CDC34 | ENSG00000099804 | NCBI 997

Details for: CDC34

Gene ID: 997

Symbol: CDC34

Ensembl ID: ENSG00000099804

Description: cell division cycle 34, ubiqiutin conjugating enzyme

Associated with

Adaptive immune system
(R-HSA-1280218)
Antigen processing: ubiquitination & proteasome degradation
(R-HSA-983168)
C-type lectin receptors (clrs)
(R-HSA-5621481)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Clec7a (dectin-1) signaling
(R-HSA-5607764)
Downstream tcr signaling
(R-HSA-202424)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Metabolism of proteins
(R-HSA-392499)
Post-translational protein modification
(R-HSA-597592)
Synthesis of active ubiquitin: roles of e1 and e2 enzymes
(R-HSA-8866652)
Tcr signaling
(R-HSA-202403)
Atp binding
(GO:0005524)
Cellular response to interferon-beta
(GO:0035458)
Cytosol
(GO:0005829)
Dna replication initiation
(GO:0006270)
G1/s transition of mitotic cell cycle
(GO:0000082)
Negative regulation of camp-mediated signaling
(GO:0043951)
Nuclear speck
(GO:0016607)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of inclusion body assembly
(GO:0090261)
Positive regulation of neuron apoptotic process
(GO:0043525)
Proteasome-mediated ubiquitin-dependent protein catabolic process
(GO:0043161)
Protein binding
(GO:0005515)
Protein k48-linked ubiquitination
(GO:0070936)
Protein modification process
(GO:0036211)
Protein polyubiquitination
(GO:0000209)
Protein ubiquitination
(GO:0016567)
Response to growth factor
(GO:0070848)
Ubiquitin-dependent protein catabolic process
(GO:0006511)
Ubiquitin-protein transferase activity
(GO:0004842)
Ubiquitin conjugating enzyme activity
(GO:0061631)

Other Information

Proteins

Ubiquitin-conjugating enzyme E2 R1

Genular Protein ID: 1339765778

Symbol: UB2R1_HUMAN

Name: Ubiquitin-conjugating enzyme E2 R1

UniProtKB Accession Codes:

P49427 A8K689

Database IDs:

Citations:

PubMed ID: 8248134

Title: Cloning of the human homolog of the CDC34 cell cycle gene by complementation in yeast.

PubMed ID: 8248134

DOI: 10.1073/pnas.90.22.10484

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10329681

Title: Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalpha.

PubMed ID: 10329681

DOI: 10.1074/jbc.274.21.14823

PubMed ID: 10373550

Title: Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis.

PubMed ID: 10373550

DOI: 10.1128/mcb.19.7.5001

PubMed ID: 10769200

Title: Association of human ubiquitin-conjugating enzyme CDC34 with the mitotic spindle in anaphase.

PubMed ID: 10769200

DOI: 10.1242/jcs.113.10.1687

PubMed ID: 10871850

Title: Degradation of B-Myb by ubiquitin-mediated proteolysis: involvement of the Cdc34-SCF(p45Skp2) pathway.

PubMed ID: 10871850

DOI: 10.1038/sj.onc.1203618

PubMed ID: 10918611

Title: SCF(beta-TRCP) and phosphorylation dependent ubiquitination of I kappa B alpha catalyzed by Ubc3 and Ubc4.

PubMed ID: 10918611

DOI: 10.1038/sj.onc.1203647

PubMed ID: 11546811

Title: Phosphorylation of the human ubiquitin-conjugating enzyme, CDC34, by casein kinase 2.

PubMed ID: 11546811

DOI: 10.1074/jbc.m106453200

PubMed ID: 11447293

Title: The infected cell protein 0 of herpes simplex virus 1 dynamically interacts with proteasomes, binds and activates the cdc34 E2 ubiquitin-conjugating enzyme, and possesses in vitro E3 ubiquitin ligase activity.

PubMed ID: 11447293

DOI: 10.1073/pnas.161283098

PubMed ID: 11675391

Title: The Nedd8-conjugated ROC1-CUL1 core ubiquitin ligase utilizes Nedd8 charged surface residues for efficient polyubiquitin chain assembly catalyzed by Cdc34.

PubMed ID: 11675391

DOI: 10.1074/jbc.m108008200

PubMed ID: 12037680

Title: CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TrCP and enhances beta-catenin degradation.

PubMed ID: 12037680

DOI: 10.1038/sj.onc.1205574

PubMed ID: 11805320

Title: Herpes simplex virus 1-infected cell protein 0 contains two E3 ubiquitin ligase sites specific for different E2 ubiquitin-conjugating enzymes.

PubMed ID: 11805320

DOI: 10.1073/pnas.022531599

PubMed ID: 12060736

Title: Characterization of the novel E3 ubiquitin ligase encoded in exon 3 of herpes simplex virus-1-infected cell protein 0.

PubMed ID: 12060736

DOI: 10.1073/pnas.122246999

PubMed ID: 15652359

Title: The human ubiquitin-conjugating enzyme Cdc34 controls cellular proliferation through regulation of p27Kip1 protein levels.

PubMed ID: 15652359

DOI: 10.1016/j.yexcr.2004.10.008

PubMed ID: 17461777

Title: Cdc34 C-terminal tail phosphorylation regulates Skp1/cullin/F-box (SCF)-mediated ubiquitination and cell cycle progression.

PubMed ID: 17461777

DOI: 10.1042/bj20061812

PubMed ID: 17588522

Title: E3-independent monoubiquitination of ubiquitin-binding proteins.

PubMed ID: 17588522

DOI: 10.1016/j.molcel.2007.05.014

PubMed ID: 17698585

Title: Human Cdc34 employs distinct sites to coordinate attachment of ubiquitin to a substrate and assembly of polyubiquitin chains.

