Details for: SLC23A1

Gene ID: 9963

Symbol: SLC23A1

Ensembl ID: ENSG00000170482

Description: solute carrier family 23 member 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 3.87
    Marker Score: 11,286
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 2.49
    Marker Score: 21,021
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 2.2
    Marker Score: 6,528
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.46
    Marker Score: 1,819
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 1.16
    Marker Score: 642
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.04
    Marker Score: 2,454
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.03
    Marker Score: 1,580
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,831
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,056
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 509
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,344
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 374
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,288
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.84
    Marker Score: 2,876
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.83
    Marker Score: 1,565
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.82
    Marker Score: 12,852
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 601
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,271
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 695
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.72
    Marker Score: 474
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.65
    Marker Score: 5,637
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.64
    Marker Score: 1,824
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.64
    Marker Score: 2,680
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.63
    Marker Score: 1,808
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 447
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.54
    Marker Score: 322
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.46
    Marker Score: 2,219
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.4
    Marker Score: 1,419
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.39
    Marker Score: 266
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.38
    Marker Score: 521
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.36
    Marker Score: 1,183
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.35
    Marker Score: 158
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.35
    Marker Score: 101
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.35
    Marker Score: 710
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.33
    Marker Score: 223
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.32
    Marker Score: 628
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.28
    Marker Score: 88
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.27
    Marker Score: 113
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.25
    Marker Score: 121
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.25
    Marker Score: 77
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.23
    Marker Score: 159
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.22
    Marker Score: 209
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.21
    Marker Score: 54
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.21
    Marker Score: 2,089
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.2
    Marker Score: 52
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.2
    Marker Score: 116
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.2
    Marker Score: 52
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.2
    Marker Score: 58
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.18
    Marker Score: 340
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.17
    Marker Score: 110
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.17
    Marker Score: 79
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.17
    Marker Score: 528
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.17
    Marker Score: 112
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.16
    Marker Score: 78
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.16
    Marker Score: 51
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.15
    Marker Score: 89
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.15
    Marker Score: 99
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.14
    Marker Score: 287
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.14
    Marker Score: 873
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.14
    Marker Score: 135
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.14
    Marker Score: 51
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.13
    Marker Score: 1,746
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.13
    Marker Score: 33
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.13
    Marker Score: 80
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.12
    Marker Score: 539
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.12
    Marker Score: 90
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.12
    Marker Score: 736
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.12
    Marker Score: 46
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.12
    Marker Score: 51
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.12
    Marker Score: 70
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.12
    Marker Score: 68
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.11
    Marker Score: 321
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.11
    Marker Score: 42
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.11
    Marker Score: 113
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.11
    Marker Score: 49
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.11
    Marker Score: 35
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.11
    Marker Score: 29
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.11
    Marker Score: 92
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.11
    Marker Score: 29
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1
    Marker Score: 48
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1
    Marker Score: 42
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.1
    Marker Score: 74
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.1
    Marker Score: 34
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.1
    Marker Score: 31
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.1
    Marker Score: 109
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.1
    Marker Score: 102
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.1
    Marker Score: 106
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.09
    Marker Score: 19
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.09
    Marker Score: 500
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.09
    Marker Score: 45

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Function:** The SLC23A1 gene encodes for a sodium-dependent L-ascorbic acid transporter, which mediates the transport of L-ascorbic acid across cellular membranes. This process is essential for maintaining the intracellular levels of L-ascorbic acid and ensuring its availability for various cellular processes, including antioxidant defense, collagen synthesis, and neurotransmission. 2. **Tissue Distribution:** The SLC23A1 gene is expressed in multiple cell types, including retinal bipolar cells, kidney proximal straight tubule epithelial cells, enterocytes of the colon, and cerebral cortex GABAergic interneurons. 3. **Regulatory Mechanisms:** The SLC23A1 gene is regulated by various transcription factors, including the nuclear factor erythroid 2-related factor 2 (Nrf2), which plays a crucial role in antioxidant defense and L-ascorbic acid metabolism. **Pathways and Functions:** 1. **Antioxidant Defense:** The SLC23A1 gene plays a crucial role in maintaining the intracellular levels of L-ascorbic acid, which is essential for antioxidant defense against reactive oxygen species (ROS). 2. **Neurotransmission:** The SLC23A1 gene is expressed in cerebral cortex GABAergic interneurons, suggesting a potential role in neurotransmission and cognitive function. 3. **Collagen Synthesis:** L-ascorbic acid is essential for collagen synthesis, and the SLC23A1 gene regulates its intracellular levels, which is crucial for maintaining skin, bone, and connective tissue health. 4. **Metabolism of Vitamins and Cofactors:** The SLC23A1 gene is involved in the metabolism of L-ascorbic acid, which is essential for maintaining the balance of various vitamins and cofactors. **Clinical Significance:** 1. **Vitamin C Deficiency:** The SLC23A1 gene plays a crucial role in maintaining the intracellular levels of L-ascorbic acid, and its dysfunction can lead to vitamin C deficiency, which can cause scurvy and other related disorders. 2. **Neurodegenerative Diseases:** The SLC23A1 gene is expressed in cerebral cortex GABAergic interneurons, and its dysfunction may contribute to neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Cancer:** The SLC23A1 gene is involved in the metabolism of L-ascorbic acid, and its dysfunction may contribute to cancer development and progression. 4. **Kidney Disease:** The SLC23A1 gene is expressed in kidney proximal straight tubule epithelial cells, and its dysfunction may contribute to kidney disease and impaired renal function. In conclusion, the SLC23A1 gene plays a crucial role in regulating the intracellular levels of L-ascorbic acid, which is essential for various cellular processes, including antioxidant defense, neurotransmission, collagen synthesis, and metabolism of vitamins and cofactors. Its dysfunction can lead to various disorders, including vitamin C deficiency, neurodegenerative diseases, cancer, and kidney disease. Further research is needed to fully understand the role of the SLC23A1 gene in human health and disease.

