Details for: CDC27

Gene ID: 996

Symbol: CDC27

Ensembl ID: ENSG00000004897

Description: cell division cycle 27

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 255.4884
    Cell Significance Index: -39.7400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 215.2629
    Cell Significance Index: -54.6000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 125.7441
    Cell Significance Index: -51.8000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 121.1338
    Cell Significance Index: -57.1900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 114.4349
    Cell Significance Index: -46.4900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 49.0499
    Cell Significance Index: -46.8300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 42.3454
    Cell Significance Index: -52.2100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 20.0533
    Cell Significance Index: -53.7200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 16.8648
    Cell Significance Index: -36.9100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 16.2659
    Cell Significance Index: -49.9600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.4512
    Cell Significance Index: -57.0300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.4270
    Cell Significance Index: 486.8600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.9341
    Cell Significance Index: 383.8300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.8830
    Cell Significance Index: 36.7500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.5638
    Cell Significance Index: 560.9000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.3326
    Cell Significance Index: 74.7800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.2276
    Cell Significance Index: 94.2100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.2263
    Cell Significance Index: 82.4600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.0972
    Cell Significance Index: 15.7800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.9752
    Cell Significance Index: 59.9400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9569
    Cell Significance Index: 104.0900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.9067
    Cell Significance Index: 627.1000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.9041
    Cell Significance Index: 39.9900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.8724
    Cell Significance Index: 33.0400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.8412
    Cell Significance Index: 23.5100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.7610
    Cell Significance Index: 19.5600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5290
    Cell Significance Index: 31.7600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.5195
    Cell Significance Index: 27.0600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.4724
    Cell Significance Index: 13.4800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.4468
    Cell Significance Index: 10.7200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4453
    Cell Significance Index: 402.1100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4412
    Cell Significance Index: 54.2500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4150
    Cell Significance Index: 74.8100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3653
    Cell Significance Index: 50.1600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3520
    Cell Significance Index: 24.3500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3421
    Cell Significance Index: 186.8500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3402
    Cell Significance Index: 640.6100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.2816
    Cell Significance Index: 6.0200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2773
    Cell Significance Index: 122.6000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2151
    Cell Significance Index: 25.3700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1745
    Cell Significance Index: 2.9900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1724
    Cell Significance Index: 32.8100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1687
    Cell Significance Index: 107.1700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1534
    Cell Significance Index: 236.1500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1366
    Cell Significance Index: 251.9000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1290
    Cell Significance Index: 58.5600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1287
    Cell Significance Index: 12.7400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.1125
    Cell Significance Index: 1.4000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0750
    Cell Significance Index: 9.6200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0700
    Cell Significance Index: 95.1800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0646
    Cell Significance Index: 1.8600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0493
    Cell Significance Index: 2.2400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0118
    Cell Significance Index: 2.0200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0149
    Cell Significance Index: -11.0200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0266
    Cell Significance Index: -0.7100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0348
    Cell Significance Index: -0.5000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0437
    Cell Significance Index: -27.3000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0487
    Cell Significance Index: -35.6900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0631
    Cell Significance Index: -47.7500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0661
    Cell Significance Index: -3.0800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0718
    Cell Significance Index: -40.4700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0922
    Cell Significance Index: -3.2400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0977
