NR1I3 | ENSG00000143257 | NCBI 9970

Details for: NR1I3

Gene ID: 9970

Symbol: NR1I3

Ensembl ID: ENSG00000143257

Description: nuclear receptor subfamily 1 group I member 3

Associated with

Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Nuclear receptor transcription pathway
(R-HSA-383280)
Rna polymerase ii transcription
(R-HSA-73857)
Cell differentiation
(GO:0030154)
Chromatin
(GO:0000785)
Cytoplasm
(GO:0005737)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Intracellular receptor signaling pathway
(GO:0030522)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nuclear receptor activity
(GO:0004879)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Osteoblast differentiation
(GO:0001649)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Sequence-specific double-stranded dna binding
(GO:1990837)
Signal transduction
(GO:0007165)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Nuclear receptor subfamily 1 group I member 3
F1DAL4_HUMAN

Genular Protein ID: 101818691

Symbol: NR1I3_HUMAN

Name: Nuclear receptor subfamily 1 group I member 3

UniProtKB Accession Codes:

Q14994 E9PB75 E9PC13 E9PDU3 E9PGH6 E9PH10 E9PHC8 E9PHN4 F1D8Q0 F1D8Q1 Q0VAC9 Q4U0F0 Q5VTW5 Q5VTW6 Q6GZ68 Q6GZ76 Q6GZ77 Q6GZ78 Q6GZ79 Q6GZ82 Q6GZ83 Q6GZ84 Q6GZ85 Q6GZ87 Q6GZ89

Database IDs:

Citations:

PubMed ID: 8114692

Title: A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements.

PubMed ID: 8114692

DOI: 10.1128/mcb.14.3.1544-1552.1994

PubMed ID: 15194709

Title: Expression of constitutive androstane receptor splice variants in human tissues and their functional consequences.

PubMed ID: 15194709

DOI: 10.1124/jpet.104.069310

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8603043

Title: A component of the 26S proteasome binds on orphan member of the nuclear hormone receptor superfamily.

PubMed ID: 8603043

DOI: 10.1016/0960-0760(95)00220-0

PubMed ID: 14573755

Title: Cytoplasmic accumulation of the nuclear receptor CAR by a tetratricopeptide repeat protein in HepG2 cells.

PubMed ID: 14573755

DOI: 10.1124/mol.64.5.1069

PubMed ID: 19858220

Title: Dephosphorylation of threonine 38 is required for nuclear translocation and activation of human xenobiotic receptor CAR (NR1I3).

PubMed ID: 19858220

DOI: 10.1074/jbc.m109.048108

PubMed ID: 15610735

Title: A structural basis for constitutive activity in the human CAR/RXRalpha heterodimer.

PubMed ID: 15610735

DOI: 10.1016/j.molcel.2004.11.042

PubMed ID: 15618763

Title: Twenty-six novel single nucleotide polymorphisms and their frequencies of the NR1I3 (CAR) gene in a Japanese population.

PubMed ID: 15618763

DOI: 10.2133/dmpk.18.413

PubMed ID: 22726846

Title: Disruption of an EHMT1-associated chromatin-modification module causes intellectual disability.

PubMed ID: 22726846

DOI: 10.1016/j.ajhg.2012.05.003

Sequence Information:

Length: 352
Mass: 39942
Checksum: 73B060FE4950D519
Sequence:

MASREDELRN CVVCGDQATG YHFNALTCEG CKGFFRRTVS KSIGPTCPFA GSCEVSKTQR 
RHCPACRLQK CLDAGMRKDM ILSAEALALR RAKQAQRRAQ QTPVQLSKEQ EELIRTLLGA 
HTRHMGTMFE QFVQFRPPAH LFIHHQPLPT LAPVLPLVTH FADINTFMVL QVIKFTKDLP 
VFRSLPIEDQ ISLLKGAAVE ICHIVLNTTF CLQTQNFLCG PLRYTIEDGA RVSPTVGFQV 
EFLELLFHFH GTLRKLQLQE PEYVLLAAMA LFSPDRPGVT QRDEIDQLQE EMALTLQSYI 
KGQQRRPRDR FLYAKLLGLL AELRSINEAY GYQIQHIQGL SAMMPLLQEI CS

Genular Protein ID: 795023608

Symbol: F1DAL4_HUMAN

Name: N/A

UniProtKB Accession Codes:

F1DAL4

Database IDs:

Sequence Information:

Length: 353
Mass: 40104
Checksum: 8F02A5C15444CD4C
Sequence:

MASREDELRN CVVCGDQATG YHFNALTCEG CKGFFRRTVS KSIGPTCPFA GSCEVSKTQR 
RHCPACRLQK CLDAGMRKDM ILSAEALALR RAKQAQRRAQ QTPVQLSKEQ EELIRTLLGA 
HTRHMGTMFE QFVQFRPPAH LFIHHQPLPT LAPVLPLVTH FADINTFMVL QVIKFTKDLP 
VFRSLPIEDQ ISLLKGAAVE ICHIVLNTTF CLQTQNFLCG PLRYTIEDGA RVGFQVEFLE 
LLFHFHGTLR KLQLQEPEYV LLAAMALFSP APYLTDRPGV TQRDEIDQLQ EEMALTLQSY 
IKGQQRRPRD RFLYAKLLGL LAELRSINEA YGYQIQHIQG LSAMMPLLQE ICS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: NR1I3

Associated with

Other Information

A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements. PubMed ID: 8114692

Expression of constitutive androstane receptor splice variants in human tissues and their functional consequences. PubMed ID: 15194709

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A component of the 26S proteasome binds on orphan member of the nuclear hormone receptor superfamily. PubMed ID: 8603043

Cytoplasmic accumulation of the nuclear receptor CAR by a tetratricopeptide repeat protein in HepG2 cells. PubMed ID: 14573755

Dephosphorylation of threonine 38 is required for nuclear translocation and activation of human xenobiotic receptor CAR (NR1I3). PubMed ID: 19858220

A structural basis for constitutive activity in the human CAR/RXRalpha heterodimer. PubMed ID: 15610735

Twenty-six novel single nucleotide polymorphisms and their frequencies of the NR1I3 (CAR) gene in a Japanese population. PubMed ID: 15618763

Disruption of an EHMT1-associated chromatin-modification module causes intellectual disability. PubMed ID: 22726846