Details for: OXSR1
Associated with
Other Information
Genular Protein ID: 3716294105
Symbol: OXSR1_HUMAN
Name: Serine/threonine-protein kinase OSR1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10083736
Title: Isolation and characterization of a novel serine threonine kinase gene on chromosome 3p22-21.3.
PubMed ID: 10083736
PubMed ID: 10470851
Title: Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
PubMed ID: 10470851
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 14707132
Title: Characterization of OSR1, a member of the mammalian Ste20p/germinal center kinase subfamily.
PubMed ID: 14707132
PubMed ID: 16389068
Title: Identification of RELT homologues that associate with RELT and are phosphorylated by OSR1.
PubMed ID: 16389068
PubMed ID: 16669787
Title: Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1.
PubMed ID: 16669787
DOI: 10.1042/bj20060220
PubMed ID: 16832045
Title: WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cells.
PubMed ID: 16832045
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 17190791
Title: Regulation of activity and localization of the WNK1 protein kinase by hyperosmotic stress.
PubMed ID: 17190791
PubMed ID: 17525332
Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
PubMed ID: 17525332
PubMed ID: 18270262
Title: Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1.
PubMed ID: 18270262
DOI: 10.1242/jcs.025312
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 18318008
Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.
PubMed ID: 18318008
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19665974
Title: Sites of regulated phosphorylation that control K-Cl cotransporter activity.
PubMed ID: 19665974
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21321328
Title: Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways.
PubMed ID: 21321328
DOI: 10.1242/jcs.077230
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22989884
Title: Interactions with WNK (with no lysine) family members regulate oxidative stress response 1 and ion co-transporter activity.
PubMed ID: 22989884
PubMed ID: 22361696
Title: Systematic validation of antibody binding and protein subcellular localization using siRNA and confocal microscopy.
PubMed ID: 22361696
PubMed ID: 22052202
Title: Identification of PLSCR1 as a protein that interacts with RELT family members.
PubMed ID: 22052202
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 23386621
Title: WNK1 protein kinase regulates embryonic cardiovascular development through the OSR1 signaling cascade.
PubMed ID: 23386621
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25362046
Title: Actions of the protein kinase WNK1 on endothelial cells are differentially mediated by its substrate kinases OSR1 and SPAK.
PubMed ID: 25362046
PubMed ID: 28688764
Title: RELT family members activate p38 and induce apoptosis by a mechanism distinct from TNFR1.
PubMed ID: 28688764
PubMed ID: 29581290
Title: OSR1 regulates a subset of inward rectifier potassium channels via a binding motif variant.
PubMed ID: 29581290
PubMed ID: 34289367
Title: Phosphorylated WNK kinase networks in recoded bacteria recapitulate physiological function.
PubMed ID: 34289367
PubMed ID: 17721439
Title: Structural insights into the recognition of substrates and activators by the OSR1 kinase.
PubMed ID: 17721439
PubMed ID: 17344846
Title: Patterns of somatic mutation in human cancer genomes.
PubMed ID: 17344846
DOI: 10.1038/nature05610
Sequence Information:
- Length: 527
- Mass: 58022
- Checksum: B46EC934E95A3A1F
- Sequence:
MSEDSSALPW SINRDDYELQ EVIGSGATAV VQAAYCAPKK EKVAIKRINL EKCQTSMDEL LKEIQAMSQC HHPNIVSYYT SFVVKDELWL VMKLLSGGSV LDIIKHIVAK GEHKSGVLDE STIATILREV LEGLEYLHKN GQIHRDVKAG NILLGEDGSV QIADFGVSAF LATGGDITRN KVRKTFVGTP CWMAPEVMEQ VRGYDFKADI WSFGITAIEL ATGAAPYHKY PPMKVLMLTL QNDPPSLETG VQDKEMLKKY GKSFRKMISL CLQKDPEKRP TAAELLRHKF FQKAKNKEFL QEKTLQRAPT ISERAKKVRR VPGSSGRLHK TEDGGWEWSD DEFDEESEEG KAAISQLRSP RVKESISNSE LFPTTDPVGT LLQVPEQISA HLPQPAGQIA TQPTQVSLPP TAEPAKTAQA LSSGSGSQET KIPISLVLRL RNSKKELNDI RFEFTPGRDT AEGVSQELIS AGLVDGRDLV IVAANLQKIV EEPQSNRSVT FKLASGVEGS DIPDDGKLIG FAQLSIS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.