    Cell Significance Index: -0.5900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1507
    Cell Significance Index: -31.7400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1714
    Cell Significance Index: -49.3200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1761
    Cell Significance Index: -25.6000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1905
    Cell Significance Index: -5.1100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2228
    Cell Significance Index: -22.7600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2293
    Cell Significance Index: -5.0200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2576
    Cell Significance Index: -33.2900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2913
    Cell Significance Index: -13.6900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2916
    Cell Significance Index: -20.6200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2947
    Cell Significance Index: -19.0100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2975
    Cell Significance Index: -34.6700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2992
    Cell Significance Index: -34.2800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3042
    Cell Significance Index: -8.7200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3161
    Cell Significance Index: -32.9100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3534
    Cell Significance Index: -18.3600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3841
    Cell Significance Index: -43.8400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3899
    Cell Significance Index: -29.0600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4215
    Cell Significance Index: -22.1300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4403
    Cell Significance Index: -6.5000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5111
    Cell Significance Index: -32.2100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.5497
    Cell Significance Index: -11.9100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5825
    Cell Significance Index: -35.7100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5929
    Cell Significance Index: -46.9600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.7714
    Cell Significance Index: -12.9100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.7898
    Cell Significance Index: -6.4400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.8631
    Cell Significance Index: -27.4900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.8785
    Cell Significance Index: -18.7100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.8904
    Cell Significance Index: -26.1500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.8905
    Cell Significance Index: -29.1600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.9050
    Cell Significance Index: -12.3500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.9207
    Cell Significance Index: -29.4900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.9255
    Cell Significance Index: -32.1600
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.9559
    Cell Significance Index: -11.9200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.9755
    Cell Significance Index: -20.7100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -1.0024
    Cell Significance Index: -27.2900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.0241
    Cell Significance Index: -20.2500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.0286
    Cell Significance Index: -20.6500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Cell Division Cycle Regulator**: CDC27 is a key regulator of the cell division cycle, specifically in the progression of mitosis. 2. **Anaphase-Promoting Complex (APC) Component**: CDC27 is a subunit of the APC, which is responsible for the degradation of mitotic proteins. 3. **Ubiquitination and Proteasome Degradation**: CDC27 facilitates the ubiquitination and proteasome degradation of mitotic proteins, allowing for the proper progression of the cell cycle. 4. **Cell Cycle Checkpoint Regulation**: CDC27 regulates the cell cycle checkpoint, ensuring that the cell cycle progresses properly and that any errors or abnormalities are detected and corrected. **Pathways and Functions** 1. **Activation of APC/C and APC/C:CDC20 Mediated Degradation of Mitotic Proteins**: CDC27 activates the APC/C complex, which then degrades mitotic proteins, allowing for the proper progression of the cell cycle. 2. **Adaptive Immune System**: CDC27 is also involved in the adaptive immune system, where it regulates the processing and presentation of antigens. 3. **Antigen Processing: Ubiquitination & Proteasome Degradation**: CDC27 facilitates the ubiquitination and proteasome degradation of antigens, allowing for their presentation to the immune system. 4. **Regulation of Mitotic Cell Cycle**: CDC27 regulates the mitotic cell cycle, ensuring that the cell cycle progresses properly and that any errors or abnormalities are detected and corrected. **Clinical Significance** 1. **Cancer**: Abnormal expression or regulation of CDC27 has been implicated in various cancers, where it can contribute to aberrant cell division and tumor growth. 2. **Mitotic Cell Cycle Disorders**: CDC27 is also involved in disorders of the mitotic cell cycle, such as aneuploidy and cancer. 3. **Immune System Disorders**: CDC27 is also involved in disorders of the immune system, such as autoimmune diseases and immunodeficiency disorders. 4. **Neurological Disorders**: CDC27 has also been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, CDC27 is a critical regulator of the cell division cycle, particularly in the progression of mitosis. Its dysregulation has been implicated in various diseases, including cancer, mitotic cell cycle disorders, immune system disorders, and neurological disorders. Further research is needed to fully understand the role of CDC27 in these diseases and to develop effective therapeutic strategies to target this gene.

