Details for: CDC34

Gene ID: 997

Symbol: CDC34

Ensembl ID: ENSG00000099804

Description: cell division cycle 34, ubiqiutin conjugating enzyme

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 147.4812
    Cell Significance Index: -22.9400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 99.5689
    Cell Significance Index: -25.2600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 58.6500
    Cell Significance Index: -27.6900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 51.2114
    Cell Significance Index: -20.8100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 49.8459
    Cell Significance Index: -25.6400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 21.8200
    Cell Significance Index: -20.8300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 19.7412
    Cell Significance Index: -24.3400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.6235
    Cell Significance Index: -25.7800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.7359
    Cell Significance Index: -26.5800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.9358
    Cell Significance Index: -15.1600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.5548
    Cell Significance Index: -7.7800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.7798
    Cell Significance Index: 323.9600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.4928
    Cell Significance Index: 23.9500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2981
    Cell Significance Index: 77.9300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2942
    Cell Significance Index: 140.7800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9985
    Cell Significance Index: 162.3900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7065
    Cell Significance Index: 48.8600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.6903
    Cell Significance Index: 43.5100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6677
    Cell Significance Index: 31.1300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6075
    Cell Significance Index: 28.5500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5757
    Cell Significance Index: 314.3900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.5563
    Cell Significance Index: 7.5900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5217
    Cell Significance Index: 71.6400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4169
    Cell Significance Index: 21.6600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3825
    Cell Significance Index: 76.7300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.3678
    Cell Significance Index: 4.7100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3641
    Cell Significance Index: 44.7700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3618
    Cell Significance Index: 65.2200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3618
    Cell Significance Index: 10.4300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3523
    Cell Significance Index: 7.3800
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.3299
    Cell Significance Index: 2.0500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3240
    Cell Significance Index: 143.2500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3215
    Cell Significance Index: 8.7500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3172
    Cell Significance Index: 8.4700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2953
    Cell Significance Index: 56.1900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2845
    Cell Significance Index: 20.1200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2770
    Cell Significance Index: 27.4100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2748
    Cell Significance Index: 54.5400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2630
    Cell Significance Index: 11.9200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1955
    Cell Significance Index: 25.2600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1816
    Cell Significance Index: 4.5400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1460
    Cell Significance Index: 5.1300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1432
    Cell Significance Index: 9.2400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1430
    Cell Significance Index: 98.9200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1303
    Cell Significance Index: 9.7100
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.1291
    Cell Significance Index: 0.9800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1279
    Cell Significance Index: 45.8700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1212
    Cell Significance Index: 4.2100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0842
    Cell Significance Index: 2.2600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0662
    Cell Significance Index: 0.7200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0646
    Cell Significance Index: 0.7700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0431
    Cell Significance Index: 5.5200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0423
    Cell Significance Index: 0.9000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0350
    Cell Significance Index: 5.9800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0227
    Cell Significance Index: 0.2400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0199
    Cell Significance Index: 0.1200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0068
    Cell Significance Index: 12.7400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0012
    Cell Significance Index: 0.0700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0016
    Cell Significance Index: -2.2200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0067
    Cell Significance Index: -12.3600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0081
    Cell Significance Index: -12.4300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0178
    Cell Significance Index: -13.0300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0216
    Cell Significance Index: -16.3700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0243
    Cell Significance Index: -15.4100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0315
    Cell Significance Index: -23.3600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0402
    Cell Significance Index: -18.2600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0409
    Cell Significance Index: -23.0700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0495
    Cell Significance Index: -30.8900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0638
    Cell Significance Index: -6.5200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0686
    Cell Significance Index: -19.7300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0775
    Cell Significance Index: -9.1400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0807
    Cell Significance Index: -1.3500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0912
    Cell Significance Index: -2.5500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0921
    Cell Significance Index: -7.0700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0946
    Cell Significance Index: -13.7500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1068
    Cell Significance Index: -12.2300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1145
    Cell Significance Index: -3.0100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1453
    Cell Significance Index: -30.6100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1535
    Cell Significance Index: -2.3000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1565
    Cell Significance Index: -4.4900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1668
    Cell Significance Index: -1.3600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1795
    Cell Significance Index: -10.0700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2053
    Cell Significance Index: -12.6200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2070
    Cell Significance Index: -13.9200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2257
    Cell Significance Index: -13.8400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2395
    Cell Significance Index: -24.9400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2498
    Cell Significance Index: -6.4200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2513
    Cell Significance Index: -8.0500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2649
    Cell Significance Index: -20.9800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3100
    Cell Significance Index: -16.1500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3239
    Cell Significance Index: -5.5500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3442
    Cell Significance Index: -3.1700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.4009
    Cell Significance Index: -3.0900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.4128
    Cell Significance Index: -4.6900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4251
    Cell Significance Index: -12.1300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4394
    Cell Significance Index: -9.5200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4426
    Cell Significance Index: -10.2300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4767
    Cell Significance Index: -10.1900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4805
    Cell Significance Index: -21.2600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5163
    Cell Significance Index: -13.1900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CDC34 is a member of the ubiquitin-conjugating enzyme family, specifically E2 enzymes, which are essential for the transfer of ubiquitin molecules to target proteins. CDC34 is ubiquitin-conjugating enzyme E2 R1 (UB2R1_HUMAN), and its primary function is to facilitate the ubiquitination of proteins, leading to their degradation or modification. CDC34 is highly expressed in various cell types, including pancreatic acinar cells, male germ cells, and cortical thymic epithelial cells, which are involved in immune system development and function. **Pathways and Functions** CDC34 is involved in multiple signaling pathways and cellular processes, including: 1. **Adaptive Immune System**: CDC34 is expressed in cortical thymic epithelial cells, where it plays a role in the development and maturation of T cells, a critical component of adaptive immunity. 2. **Antigen Processing and Presentation**: CDC34 is involved in the ubiquitination of proteins, which are then processed and presented by MHC class I molecules, a key step in the immune response against viral infections and tumor cells. 3. **Cytokine Signaling**: CDC34 is involved in the regulation of cytokine signaling pathways, including the NF-kB pathway, which is essential for the immune response against pathogens and tumor cells. 4. **Protein Degradation**: CDC34 facilitates the ubiquitination and degradation of proteins, which is essential for maintaining protein homeostasis and regulating cellular processes. **Clinical Significance** CDC34 has potential implications in various diseases, including: 1. **Immunodeficiency Disorders**: Mutations in CDC34 may lead to impaired T cell development and function, resulting in immunodeficiency disorders. 2. **Cancer**: CDC34 may play a role in the regulation of protein degradation and ubiquitination in cancer cells, leading to the development of targeted therapies. 3. **Neurological Disorders**: CDC34 may be involved in the regulation of protein degradation and ubiquitination in neurons, leading to the development of neurodegenerative diseases. In conclusion, CDC34 is a ubiquitin-conjugating enzyme that plays a critical role in various cellular processes, including immune system function and protein degradation. Further research is necessary to fully understand the implications of CDC34 in disease and to develop targeted therapies. **Future Directions** 1. **Investigate CDC34 in Immunodeficiency Disorders**: Further studies are necessary to understand the role of CDC34 in T cell development and function and to develop targeted therapies for immunodeficiency disorders. 2. **Explore CDC34 in Cancer**: Research is needed to understand the role of CDC34 in cancer cell biology and to develop targeted therapies for cancer treatment. 3. **Investigate CDC34 in Neurological Disorders**: Further studies are necessary to understand the role of CDC34 in neuronal protein degradation and ubiquitination and to develop targeted therapies for neurodegenerative diseases. In summary, CDC34 is a critical gene involved in various cellular processes, including immune system function and protein degradation. Further research is necessary to fully understand its implications in disease and to develop targeted therapies.

