Details for: MED12

Gene ID: 9968

Symbol: MED12

Ensembl ID: ENSG00000184634

Description: mediator complex subunit 12

Associated with

Other Information

Genular Protein ID: 1063635135

Symbol: MED12_HUMAN

Name: Mediator of RNA polymerase II transcription subunit 12

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10198638

Title: Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators.

PubMed ID: 10198638

DOI: 10.1016/s1097-2765(00)80463-3

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 8724849

Title: Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1.

PubMed ID: 8724849

DOI: 10.1093/dnares/3.1.17

PubMed ID: 9702738

Title: Association of an X-chromosome dodecamer insertional variant allele with mental retardation.

PubMed ID: 9702738

DOI: 10.1038/sj.mp.4000442

PubMed ID: 10480376

Title: The genomic structure and developmental expression patterns of the human OPA-containing gene (HOPA).

PubMed ID: 10480376

DOI: 10.1007/s004399900084

PubMed ID: 10235266

Title: Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex.

PubMed ID: 10235266

DOI: 10.1038/19783

PubMed ID: 9225980

Title: cDNAs with long CAG trinucleotide repeats from human brain.

PubMed ID: 9225980

DOI: 10.1007/s004390050476

PubMed ID: 10235267

Title: Composite co-activator ARC mediates chromatin-directed transcriptional activation.

PubMed ID: 10235267

DOI: 10.1038/19789

PubMed ID: 15175163

Title: A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology.

PubMed ID: 15175163

DOI: 10.1016/j.molcel.2004.05.006

PubMed ID: 15989967

Title: MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription.

PubMed ID: 15989967

DOI: 10.1016/j.molcel.2005.05.015

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16565090

Title: Mediator is a transducer of Wnt/beta-catenin signaling.

PubMed ID: 16565090

DOI: 10.1074/jbc.m602696200

PubMed ID: 16595664

Title: Human Mediator enhances basal transcription by facilitating recruitment of transcription factor IIB during preinitiation complex assembly.

PubMed ID: 16595664

DOI: 10.1074/jbc.m601983200

PubMed ID: 17000779

Title: Mediator modulates Gli3-dependent Sonic hedgehog signaling.

PubMed ID: 17000779

DOI: 10.1128/mcb.00443-06

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 17369503

Title: The original Lujan syndrome family has a novel missense mutation (p.N1007S) in the MED12 gene.

PubMed ID: 17369503

DOI: 10.1136/jmg.2006.048637

PubMed ID: 17334363

Title: A recurrent mutation in MED12 leading to R961W causes Opitz-Kaveggia syndrome.

PubMed ID: 17334363

DOI: 10.1038/ng1992

PubMed ID: 23395478

Title: Mutations in MED12 cause X-linked Ohdo syndrome.

PubMed ID: 23395478

DOI: 10.1016/j.ajhg.2013.01.007

PubMed ID: 26273451

Title: Nonsyndromic X-linked intellectual deficiency in three brothers with a novel MED12 missense mutation [c.5922G>T (p.Glu1974His)].

PubMed ID: 26273451

DOI: 10.1002/ccr3.301

PubMed ID: 33244166

Title: De novo loss-of-function variants in X-linked MED12 are associated with Hardikar syndrome in females.

PubMed ID: 33244166

DOI: 10.1038/s41436-020-01031-7

Sequence Information:

