Details for: CDC25B

Gene ID: 994

Symbol: CDC25B

Ensembl ID: ENSG00000101224

Description: cell division cycle 25B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 105.8856
    Cell Significance Index: -16.4700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 78.3383
    Cell Significance Index: -19.8700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 43.0608
    Cell Significance Index: -20.3300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.1401
    Cell Significance Index: -19.9000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.5667
    Cell Significance Index: -20.2700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.7465
    Cell Significance Index: -17.6500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.1989
    Cell Significance Index: -20.5200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 3.3386
    Cell Significance Index: 98.0500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2872
    Cell Significance Index: 258.2100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2319
    Cell Significance Index: 1112.3100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.9730
    Cell Significance Index: 113.3900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8444
    Cell Significance Index: 91.8400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8115
    Cell Significance Index: 291.0600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.7395
    Cell Significance Index: 32.7100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.7170
    Cell Significance Index: 27.1500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6332
    Cell Significance Index: 74.6700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5961
    Cell Significance Index: 96.9600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5192
    Cell Significance Index: 14.5100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4182
    Cell Significance Index: 28.9200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2900
    Cell Significance Index: 158.3600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2775
    Cell Significance Index: 16.6600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2729
    Cell Significance Index: 37.4800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.2526
    Cell Significance Index: 2.8700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2467
    Cell Significance Index: 11.1800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1530
    Cell Significance Index: 19.6200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1509
    Cell Significance Index: 14.9300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1492
    Cell Significance Index: 29.6000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1336
    Cell Significance Index: 6.2800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1332
    Cell Significance Index: 25.3500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1220
    Cell Significance Index: 3.0500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.1024
    Cell Significance Index: 1.2700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0945
    Cell Significance Index: 1.6200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0639
    Cell Significance Index: 1.8400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0365
    Cell Significance Index: 0.7900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0324
    Cell Significance Index: 49.8900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0231
    Cell Significance Index: 10.2000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0195
    Cell Significance Index: 0.4100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0172
    Cell Significance Index: 32.4300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0165
    Cell Significance Index: 12.4700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0165
    Cell Significance Index: 30.4200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0110
    Cell Significance Index: 6.9900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0071
    Cell Significance Index: 0.1100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0051
    Cell Significance Index: 0.0700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0024
    Cell Significance Index: 0.4300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0113
    Cell Significance Index: -7.8500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0129
    Cell Significance Index: -17.5200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0232
    Cell Significance Index: -0.4900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0262
    Cell Significance Index: -19.4100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0265
    Cell Significance Index: -19.4200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0297
    Cell Significance Index: -13.4900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0329
    Cell Significance Index: -4.7800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0336
    Cell Significance Index: -18.9700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0354
    Cell Significance Index: -22.0900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0440
    Cell Significance Index: -5.4200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0553
    Cell Significance Index: -15.9000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0556
    Cell Significance Index: -1.7800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0562
    Cell Significance Index: -3.7800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0615
    Cell Significance Index: -2.1600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0620
    Cell Significance Index: -6.3300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0714
    Cell Significance Index: -1.2000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0799
    Cell Significance Index: -4.1900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0832
    Cell Significance Index: -14.2100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0970
    Cell Significance Index: -12.5400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1069
    Cell Significance Index: -22.5100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1125
    Cell Significance Index: -3.9100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1146
    Cell Significance Index: -6.4300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1150
    Cell Significance Index: -3.0800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1251
    Cell Significance Index: -3.2000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1468
    Cell Significance Index: -16.8200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1611
    Cell Significance Index: -9.9000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1728
    Cell Significance Index: -9.0000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1821
    Cell Significance Index: -13.5700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1835
    Cell Significance Index: -11.8400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1883
    Cell Significance Index: -19.6100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1960
    Cell Significance Index: -10.1800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2022
    Cell Significance Index: -15.5200
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.2222
    Cell Significance Index: -2.3200
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.2300
    Cell Significance Index: -1.4400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2363
    Cell Significance Index: -16.7100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2426
    Cell Significance Index: -5.1500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2459
    Cell Significance Index: -15.5000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2473
    Cell Significance Index: -11.5300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2557
    Cell Significance Index: -1.5500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2568
    Cell Significance Index: -20.3400
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.2584
    Cell Significance Index: -2.2200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2732
    Cell Significance Index: -16.7500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2893
    Cell Significance Index: -6.2500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2922
    Cell Significance Index: -7.8300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3149
    Cell Significance Index: -4.5100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3197
    Cell Significance Index: -5.6500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3266
    Cell Significance Index: -9.3200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3294
    Cell Significance Index: -10.4900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3308
    Cell Significance Index: -6.5400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3422
    Cell Significance Index: -6.8700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.3771
    Cell Significance Index: -6.5000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3783
    Cell Significance Index: -12.3900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3824
    Cell Significance Index: -10.2100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3898
    Cell Significance Index: -8.1600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3938
    Cell Significance Index: -11.6000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3971
    Cell Significance Index: -13.9100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **M Phase Inducer Phosphatase**: CDC25B is a phosphatase enzyme that specifically removes phosphate groups from the CDK1 (also known as cdc2) and CDK2, thereby activating them and driving the cell cycle forward. 2. **G2/M Transition**: CDC25B is particularly important for the G2/M transition phase, where it regulates the activation of CDK2 and CDK1, leading to the completion of the cell cycle. 3. **Cyclin-CDK Interactions**: CDC25B interacts with cyclins A, B1, and B2, which are essential for the activation of CDK2 and CDK1, respectively. 4. **Protein Phosphorylation**: CDC25B is a protein phosphatase that dephosphorylates and activates CDK2 and CDK1, which are critical for the progression of the cell cycle. **Pathways and Functions** 1. **Cell Cycle Regulation**: CDC25B plays a crucial role in regulating the cell cycle, particularly during the G2/M transition phase. 2. **Mitotic Spindle Formation**: CDC25B is involved in the formation of the mitotic spindle, which is essential for proper mitosis and cytokinesis. 3. **Apoptosis Regulation**: CDC25B has been implicated in the regulation of apoptosis, particularly in the context of defective intrinsic pathways. 4. **Neurodegenerative Diseases**: CDC25B has been shown to be involved in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease, where it triggers multiple neurodegenerative pathways. **Clinical Significance** 1. **Cancer**: Dysregulation of CDC25B has been implicated in various cancers, including breast, lung, and colon cancer, where it can lead to uncontrolled cell proliferation and tumor formation. 2. **Neurodegenerative Diseases**: CDC25B has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease, where it can lead to neuronal damage and dysfunction. 3. **Immunological Disorders**: CDC25B has been shown to play a role in the regulation of immune cell function, particularly in the context of T-cell activation and proliferation. 4. **Therapeutic Targeting**: CDC25B has been identified as a potential therapeutic target for the treatment of various diseases, including cancer and neurodegenerative disorders. In conclusion, CDC25B is a critical regulator of the cell cycle, particularly during the G2/M transition phase. Its dysregulation has been implicated in various diseases, including cancer, neurodegenerative disorders, and immunological disorders. Further research is needed to fully elucidate the role of CDC25B in human disease and to identify potential therapeutic targets for the treatment of these diseases.

