MAFB | ENSG00000204103 | NCBI 9935

Details for: MAFB

Gene ID: 9935

Symbol: MAFB

Ensembl ID: ENSG00000204103

Description: MAF bZIP transcription factor B

Associated with

Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
Developmental biology
(R-HSA-1266738)
Abducens nerve formation
(GO:0021599)
Brain segmentation
(GO:0035284)
Chromatin
(GO:0000785)
Cornified envelope assembly
(GO:1903575)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Fat cell differentiation
(GO:0045444)
Identical protein binding
(GO:0042802)
Inner ear morphogenesis
(GO:0042472)
Integrated stress response signaling
(GO:0140467)
Keratinocyte differentiation
(GO:0030216)
Negative regulation of erythrocyte differentiation
(GO:0045647)
Negative regulation of osteoclast differentiation
(GO:0045671)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleus
(GO:0005634)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein processing
(GO:0016485)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of myeloid cell differentiation
(GO:0045637)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Respiratory gaseous exchange by respiratory system
(GO:0007585)
Rhombomere 5 development
(GO:0021571)
Rhombomere 6 development
(GO:0021572)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulator complex
(GO:0090575)
Segment specification
(GO:0007379)
Sensory organ development
(GO:0007423)
Sequence-specific dna binding
(GO:0043565)
T cell differentiation in thymus
(GO:0033077)
Thymus development
(GO:0048538)

Other Information

Proteins

Transcription factor MafB

Genular Protein ID: 2361589380

Symbol: MAFB_HUMAN

Name: Transcription factor MafB

UniProtKB Accession Codes:

Q9Y5Q3 B3KNE1 Q9H1F1

Database IDs:

Citations:

PubMed ID: 10444328

Title: Human KRML (MAFB): cDNA cloning, genomic structure, and evaluation as a candidate tumor suppressor gene in myeloid leukemias.

PubMed ID: 10444328

DOI: 10.1006/geno.1999.5884

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15135046

Title: Low-density lipoprotein receptor-related protein interacts with MafB, a regulator of hindbrain development.

PubMed ID: 15135046

DOI: 10.1016/j.febslet.2004.03.069

PubMed ID: 15963504

Title: MafA transcription factor is phosphorylated by p38 MAP kinase.

PubMed ID: 15963504

DOI: 10.1016/j.febslet.2005.04.086

PubMed ID: 18042454

Title: GSK-3-mediated phosphorylation enhances Maf-transforming activity.

PubMed ID: 18042454

DOI: 10.1016/j.molcel.2007.11.009

PubMed ID: 19143053

Title: A new MAFia in cancer.

PubMed ID: 19143053

DOI: 10.1038/nrc2460

PubMed ID: 22387013

Title: Multicentric carpotarsal osteolysis is caused by mutations clustering in the amino-terminal transcriptional activation domain of MAFB.

PubMed ID: 22387013

DOI: 10.1016/j.ajhg.2012.01.003

PubMed ID: 27181683

Title: Loss of MAFB function in humans and mice causes Duane syndrome, aberrant extraocular muscle innervation, and inner-ear defects.

PubMed ID: 27181683

DOI: 10.1016/j.ajhg.2016.03.023

Sequence Information:

Length: 323
Mass: 35792
Checksum: A0F3C09F8936CB16
Sequence:

MAAELSMGPE LPTSPLAMEY VNDFDLLKFD VKKEPLGRAE RPGRPCTRLQ PAGSVSSTPL 
STPCSSVPSS PSFSPTEQKT HLEDLYWMAS NYQQMNPEAL NLTPEDAVEA LIGSHPVPQP 
LQSFDSFRGA HHHHHHHHPH PHHAYPGAGV AHDELGPHAH PHHHHHHQAS PPPSSAASPA 
QQLPTSHPGP GPHATASATA AGGNGSVEDR FSDDQLVSMS VRELNRHLRG FTKDEVIRLK 
QKRRTLKNRG YAQSCRYKRV QQKHHLENEK TQLIQQVEQL KQEVSRLARE RDAYKVKCEK 
LANSGFREAG STSDSPSSPE FFL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: MAFB

Associated with

Other Information

Human KRML (MAFB): cDNA cloning, genomic structure, and evaluation as a candidate tumor suppressor gene in myeloid leukemias. PubMed ID: 10444328

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and comparative analysis of human chromosome 20. PubMed ID: 11780052

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Low-density lipoprotein receptor-related protein interacts with MafB, a regulator of hindbrain development. PubMed ID: 15135046

MafA transcription factor is phosphorylated by p38 MAP kinase. PubMed ID: 15963504

GSK-3-mediated phosphorylation enhances Maf-transforming activity. PubMed ID: 18042454

A new MAFia in cancer. PubMed ID: 19143053

Multicentric carpotarsal osteolysis is caused by mutations clustering in the amino-terminal transcriptional activation domain of MAFB. PubMed ID: 22387013

Loss of MAFB function in humans and mice causes Duane syndrome, aberrant extraocular muscle innervation, and inner-ear defects. PubMed ID: 27181683