Genular Protein ID: 871192718

Symbol: S23A1_HUMAN

Name: Na(+)/L-ascorbic acid transporter 1

UniProtKB Accession Codes:

Q9UHI7 O95191 Q8WWB6 Q9UGH4 Q9UI39

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EMBL 10 Ensembl 2 ExpressionAtlas 1 GO 20 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 2 Rhea 4 SAM 1 SMR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9804989

Title: Molecular characterization of two novel transporters from human and mouse kidney and from LLC-PK1 cells reveals a novel conserved family that is homologous to bacterial and Aspergillus nucleobase transporters.

PubMed ID: 9804989

DOI: 10.1016/s0167-4781(98)00151-1

PubMed ID: 10556483

Title: Human Na(+)-dependent vitamin C transporter 1 (hSVCT1): primary structure, functional characteristics and evidence for a non-functional splice variant.

PubMed ID: 10556483

DOI: 10.1016/s0005-2736(99)00182-0

PubMed ID: 10556521

Title: Cloning and functional characterization of the human sodium-dependent vitamin C transporters hSVCT1 and hSVCT2.

PubMed ID: 10556521

DOI: 10.1016/s0014-5793(99)01393-9

PubMed ID: 10631088

Title: Human vitamin C (L-ascorbic acid) transporter SVCT1.

PubMed ID: 10631088

DOI: 10.1006/bbrc.1999.1929

PubMed ID: 11584081

Title: Characterization of the genomic structure of the human vitamin C transporter SVCT1 (SLC23A2).

PubMed ID: 11584081

DOI: 10.1093/jn/131.10.2623

PubMed ID: 11396616

Title: Vitamin C transport systems of mammalian cells.

PubMed ID: 11396616

DOI: 10.1080/09687680110033774

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19379732

Title: Topological studies of hSVCT1, the human sodium-dependent vitamin C transporter and the influence of N-glycosylation on its intracellular targeting.

PubMed ID: 19379732

DOI: 10.1016/j.yexcr.2009.04.007

PubMed ID: 36749388

Title: Vitamin C transporter SVCT1 serves a physiological role as a urate importer: functional analyses and in vivo investigations.

PubMed ID: 36749388

DOI: 10.1007/s00424-023-02792-1

Sequence Information:

  • Length: 598
  • Mass: 64815
  • Checksum: 939C52B9D1157029
  • Sequence:
    • MRAQEDLEGR TQHETTRDPS TPLPTEPKFD MLYKIEDVPP WYLCILLGFQ HYLTCFSGTI 
AVPFLLAEAL CVGHDQHMVS QLIGTIFTCV GITTLIQTTV GIRLPLFQAS AFAFLVPAKA 
ILALERWKCP PEEEIYGNWS LPLNTSHIWH PRIREVQGAI MVSSVVEVVI GLLGLPGALL 
NYIGPLTVTP TVSLIGLSVF QAAGDRAGSH WGISACSILL IILFSQYLRN LTFLLPVYRW 
GKGLTLLRIQ IFKMFPIMLA IMTVWLLCYV LTLTDVLPTD PKAYGFQART DARGDIMAIA 
PWIRIPYPCQ WGLPTVTAAA VLGMFSATLA GIIESIGDYY ACARLAGAPP PPVHAINRGI 
FTEGICCIIA GLLGTGNGST SSSPNIGVLG ITKVGSRRVV QYGAAIMLVL GTIGKFTALF 
ASLPDPILGG MFCTLFGMIT AVGLSNLQFV DMNSSRNLFV LGFSMFFGLT LPNYLESNPG 
AINTGILEVD QILIVLLTTE MFVGGCLAFI LDNTVPGSPE ERGLIQWKAG AHANSDMSSS 
LKSYDFPIGM GIVKRITFLK YIPICPVFKG FSSSSKDQIA IPEDTPENTE TASVCTKV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.