Genular Protein ID: 1308964814

Symbol: MPIP2_HUMAN

Name: M-phase inducer phosphatase 2

UniProtKB Accession Codes:

P30305 D3DVY1 D3DVY2 D3DVY3 D3DVY4 O43551 Q13971 Q5JX77 Q6RSS1 Q9BRA6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CPTAC 5 CPTC 1 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DEPOD 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 1 ELM 1 EMBL 19 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 17 PDBsum 17 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 3 RefSeq 5 Rhea 4 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1836978

Title: Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins.

PubMed ID: 1836978

DOI: 10.1016/0092-8674(91)90294-9

PubMed ID: 1662986

Title: An additional homolog of the fission yeast cdc25+ gene occurs in humans and is highly expressed in some cancer cells.

PubMed ID: 1662986

PubMed ID: 9188863

Title: Alternative splicing of the human CDC25B tyrosine phosphatase. Possible implications for growth control?

PubMed ID: 9188863

DOI: 10.1038/sj.onc.1201063

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11333986

Title: Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase.

PubMed ID: 11333986

DOI: 10.1038/35075107

PubMed ID: 12400006

Title: Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation.

PubMed ID: 12400006

DOI: 10.1038/sj.onc.1205870

PubMed ID: 15150265

Title: Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function.

PubMed ID: 15150265

DOI: 10.1074/jbc.m404728200

PubMed ID: 15128871

Title: Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2-M transition.

PubMed ID: 15128871

DOI: 10.1242/jcs.01108

PubMed ID: 15311285

Title: Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase.

