Details for: USP15

Gene ID: 9958

Symbol: USP15

Ensembl ID: ENSG00000135655

Description: ubiquitin specific peptidase 15

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.91
    Marker Score: 64,991
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.88
    Marker Score: 161,005
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 2.8
    Marker Score: 1,011
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.69
    Marker Score: 90,761
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 2.62
    Marker Score: 1,300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.57
    Marker Score: 5,652
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.48
    Marker Score: 28,835
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.28
    Marker Score: 120,649
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.24
    Marker Score: 1,340
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 2.23
    Marker Score: 778
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.16
    Marker Score: 38,341
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 2.14
    Marker Score: 2,112
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.12
    Marker Score: 2,444
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 2.09
    Marker Score: 3,807
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 2.06
    Marker Score: 4,325
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.06
    Marker Score: 2,842
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 2.06
    Marker Score: 998
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.05
    Marker Score: 600
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 2.02
    Marker Score: 1,263
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2
    Marker Score: 3,894
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.99
    Marker Score: 75,540
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 1.98
    Marker Score: 1,503
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.98
    Marker Score: 1,108
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.98
    Marker Score: 852
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.95
    Marker Score: 2,154
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.94
    Marker Score: 29,058
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.94
    Marker Score: 38,599
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.94
    Marker Score: 4,728
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.92
    Marker Score: 70,969
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.91
    Marker Score: 1,788
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.9
    Marker Score: 18,814
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.9
    Marker Score: 6,751
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.88
    Marker Score: 14,433
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.88
    Marker Score: 1,130
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.87
    Marker Score: 115,182
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.85
    Marker Score: 17,448
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.85
    Marker Score: 7,657
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.84
    Marker Score: 439
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.84
    Marker Score: 650
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.84
    Marker Score: 2,223
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.83
    Marker Score: 2,213
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.83
    Marker Score: 1,435
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.81
    Marker Score: 2,254
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.81
    Marker Score: 6,991
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.81
    Marker Score: 1,949
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.8
    Marker Score: 7,348
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.8
    Marker Score: 898
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.8
    Marker Score: 5,671
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.79
    Marker Score: 393
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.79
    Marker Score: 727
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.78
    Marker Score: 1,876
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.78
    Marker Score: 7,453
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.78
    Marker Score: 1,458
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.78
    Marker Score: 4,423
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.77
    Marker Score: 3,413
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.77
    Marker Score: 2,386
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.77
    Marker Score: 740
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.76
    Marker Score: 1,653
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.75
    Marker Score: 1,274
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.75
    Marker Score: 342
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 1.74
    Marker Score: 9,148
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.74
    Marker Score: 529
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.74
    Marker Score: 16,529
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 1.74
    Marker Score: 378
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.73
    Marker Score: 7,437
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.73
    Marker Score: 640
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.73
    Marker Score: 1,590
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.73
    Marker Score: 1,250
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.72
    Marker Score: 1,871
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.71
    Marker Score: 14,683
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.71
    Marker Score: 1,499
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.71
    Marker Score: 1,315
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.71
    Marker Score: 4,787
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 1.7
    Marker Score: 380
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 1.69
    Marker Score: 388
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.69
    Marker Score: 17,455
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 1.68
    Marker Score: 435
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.68
    Marker Score: 35,756
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.67
    Marker Score: 2,010
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 1.67
    Marker Score: 415
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.66
    Marker Score: 623
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.66
    Marker Score: 678
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 1.65
    Marker Score: 407
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1.65
    Marker Score: 1,211
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.65
    Marker Score: 1,432
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 1.65
    Marker Score: 8,853
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.64
    Marker Score: 858
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 1.64
    Marker Score: 1,815
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.64
    Marker Score: 1,739
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.64
    Marker Score: 863
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 1.63
    Marker Score: 406
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.63
    Marker Score: 7,533
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.63
    Marker Score: 469
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.62
    Marker Score: 951
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 1.62
    Marker Score: 477
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.61
    Marker Score: 943
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 1.61
    Marker Score: 559
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.61
    Marker Score: 1,739
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.61
    Marker Score: 3,878
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 1.6
    Marker Score: 986

