CDC25C | ENSG00000158402 | NCBI 995

Details for: CDC25C

Gene ID: 995

Symbol: CDC25C

Ensembl ID: ENSG00000158402

Description: cell division cycle 25C

Associated with

Activation of atr in response to replication stress
(R-HSA-176187)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Chk1/chk2(cds1) mediated inactivation of cyclin b:cdk1 complex
(R-HSA-75035)
Cyclin a/b1/b2 associated events during g2/m transition
(R-HSA-69273)
Defective intrinsic pathway for apoptosis
(R-HSA-9734009)
Deregulated cdk5 triggers multiple neurodegenerative pathways in alzheimer's disease models
(R-HSA-8862803)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
G2/m checkpoints
(R-HSA-69481)
G2/m dna damage checkpoint
(R-HSA-69473)
G2/m transition
(R-HSA-69275)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Mitotic g2-g2/m phases
(R-HSA-453274)
Neurodegenerative diseases
(R-HSA-8863678)
Polo-like kinase mediated events
(R-HSA-156711)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate pkns
(R-HSA-5625740)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
Tp53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
(R-HSA-6804115)
Tp53 regulates transcription of cell cycle genes
(R-HSA-6791312)
Tp53 regulates transcription of genes involved in g2 cell cycle arrest
(R-HSA-6804114)
Transcriptional regulation by tp53
(R-HSA-3700989)
Cell division
(GO:0051301)
Cell population proliferation
(GO:0008283)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
G2/m transition of mitotic cell cycle
(GO:0000086)
Mitochondrial intermembrane space
(GO:0005758)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Perinuclear region of cytoplasm
(GO:0048471)
Phosphoprotein phosphatase activity
(GO:0004721)
Positive regulation of g2/mi transition of meiotic cell cycle
(GO:0110032)
Positive regulation of g2/m transition of mitotic cell cycle
(GO:0010971)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Protein tyrosine phosphatase activity
(GO:0004725)
Regulation of cyclin-dependent protein serine/threonine kinase activity
(GO:0000079)
Regulation of mitotic nuclear division
(GO:0007088)
Spermatogenesis
(GO:0007283)
Ww domain binding
(GO:0050699)

Other Information

Proteins

M-phase inducer phosphatase 3
B4DX61_HUMAN

Genular Protein ID: 1959914231

Symbol: MPIP3_HUMAN

Name: M-phase inducer phosphatase 3

UniProtKB Accession Codes:

P30307 D3DQB8 Q96PL3 Q9H168 Q9H2E8 Q9H2E9 Q9H2F1

Database IDs:

Citations:

PubMed ID: 2195549

Title: Human homolog of fission yeast cdc25 mitotic inducer is predominantly expressed in G2.

PubMed ID: 2195549

DOI: 10.1073/pnas.87.13.5139

PubMed ID: 11078813

Title: An additional transcript of the cdc25C gene from A431 cells encodes a functional protein.

PubMed ID: 11078813

DOI: 10.3892/ijo.17.6.1251

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11139144

Title: Alternative splicing in the regulatory region of the human phosphatases CDC25A and CDC25C.

PubMed ID: 11139144

DOI: 10.1078/0171-9335-00115

PubMed ID: 11304565

Title: Differential expression of cdc25 cell-cycle-activating phosphatases in human colorectal carcinoma.

PubMed ID: 11304565

DOI: 10.1038/labinvest.3780254

PubMed ID: 8119945

Title: Activation of p34cdc2 protein kinase by microinjection of human cdc25C into mammalian cells. Requirement for prior phosphorylation of cdc25C by p34cdc2 on sites phosphorylated at mitosis.

PubMed ID: 8119945

DOI: 10.1016/s0021-9258(17)37560-9

PubMed ID: 10557092

Title: The physical association and phosphorylation of Cdc25C protein phosphatase by Prk.

PubMed ID: 10557092

DOI: 10.1038/sj.onc.1202983

PubMed ID: 11202906

Title: The human polo-like kinase, PLK, regulates cdc2/cyclin B through phosphorylation and activation of the cdc25C phosphatase.

PubMed ID: 11202906

DOI: 10.1016/s0898-6568(00)00080-2

PubMed ID: 11333986

Title: Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase.

PubMed ID: 11333986

DOI: 10.1038/35075107

PubMed ID: 12941695

Title: Functional analysis of C-TAK1 substrate binding and identification of PKP2 as a new C-TAK1 substrate.

PubMed ID: 12941695

DOI: 10.1093/emboj/cdg426

PubMed ID: 12595692

Title: Proteomic screen finds pSer/pThr-binding domain localizing Plk1 to mitotic substrates.

PubMed ID: 12595692

DOI: 10.1126/science.1079079

PubMed ID: 15150265

Title: Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function.

PubMed ID: 15150265

DOI: 10.1074/jbc.m404728200

PubMed ID: 14968113

Title: Cdc25C phosphorylation on serine 191 by Plk3 promotes its nuclear translocation.