PubMed ID: 15311285

DOI: 10.1038/ncb1165

PubMed ID: 15908796

Title: CDC25B phosphorylated by pEg3 localizes to the centrosome and the spindle poles at mitosis.

PubMed ID: 15908796

DOI: 10.4161/cc.4.6.1716

PubMed ID: 15629715

Title: MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation.

PubMed ID: 15629715

DOI: 10.1016/j.molcel.2004.11.021

PubMed ID: 17332740

Title: Rho GTPases regulate PRK2/PKN2 to control entry into mitosis and exit from cytokinesis.

PubMed ID: 17332740

DOI: 10.1038/sj.emboj.7601637

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20360007

Title: Cdc25 phosphatases are required for timely assembly of CDK1-cyclin B at the G2/M transition.

PubMed ID: 20360007

DOI: 10.1074/jbc.m109.096552

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 10543950

Title: Crystal structure of the catalytic subunit of Cdc25B required for G2/M phase transition of the cell cycle.

PubMed ID: 10543950

DOI: 10.1006/jmbi.1999.3168

Sequence Information:

  • Length: 580
  • Mass: 64987
  • Checksum: EDE24B0E84AC1BE3
  • Sequence:
    • MEVPQPEPAP GSALSPAGVC GGAQRPGHLP GLLLGSHGLL GSPVRAAASS PVTTLTQTMH 
DLAGLGSETP KSQVGTLLFR SRSRLTHLSL SRRASESSLS SESSESSDAG LCMDSPSPMD 
PHMAEQTFEQ AIQAASRIIR NEQFAIRRFQ SMPVRLLGHS PVLRNITNSQ APDGRRKSEA 
GSGAASSSGE DKENDGFVFK MPWKPTHPSS THALAEWASR REAFAQRPSS APDLMCLSPD 
RKMEVEELSP LALGRFSLTP AEGDTEEDDG FVDILESDLK DDDAVPPGME SLISAPLVKT 
LEKEEEKDLV MYSKCQRLFR SPSMPCSVIR PILKRLERPQ DRDTPVQNKR RRSVTPPEEQ 
QEAEEPKARV LRSKSLCHDE IENLLDSDHR ELIGDYSKAF LLQTVDGKHQ DLKYISPETM 
VALLTGKFSN IVDKFVIVDC RYPYEYEGGH IKTAVNLPLE RDAESFLLKS PIAPCSLDKR 
VILIFHCEFS SERGPRMCRF IRERDRAVND YPSLYYPEMY ILKGGYKEFF PQHPNFCEPQ 
DYRPMNHEAF KDELKTFRLK TRSWAGERSR RELCSRLQDQ

Genular Protein ID: 1332620993

Symbol: G8JLH2_HUMAN

Name: N/A

UniProtKB Accession Codes:

G8JLH2

Database IDs:

ARBA 7 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 4 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 3 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 2 RefSeq 1 Rhea 4 RuleBase 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 489
  • Mass: 55960
  • Checksum: F2561B9EFAD9DC01
  • Sequence:
    • MHSETPKSQV GTLLFRSRSR LTHLSLSRRA SESSLSSESS ESSDAGLCMD SPSPMDPHMA 
EQTFEQAIQA ASRIIRNEQF AIRRFQSMPV RLLGHSPVLR NITNSQAPDG RRKSEAGSGA 
ASSSGEDKEN DGFVFKMPWK PTHPSSTHAL AEWASRREAF AQRPSSAPDL MCLSPDRKME 
VEELSPLALG RFSLTPAEGD TEEDDGFVDI LESDLKDLVM YSKCQRLFRS PSMPCSVIRP 
ILKRLERPQD RDTPVQNKRR RSVTPPEEQQ EAEEPKARVL RSKSLCHDEI ENLLDSDHRE 
LIGDYSKAFL LQTVDGKHQD LKYISPETMV ALLTGKFSNI VDKFVIVDCR YPYEYEGGHI 
KTAVNLPLER DAESFLLKSP IAPCSLDKRV ILIFHCEFSS ERGPRMCRFI RERDRAVNDY 
PSLYYPEMYI LKGGYKEFFP QHPNFCEPQD YRPMNHEAFK DELKTFRLKT RSWAGERSRR 
ELCSRLQDQ