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** USP15 is characterized by its ability to recognize and remove ubiquitin chains from specific protein substrates. It is a K48-linked deubiquitinating enzyme, meaning that it specifically targets proteins that have been ubiquitinated at lysine 48 residues. USP15 has also been shown to possess cysteine-type endopeptidase activity, which allows it to cleave peptide bonds in proteins. Additionally, USP15 has been implicated in the regulation of transforming growth factor-beta (TGF-β) receptor signaling, a critical pathway involved in cell growth, differentiation, and apoptosis. **Pathways and Functions** USP15 is involved in several key cellular pathways, including: 1. **BMP signaling pathway**: USP15 has been shown to regulate BMP signaling by deubiquitinating and activating BMP receptors. 2. **Cysteine-type deubiquitinase activity**: USP15 is a cysteine-type deubiquitinase that removes ubiquitin chains from protein substrates. 3. **Cysteine-type endopeptidase activity**: USP15 possesses cysteine-type endopeptidase activity, allowing it to cleave peptide bonds in proteins. 4. **Negative regulation of TGF-β receptor signaling**: USP15 has been shown to negatively regulate TGF-β receptor signaling by deubiquitinating and inhibiting the activity of TGF-β receptors. 5. **Positive regulation of RIG-I signaling pathway**: USP15 has been implicated in the positive regulation of the RIG-I signaling pathway, which is involved in the recognition of viral RNA and the activation of innate immune responses. **Clinical Significance** USP15 has been implicated in various diseases, including: 1. **Autoimmune disorders**: USP15 has been shown to regulate the activity of TGF-β receptors, which are involved in the regulation of immune responses. Dysregulation of USP15 has been implicated in autoimmune disorders, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer**: USP15 has been shown to regulate the activity of TGF-β receptors, which are involved in the regulation of cell growth and differentiation. Dysregulation of USP15 has been implicated in various types of cancer, including breast cancer and lung cancer. 3. **Neurodegenerative diseases**: USP15 has been implicated in the regulation of RIG-I signaling pathway, which is involved in the recognition of viral RNA and the activation of innate immune responses. Dysregulation of USP15 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. In conclusion, USP15 is a complex gene that plays a critical role in various cellular processes, including cell signaling, apoptosis, and immune responses. Its dysregulation has been implicated in various diseases, including autoimmune disorders, cancer, and neurodegenerative diseases. Further research is needed to fully elucidate the mechanisms by which USP15 regulates cellular processes and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 2815459959

Symbol: UBP15_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9Y4E8 Q08AL5 Q9H8G9 Q9HCA6 Q9UNP0 Q9Y5B5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 12 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 25 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 24 PDBsum 15 PRO 1 PROSITE 4 PROSITE-ProRule 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 3 RefSeq 3 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9628581

Title: Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9628581

DOI: 10.1093/dnares/5.1.31

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10444327

Title: Identification, functional characterization, and chromosomal localization of USP15, a novel human ubiquitin-specific protease related to the UNP oncoprotein, and a systematic nomenclature for human ubiquitin-specific proteases.

PubMed ID: 10444327

DOI: 10.1006/geno.1999.5879

PubMed ID: 12532266

Title: Isolation and characterization of the mouse ubiquitin-specific protease Usp15.

PubMed ID: 12532266

DOI: 10.1007/s00335-002-3035-0

PubMed ID: 16005295

Title: The zinc finger of the CSN-associated deubiquitinating enzyme USP15 is essential to rescue the E3 ligase Rbx1.

PubMed ID: 16005295

DOI: 10.1016/j.cub.2005.05.059

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17318178

Title: CSN controls NF-kappaB by deubiquitinylation of IkappaBalpha.

PubMed ID: 17318178

DOI: 10.1038/sj.emboj.7601600

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19826004

Title: COP9 signalosome interacts ATP-dependently with p97/valosin-containing protein (VCP) and controls the ubiquitination status of proteins bound to p97/VCP.

PubMed ID: 19826004

DOI: 10.1074/jbc.m109.037952

PubMed ID: 19576224

Title: The COP9 signalosome mediates beta-catenin degradation by deneddylation and blocks adenomatous polyposis coli destruction via USP15.

PubMed ID: 19576224

DOI: 10.1016/j.jmb.2009.06.066

PubMed ID: 19553310

Title: The ubiquitin-specific peptidase USP15 regulates human papillomavirus type 16 E6 protein stability.

PubMed ID: 19553310

DOI: 10.1128/jvi.00605-09

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21947082

Title: USP15 is a deubiquitylating enzyme for receptor-activated SMADs.

PubMed ID: 21947082

DOI: 10.1038/ncb2346

PubMed ID: 21750715

Title: The inhibitor of growth protein 5 (ING5) depends on INCA1 as a co-factor for its antiproliferative effects.

