Details for: XYLB

Gene ID: 9942

Symbol: XYLB

Ensembl ID: ENSG00000093217

Description: xylulokinase

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 2.16
    Marker Score: 7,072
  • Cell Name: interneuron (CL0000099)
    Fold Change: 1.87
    Marker Score: 855
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 1.77
    Marker Score: 1,162
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.57
    Marker Score: 5,586
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.55
    Marker Score: 9,343
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.5
    Marker Score: 6,107
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.5
    Marker Score: 92,029
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169,246
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.44
    Marker Score: 9,244
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.43
    Marker Score: 13,568
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.37
    Marker Score: 11,764
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.35
    Marker Score: 12,728
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.34
    Marker Score: 50,806
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.34
    Marker Score: 7,183
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.33
    Marker Score: 13,687
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.32
    Marker Score: 5,700
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.28
    Marker Score: 4,946
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.27
    Marker Score: 1,966
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.27
    Marker Score: 9,708
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.22
    Marker Score: 44,948
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.18
    Marker Score: 23,510
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.1
    Marker Score: 2,588
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.02
    Marker Score: 15,246
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,806
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,030
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 500
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 454
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.94
    Marker Score: 1,533
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,735
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5,182
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 318
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,296
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.87
    Marker Score: 364
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.86
    Marker Score: 3,547
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.82
    Marker Score: 1,669
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.79
    Marker Score: 252
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 389
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 572
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.75
    Marker Score: 299
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.75
    Marker Score: 3,125
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.73
    Marker Score: 1,389
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.71
    Marker Score: 650
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.7
    Marker Score: 190
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.67
    Marker Score: 374
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.66
    Marker Score: 2,777
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.65
    Marker Score: 446
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.63
    Marker Score: 1,106
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6
    Marker Score: 9,443
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.6
    Marker Score: 2,782
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.59
    Marker Score: 992
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.57
    Marker Score: 643
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.56
    Marker Score: 11,983
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.54
    Marker Score: 200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.53
    Marker Score: 899
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.53
    Marker Score: 348
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.52
    Marker Score: 153
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.52
    Marker Score: 312
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.52
    Marker Score: 555
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.51
    Marker Score: 193
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.5
    Marker Score: 964
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.48
    Marker Score: 1,361
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.46
    Marker Score: 396
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.45
    Marker Score: 521
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.44
    Marker Score: 164
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.43
    Marker Score: 240
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.43
    Marker Score: 251
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.43
    Marker Score: 137
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.4
    Marker Score: 436
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.4
    Marker Score: 163
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4
    Marker Score: 154
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.4
    Marker Score: 1,135
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.39
    Marker Score: 123
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.39
    Marker Score: 937
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.37
    Marker Score: 448
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.37
    Marker Score: 12,507
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.36
    Marker Score: 123
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.35
    Marker Score: 147
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.35
    Marker Score: 172
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.35
    Marker Score: 632
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.34
    Marker Score: 200
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.34
    Marker Score: 164
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.34
    Marker Score: 171
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.34
    Marker Score: 301
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.34
    Marker Score: 89
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.34
    Marker Score: 210
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.33
    Marker Score: 120
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.33
    Marker Score: 365
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.33
    Marker Score: 164
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.33
    Marker Score: 114
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.31
    Marker Score: 387
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.31
    Marker Score: 1,209
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.31
    Marker Score: 1,296
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.31
    Marker Score: 327
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.31
    Marker Score: 231
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.31
    Marker Score: 106
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.31
    Marker Score: 245

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Xylulokinase is a glycosyltransferase enzyme that catalyzes the phosphorylation of xylulose to form xylulose-5-phosphate. This reaction is a critical step in the metabolism of carbohydrates, particularly in the pentose phosphate pathway. The enzyme exhibits high specificity for xylulose, with minimal activity towards other sugars. Xylulokinase is also involved in the generation of precursor metabolites and energy, highlighting its significance in energy homeostasis. **Pathways and Functions:** Xylulokinase is integral to several metabolic pathways, including: 1. **Carbohydrate Phosphorylation:** The enzyme phosphorylates xylulose to form xylulose-5-phosphate, which is a crucial intermediate in the pentose phosphate pathway. 2. **D-Xylose Metabolic Process:** Xylulokinase is involved in the conversion of D-xylose to xylulose-5-phosphate, which is essential for the metabolism of this sugar. 3. **Generation of Precursor Metabolites and Energy:** The enzyme contributes to the generation of precursor metabolites, which are essential for energy production and other cellular processes. 4. **Xylulose Catabolic Process:** Xylulokinase is also involved in the catabolism of xylulose, further emphasizing its role in carbohydrate metabolism. **Clinical Significance:** Xylulokinase has been implicated in various diseases and disorders, including: 1. **Neurological Disorders:** Abnormalities in xylulokinase expression have been linked to neurological disorders, such as autism and schizophrenia. 2. **Metabolic Disorders:** Impaired xylulokinase activity has been associated with metabolic disorders, such as type 2 diabetes and obesity. 3. **Cancer:** The enzyme has been shown to play a role in cancer cell metabolism, with implications for cancer therapy. In conclusion, xylulokinase (XYLB) is a vital enzyme in carbohydrate metabolism, with far-reaching implications for energy homeostasis, neurotransmitter synthesis, and disease susceptibility. Further research is necessary to fully elucidate the mechanisms underlying xylulokinase function and its role in human health and disease.

Genular Protein ID: 4291197485

Symbol: XYLB_HUMAN

Name: Xylulose kinase

UniProtKB Accession Codes:

O75191 B2RAW4 B4DDT2 B9EH64

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 8 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 2 EMBL 8 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 4 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9763671

Title: Genomic structure of a novel human gene (XYLB) on chromosome 3p22-->p21.3 encoding a xylulokinase-like protein.

PubMed ID: 9763671

DOI: 10.1159/000015076

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 23179721

Title: Structure and function of human xylulokinase, an enzyme with important roles in carbohydrate metabolism.

PubMed ID: 23179721

DOI: 10.1074/jbc.m112.427997

Sequence Information:

  • Length: 536
  • Mass: 58382
  • Checksum: E2FC1C45308D71A8
  • Sequence:
    • MAEHAPRRCC LGWDFSTQQV KVVAVDAELN VFYEESVHFD RDLPEFGTQG GVHVHKDGLT 
VTSPVLMWVQ ALDIILEKMK ASGFDFSQVL ALSGAGQQHG SIYWKAGAQQ ALTSLSPDLR 
LHQQLQDCFS ISDCPVWMDS STTAQCRQLE AAVGGAQALS CLTGSRAYER FTGNQIAKIY 
QQNPEAYSHT ERISLVSSFA ASLFLGSYSP IDYSDGSGMN LLQIQDKVWS QACLGACAPH 
LEEKLSPPVP SCSVVGAISS YYVQRYGFPP GCKVVAFTGD NPASLAGMRL EEGDIAVSLG 
TSDTLFLWLQ EPMPALEGHI FCNPVDSQHY MALLCFKNGS LMREKIRNES VSRSWSDFSK 
ALQSTEMGNG GNLGFYFDVM EITPEIIGRH RFNTENHKVA AFPGDVEVRA LIEGQFMAKR 
IHAEGLGYRV MSKTKILATG GASHNREILQ VLADVFDAPV YVIDTANSAC VGSAYRAFHG 
LAGGTDVPFS EVVKLAPNPR LAATPSPGAS QVYEALLPQY AKLEQRILSQ TRGPPE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.