Details for: NR1H4

Gene ID: 9971

Symbol: NR1H4

Ensembl ID: ENSG00000012504

Description: nuclear receptor subfamily 1 group H member 4

Associated with

  • Bile acid and bile salt metabolism
    (R-HSA-194068)
  • Biological oxidations
    (R-HSA-211859)
  • Cytochrome p450 - arranged by substrate type
    (R-HSA-211897)
  • Endogenous sterols
    (R-HSA-211976)
  • Gene expression (transcription)
    (R-HSA-74160)
  • Generic transcription pathway
    (R-HSA-212436)
  • Metabolism
    (R-HSA-1430728)
  • Metabolism of lipids
    (R-HSA-556833)
  • Metabolism of proteins
    (R-HSA-392499)
  • Metabolism of steroids
    (R-HSA-8957322)
  • Nuclear receptor transcription pathway
    (R-HSA-383280)
  • Phase i - functionalization of compounds
    (R-HSA-211945)
  • Post-translational protein modification
    (R-HSA-597592)
  • Ppara activates gene expression
    (R-HSA-1989781)
  • Recycling of bile acids and salts
    (R-HSA-159418)
  • Regulation of lipid metabolism by pparalpha
    (R-HSA-400206)
  • Rna polymerase ii transcription
    (R-HSA-73857)
  • Sumo e3 ligases sumoylate target proteins
    (R-HSA-3108232)
  • Sumoylation
    (R-HSA-2990846)
  • Sumoylation of intracellular receptors
    (R-HSA-4090294)
  • Synthesis of bile acids and bile salts
    (R-HSA-192105)
  • Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
    (R-HSA-193368)
  • Synthesis of bile acids and bile salts via 27-hydroxycholesterol
    (R-HSA-193807)
  • Bile acid binding
    (GO:0032052)
  • Bile acid metabolic process
    (GO:0008206)
  • Bile acid receptor activity
    (GO:0038181)
  • Bile acid signaling pathway
    (GO:0038183)
  • Cell-cell junction assembly
    (GO:0007043)
  • Cell differentiation
    (GO:0030154)
  • Cellular response to bile acid
    (GO:1903413)
  • Cellular response to fatty acid
    (GO:0071398)
  • Cellular response to lipopolysaccharide
    (GO:0071222)
  • Cellular response to organonitrogen compound
    (GO:0071417)
  • Chenodeoxycholic acid binding
    (GO:1902122)
  • Cholesterol homeostasis
    (GO:0042632)
  • Chromatin
    (GO:0000785)
  • Defense response to bacterium
    (GO:0042742)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Euchromatin
    (GO:0000791)
  • Fatty acid homeostasis
    (GO:0055089)
  • Inflammatory response
    (GO:0006954)
  • Innate immune response
    (GO:0045087)
  • Intracellular bile acid receptor signaling pathway
    (GO:0038185)
  • Intracellular glucose homeostasis
    (GO:0001678)
  • Intracellular receptor signaling pathway
    (GO:0030522)
  • Intracellular triglyceride homeostasis
    (GO:0035356)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Negative regulation of canonical nf-kappab signal transduction
    (GO:0043124)
  • Negative regulation of inflammatory response
    (GO:0050728)
  • Negative regulation of interleukin-1 production
    (GO:0032692)
  • Negative regulation of interleukin-2 production
    (GO:0032703)
  • Negative regulation of interleukin-6 production
    (GO:0032715)
  • Negative regulation of monocyte chemotactic protein-1 production
    (GO:0071638)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Negative regulation of tumor necrosis factor-mediated signaling pathway
    (GO:0010804)
  • Negative regulation of tumor necrosis factor production
    (GO:0032720)
  • Negative regulation of type ii interferon production
    (GO:0032689)
  • Negative regulation of very-low-density lipoprotein particle remodeling
    (GO:0010903)
  • Nitrogen catabolite activation of transcription from rna polymerase ii promoter
    (GO:0001080)
  • Notch signaling pathway
    (GO:0007219)
  • Nuclear receptor activity
    (GO:0004879)
  • Nuclear receptor binding
    (GO:0016922)
  • Nuclear retinoid x receptor binding
    (GO:0046965)
  • Positive regulation of adipose tissue development
    (GO:1904179)
  • Positive regulation of ammonia assimilation cycle
    (GO:2001250)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of glutamate metabolic process
    (GO:2000213)
  • Positive regulation of insulin receptor signaling pathway
    (GO:0046628)
  • Positive regulation of insulin secretion involved in cellular response to glucose stimulus
    (GO:0035774)
  • Positive regulation of interleukin-17 production
    (GO:0032740)
  • Positive regulation of phosphatidic acid biosynthetic process
    (GO:1905695)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of bile acid biosynthetic process
    (GO:0070857)
  • Regulation of cholesterol metabolic process
    (GO:0090181)
  • Regulation of insulin secretion involved in cellular response to glucose stimulus
    (GO:0061178)
  • Regulation of low-density lipoprotein particle clearance
    (GO:0010988)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Regulation of urea metabolic process
    (GO:0034255)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sequence-specific dna binding
    (GO:0043565)
  • Toll-like receptor 9 signaling pathway
    (GO:0034162)
  • Transcription by rna polymerase ii
    (GO:0006366)
  • Transcription coregulator binding
    (GO:0001221)
  • Zinc ion binding
    (GO:0008270)

