FGF19 | ENSG00000162344 | NCBI 9965

Details for: FGF19

Gene ID: 9965

Symbol: FGF19

Ensembl ID: ENSG00000162344

Description: fibroblast growth factor 19

Associated with

Betaklotho-mediated ligand binding
(R-HSA-1307965)
Constitutive signaling by aberrant pi3k in cancer
(R-HSA-2219530)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Downstream signaling of activated fgfr4
(R-HSA-5654716)
Fgfr4 ligand binding and activation
(R-HSA-190322)
Frs-mediated fgfr4 signaling
(R-HSA-5654712)
Igf1r signaling cascade
(R-HSA-2428924)
Insulin receptor signalling cascade
(R-HSA-74751)
Intracellular signaling by second messengers
(R-HSA-9006925)
Irs-mediated signalling
(R-HSA-112399)
Irs-related events triggered by igf1r
(R-HSA-2428928)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Negative regulation of fgfr4 signaling
(R-HSA-5654733)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Phospholipase c-mediated cascade; fgfr4
(R-HSA-5654228)
Pi-3k cascade:fgfr4
(R-HSA-5654720)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pi3k cascade
(R-HSA-109704)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-HSA-6811558)
Pip3 activates akt signaling
(R-HSA-1257604)
Raf/map kinase cascade
(R-HSA-5673001)
Shc-mediated cascade:fgfr4
(R-HSA-5654719)
Signaling by fgfr
(R-HSA-190236)
Signaling by fgfr4
(R-HSA-5654743)
Signaling by insulin receptor
(R-HSA-74752)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
(R-HSA-2404192)
Signal transduction
(R-HSA-162582)
Animal organ morphogenesis
(GO:0009887)
Cell differentiation
(GO:0030154)
Cytoplasm
(GO:0005737)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Fibroblast growth factor receptor binding
(GO:0005104)
Fibroblast growth factor receptor signaling pathway
(GO:0008543)
Growth factor activity
(GO:0008083)
Negative regulation of bile acid biosynthetic process
(GO:0070858)
Negative regulation of gene expression
(GO:0010629)
Nervous system development
(GO:0007399)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of glucose import
(GO:0046326)
Positive regulation of jnk cascade
(GO:0046330)
Positive regulation of protein phosphorylation
(GO:0001934)
Protein binding
(GO:0005515)
Regulation of cell migration
(GO:0030334)

Other Information

Proteins

Fibroblast growth factor 19

Genular Protein ID: 2756561367

Symbol: FGF19_HUMAN

Name: Fibroblast growth factor 19

UniProtKB Accession Codes:

O95750

Database IDs:

Citations:

PubMed ID: 9931477

Title: Structure and expression of a novel human FGF, FGF-19, expressed in the fetal brain.

PubMed ID: 9931477

DOI: 10.1016/s0167-4781(98)00255-3

PubMed ID: 10525310

Title: FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4.

PubMed ID: 10525310

DOI: 10.1006/cyto.1999.0485

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 12815072

Title: Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis.

PubMed ID: 12815072

DOI: 10.1101/gad.1083503

PubMed ID: 16597617

Title: Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.

PubMed ID: 16597617

DOI: 10.1074/jbc.m601252200

PubMed ID: 17623664

Title: Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21.

PubMed ID: 17623664

DOI: 10.1074/jbc.m704165200

PubMed ID: 18829467

Title: C-terminal tail of FGF19 determines its specificity toward Klotho co-receptors.

PubMed ID: 18829467

DOI: 10.1074/jbc.m803319200

PubMed ID: 19085950

Title: Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression.

PubMed ID: 19085950

DOI: 10.1002/hep.22627

PubMed ID: 20094046

Title: Fibroblast growth factor signalling: from development to cancer.

PubMed ID: 20094046

DOI: 10.1038/nrc2780

PubMed ID: 23747249

Title: Diet1 functions in the FGF15/19 enterohepatic signaling axis to modulate bile acid and lipid levels.

PubMed ID: 23747249

DOI: 10.1016/j.cmet.2013.04.007

PubMed ID: 14730967

Title: The crystal structure of fibroblast growth factor (FGF) 19 reveals novel features of the FGF family and offers a structural basis for its unusual receptor affinity.

PubMed ID: 14730967

DOI: 10.1021/bi035320k

PubMed ID: 17339340

Title: Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members.

PubMed ID: 17339340

DOI: 10.1128/mcb.02249-06

Sequence Information:

Length: 216
Mass: 24003
Checksum: E0BCBC9C220F9832
Sequence:

MRSGCVVVHV WILAGLWLAV AGRPLAFSDA GPHVHYGWGD PIRLRHLYTS GPHGLSSCFL 
RIRADGVVDC ARGQSAHSLL EIKAVALRTV AIKGVHSVRY LCMGADGKMQ GLLQYSEEDC 
AFEEEIRPDG YNVYRSEKHR LPVSLSSAKQ RQLYKNRGFL PLSHFLPMLP MVPEEPEDLR 
GHLESDMFSS PLETDSMDPF GLVTGLEAVR SPSFEK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: FGF19

Associated with

Other Information

Structure and expression of a novel human FGF, FGF-19, expressed in the fetal brain. PubMed ID: 9931477

FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4. PubMed ID: 10525310

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. PubMed ID: 12975309

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Signal peptide prediction based on analysis of experimentally verified cleavage sites. PubMed ID: 15340161

Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis. PubMed ID: 12815072

Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. PubMed ID: 16597617

Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21. PubMed ID: 17623664

C-terminal tail of FGF19 determines its specificity toward Klotho co-receptors. PubMed ID: 18829467

Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression. PubMed ID: 19085950

Fibroblast growth factor signalling: from development to cancer. PubMed ID: 20094046

Diet1 functions in the FGF15/19 enterohepatic signaling axis to modulate bile acid and lipid levels. PubMed ID: 23747249

The crystal structure of fibroblast growth factor (FGF) 19 reveals novel features of the FGF family and offers a structural basis for its unusual receptor affinity. PubMed ID: 14730967

Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members. PubMed ID: 17339340