PubMed ID: 14968113

DOI: 10.1038/sj.onc.1207425

PubMed ID: 14972559

Title: The human immunodeficiency virus Vpr protein binds Cdc25C: implications for G2 arrest.

PubMed ID: 14972559

DOI: 10.1016/j.virol.2003.10.007

PubMed ID: 15629715

Title: MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation.

PubMed ID: 15629715

DOI: 10.1016/j.molcel.2004.11.021

PubMed ID: 18239451

Title: Human Plk4 phosphorylates Cdc25C.

PubMed ID: 18239451

DOI: 10.4161/cc.7.4.5387

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

Length: 473
Mass: 53365
Checksum: 0658A1F1B9B8996A
Sequence:

MSTELFSSTR EEGSSGSGPS FRSNQRKMLN LLLERDTSFT VCPDVPRTPV GKFLGDSANL 
SILSGGTPKR CLDLSNLSSG EITATQLTTS ADLDETGHLD SSGLQEVHLA GMNHDQHLMK 
CSPAQLLCST PNGLDRGHRK RDAMCSSSAN KENDNGNLVD SEMKYLGSPI TTVPKLDKNP 
NLGEDQAEEI SDELMEFSLK DQEAKVSRSG LYRSPSMPEN LNRPRLKQVE KFKDNTIPDK 
VKKKYFSGQG KLRKGLCLKK TVSLCDITIT QMLEEDSNQG HLIGDFSKVC ALPTVSGKHQ 
DLKYVNPETV AALLSGKFQG LIEKFYVIDC RYPYEYLGGH IQGALNLYSQ EELFNFFLKK 
PIVPLDTQKR IIIVFHCEFS SERGPRMCRC LREEDRSLNQ YPALYYPELY ILKGGYRDFF 
PEYMELCEPQ SYCPMHHQDH KTELLRCRSQ SKVQEGERQL REQIALLVKD MSP

Genular Protein ID: 1906827771

Symbol: B4DX61_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DX61

Database IDs:

Sequence Information:

Length: 490
Mass: 55233
Checksum: C7887A2D35921EF4
Sequence:

MSEEARFCFS PGENSKTMST ELFSSTREEG SSGSGPSFRS NQRKMLNLLL ERDTSFTVCP 
DVPRTPVGKF LGDSANLSIL SGGTPKRCLD LSNLSSGEIT ATQLTTSADL DETGHLDSSG 
LQEVHLAGMN HDQHLMKCSP AQLLCSTPNG LDRGHRKRDA MCSSSANKEN DNGNLVDSEM 
KYLGSPITTV PKLDKNPNLG EDQAEEISDE LMEFSLKDQE AKVSRSGLYR SPSMPENLNR 
PRLKQVEKFK DNTIPDKVKK KYFSGQGKLR KGLCLKKTVS LCDITITQML EEDSNQGHLI 
GDFSKVCALP TVSGKHQDLK YVNPETVAAL LSGKFQGLIE KFYVIDCRYP YEYLGGHIQG 
ALNLYSQEEL FNFFLKKPIV PLDTQKRIII VLHCEFSSER GPRMCRCLRE EDRSLNQYPA 
LYYPELYILK GGYRDFFPEY MELCEPQSYC PMHHQDHKTE LLRCRSQSKV QEGERQLREQ 
IALLVKDMSP

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CDC25C

Associated with

Other Information

Human homolog of fission yeast cdc25 mitotic inducer is predominantly expressed in G2. PubMed ID: 2195549

An additional transcript of the cdc25C gene from A431 cells encodes a functional protein. PubMed ID: 11078813

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Alternative splicing in the regulatory region of the human phosphatases CDC25A and CDC25C. PubMed ID: 11139144

Differential expression of cdc25 cell-cycle-activating phosphatases in human colorectal carcinoma. PubMed ID: 11304565

Activation of p34cdc2 protein kinase by microinjection of human cdc25C into mammalian cells. Requirement for prior phosphorylation of cdc25C by p34cdc2 on sites phosphorylated at mitosis. PubMed ID: 8119945

The physical association and phosphorylation of Cdc25C protein phosphatase by Prk. PubMed ID: 10557092

The human polo-like kinase, PLK, regulates cdc2/cyclin B through phosphorylation and activation of the cdc25C phosphatase. PubMed ID: 11202906

Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase. PubMed ID: 11333986

Functional analysis of C-TAK1 substrate binding and identification of PKP2 as a new C-TAK1 substrate. PubMed ID: 12941695

Proteomic screen finds pSer/pThr-binding domain localizing Plk1 to mitotic substrates. PubMed ID: 12595692

Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function. PubMed ID: 15150265

Cdc25C phosphorylation on serine 191 by Plk3 promotes its nuclear translocation. PubMed ID: 14968113

The human immunodeficiency virus Vpr protein binds Cdc25C: implications for G2 arrest. PubMed ID: 14972559

MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation. PubMed ID: 15629715

Human Plk4 phosphorylates Cdc25C. PubMed ID: 18239451

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163