Other Information

Genular Protein ID: 2234986707

Symbol: NR1H4_HUMAN

Name: Bile acid receptor

UniProtKB Accession Codes:

Q96RI1 A1L4K5 B7Z412 B7ZM06 F8VYG8 Q8NFP5 Q8NFP6 Q92943

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 2 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 14 DrugCentral 1 EMBL 10 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 68 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 94 PDBsum 85 PRINTS 3 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 RNAct 1 Reactome 8 RefSeq 7 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12062799

Title: Generation of multiple farnesoid-X-receptor isoforms through the use of alternative promoters.

PubMed ID: 12062799

DOI: 10.1016/s0378-1119(02)00557-7

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10514450

Title: Identification of a bile acid-responsive element in the human ileal bile acid-binding protein gene. Involvement of the farnesoid X receptor/9-cis-retinoic acid receptor heterodimer.

PubMed ID: 10514450

DOI: 10.1074/jbc.274.42.29749

PubMed ID: 10334992

Title: Identification of a nuclear receptor for bile acids.

PubMed ID: 10334992

DOI: 10.1126/science.284.5418.1362

PubMed ID: 10334993

Title: Bile acids: natural ligands for an orphan nuclear receptor.

PubMed ID: 10334993

DOI: 10.1126/science.284.5418.1365

PubMed ID: 11579204

Title: Farnesoid X-activated receptor induces apolipoprotein C-II transcription: a molecular mechanism linking plasma triglyceride levels to bile acids.

PubMed ID: 11579204

DOI: 10.1210/mend.15.10.0712

PubMed ID: 11927623

Title: Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element.

PubMed ID: 11927623

DOI: 10.1172/jci14505

PubMed ID: 12016314

Title: Vitamin D receptor as an intestinal bile acid sensor.

PubMed ID: 12016314

DOI: 10.1126/science.1070477

PubMed ID: 12815072

Title: Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis.

PubMed ID: 12815072

DOI: 10.1101/gad.1083503

PubMed ID: 12806625

Title: FXR induces the UGT2B4 enzyme in hepatocytes: a potential mechanism of negative feedback control of FXR activity.

PubMed ID: 12806625

DOI: 10.1016/s0016-5085(03)00388-3

PubMed ID: 12891557

Title: Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression.

PubMed ID: 12891557

DOI: 10.1016/s0016-5085(03)00896-5

PubMed ID: 12660231

Title: Syndecan-1 expression is regulated in an isoform-specific manner by the farnesoid-X receptor.

PubMed ID: 12660231

DOI: 10.1074/jbc.m302505200

PubMed ID: 12754200

Title: Farnesoid X receptor regulates bile acid-amino acid conjugation.

PubMed ID: 12754200

DOI: 10.1074/jbc.m302128200

PubMed ID: 12554753

Title: Bile acids induce the expression of the human peroxisome proliferator-activated receptor alpha gene via activation of the farnesoid X receptor.

PubMed ID: 12554753

DOI: 10.1210/me.2002-0120

PubMed ID: 15202934

Title: The nuclear bile acid receptor FXR is activated by PGC-1alpha in a ligand-dependent manner.

PubMed ID: 15202934

DOI: 10.1042/bj20040432

PubMed ID: 14684751

Title: The farnesoid X receptor controls gene expression in a ligand- and promoter-selective fashion.

PubMed ID: 14684751

DOI: 10.1074/jbc.m306422200

PubMed ID: 15239098

Title: Bile acid-induced negative feedback regulation of the human ileal bile acid transporter.