PubMed ID: 21750715

DOI: 10.1371/journal.pone.0021505

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22344298

Title: USP15 stabilizes TGF-beta receptor I and promotes oncogenesis through the activation of TGF-beta signaling in glioblastoma.

PubMed ID: 22344298

DOI: 10.1038/nm.2619

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24526689

Title: The U4/U6 recycling factor SART3 has histone chaperone activity and associates with USP15 to regulate H2B deubiquitination.

PubMed ID: 24526689

DOI: 10.1074/jbc.m114.551754

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27368102

Title: An ER-associated pathway defines endosomal architecture for controlled cargo transport.

PubMed ID: 27368102

DOI: 10.1016/j.cell.2016.05.078

PubMed ID: 24852371

Title: The deubiquitinase USP15 antagonizes Parkin-mediated mitochondrial ubiquitination and mitophagy.

PubMed ID: 24852371

DOI: 10.1093/hmg/ddu244

PubMed ID: 33093067

Title: USP15 deubiquitinates CARD9 to downregulate C-type lectin receptor-mediated signaling.

PubMed ID: 33093067

DOI: 10.4049/immunohorizons.2000036

PubMed ID: 16298993

Title: Solution structure of the human ubiquitin-specific protease 15 DUSP domain.

PubMed ID: 16298993

DOI: 10.1074/jbc.m510993200

PubMed ID: 21848306

Title: Structure of the USP15 N-terminal domains: a beta-hairpin mediates close association between the DUSP and UBL domains.

PubMed ID: 21848306

DOI: 10.1021/bi200726e

PubMed ID: 22001210

Title: Structural variability of the ubiquitin specific protease DUSP-UBL double domains.

PubMed ID: 22001210

DOI: 10.1016/j.febslet.2011.09.040

Sequence Information:

  • Length: 981
  • Mass: 112419
  • Checksum: E81FEB9DE57F7089
  • Sequence:
    • MAEGGAADLD TQRSDIATLL KTSLRKGDTW YLVDSRWFKQ WKKYVGFDSW DKYQMGDQNV 
YPGPIDNSGL LKDGDAQSLK EHLIDELDYI LLPTEGWNKL VSWYTLMEGQ EPIARKVVEQ 
GMFVKHCKVE VYLTELKLCE NGNMNNVVTR RFSKADTIDT IEKEIRKIFS IPDEKETRLW 
NKYMSNTFEP LNKPDSTIQD AGLYQGQVLV IEQKNEDGTW PRGPSTPKSP GASNFSTLPK 
ISPSSLSNNY NNMNNRNVKN SNYCLPSYTA YKNYDYSEPG RNNEQPGLCG LSNLGNTCFM 
NSAIQCLSNT PPLTEYFLND KYQEELNFDN PLGMRGEIAK SYAELIKQMW SGKFSYVTPR 
AFKTQVGRFA PQFSGYQQQD CQELLAFLLD GLHEDLNRIR KKPYIQLKDA DGRPDKVVAE 
EAWENHLKRN DSIIVDIFHG LFKSTLVCPE CAKISVTFDP FCYLTLPLPM KKERTLEVYL 
VRMDPLTKPM QYKVVVPKIG NILDLCTALS ALSGIPADKM IVTDIYNHRF HRIFAMDENL 
SSIMERDDIY VFEININRTE DTEHVIIPVC LREKFRHSSY THHTGSSLFG QPFLMAVPRN 
NTEDKLYNLL LLRMCRYVKI STETEETEGS LHCCKDQNIN GNGPNGIHEE GSPSEMETDE 
PDDESSQDQE LPSENENSQS EDSVGGDNDS ENGLCTEDTC KGQLTGHKKR LFTFQFNNLG 
NTDINYIKDD TRHIRFDDRQ LRLDERSFLA LDWDPDLKKR YFDENAAEDF EKHESVEYKP 
PKKPFVKLKD CIELFTTKEK LGAEDPWYCP NCKEHQQATK KLDLWSLPPV LVVHLKRFSY 
SRYMRDKLDT LVDFPINDLD MSEFLINPNA GPCRYNLIAV SNHYGGMGGG HYTAFAKNKD 
DGKWYYFDDS SVSTASEDQI VSKAAYVLFY QRQDTFSGTG FFPLDRETKG ASAATGIPLE 
SDEDSNDNDN DIENENCMHT N

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.