHQDLKYI 
SPEIMASVLN GKFANLIKEF VIIDCRYPYE YEGGHIKGAV NLHMEEEVED FLLKKPIVPT 
DGKRVIVVFH CEFSSERGPR MCRYVRERDR LGNEYPKLHY PELYVLKGGY KEFFMKCQSY 
CEPPSYRPMH HEDFKEDLKK FRTKSRTWAG EKSKREMYSR LKKL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CDC25A

Associated with

Other Information

Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins. PubMed ID: 1836978

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Alternative splicing in the regulatory region of the human phosphatases CDC25A and CDC25C. PubMed ID: 11139144

The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. PubMed ID: 11298456

Dual mode of degradation of Cdc25 A phosphatase. PubMed ID: 12234927

Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints. PubMed ID: 12399544

Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A. PubMed ID: 12676583

SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase. PubMed ID: 14681206

Chk1 mediates S and G2 arrests through Cdc25A degradation in response to DNA-damaging agents. PubMed ID: 12676925

Phosphorylation at serine 75 is required for UV-mediated degradation of human Cdc25A phosphatase at the S-phase checkpoint. PubMed ID: 12759351

Chk1 kinase negatively regulates mitotic function of Cdc25A phosphatase through 14-3-3 binding. PubMed ID: 14559997

The oncogenic serine/threonine kinase Pim-1 directly phosphorylates and activates the G2/M specific phosphatase Cdc25C. PubMed ID: 16356754

NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint. PubMed ID: 19734889

NEK11: linking CHK1 and CDC25A in DNA damage checkpoint signaling. PubMed ID: 20090422

Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A. PubMed ID: 20228808

Absence of polo-like kinase 3 in mice stabilizes Cdc25A after DNA damage but is not sufficient to produce tumors. PubMed ID: 21376736

Hsp90 stabilizes Cdc25A and counteracts heat shock-mediated Cdc25A degradation and cell-cycle attenuation in pancreatic carcinoma cells. PubMed ID: 22843495

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Crystal structure of the catalytic domain of the human cell cycle control phosphatase, Cdc25A. PubMed ID: 9604936