PubMed ID: 15239098

DOI: 10.1002/hep.20295

PubMed ID: 15187081

Title: Identification of DRIP205 as a coactivator for the Farnesoid X receptor.

PubMed ID: 15187081

DOI: 10.1074/jbc.m405126200

PubMed ID: 15337761

Title: Bile acid reduces the secretion of very low density lipoprotein by repressing microsomal triglyceride transfer protein gene expression mediated by hepatocyte nuclear factor-4.

PubMed ID: 15337761

DOI: 10.1074/jbc.m404255200

PubMed ID: 15471871

Title: Ligand-dependent activation of the farnesoid X-receptor directs arginine methylation of histone H3 by CARM1.

PubMed ID: 15471871

DOI: 10.1074/jbc.m410021200

PubMed ID: 15911693

Title: The methyl transferase PRMT1 functions as co-activator of farnesoid X receptor (FXR)/9-cis retinoid X receptor and regulates transcription of FXR responsive genes.

PubMed ID: 15911693

DOI: 10.1124/mol.105.012104

PubMed ID: 16269519

Title: The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes.

PubMed ID: 16269519

DOI: 10.1152/ajpgi.00430.2005

PubMed ID: 16946559

Title: Chenodeoxycholic acid-mediated activation of the farnesoid X receptor negatively regulates hydroxysteroid sulfotransferase.

PubMed ID: 16946559

DOI: 10.2133/dmpk.21.315

PubMed ID: 17681172

Title: Functional variants of the central bile acid sensor FXR identified in intrahepatic cholestasis of pregnancy.

PubMed ID: 17681172

DOI: 10.1053/j.gastro.2007.05.015

PubMed ID: 17895379

Title: Involvement of corepressor complex subunit GPS2 in transcriptional pathways governing human bile acid biosynthesis.

PubMed ID: 17895379

DOI: 10.1073/pnas.0706736104

PubMed ID: 18668687

Title: The membrane protein ATPase class I type 8B member 1 signals through protein kinase C zeta to activate the farnesoid X receptor.

PubMed ID: 18668687

DOI: 10.1002/hep.22431

PubMed ID: 17931734

Title: Variation of the gene encoding the nuclear bile salt receptor FXR and gallstone susceptibility in mice and humans.

PubMed ID: 17931734

DOI: 10.1016/j.jhep.2007.07.027

PubMed ID: 18755856

Title: Phosphorylation of farnesoid X receptor by protein kinase C promotes its transcriptional activity.

PubMed ID: 18755856

DOI: 10.1210/me.2008-0092

PubMed ID: 19833092

Title: Ku proteins function as corepressors to regulate farnesoid X receptor-mediated gene expression.

PubMed ID: 19833092

DOI: 10.1016/j.bbrc.2009.10.040

PubMed ID: 19393742

Title: Reciprocal regulation of the bile acid-activated receptor FXR and the interferon-gamma-STAT-1 pathway in macrophages.

PubMed ID: 19393742

DOI: 10.1016/j.bbadis.2009.04.004

PubMed ID: 19883617

Title: FXR acetylation is normally dynamically regulated by p300 and SIRT1 but constitutively elevated in metabolic disease states.

PubMed ID: 19883617

DOI: 10.1016/j.cmet.2009.09.009

PubMed ID: 19864602

Title: The bile acid receptor FXR is a modulator of intestinal innate immunity.

PubMed ID: 19864602

DOI: 10.4049/jimmunol.0803978

PubMed ID: 19085950

Title: Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression.

PubMed ID: 19085950

DOI: 10.1002/hep.22627

PubMed ID: 19805516

Title: Functional specificities of Brm and Brg-1 Swi/Snf ATPases in the feedback regulation of hepatic bile acid biosynthesis.

PubMed ID: 19805516

DOI: 10.1128/mcb.00825-09

PubMed ID: 19556342

Title: ASCOM controls farnesoid X receptor transactivation through its associated histone H3 lysine 4 methyltransferase activity.

PubMed ID: 19556342

DOI: 10.1210/me.2009-0099

PubMed ID: 20447400

Title: The nuclear receptor FXR is expressed in pancreatic beta-cells and protects human islets from lipotoxicity.

PubMed ID: 20447400

DOI: 10.1016/j.febslet.2010.04.068

PubMed ID: 21383957

Title: Deciphering the nuclear bile acid receptor FXR paradigm.

