Details for: CDC25C
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 17.2289
Cell Significance Index: -4.3700 - Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 13.2759
Cell Significance Index: -2.0700 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 10.3875
Cell Significance Index: -4.2200 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 4.4515
Cell Significance Index: -4.2500 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 3.5038
Cell Significance Index: -4.3200 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 2.5114
Cell Significance Index: 153.9700 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 1.0143
Cell Significance Index: 14.5300 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.6906
Cell Significance Index: 137.0500 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 0.6671
Cell Significance Index: -1.4600 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.6286
Cell Significance Index: 13.0400 - Cell Name: salivary gland cell (CL0009005)
Fold Change: 0.6169
Cell Significance Index: 7.6600 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.5993
Cell Significance Index: 33.6300 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.5685
Cell Significance Index: 6.1800 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4863
Cell Significance Index: 48.1100 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.4568
Cell Significance Index: 49.6900 - Cell Name: hepatoblast (CL0005026)
Fold Change: 0.4423
Cell Significance Index: 7.4400 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.4372
Cell Significance Index: 83.2100 - Cell Name: sensory neuron (CL0000101)
Fold Change: 0.3835
Cell Significance Index: 2.1800 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.3714
Cell Significance Index: 10.3800 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.3174
Cell Significance Index: 5.4400 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.2610
Cell Significance Index: 235.7000 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.2538
Cell Significance Index: 6.8000 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.2064
Cell Significance Index: 4.3200 - Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 0.2054
Cell Significance Index: 2.8500 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.1990
Cell Significance Index: 23.1900 - Cell Name: colon endothelial cell (CL1001572)
Fold Change: 0.1965
Cell Significance Index: 0.1500 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.1901
Cell Significance Index: 6.0900 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1899
Cell Significance Index: 13.1400 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.1706
Cell Significance Index: 5.9300 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.1486
Cell Significance Index: 17.5200 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 0.1472
Cell Significance Index: 4.3400 - Cell Name: lens fiber cell (CL0011004)
Fold Change: 0.1277
Cell Significance Index: 4.0400 - Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
Fold Change: 0.1243
Cell Significance Index: 1.1300 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.1143
Cell Significance Index: 6.8600 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.1088
Cell Significance Index: 5.6500 - Cell Name: glioblast (CL0000030)
Fold Change: 0.0971
Cell Significance Index: 0.6100 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0710
Cell Significance Index: 3.2200 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0632
Cell Significance Index: 1.8200 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0608
Cell Significance Index: 12.2000 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.0588
Cell Significance Index: 9.5600 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0536
Cell Significance Index: 1.3400 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0388
Cell Significance Index: 21.1900 - Cell Name: radial glial cell (CL0000681)
Fold Change: 0.0303
Cell Significance Index: 0.1800 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0248
Cell Significance Index: 8.9000 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0175
Cell Significance Index: 3.1500 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.0148
Cell Significance Index: 0.3200 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0136
Cell Significance Index: 0.2900 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.0093
Cell Significance Index: 1.3500 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 0.0078
Cell Significance Index: 0.0500 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0071
Cell Significance Index: 0.2500 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0064
Cell Significance Index: 0.1700 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0040
Cell Significance Index: 1.7700 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0025
Cell Significance Index: 4.6800 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0015
Cell Significance Index: 2.0000 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0008
Cell Significance Index: 1.3900 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0000
Cell Significance Index: 0.0000 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0006
Cell Significance Index: -0.9200 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0034
Cell Significance Index: -0.1500 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0040
Cell Significance Index: -2.5700 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0053
Cell Significance Index: -3.9400 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: -0.0055
Cell Significance Index: -0.0400 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0056
Cell Significance Index: -4.2300 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0066
Cell Significance Index: -2.9800 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0071
Cell Significance Index: -4.0100 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0076
Cell Significance Index: -4.7400 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0081
Cell Significance Index: -1.0000 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0084
Cell Significance Index: -2.4200 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0092
Cell Significance Index: -1.5700 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0101
Cell Significance Index: -1.0300 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0165
Cell Significance Index: -2.2700 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0214
Cell Significance Index: -4.5000 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0247
Cell Significance Index: -2.8300 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.0249
Cell Significance Index: -0.3400 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.0301
Cell Significance Index: -0.7300 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0307
Cell Significance Index: -1.8900 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.0319
Cell Significance Index: -0.3300 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0334
Cell Significance Index: -4.3200 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0342
Cell Significance Index: -2.3000 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0400
Cell Significance Index: -4.1700 - Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: -0.0416
Cell Significance Index: -0.4200 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.0449
Cell Significance Index: -1.2000 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0457
Cell Significance Index: -3.5100 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0481
Cell Significance Index: -1.8200 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0484
Cell Significance Index: -2.1400 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0503
Cell Significance Index: -3.5600 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0552
Cell Significance Index: -1.4100 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0636
Cell Significance Index: -4.7400 - Cell Name: germ cell (CL0000586)
Fold Change: -0.0642
Cell Significance Index: -0.4800 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0643
Cell Significance Index: -3.3500 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0677
Cell Significance Index: -4.3700 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.0697
Cell Significance Index: -1.0500 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0726
Cell Significance Index: -3.4100 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.0754
Cell Significance Index: -1.8800 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0754
Cell Significance Index: -2.6400 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.0847
Cell Significance Index: -1.8100 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0870
Cell Significance Index: -4.5700 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0899
Cell Significance Index: -2.3100 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0926
Cell Significance Index: -2.9500 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.0933
Cell Significance Index: -1.8200 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0944
Cell Significance Index: -3.0900
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1959914231
Symbol: MPIP3_HUMAN
Name: M-phase inducer phosphatase 3
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2195549
Title: Human homolog of fission yeast cdc25 mitotic inducer is predominantly expressed in G2.
