Details for: RBM8A

Gene ID: 9939

Symbol: RBM8A

Ensembl ID: ENSG00000265241

Description: RNA binding motif protein 8A

Associated with

Other Information

Genular Protein ID: 3358381655

Symbol: RBM8A_HUMAN

Name: RNA-binding protein 8A

UniProtKB Accession Codes:

Q9Y5S9 B3KQI9 Q6FHD1 Q6IQ40 Q9GZX8 Q9NZI4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 4 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 14 EMDB 9 EPD 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 20 PDBsum 16 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 6 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11004516

Title: Cloning and gene expression of a novel human ribonucleoprotein.

PubMed ID: 11004516

DOI: 10.1016/s0167-4781(00)00090-7

PubMed ID: 10662555

Title: MAGOH interacts with a novel RNA-binding protein.

PubMed ID: 10662555

DOI: 10.1006/geno.1999.6064

PubMed ID: 11013075

Title: Identification and structural analysis of human RBM8A and RBM8B: two highly conserved RNA-binding motif proteins that interact with OVCA1, a candidate tumor suppressor.

PubMed ID: 11013075

DOI: 10.1006/geno.2000.6315

PubMed ID: 11030346

Title: Pre-mRNA splicing imprints mRNA in the nucleus with a novel RNA-binding protein that persists in the cytoplasm.

PubMed ID: 11030346

DOI: 10.1016/s1097-2765(00)00065-4

PubMed ID: 11707068

Title: The genes encoding the type II gonadotropin-releasing hormone receptor and the ribonucleoprotein RBM8A in humans overlap in two genomic loci.

PubMed ID: 11707068

DOI: 10.1006/geno.2001.6650

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11118221

Title: The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions.

PubMed ID: 11118221

DOI: 10.1093/emboj/19.24.6860

PubMed ID: 11447110

Title: Importin 13: a novel mediator of nuclear import and export.

PubMed ID: 11447110

DOI: 10.1093/emboj/20.14.3685

PubMed ID: 11707413

Title: Magoh, a human homolog of Drosophila mago nashi protein, is a component of the splicing-dependent exon-exon junction complex.

PubMed ID: 11707413

DOI: 10.1093/emboj/20.22.6424

PubMed ID: 11546873

Title: Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon-exon junction complex.

PubMed ID: 11546873

DOI: 10.1126/science.1062829

PubMed ID: 11546874

Title: Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1.

PubMed ID: 11546874

DOI: 10.1126/science.1062786

PubMed ID: 12121612

Title: Translation is required to remove Y14 from mRNAs in the cytoplasm.

PubMed ID: 12121612

DOI: 10.1016/s0960-9822(02)00902-8

PubMed ID: 11991638

Title: Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.

PubMed ID: 11991638

DOI: 10.1017/s1355838202021088

PubMed ID: 12944400

Title: An evolutionarily conserved role for SRm160 in 3'-end processing that functions independently of exon junction complex formation.

PubMed ID: 12944400

DOI: 10.1074/jbc.m306856200

PubMed ID: 12718880

Title: Y14 and hUpf3b form an NMD-activating complex.

PubMed ID: 12718880

DOI: 10.1016/s1097-2765(03)00142-4

PubMed ID: 12730685

Title: A novel mode of RBD-protein recognition in the Y14-Mago complex.

PubMed ID: 12730685

DOI: 10.1038/nsb926

PubMed ID: 14968132

Title: Molecular insights into the interaction of PYM with the Mago-Y14 core of the exon junction complex.

PubMed ID: 14968132

DOI: 10.1038/sj.embor.7400091

PubMed ID: 14625303

Title: A simple whole cell lysate system for in vitro splicing reveals a stepwise assembly of the exon-exon junction complex.

PubMed ID: 14625303

DOI: 10.1074/jbc.m307692200

PubMed ID: 16209946

Title: Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements.

PubMed ID: 16209946

DOI: 10.1016/j.molcel.2005.08.012

PubMed ID: 16170325

Title: The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity.

PubMed ID: 16170325

DOI: 10.1038/nsmb990

PubMed ID: 16314458

Title: Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.

PubMed ID: 16314458

DOI: 10.1261/rna.2155905

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18026120

Title: PYM binds the cytoplasmic exon-junction complex and ribosomes to enhance translation of spliced mRNAs.

PubMed ID: 18026120

DOI: 10.1038/nsmb1321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19409878

Title: Exon junction complex enhances translation of spliced mRNAs at multiple steps.

PubMed ID: 19409878

DOI: 10.1016/j.bbrc.2009.04.123

PubMed ID: 19410547

Title: Disassembly of exon junction complexes by PYM.

PubMed ID: 19410547

DOI: 10.1016/j.cell.2009.02.042

PubMed ID: 19324961

Title: Assembly and mobility of exon-exon junction complexes in living cells.

PubMed ID: 19324961

DOI: 10.1261/rna.1387009

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22203037

Title: Proteins associated with the exon junction complex also control the alternative splicing of apoptotic regulators.

PubMed ID: 22203037

DOI: 10.1128/mcb.06130-11

PubMed ID: 22366785

Title: Compound inheritance of a low-frequency regulatory SNP and a rare null mutation in exon-junction complex subunit RBM8A causes TAR syndrome.

PubMed ID: 22366785

DOI: 10.1038/ng.1083

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23917022

Title: Two mammalian MAGOH genes contribute to exon junction complex composition and nonsense-mediated decay.

PubMed ID: 23917022

DOI: 10.4161/rna.25827

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 12781131

Title: Structure of the Y14-Magoh core of the exon junction complex.

PubMed ID: 12781131

DOI: 10.1016/s0960-9822(03)00328-2

PubMed ID: 16923391

Title: The crystal structure of the exon junction complex reveals how it maintains a stable grip on mRNA.

PubMed ID: 16923391

DOI: 10.1016/j.cell.2006.08.006

PubMed ID: 16931718

Title: Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA.

PubMed ID: 16931718

DOI: 10.1126/science.1131981

PubMed ID: 19033377

Title: Mechanism of ATP turnover inhibition in the EJC.

PubMed ID: 19033377

DOI: 10.1261/rna.1283109

PubMed ID: 20479275

Title: Insights into the recruitment of the NMD machinery from the crystal structure of a core EJC-UPF3b complex.

PubMed ID: 20479275

DOI: 10.1073/pnas.1000993107

PubMed ID: 28502770

Title: An Atomic Structure of the Human Spliceosome.

PubMed ID: 28502770

DOI: 10.1016/j.cell.2017.04.033

PubMed ID: 29301961

Title: Structure of a human catalytic step I spliceosome.

PubMed ID: 29301961

DOI: 10.1126/science.aar6401

Sequence Information:

  • Length: 174
  • Mass: 19889
  • Checksum: 70BBD03CDDFEECFE
  • Sequence:
    • MADVLDLHEA GGEDFAMDED GDESIHKLKE KAKKRKGRGF GSEEGSRARM REDYDSVEQD 
GDEPGPQRSV EGWILFVTGV HEEATEEDIH DKFAEYGEIK NIHLNLDRRT GYLKGYTLVE 
YETYKEAQAA MEGLNGQDLM GQPISVDWCF VRGPPKGKRR GGRRRSRSPD RRRR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.