  • Length: 2177
  • Mass: 243081
  • Checksum: 7492B07BA0F6EA9D
  • Sequence:
  • MAAFGILSYE HRPLKRPRLG PPDVYPQDPK QKEDELTALN VKQGFNNQPA VSGDEHGSAK 
    NVSFNPAKIS SNFSSIIAEK LRCNTLPDTG RRKPQVNQKD NFWLVTARSQ SAINTWFTDL 
    AGTKPLTQLA KKVPIFSKKE EVFGYLAKYT VPVMRAAWLI KMTCAYYAAI SETKVKKRHV 
    DPFMEWTQII TKYLWEQLQK MAEYYRPGPA GSGGCGSTIG PLPHDVEVAI RQWDYTEKLA 
    MFMFQDGMLD RHEFLTWVLE CFEKIRPGED ELLKLLLPLL LRYSGEFVQS AYLSRRLAYF 
    CTRRLALQLD GVSSHSSHVI SAQSTSTLPT TPAPQPPTSS TPSTPFSDLL MCPQHRPLVF 
    GLSCILQTIL LCCPSALVWH YSLTDSRIKT GSPLDHLPIA PSNLPMPEGN SAFTQQVRAK 
    LREIEQQIKE RGQAVEVRWS FDKCQEATAG FTIGRVLHTL EVLDSHSFER SDFSNSLDSL 
    CNRIFGLGPS KDGHEISSDD DAVVSLLCEW AVSCKRSGRH RAMVVAKLLE KRQAEIEAER 
    CGESEAADEK GSIASGSLSA PSAPIFQDVL LQFLDTQAPM LTDPRSESER VEFFNLVLLF 
    CELIRHDVFS HNMYTCTLIS RGDLAFGAPG PRPPSPFDDP ADDPEHKEAE GSSSSKLEDP 
    GLSESMDIDP SSSVLFEDME KPDFSLFSPT MPCEGKGSPS PEKPDVEKEV KPPPKEKIEG 
    TLGVLYDQPR HVQYATHFPI PQEESCSHEC NQRLVVLFGV GKQRDDARHA IKKITKDILK 
    VLNRKGTAET DQLAPIVPLN PGDLTFLGGE DGQKRRRNRP EAFPTAEDIF AKFQHLSHYD 
    QHQVTAQVSR NVLEQITSFA LGMSYHLPLV QHVQFIFDLM EYSLSISGLI DFAIQLLNEL 
    SVVEAELLLK SSDLVGSYTT SLCLCIVAVL RHYHACLILN QDQMAQVFEG LCGVVKHGMN 
    RSDGSSAERC ILAYLYDLYT SCSHLKNKFG ELFSDFCSKV KNTIYCNVEP SESNMRWAPE 
    FMIDTLENPA AHTFTYTGLG KSLSENPANR YSFVCNALMH VCVGHHDPDR VNDIAILCAE 
    LTGYCKSLSA EWLGVLKALC CSSNNGTCGF NDLLCNVDVS DLSFHDSLAT FVAILIARQC 
    LLLEDLIRCA AIPSLLNAAC SEQDSEPGAR LTCRILLHLF KTPQLNPCQS DGNKPTVGIR 
    SSCDRHLLAA SQNRIVDGAV FAVLKAVFVL GDAELKGSGF TVTGGTEELP EEEGGGGSGG 
    RRQGGRNISV ETASLDVYAK YVLRSICQQE WVGERCLKSL CEDSNDLQDP VLSSAQAQRL 
    MQLICYPHRL LDNEDGENPQ RQRIKRILQN LDQWTMRQSS LELQLMIKQT PNNEMNSLLE 
    NIAKATIEVF QQSAETGSSS GSTASNMPSS SKTKPVLSSL ERSGVWLVAP LIAKLPTSVQ 
    GHVLKAAGEE LEKGQHLGSS SRKERDRQKQ KSMSLLSQQP FLSLVLTCLK GQDEQREGLL 
    TSLYSQVHQI VNNWRDDQYL DDCKPKQLMH EALKLRLNLV GGMFDTVQRS TQQTTEWAML 
    LLEIIISGTV DMQSNNELFT TVLDMLSVLI NGTLAADMSS ISQGSMEENK RAYMNLAKKL 
    QKELGERQSD SLEKVRQLLP LPKQTRDVIT CEPQGSLIDT KGNKIAGFDS IFKKEGLQVS 
    TKQKISPWDL FEGLKPSAPL SWGWFGTVRV DRRVARGEEQ QRLLLYHTHL RPRPRAYYLE 
    PLPLPPEDEE PPAPTLLEPE KKAPEPPKTD KPGAAPPSTE ERKKKSTKGK KRSQPATKTE 
    DYGMGPGRSG PYGVTVPPDL LHHPNPGSIT HLNYRQGSIG LYTQNQPLPA GGPRVDPYRP 
    VRLPMQKLPT RPTYPGVLPT TMTGVMGLEP SSYKTSVYRQ QQPAVPQGQR LRQQLQQSQG 
    MLGQSSVHQM TPSSSYGLQT SQGYTPYVSH VGLQQHTGPA GTMVPPSYSS QPYQSTHPST 
    NPTLVDPTRH LQQRPSGYVH QQAPTYGHGL TSTQRFSHQT LQQTPMISTM TPMSAQGVQA 
    GVRSTAILPE QQQQQQQQQQ QQQQQQQQQQ QQQQQQYHIR QQQQQQILRQ QQQQQQQQQQ 
    QQQQQQQQQQ QQQQQHQQQQ QQQAAPPQPQ PQSQPQFQRQ GLQQTQQQQQ TAALVRQLQQ 
    QLSNTQPQPS TNIFGRY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.