PubMed ID: 17698585

DOI: 10.1128/mcb.00812-07

PubMed ID: 18851830

Title: Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation.

PubMed ID: 18851830

DOI: 10.1016/j.molcel.2008.08.021

PubMed ID: 19945379

Title: Rapid E2-E3 assembly and disassembly enable processive ubiquitylation of cullin-RING ubiquitin ligase substrates.

PubMed ID: 19945379

DOI: 10.1016/j.cell.2009.10.030

PubMed ID: 19112177

Title: Histidine triad nucleotide-binding protein 1 up-regulates cellular levels of p27KIP1 by targeting ScfSKP2 ubiquitin ligase and Src.

PubMed ID: 19112177

DOI: 10.1074/jbc.m804531200

PubMed ID: 19126550

Title: let-7 Overexpression leads to an increased fraction of cells in G2/M, direct down-regulation of Cdc34, and stabilization of Wee1 kinase in primary fibroblasts.

PubMed ID: 19126550

DOI: 10.1074/jbc.c900002200

PubMed ID: 20061386

Title: The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines.

PubMed ID: 20061386

DOI: 10.1074/jbc.m109.089003

PubMed ID: 20347421

Title: Priming and extending: a UbcH5/Cdc34 E2 handoff mechanism for polyubiquitination on a SCF substrate.

PubMed ID: 20347421

DOI: 10.1016/j.molcel.2010.02.025

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21683433

Title: An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme.

PubMed ID: 21683433

DOI: 10.1016/j.cell.2011.05.039

PubMed ID: 22496338

Title: A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen.

PubMed ID: 22496338

DOI: 10.1074/mcp.o111.013706

PubMed ID: 24316736

Title: E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin.

PubMed ID: 24316736

DOI: 10.1038/nchembio.1412

Sequence Information:

Length: 236
Mass: 26737
Checksum: 258960666B589DB3
Sequence:

MARPLVPSSQ KALLLELKGL QEEPVEGFRV TLVDEGDLYN WEVAIFGPPN TYYEGGYFKA 
RLKFPIDYPY SPPAFRFLTK MWHPNIYETG DVCISILHPP VDDPQSGELP SERWNPTQNV 
RTILLSVISL LNEPNTFSPA NVDASVMYRK WKESKGKDRE YTDIIRKQVL GTKVDAERDG 
VKVPTTLAEY CVKTKAPAPD EGSDLFYDDY YEDGEVEEEA DSCFGDDEDD SGTEES

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CDC34

Associated with

Other Information

Cloning of the human homolog of the CDC34 cell cycle gene by complementation in yeast. PubMed ID: 8248134

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalpha. PubMed ID: 10329681

Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis. PubMed ID: 10373550

Association of human ubiquitin-conjugating enzyme CDC34 with the mitotic spindle in anaphase. PubMed ID: 10769200

Degradation of B-Myb by ubiquitin-mediated proteolysis: involvement of the Cdc34-SCF(p45Skp2) pathway. PubMed ID: 10871850

SCF(beta-TRCP) and phosphorylation dependent ubiquitination of I kappa B alpha catalyzed by Ubc3 and Ubc4. PubMed ID: 10918611

Phosphorylation of the human ubiquitin-conjugating enzyme, CDC34, by casein kinase 2. PubMed ID: 11546811

The infected cell protein 0 of herpes simplex virus 1 dynamically interacts with proteasomes, binds and activates the cdc34 E2 ubiquitin-conjugating enzyme, and possesses in vitro E3 ubiquitin ligase activity. PubMed ID: 11447293

The Nedd8-conjugated ROC1-CUL1 core ubiquitin ligase utilizes Nedd8 charged surface residues for efficient polyubiquitin chain assembly catalyzed by Cdc34. PubMed ID: 11675391

CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TrCP and enhances beta-catenin degradation. PubMed ID: 12037680

Herpes simplex virus 1-infected cell protein 0 contains two E3 ubiquitin ligase sites specific for different E2 ubiquitin-conjugating enzymes. PubMed ID: 11805320

Characterization of the novel E3 ubiquitin ligase encoded in exon 3 of herpes simplex virus-1-infected cell protein 0. PubMed ID: 12060736

The human ubiquitin-conjugating enzyme Cdc34 controls cellular proliferation through regulation of p27Kip1 protein levels. PubMed ID: 15652359

Cdc34 C-terminal tail phosphorylation regulates Skp1/cullin/F-box (SCF)-mediated ubiquitination and cell cycle progression. PubMed ID: 17461777

E3-independent monoubiquitination of ubiquitin-binding proteins. PubMed ID: 17588522

Human Cdc34 employs distinct sites to coordinate attachment of ubiquitin to a substrate and assembly of polyubiquitin chains. PubMed ID: 17698585

Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation. PubMed ID: 18851830

Rapid E2-E3 assembly and disassembly enable processive ubiquitylation of cullin-RING ubiquitin ligase substrates. PubMed ID: 19945379

Histidine triad nucleotide-binding protein 1 up-regulates cellular levels of p27KIP1 by targeting ScfSKP2 ubiquitin ligase and Src. PubMed ID: 19112177

let-7 Overexpression leads to an increased fraction of cells in G2/M, direct down-regulation of Cdc34, and stabilization of Wee1 kinase in primary fibroblasts. PubMed ID: 19126550

The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines. PubMed ID: 20061386

Priming and extending: a UbcH5/Cdc34 E2 handoff mechanism for polyubiquitination on a SCF substrate. PubMed ID: 20347421

Initial characterization of the human central proteome. PubMed ID: 21269460

An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme. PubMed ID: 21683433

A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen. PubMed ID: 22496338

E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin. PubMed ID: 24316736