Genular Protein ID: 1397570376

Symbol: CDC27_HUMAN

Name: Cell division cycle protein 27 homolog

UniProtKB Accession Codes:

P30260 G3V1C4 Q16349 Q96F35

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 ELM 1 EMBL 6 EMDB 21 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 23 PDBsum 23 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 18 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8234252

Title: Linking yeast genetics to mammalian genomes: identification and mapping of the human homolog of CDC27 via the expressed sequence tag (EST) data base.

PubMed ID: 8234252

DOI: 10.1073/pnas.90.21.10031

PubMed ID: 7756179

Title: Identification of a human homologue of yeast nuc2 which interacts with the retinoblastoma protein in a specific manner.

PubMed ID: 7756179

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14657031

Title: Mitotic regulation of the human anaphase-promoting complex by phosphorylation.

PubMed ID: 14657031

DOI: 10.1093/emboj/cdg627

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18485873

Title: Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex.

PubMed ID: 18485873

DOI: 10.1016/j.cell.2008.04.012

PubMed ID: 18445686

Title: EML3 is a nuclear microtubule-binding protein required for the correct alignment of chromosomes in metaphase.

PubMed ID: 18445686

DOI: 10.1242/jcs.019174

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21307936

Title: Structural basis for the subunit assembly of the anaphase-promoting complex.

PubMed ID: 21307936

DOI: 10.1038/nature09756

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 29033132

Title: Assembly and function of heterotypic ubiquitin chains in cell-cycle and protein quality control.

PubMed ID: 29033132

DOI: 10.1016/j.cell.2017.09.040

PubMed ID: 16364912

Title: Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C.

PubMed ID: 16364912

DOI: 10.1016/j.molcel.2005.11.008

PubMed ID: 22139841

Title: Molecular basis for the association of microcephalin (MCPH1) protein with the cell division cycle protein 27 (Cdc27) subunit of the anaphase-promoting complex.

PubMed ID: 22139841

DOI: 10.1074/jbc.m111.307868

PubMed ID: 25043029

Title: Molecular architecture and mechanism of the anaphase-promoting complex.

PubMed ID: 25043029

DOI: 10.1038/nature13543

PubMed ID: 26083744

Title: Atomic structure of the APC/C and its mechanism of protein ubiquitination.

PubMed ID: 26083744

DOI: 10.1038/nature14471

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 824
  • Mass: 91867
  • Checksum: E6C8F59C1EF1DCBA
  • Sequence:
    • MTVLQEPVQA AIWQALNHYA YRDAVFLAER LYAEVHSEEA LFLLATCYYR SGKAYKAYRL 
LKGHSCTTPQ CKYLLAKCCV DLSKLAEGEQ ILSGGVFNKQ KSHDDIVTEF GDSACFTLSL 
LGHVYCKTDR LAKGSECYQK SLSLNPFLWS PFESLCEIGE KPDPDQTFKF TSLQNFSNCL 
PNSCTTQVPN HSLSHRQPET VLTETPQDTI ELNRLNLESS NSKYSLNTDS SVSYIDSAVI 
SPDTVPLGTG TSILSKQVQN KPKTGRSLLG GPAALSPLTP SFGILPLETP SPGDGSYLQN 
YTNTPPVIDV PSTGAPSKKS VARIGQTGTK SVFSQSGNSR EVTPILAQTQ SSGPQTSTTP 
QVLSPTITSP PNALPRRSSR LFTSDSSTTK ENSKKLKMKF PPKIPNRKTK SKTNKGGITQ 
PNINDSLEIT KLDSSIISEG KISTITPQIQ AFNLQKAAAE GLMSLLREMG KGYLALCSYN 
CKEAINILSH LPSHHYNTGW VLCQIGRAYF ELSEYMQAER IFSEVRRIEN YRVEGMEIYS 
TTLWHLQKDV ALSVLSKDLT DMDKNSPEAW CAAGNCFSLQ REHDIAIKFF QRAIQVDPNY 
AYAYTLLGHE FVLTEELDKA LACFRNAIRV NPRHYNAWYG LGMIYYKQEK FSLAEMHFQK 
ALDINPQSSV LLCHIGVVQH ALKKSEKALD TLNKAIVIDP KNPLCKFHRA SVLFANEKYK 
SALQELEELK QIVPKESLVY FLIGKVYKKL GQTHLALMNF SWAMDLDPKG ANNQIKEAID 
KRYLPDDEEP ITQEEQIMGT DESQESSMTD ADDTQLHAAE SDEF