Genular Protein ID: 1339765778

Symbol: UB2R1_HUMAN

Name: Ubiquitin-conjugating enzyme E2 R1

UniProtKB Accession Codes:

P49427 A8K689

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTC 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EC 2 EMBL 8 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 5 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8248134

Title: Cloning of the human homolog of the CDC34 cell cycle gene by complementation in yeast.

PubMed ID: 8248134

DOI: 10.1073/pnas.90.22.10484

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10329681

Title: Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalpha.

PubMed ID: 10329681

DOI: 10.1074/jbc.274.21.14823

PubMed ID: 10373550

Title: Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis.

PubMed ID: 10373550

DOI: 10.1128/mcb.19.7.5001

PubMed ID: 10769200

Title: Association of human ubiquitin-conjugating enzyme CDC34 with the mitotic spindle in anaphase.

PubMed ID: 10769200

DOI: 10.1242/jcs.113.10.1687

PubMed ID: 10871850

Title: Degradation of B-Myb by ubiquitin-mediated proteolysis: involvement of the Cdc34-SCF(p45Skp2) pathway.

PubMed ID: 10871850

DOI: 10.1038/sj.onc.1203618

PubMed ID: 10918611

Title: SCF(beta-TRCP) and phosphorylation dependent ubiquitination of I kappa B alpha catalyzed by Ubc3 and Ubc4.

PubMed ID: 10918611

DOI: 10.1038/sj.onc.1203647

PubMed ID: 11546811

Title: Phosphorylation of the human ubiquitin-conjugating enzyme, CDC34, by casein kinase 2.