PubMed ID: 2195549
PubMed ID: 11078813
Title: An additional transcript of the cdc25C gene from A431 cells encodes a functional protein.
PubMed ID: 11078813
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11139144
Title: Alternative splicing in the regulatory region of the human phosphatases CDC25A and CDC25C.
PubMed ID: 11139144
PubMed ID: 11304565
Title: Differential expression of cdc25 cell-cycle-activating phosphatases in human colorectal carcinoma.
PubMed ID: 11304565
PubMed ID: 8119945
Title: Activation of p34cdc2 protein kinase by microinjection of human cdc25C into mammalian cells. Requirement for prior phosphorylation of cdc25C by p34cdc2 on sites phosphorylated at mitosis.
PubMed ID: 8119945
PubMed ID: 10557092
Title: The physical association and phosphorylation of Cdc25C protein phosphatase by Prk.
PubMed ID: 10557092
PubMed ID: 11202906
Title: The human polo-like kinase, PLK, regulates cdc2/cyclin B through phosphorylation and activation of the cdc25C phosphatase.
PubMed ID: 11202906
PubMed ID: 11333986
Title: Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase.
PubMed ID: 11333986
DOI: 10.1038/35075107
PubMed ID: 12941695
Title: Functional analysis of C-TAK1 substrate binding and identification of PKP2 as a new C-TAK1 substrate.
PubMed ID: 12941695
DOI: 10.1093/emboj/cdg426
PubMed ID: 12595692
Title: Proteomic screen finds pSer/pThr-binding domain localizing Plk1 to mitotic substrates.
PubMed ID: 12595692
PubMed ID: 15150265
Title: Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function.
PubMed ID: 15150265
PubMed ID: 14968113
Title: Cdc25C phosphorylation on serine 191 by Plk3 promotes its nuclear translocation.
PubMed ID: 14968113
PubMed ID: 14972559
Title: The human immunodeficiency virus Vpr protein binds Cdc25C: implications for G2 arrest.
PubMed ID: 14972559
PubMed ID: 15629715
Title: MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation.
PubMed ID: 15629715
PubMed ID: 18239451
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
Sequence Information:
- Length: 473
- Mass: 53365
- Checksum: 0658A1F1B9B8996A
- Sequence:
MSTELFSSTR EEGSSGSGPS FRSNQRKMLN LLLERDTSFT VCPDVPRTPV GKFLGDSANL SILSGGTPKR CLDLSNLSSG EITATQLTTS ADLDETGHLD SSGLQEVHLA GMNHDQHLMK CSPAQLLCST PNGLDRGHRK RDAMCSSSAN KENDNGNLVD SEMKYLGSPI TTVPKLDKNP NLGEDQAEEI SDELMEFSLK DQEAKVSRSG LYRSPSMPEN LNRPRLKQVE KFKDNTIPDK VKKKYFSGQG KLRKGLCLKK TVSLCDITIT QMLEEDSNQG HLIGDFSKVC ALPTVSGKHQ DLKYVNPETV AALLSGKFQG LIEKFYVIDC RYPYEYLGGH IQGALNLYSQ EELFNFFLKK PIVPLDTQKR IIIVFHCEFS SERGPRMCRC LREEDRSLNQ YPALYYPELY ILKGGYRDFF PEYMELCEPQ SYCPMHHQDH KTELLRCRSQ SKVQEGERQL REQIALLVKD MSP
Genular Protein ID: 1906827771
Symbol: B4DX61_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 490
- Mass: 55233
- Checksum: C7887A2D35921EF4
- Sequence:
MSEEARFCFS PGENSKTMST ELFSSTREEG SSGSGPSFRS NQRKMLNLLL ERDTSFTVCP DVPRTPVGKF LGDSANLSIL SGGTPKRCLD LSNLSSGEIT ATQLTTSADL DETGHLDSSG LQEVHLAGMN HDQHLMKCSP AQLLCSTPNG LDRGHRKRDA MCSSSANKEN DNGNLVDSEM KYLGSPITTV PKLDKNPNLG EDQAEEISDE LMEFSLKDQE AKVSRSGLYR SPSMPENLNR PRLKQVEKFK DNTIPDKVKK KYFSGQGKLR KGLCLKKTVS LCDITITQML EEDSNQGHLI GDFSKVCALP TVSGKHQDLK YVNPETVAAL LSGKFQGLIE KFYVIDCRYP YEYLGGHIQG ALNLYSQEEL FNFFLKKPIV PLDTQKRIII VLHCEFSSER GPRMCRCLRE EDRSLNQYPA LYYPELYILK GGYRDFFPEY MELCEPQSYC PMHHQDHKTE LLRCRSQSKV QEGERQLREQ IALLVKDMSP
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.