Details for: HS3ST4

Gene ID: 9951

Symbol: HS3ST4

Ensembl ID: ENSG00000182601

Description: heparan sulfate-glucosamine 3-sulfotransferase 4

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granule cell (CL0000120)
    Fold Change: 5.6
    Marker Score: 42,212
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 5.07
    Marker Score: 1,834
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 4.8
    Marker Score: 11,031
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 4.16
    Marker Score: 22,333
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 4.15
    Marker Score: 2,848
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 3.85
    Marker Score: 11,036
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 3.48
    Marker Score: 1,732
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 3.31
    Marker Score: 1,924
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.66
    Marker Score: 3,677
  • Cell Name: T cell (CL0000084)
    Fold Change: 2.52
    Marker Score: 4,349
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.19
    Marker Score: 20,564
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.17
    Marker Score: 1,498
  • Cell Name: monocyte (CL0000576)
    Fold Change: 2.16
    Marker Score: 2,810
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 2.08
    Marker Score: 10,917
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2
    Marker Score: 122,946
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.98
    Marker Score: 888
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.95
    Marker Score: 3,703
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.92
    Marker Score: 18,283
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.88
    Marker Score: 16,113
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.81
    Marker Score: 953
  • Cell Name: interneuron (CL0000099)
    Fold Change: 1.69
    Marker Score: 773
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.53
    Marker Score: 1,149
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 1.49
    Marker Score: 1,933
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 867
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.35
    Marker Score: 2,269
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.35
    Marker Score: 13,951
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.33
    Marker Score: 2,416
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.27
    Marker Score: 1,209
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.27
    Marker Score: 2,575
  • Cell Name: macrophage (CL0000235)
    Fold Change: 1.26
    Marker Score: 1,397
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.21
    Marker Score: 1,491
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.18
    Marker Score: 1,024
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 1.14
    Marker Score: 376
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.14
    Marker Score: 4,625
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.11
    Marker Score: 3,819
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.11
    Marker Score: 377
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.02
    Marker Score: 705
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,741
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,964
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.99
    Marker Score: 578
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,402
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.97
    Marker Score: 582
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.96
    Marker Score: 5,834
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,325
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.93
    Marker Score: 1,048
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.92
    Marker Score: 705
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.92
    Marker Score: 14,433
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,740
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.91
    Marker Score: 2,203
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.91
    Marker Score: 6,063
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.88
    Marker Score: 3,652
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.86
    Marker Score: 945
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.83
    Marker Score: 738
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.8
    Marker Score: 532
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.79
    Marker Score: 249
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.79
    Marker Score: 1,626
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.78
    Marker Score: 2,226
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,259
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 704
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.76
    Marker Score: 936
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.74
    Marker Score: 664
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.74
    Marker Score: 1,071
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.72
    Marker Score: 5,544
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.72
    Marker Score: 556
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 182
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.69
    Marker Score: 4,151
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.68
    Marker Score: 845
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.67
    Marker Score: 319
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.67
    Marker Score: 278
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.66
    Marker Score: 239
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.66
    Marker Score: 248
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.63
    Marker Score: 505
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.63
    Marker Score: 703
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.63
    Marker Score: 2,614
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.62
    Marker Score: 217
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.61
    Marker Score: 594
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.61
    Marker Score: 370
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.6
    Marker Score: 964
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.59
    Marker Score: 8,866
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.58
    Marker Score: 1,376
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.58
    Marker Score: 680
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 152
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.57
    Marker Score: 115
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.57
    Marker Score: 182
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.56
    Marker Score: 868
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.56
    Marker Score: 202
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.56
    Marker Score: 310
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.55
    Marker Score: 172
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.54
    Marker Score: 4,546
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.53
    Marker Score: 300
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.51
    Marker Score: 493
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.51
    Marker Score: 296
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.51
    Marker Score: 284
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.5
    Marker Score: 1,438
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.5
    Marker Score: 131
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.5
    Marker Score: 290
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 477
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.49
    Marker Score: 494