PubMed ID: 11546811

DOI: 10.1074/jbc.m106453200

PubMed ID: 11447293

Title: The infected cell protein 0 of herpes simplex virus 1 dynamically interacts with proteasomes, binds and activates the cdc34 E2 ubiquitin-conjugating enzyme, and possesses in vitro E3 ubiquitin ligase activity.

PubMed ID: 11447293

DOI: 10.1073/pnas.161283098

PubMed ID: 11675391

Title: The Nedd8-conjugated ROC1-CUL1 core ubiquitin ligase utilizes Nedd8 charged surface residues for efficient polyubiquitin chain assembly catalyzed by Cdc34.

PubMed ID: 11675391

DOI: 10.1074/jbc.m108008200

PubMed ID: 12037680

Title: CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TrCP and enhances beta-catenin degradation.

PubMed ID: 12037680

DOI: 10.1038/sj.onc.1205574

PubMed ID: 11805320

Title: Herpes simplex virus 1-infected cell protein 0 contains two E3 ubiquitin ligase sites specific for different E2 ubiquitin-conjugating enzymes.

PubMed ID: 11805320

DOI: 10.1073/pnas.022531599

PubMed ID: 12060736

Title: Characterization of the novel E3 ubiquitin ligase encoded in exon 3 of herpes simplex virus-1-infected cell protein 0.

PubMed ID: 12060736

DOI: 10.1073/pnas.122246999

PubMed ID: 15652359

Title: The human ubiquitin-conjugating enzyme Cdc34 controls cellular proliferation through regulation of p27Kip1 protein levels.

PubMed ID: 15652359

DOI: 10.1016/j.yexcr.2004.10.008

PubMed ID: 17461777

Title: Cdc34 C-terminal tail phosphorylation regulates Skp1/cullin/F-box (SCF)-mediated ubiquitination and cell cycle progression.

PubMed ID: 17461777

DOI: 10.1042/bj20061812

PubMed ID: 17588522

Title: E3-independent monoubiquitination of ubiquitin-binding proteins.

PubMed ID: 17588522

DOI: 10.1016/j.molcel.2007.05.014

PubMed ID: 17698585

Title: Human Cdc34 employs distinct sites to coordinate attachment of ubiquitin to a substrate and assembly of polyubiquitin chains.

PubMed ID: 17698585

DOI: 10.1128/mcb.00812-07

PubMed ID: 18851830

Title: Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation.

PubMed ID: 18851830

DOI: 10.1016/j.molcel.2008.08.021

PubMed ID: 19945379

Title: Rapid E2-E3 assembly and disassembly enable processive ubiquitylation of cullin-RING ubiquitin ligase substrates.

PubMed ID: 19945379

DOI: 10.1016/j.cell.2009.10.030

PubMed ID: 19112177

Title: Histidine triad nucleotide-binding protein 1 up-regulates cellular levels of p27KIP1 by targeting ScfSKP2 ubiquitin ligase and Src.

PubMed ID: 19112177

DOI: 10.1074/jbc.m804531200

PubMed ID: 19126550

Title: let-7 Overexpression leads to an increased fraction of cells in G2/M, direct down-regulation of Cdc34, and stabilization of Wee1 kinase in primary fibroblasts.

PubMed ID: 19126550

DOI: 10.1074/jbc.c900002200

PubMed ID: 20061386

Title: The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines.

PubMed ID: 20061386

DOI: 10.1074/jbc.m109.089003

PubMed ID: 20347421

Title: Priming and extending: a UbcH5/Cdc34 E2 handoff mechanism for polyubiquitination on a SCF substrate.

PubMed ID: 20347421

DOI: 10.1016/j.molcel.2010.02.025

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21683433

Title: An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme.

PubMed ID: 21683433

DOI: 10.1016/j.cell.2011.05.039

PubMed ID: 22496338

Title: A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen.

PubMed ID: 22496338

DOI: 10.1074/mcp.o111.013706

PubMed ID: 24316736

Title: E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin.

PubMed ID: 24316736

DOI: 10.1038/nchembio.1412

Sequence Information:

  • Length: 236
  • Mass: 26737
  • Checksum: 258960666B589DB3
  • Sequence:
    • MARPLVPSSQ KALLLELKGL QEEPVEGFRV TLVDEGDLYN WEVAIFGPPN TYYEGGYFKA 
RLKFPIDYPY SPPAFRFLTK MWHPNIYETG DVCISILHPP VDDPQSGELP SERWNPTQNV 
RTILLSVISL LNEPNTFSPA NVDASVMYRK WKESKGKDRE YTDIIRKQVL GTKVDAERDG 
VKVPTTLAEY CVKTKAPAPD EGSDLFYDDY YEDGEVEEEA DSCFGDDEDD SGTEES

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.