Genular Protein ID: 2811572140

Symbol: B4DL80_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DL80 E7EN31

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 Gene3D 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 763
  • Mass: 84888
  • Checksum: 6E34E1052FAB5AFA
  • Sequence:
    • MASTKPLCLP RCGFPRRTPL CRRLAEGEQI LSGGVFNKQK SHDDIVTEFG DSACFTLSLL 
GHVYCKTDRL AKGSECYQKS LSLNPFLWSP FESLCEIGEK PDPDQTFKFT SLQNFSNCLP 
NSCTTQVPNH SLSHRQPETV LTETPQDTIE LNRLNLESSN SKYSLNTDSS VSYIDSAVIS 
PDTVPLGTGT SILSKQVQNK PKTGRSLLGG PAALSPLTPS FGILPLETPS PGDGSYLQNY 
TNTPPVIDVP STGAPSKKSV ARIGQTGTKS VFSQSGNSRE VTPILAQTQS SGPQTSTTPQ 
VLSPTITSPP NALPRRSSRL FTSDSSTTKE NSKKLKMKFP PKIPNRKTKS KTNKGGITQP 
NINDSLEITK LDSSIISEGK ISTITPQIQA FNLQKAAAEG LMSLLREMGK GYLALCSYNC 
KEAINILSHL PSHHYNTGWV LCQIGRAYFE LSEYMQAERI FSEVRRIENY RVEGMEIYST 
TLWHLQKDVA LSVLSKDLTD MDKNSPEAWC AAGNCFSLQR EHDIAIKFFQ RAIQVDPNYA 
YAYTLLGHEF VLTEELDKAL ACFRNAIRVN PRHYNAWYGL GMIYYKQEKF SLAEMHFQKA 
LDINPQSSVL LCHIGVVQHA LKKSEKALDT LNKAIVIDPK NPLCKFHRAS VLFANEKYKS 
ALQELEELKQ IVPKESLVYF LIGKVYKKLG QTHLALMNFS WAMDLDPKGA NNQIKEAIDK 
RYLPDDEEPI TQEEQIMGTD ESQESSMTDA DDTQLHAAES DEF

Genular Protein ID: 787908662

Symbol: G5EA36_HUMAN

Name: N/A

UniProtKB Accession Codes:

G5EA36

Database IDs:

ARBA 2 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 GO 2 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 IntAct 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 3 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 SMART 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 823
  • Mass: 91738
  • Checksum: EB357625BA6FF02B
  • Sequence:
    • MTVLQEPVQA AIWQALNHYA YRDAVFLAER LYAEVHSEEA LFLLATCYYR SGKAYKAYRL 
LKGHSCTTPQ CKYLLAKCCV DLSKLAEGEQ ILSGGVFNKQ KSHDDIVTEF GDSACFTLSL 
LGHVYCKTDR LAKGSECYQK SLSLNPFLWS PFESLCEIGE KPDPDQTFKF TSLQNFSNCL 
PNSCTTQVPN HSLSHRQPET VLTETPQDTI ELNRLNLESS NSKYSLNTDS SVSYIDSAVI 
SPDTVPLGTG TSILSKQVQN KPKTGRSLLG GPAALSPLTP SFGILPLETP SPGDGSYLQN 
YTNTPPVIDV PSTGAPSKKS VARIGQTGTK SVFSQSGNSR EVTPILAQTQ SSGPQTSTTP 
QVLSPTITSP PNALPRRSSR LFTSDSSTTK ENSKKLKMKF PPKIPNRKTK SKTNKGGITQ 
PNINDSLEIT KLDSSIISEG KISTITPQIQ AFNLQKAAAG LMSLLREMGK GYLALCSYNC 
KEAINILSHL PSHHYNTGWV LCQIGRAYFE LSEYMQAERI FSEVRRIENY RVEGMEIYST 
TLWHLQKDVA LSVLSKDLTD MDKNSPEAWC AAGNCFSLQR EHDIAIKFFQ RAIQVDPNYA 
YAYTLLGHEF VLTEELDKAL ACFRNAIRVN PRHYNAWYGL GMIYYKQEKF SLAEMHFQKA 
LDINPQSSVL LCHIGVVQHA LKKSEKALDT LNKAIVIDPK NPLCKFHRAS VLFANEKYKS 
ALQELEELKQ IVPKESLVYF LIGKVYKKLG QTHLALMNFS WAMDLDPKGA NNQIKEAIDK 
RYLPDDEEPI TQEEQIMGTD ESQESSMTDA DDTQLHAAES DEF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.