PubMed ID: 21383957

DOI: 10.1621/nrs.08005

PubMed ID: 21242261

Title: Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease.

PubMed ID: 21242261

DOI: 10.1136/gut.2010.212159

PubMed ID: 21804189

Title: Farnesoid X receptor represses hepatic human APOA gene expression.

PubMed ID: 21804189

DOI: 10.1172/jci45277

PubMed ID: 22820415

Title: Anti-inflammatory and metabolic actions of FXR: insights into molecular mechanisms.

PubMed ID: 22820415

DOI: 10.1016/j.bbalip.2012.07.004

PubMed ID: 22345554

Title: Direct methylation of FXR by Set7/9, a lysine methyltransferase, regulates the expression of FXR target genes.

PubMed ID: 22345554

DOI: 10.1152/ajpgi.00441.2011

PubMed ID: 23235576

Title: Ursodeoxycholic acid for primary biliary cirrhosis.

PubMed ID: 23235576

DOI: 10.1002/14651858.cd000551.pub3

PubMed ID: 23928191

Title: Differential activation of the human farnesoid X receptor depends on the pattern of expressed isoforms and the bile acid pool composition.

PubMed ID: 23928191

DOI: 10.1016/j.bcp.2013.07.022

PubMed ID: 23546875

Title: SUMOylation of the farnesoid X receptor (FXR) regulates the expression of FXR target genes.

PubMed ID: 23546875

DOI: 10.1074/jbc.m112.443937

PubMed ID: 23462506

Title: Identification of functionally relevant lysine residues that modulate human farnesoid X receptor activation.

PubMed ID: 23462506

DOI: 10.1124/mol.113.084772

PubMed ID: 26888176

Title: Mutations in the nuclear bile acid receptor FXR cause progressive familial intrahepatic cholestasis.

PubMed ID: 26888176

DOI: 10.1038/ncomms10713

PubMed ID: 12718892

Title: A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR.

PubMed ID: 12718892

DOI: 10.1016/s1097-2765(03)00104-7

PubMed ID: 12718893

Title: Structural basis for bile acid binding and activation of the nuclear receptor FXR.

PubMed ID: 12718893

DOI: 10.1016/s1097-2765(03)00112-6

PubMed ID: 18621523

Title: Conformationally constrained farnesoid X receptor (FXR) agonists: Naphthoic acid-based analogs of GW 4064.

PubMed ID: 18621523

DOI: 10.1016/j.bmcl.2008.06.073

PubMed ID: 18391212

Title: Identification of a potent synthetic FXR agonist with an unexpected mode of binding and activation.

PubMed ID: 18391212

DOI: 10.1073/pnas.0710981105

PubMed ID: 19410460

Title: Substituted isoxazole analogs of farnesoid X receptor (FXR) agonist GW4064.

PubMed ID: 19410460

DOI: 10.1016/j.bmcl.2009.04.047

PubMed ID: 19586769

Title: FXR agonist activity of conformationally constrained analogs of GW 4064.

PubMed ID: 19586769

DOI: 10.1016/j.bmcl.2009.06.062

PubMed ID: 19159286

Title: Discovery of XL335 (WAY-362450), a highly potent, selective, and orally active agonist of the farnesoid X receptor (FXR).

PubMed ID: 19159286

DOI: 10.1021/jm8014124

PubMed ID: 20095622

Title: Improvement of physiochemical properties of the tetrahydroazepinoindole series of farnesoid X receptor (FXR) agonists: beneficial modulation of lipids in primates.

PubMed ID: 20095622

DOI: 10.1021/jm901650u

PubMed ID: 30275017

Title: Ligand binding and heterodimerization with retinoid X receptor alpha (RXRalpha) induce farnesoid X receptor (FXR) conformational changes affecting coactivator binding.