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HS3ST4 is a type II transmembrane glycosyltransferase, which implies that it is anchored to the Golgi membrane and capable of transferring glucosamine residues to heparan sulfate chains. This enzyme is specifically expressed in various cell types, including granule cells, mature microglial cells, macroglial cells, stellate neurons, dendritic cells, retinal cone cells, central nervous system macrophages, brainstem motor neurons, double negative thymocytes, and T cells. The expression of HS3ST4 is often associated with the formation of HSPGs, which are involved in the regulation of cell signaling, cell adhesion, and immune responses. **Pathways and Functions:** HS3ST4 is involved in the biosynthesis of heparan sulfate proteoglycans, which are complex molecules composed of a core protein and a heparan sulfate chain. The sulfation of glucosamine residues by HS3ST4 is a critical step in the formation of HSPGs, which play a crucial role in various physiological processes, including: 1. **Cell signaling:** HSPGs serve as co-receptors for growth factors and other signaling molecules, regulating cell proliferation, differentiation, and survival. 2. **Immune responses:** HSPGs are involved in the regulation of immune cell functions, including cell adhesion, migration, and activation. 3. **Cell adhesion:** HSPGs interact with cell surface receptors, regulating cell-cell and cell-extracellular matrix interactions. **Clinical Significance:** Dysregulation of HS3ST4 and HSPG biosynthesis has been implicated in various diseases, including: 1. **Neurological disorders:** Abnormal HSPG expression has been linked to neurodegenerative diseases, such as Alzheimer's disease and amyotrophic lateral sclerosis. 2. **Cancer:** Altered HSPG expression has been observed in various types of cancer, including breast, lung, and colon cancer. 3. **Autoimmune diseases:** Dysregulation of HSPG expression has been implicated in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. In conclusion, HS3ST4 is a critical enzyme involved in the biosynthesis of heparan sulfate proteoglycans, which play a vital role in various physiological processes, including cell signaling, immune responses, and cellular differentiation. Further research on HS3ST4 and its dysregulation is essential to understand the underlying mechanisms of various diseases and to develop novel therapeutic strategies.

Genular Protein ID: 4080601310

Symbol: HS3S4_HUMAN

Name: Heparan sulfate glucosamine 3-O-sulfotransferase 4

UniProtKB Accession Codes:

Q9Y661 Q5QI42 Q8NDC2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 9 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 5 Ensembl 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 3 SAM 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 9988767

Title: Multiple isoforms of heparan sulfate D-glucosaminyl 3-O-sulfotransferase. Isolation, characterization, and expression of human cDNAs and identification of distinct genomic loci.

PubMed ID: 9988767

DOI: 10.1074/jbc.274.8.5170

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

Sequence Information:

  • Length: 456
  • Mass: 49799
  • Checksum: A1BA47F9817F6B38
  • Sequence:
    • MARWPAPPPP PPPPPPLAAP PPPGASAKGP PARKLLFMCT LSLSVTYLCY SLLGGSGSLQ 
FPLALQESPG AAAEPPPSPP PPSLLPTPVR LGAPSQPPAP PPLDNASHGE PPEPPEQPAA 
PGTDGWGLPS GGGGAQDAWL RTPLAPSEMI TAQSALPERE AQESSTTDED LAGRRAANGS 
SERGGAVSTP DYGEKKLPQA LIIGVKKGGT RALLEAIRVH PDVRAVGVEP HFFDRNYEKG 
LEWYRNVMPK TLDGQITMEK TPSYFVTNEA PKRIHSMAKD IKLIVVVRNP VTRAISDYTQ 
TLSKKPEIPT FEVLAFKNRT LGLIDASWSA IRIGIYALHL ENWLQYFPLS QILFVSGERL 
IVDPAGEMAK VQDFLGLKRV VTEKHFYFNK TKGFPCLKKP EDSSAPRCLG KSKGRTHPRI 
DPDVIHRLRK FYKPFNLMFY QMTGQDFQWE QEEGDK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.