SLC23A1 | ENSG00000170482 | NCBI 9963

Details for: SLC23A1

Gene ID: 9963

Symbol: SLC23A1

Ensembl ID: ENSG00000170482

Description: solute carrier family 23 member 1

Associated with

Metabolism
(R-HSA-1430728)
Metabolism of vitamins and cofactors
(R-HSA-196854)
Metabolism of water-soluble vitamins and cofactors
(R-HSA-196849)
Vitamin c (ascorbate) metabolism
(R-HSA-196836)
Apical plasma membrane
(GO:0016324)
Basal plasma membrane
(GO:0009925)
Brain development
(GO:0007420)
Cytoplasm
(GO:0005737)
Dehydroascorbic acid transmembrane transporter activity
(GO:0033300)
Dehydroascorbic acid transport
(GO:0070837)
Extracellular exosome
(GO:0070062)
Intracellular organelle
(GO:0043229)
L-ascorbate:sodium symporter activity
(GO:0008520)
L-ascorbic acid metabolic process
(GO:0019852)
L-ascorbic acid transmembrane transport
(GO:0015882)
L-ascorbic acid transmembrane transporter activity
(GO:0015229)
Lung development
(GO:0030324)
Nucleobase transmembrane transporter activity
(GO:0015205)
Nucleobase transport
(GO:0015851)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Response to toxic substance
(GO:0009636)
Sodium ion transmembrane transport
(GO:0035725)
Sodium ion transmembrane transporter activity
(GO:0015081)
Sodium ion transport
(GO:0006814)
Transporter activity
(GO:0005215)
Urate transmembrane transporter activity
(GO:0015143)
Urate transport
(GO:0015747)

Other Information

Proteins

Na(+)/L-ascorbic acid transporter 1

Genular Protein ID: 871192718

Symbol: S23A1_HUMAN

Name: Na(+)/L-ascorbic acid transporter 1

UniProtKB Accession Codes:

Q9UHI7 O95191 Q8WWB6 Q9UGH4 Q9UI39

Database IDs:

Citations:

PubMed ID: 9804989

Title: Molecular characterization of two novel transporters from human and mouse kidney and from LLC-PK1 cells reveals a novel conserved family that is homologous to bacterial and Aspergillus nucleobase transporters.

PubMed ID: 9804989

DOI: 10.1016/s0167-4781(98)00151-1

PubMed ID: 10556483

Title: Human Na(+)-dependent vitamin C transporter 1 (hSVCT1): primary structure, functional characteristics and evidence for a non-functional splice variant.

PubMed ID: 10556483

DOI: 10.1016/s0005-2736(99)00182-0

PubMed ID: 10556521

Title: Cloning and functional characterization of the human sodium-dependent vitamin C transporters hSVCT1 and hSVCT2.

PubMed ID: 10556521

DOI: 10.1016/s0014-5793(99)01393-9

PubMed ID: 10631088

Title: Human vitamin C (L-ascorbic acid) transporter SVCT1.

PubMed ID: 10631088

DOI: 10.1006/bbrc.1999.1929

PubMed ID: 11584081

Title: Characterization of the genomic structure of the human vitamin C transporter SVCT1 (SLC23A2).

PubMed ID: 11584081

DOI: 10.1093/jn/131.10.2623

PubMed ID: 11396616

Title: Vitamin C transport systems of mammalian cells.

PubMed ID: 11396616

DOI: 10.1080/09687680110033774

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19379732

Title: Topological studies of hSVCT1, the human sodium-dependent vitamin C transporter and the influence of N-glycosylation on its intracellular targeting.

PubMed ID: 19379732

DOI: 10.1016/j.yexcr.2009.04.007

PubMed ID: 36749388

Title: Vitamin C transporter SVCT1 serves a physiological role as a urate importer: functional analyses and in vivo investigations.

PubMed ID: 36749388

DOI: 10.1007/s00424-023-02792-1

Sequence Information:

Length: 598
Mass: 64815
Checksum: 939C52B9D1157029
Sequence:

MRAQEDLEGR TQHETTRDPS TPLPTEPKFD MLYKIEDVPP WYLCILLGFQ HYLTCFSGTI 
AVPFLLAEAL CVGHDQHMVS QLIGTIFTCV GITTLIQTTV GIRLPLFQAS AFAFLVPAKA 
ILALERWKCP PEEEIYGNWS LPLNTSHIWH PRIREVQGAI MVSSVVEVVI GLLGLPGALL 
NYIGPLTVTP TVSLIGLSVF QAAGDRAGSH WGISACSILL IILFSQYLRN LTFLLPVYRW 
GKGLTLLRIQ IFKMFPIMLA IMTVWLLCYV LTLTDVLPTD PKAYGFQART DARGDIMAIA 
PWIRIPYPCQ WGLPTVTAAA VLGMFSATLA GIIESIGDYY ACARLAGAPP PPVHAINRGI 
FTEGICCIIA GLLGTGNGST SSSPNIGVLG ITKVGSRRVV QYGAAIMLVL GTIGKFTALF 
ASLPDPILGG MFCTLFGMIT AVGLSNLQFV DMNSSRNLFV LGFSMFFGLT LPNYLESNPG 
AINTGILEVD QILIVLLTTE MFVGGCLAFI LDNTVPGSPE ERGLIQWKAG AHANSDMSSS 
LKSYDFPIGM GIVKRITFLK YIPICPVFKG FSSSSKDQIA IPEDTPENTE TASVCTKV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: SLC23A1

Associated with

Other Information

Molecular characterization of two novel transporters from human and mouse kidney and from LLC-PK1 cells reveals a novel conserved family that is homologous to bacterial and Aspergillus nucleobase transporters. PubMed ID: 9804989

Human Na(+)-dependent vitamin C transporter 1 (hSVCT1): primary structure, functional characteristics and evidence for a non-functional splice variant. PubMed ID: 10556483

Cloning and functional characterization of the human sodium-dependent vitamin C transporters hSVCT1 and hSVCT2. PubMed ID: 10556521

Human vitamin C (L-ascorbic acid) transporter SVCT1. PubMed ID: 10631088

Characterization of the genomic structure of the human vitamin C transporter SVCT1 (SLC23A2). PubMed ID: 11584081

Vitamin C transport systems of mammalian cells. PubMed ID: 11396616

The DNA sequence and comparative analysis of human chromosome 5. PubMed ID: 15372022

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Topological studies of hSVCT1, the human sodium-dependent vitamin C transporter and the influence of N-glycosylation on its intracellular targeting. PubMed ID: 19379732

Vitamin C transporter SVCT1 serves a physiological role as a urate importer: functional analyses and in vivo investigations. PubMed ID: 36749388