PubMed ID: 30275017

DOI: 10.1074/jbc.ra118.004652

Sequence Information:

  • Length: 486
  • Mass: 55914
  • Checksum: C23283576A8CF76B
  • Sequence:
    • MVMQFQGLEN PIQISPHCSC TPSGFFMEMM SMKPAKGVLT EQVAGPLGQN LEVEPYSQYS 
NVQFPQVQPQ ISSSSYYSNL GFYPQQPEEW YSPGIYELRR MPAETLYQGE TEVAEMPVTK 
KPRMGASAGR IKGDELCVVC GDRASGYHYN ALTCEGCKGF FRRSITKNAV YKCKNGGNCV 
MDMYMRRKCQ ECRLRKCKEM GMLAECMYTG LLTEIQCKSK RLRKNVKQHA DQTVNEDSEG 
RDLRQVTSTT KSCREKTELT PDQQTLLHFI MDSYNKQRMP QEITNKILKE EFSAEENFLI 
LTEMATNHVQ VLVEFTKKLP GFQTLDHEDQ IALLKGSAVE AMFLRSAEIF NKKLPSGHSD 
LLEERIRNSG ISDEYITPMF SFYKSIGELK MTQEEYALLT AIVILSPDRQ YIKDREAVEK 
LQEPLLDVLQ KLCKIHQPEN PQHFACLLGR LTELRTFNHH HAEMLMSWRV NDHKFTPLLC 
EIWDVQ

Genular Protein ID: 1045979573

Symbol: F1DAL1_HUMAN

Name: N/A

UniProtKB Accession Codes:

F1DAL1

Database IDs:

ARBA 9 Antibodypedia 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 ExpressionAtlas 1 GO 36 Gene3D 2 GenomeRNAi 1 InterPro 7 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 3 PROSITE 3 Pfam 2 RefSeq 3 RuleBase 1 SMART 2 SMR 1 SUPFAM 2 VEuPathDB 1

Sequence Information:

  • Length: 476
  • Mass: 54862
  • Checksum: 37FB0351FB447544
  • Sequence:
    • MGSKMNLIEH SHLPTTDEFS FSENLFGVLT EQVAGPLGQN LEVEPYSQYS NVQFPQVQPQ 
ISSSSYYSNL GFYPQQPEEW YSPGIYELRR MPAETLYQGE TEVAEMPVTK KPRMGASAGR 
IKGDELCVVC GDRASGYHYN ALTCEGCKGF FRRSITKNAV YKCKNGGNCV MDMYMRRKCQ 
ECRLRKCKEM GMLAECMYTG LLTEIQCKSK RLRKNVKQHA DQTVNEDSEG RDLRQVTSTT 
KSCREKTELT PDQQTLLHFI MDSYNKQRMP QEITNKILKE EFSAEENFLI LTEMATNHVQ 
VLVEFTKKLP GFQTLDHEDQ IALLKGSAVE AMFLRSAEIF NKKLPSGHSD LLEERIRNSG 
ISDEYITPMF SFYKSIGELK MTQEEYALLT AIVILSPDRQ YIKDREAVEK LQEPLLDVLQ 
KLCKIHQPEN PQHFACLLGR LTELRTFNHH HAEMLMSWRV NDHKFTPLLC EIWDVQ

Genular Protein ID: 3704788431

Symbol: B6ZGS9_HUMAN

Name: N/A

UniProtKB Accession Codes:

B6ZGS9

Database IDs:

ARBA 9 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 ExpressionAtlas 1 GO 6 Gene3D 2 GenomeRNAi 1 InterPro 7 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 3 PROSITE 5 Pfam 2 PharmGKB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 2 SMR 1 SUPFAM 2 TCDB 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 472
  • Mass: 54409
  • Checksum: 0A53D414B9049C4C
  • Sequence:
    • MGSKMNLIEH SHLPTTDEFS FSENLFGVLT EQVAGPLGQN LEVEPYSQYS NVQFPQVQPQ 
ISSSSYYSNL GFYPQQPEEW YSPGIYELRR MPAETLYQGE TEVAEMPVTK KPRMGASAGR 
IKGDELCVVC GDRASGYHYN ALTCEGCKGF FRRSITKNAV YKCKNGGNCV MDMYMRRKCQ 
ECRLRKCKEM GMLAECLLTE IQCKSKRLRK NVKQHADQTV NEDSEGRDLR QVTSTTKSCR 
EKTELTPDQQ TLLHFIMDSY NKQRMPQEIT NKILKEEFSA EENFLILTEM ATNHVQVLVE 
FTKKLPGFQT LDHEDQIALL KGSAVEAMFL RSAEIFNKKL PSGHSDLLEE RIRNSGISDE 
YITPMFSFYK SIGELKMTQE EYALLTAIVI LSPDRQYIKD REAVEKLQEP LLDVLQKLCK 
IHQPENPQHF ACLLGRLTEL RTFNHHHAEM LMSWRVNDHK FTPLLCEIWD VQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.