Genular Protein ID: 770630232

Symbol: B3KS38_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KS38

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 4 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 6 GO 3 Gene3D 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 5 Rhea 4 RuleBase 1 SAM 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 468
  • Mass: 53705
  • Checksum: 9C8F1C64B4285698
  • Sequence:
    • MDSPSPMDPH MAEQTFEQAI QAASRIIRNE QFAIRRFQSM PVRLLGHSPV LRNITNSQAP 
DGRRKSEAGS GAASSSGEDK ENDGFVFKMP WKPTHPSSTH ALAEWASRRE AFAQRPSSAP 
DLMCLSPDRK MEVEELSPLA LGRFSLTPAE GDTEEDDGFV DILESDLKDD DAVPPGMESL 
ISAPLVKTLE KEEEKDLVMY SKCQRLFRSP SMPCSVIRPI LKRLERPQDR DTPVQNKRRR 
SVTPPEEQQE AEEPKARVLR SKSLCHDEIE NLLDSDHREL IGDYSKAFLL QTVDGKHQDL 
KYISPETMVA LLTGKFSNIV DKFVIVDCRY PYEYEGGHIK TAVNLPLERD AESFLLKSPI 
APCSLDKRVI LIFHCEFSSE RGPRMCRFIR ERDRAVNDYP SLYYPEMYIL KGGYKEFFPQ 
HPNFCEPQDY RPMNHEAFKD ELKTFRLKTR SWAGERSRRE LCSRLQDQ

Genular Protein ID: 745472377

Symbol: B4DRC3_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DRC3

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 4 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 3 Gene3D 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 2 RefSeq 1 Rhea 4 RuleBase 1 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 502
  • Mass: 57339
  • Checksum: A3E0062FF9FA875B
  • Sequence:
    • MHSRSRLTHL SLSRRASESS LSSESSESSD AGLCMDSPSP MDPHMAEQTF EQAIQAASRI 
IRNEQFAIRR FQSMPVRLLG HSPVLRNITN SQAPDGRRKS EAGSGAASSS GEDKENDGFV 
FKMPWKPTHP SSTHALAEWA SRREAFAQRP SSAPDLMCLS PDRKMEVEEL SPLALGRFSL 
TPAEGDTEED DGFVDILESD LKDDDAVPPG MESLISAPLV KTLEKEEEKD LVMYSKCQRL 
FRSPSMPCSV IRPILKRLER PQDRDTPVQN KRRRSVTPPE EQQEAEEPKA RVLRSKSLCH 
DEIENLLDSD HRELIGDYSK AFLLQTVDGK HQDLKYISPE TMVALLTGKF SNIVDKFVIV 
DCRYPYEYEG GHIKTAVNLP LERDAESFLL KSPIAPCSLD KRVILIFHCE FSSERGPRMC 
RFIRERDRAV NDYPSLYYPE MYILKGGYKE FFPQHPNFCE PQDYRPMNHE AFKDELKTFR 
LKTRSWAGER SRRELCSRLQ DQ

Genular Protein ID: 659168238

Symbol: B4DQZ3_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DQZ3

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 4 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 3 Gene3D 1 IntAct 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 2 RefSeq 1 Rhea 4 RuleBase 1 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 489
  • Mass: 55989
  • Checksum: 303CF665BBB0DC19
  • Sequence:
    • MHSETPKSQV GTLLFRSRSR LTHLSLSRRA SESSLSSESS ESSDAGLCMD SPSPMDPHMA 
EQTFEQAIQA ASRIIRNEQF AIRRFQSMPV RLLGHSPVLR NITNSQAPDG RRKSEAGSGA 
ASSSGEDKEN DGFVFKMPWK PTHPSSTHAL AEWASRREAF AQRPSSAPDL MCLSPDRKME 
VEELSPLALG RFSLTPAEGD TEEDDGFVDI LESDLKDLVM YSKCQRLFRS PSMPCSVIRP 
ILKRLERPQD RDTPVQNKRR RSVTPPEEQQ EAEEPKARVL RSKSLCHDEI ENLLDSDHRE 
LIGDYSKAFL LQTVDGKHQD LKYISPETMV ALLTGRFSNI VDKFVIVDCR YPYEYEGGHI 
KTAVNLPLER DAESFLLKSP IAPCSLDKRV ILIFHCEFSS ERGPRMCRFI RERDRAVNDY 
PSLYYPEMYI LKGGYKEFFP QHPNFCEPQD YRPMDHEAFK DELKTFRLKT RSWAGERSRR 
ELCSRLQDQ

Genular Protein ID: 2543048274

Symbol: E1YMX4_HUMAN

Name: N/A

UniProtKB Accession Codes:

E1YMX4

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 4 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 7 Gene3D 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 2 RefSeq 1 Rhea 4 RuleBase 1 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 427
  • Mass: 49473
  • Checksum: C05C71DDE701A375
  • Sequence:
    • MDSPSPMDPH MAEQTFEQAI QAASRIIRNE QFAIRRFQSM PDGFVFKMPW KPTHPSSTHA 
LAEWASRREA FAQRPSSAPD LMCLSPDRKM EVEELSPLAL GRFSLTPAEG DTEEDDGFVD 
ILESDLKDDD AVPPGMESLI SAPLVKTLEK EEEKDLVMYS KCQRLFRSPS MPCSVIRPIL 
KRLERPQDRD TPVQNKRRRS VTPPEEQQEA EEPKARVLRS KSLCHDEIEN LLDSDHRELI 
GDYSKAFLLQ TVDGKHQDLK YISPETMVAL LTGKFSNIVD KFVIVDCRYP YEYEGGHIKT 
AVNLPLERDA ESFLLKSPIA PCSLDKRVIL IFHCEFSSER GPRMCRFIRE RDRAVNDYPS 
LYYPEMYILK GGYKEFFPQH PNFCEPQDYR PMNHEAFKDE LKTFRLKTRS WAGERSRREL 
CSRLQDQ

Genular Protein ID: 2862378060

Symbol: B4DIG0_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DIG0 E9PCK4

Database IDs:

ARBA 7 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 4 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 3 Ensembl 2 GO 3 Gene3D 1 GeneTree 1 HGNC 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 2 RefSeq 1 Rhea 4 RuleBase 1 SAM 1 SMART 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 516
  • Mass: 58884
  • Checksum: 862ADAFD01CC5A80
  • Sequence:
    • MHSETPKSQV GTLLFRSRSR LTHLSLSRRA SESSLSSESS ESSDAGLCMD SPSPMDPHMA 
EQTFEQAIQA ASRIIRNEQF AIRRFQSMPV RLLGHSPVLR NITNSQAPDG RRKSEAGSGA 
ASSSGEDKEN DGFVFKMPWK PTHPSSTHAL AEWASRREAF AQRPSSAPDL MCLSPDRKME 
VEELSPLALG RFSLTPAEGD TEEDDGFVDI LESDLKDDDA VPPGMESLIS APLVKTLEKE 
EEKDLVMYSK CQRLFRSPSM PCSVIRPILK RLERPQDRDT PVQNKRRRSV TPPEEQQEAE 
EPKARVLRSK SLCHDEIENL LDSDHRELIG DYSKAFLLQT VDGKHQDLKY ISPETMVALL 
TGKFSNIVDK FVIVDCRYPY EYEGGHIKTA VNLPLERDAE SFLLKSPIAP CSLDKRVILI 
FHCEFSSERG PRMCRFIRER DRAVNDYPSL YYPEMYILKG GYKEFFPQHP NFCEPQDYRP 
MNHEAFKDEL KTFRLKTRSW AGERSRRELC SRLQDQ

Genular Protein ID: 3246284728

Symbol: Q6MZW8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6MZW8

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 4 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 7 Gene3D 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 4 Rhea 4 RuleBase 1 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 412
  • Mass: 47875
  • Checksum: 2C0A833DA3D8C2CA
  • Sequence:
    • FEQAIQAASR IIRNEQFAIR RFQSMPDGFV FKMPWKPTHP SSTHALAEWA SRREAFAQRP 
SSAPDLMCLS PDRKMEVEEL SPLALGRFSL TPAEGDTEED DGFVDILESD LKDDDAVPPD 
MESLISAPLV KTLEKEEEKD LVMYSKCQRL FRSPSMPCSV IRPILKRLER PQDRDTPVQN 
KRRRSVTPPE EQQEAEEPKA RVLRSKSLCH DEIENLLDSD HRELIGDYSK AFLLQTVDGK 
HQDLKYISPE TMVALLTGKF SNIVDKFVIV DCRYPYEYEG GHIKTAVNLP LERDAESFLL 
KSPIAPCSLD KRVILIFHCE FSSERGPRMC RFIRERDRAV NDYPSLYYPE MYILKGGYKE 
FFPQHPNFCE PQDYRPMNHE AFKDELKTFR LKTRSWAGER SRRELCSRLQ DQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.