RBX1 | ENSG00000100387 | NCBI 9978

Details for: RBX1

Gene ID: 9978

Symbol: RBX1

Ensembl ID: ENSG00000100387

Description: ring-box 1

Associated with

Adaptive immune system
(R-HSA-1280218)
Antigen processing: ubiquitination & proteasome degradation
(R-HSA-983168)
Axon guidance
(R-HSA-422475)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Cellular response to hypoxia
(R-HSA-1234174)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Constitutive signaling by notch1 hd+pest domain mutants
(R-HSA-2894862)
Constitutive signaling by notch1 pest domain mutants
(R-HSA-2644606)
Cytokine signaling in immune system
(R-HSA-1280215)
Degradation of beta-catenin by the destruction complex
(R-HSA-195253)
Degradation of dvl
(R-HSA-4641258)
Degradation of gli1 by the proteasome
(R-HSA-5610780)
Degradation of gli2 by the proteasome
(R-HSA-5610783)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Dna damage bypass
(R-HSA-73893)
Dna damage recognition in gg-ner
(R-HSA-5696394)
Dna repair
(R-HSA-73894)
Dna replication
(R-HSA-69306)
Dual incision in gg-ner
(R-HSA-5696400)
Dual incision in tc-ner
(R-HSA-6782135)
Evasion by rsv of host interferon responses
(R-HSA-9833109)
Fbxl7 down-regulates aurka during mitotic entry and in early mitosis
(R-HSA-8854050)
Fbxw7 mutants and notch1 in cancer
(R-HSA-2644605)
Formation of incision complex in gg-ner
(R-HSA-5696395)
Formation of tc-ner pre-incision complex
(R-HSA-6781823)
G2/m transition
(R-HSA-69275)
Gap-filling dna repair synthesis and ligation in tc-ner
(R-HSA-6782210)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gli3 is processed to gli3r by the proteasome
(R-HSA-5610785)
Global genome nucleotide excision repair (gg-ner)
(R-HSA-5696399)
Gsk3b and btrc:cul1-mediated-degradation of nfe2l2
(R-HSA-9762114)
Hedgehog 'off' state
(R-HSA-5610787)
Hedgehog 'on' state
(R-HSA-5632684)
Hiv infection
(R-HSA-162906)
Host interactions of hiv factors
(R-HSA-162909)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Interleukin-1 family signaling
(R-HSA-446652)
Interleukin-1 signaling
(R-HSA-9020702)
Keap1-nfe2l2 pathway
(R-HSA-9755511)
Loss of function of fbxw7 in cancer and notch1 signaling
(R-HSA-2644607)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Metabolism of proteins
(R-HSA-392499)
Mitotic g2-g2/m phases
(R-HSA-453274)
Neddylation
(R-HSA-8951664)
Negative regulation of notch4 signaling
(R-HSA-9604323)
Nervous system development
(R-HSA-9675108)
Notch1 intracellular domain regulates transcription
(R-HSA-2122947)
Nuclear events mediated by nfe2l2
(R-HSA-9759194)
Nuclear events stimulated by alk signaling in cancer
(R-HSA-9725371)
Nucleotide excision repair
(R-HSA-5696398)
Orc1 removal from chromatin
(R-HSA-68949)
Oxygen-dependent proline hydroxylation of hypoxia-inducible factor alpha
(R-HSA-1234176)
Post-translational protein modification
(R-HSA-597592)
Potential therapeutics for sars
(R-HSA-9679191)
Prolactin receptor signaling
(R-HSA-1170546)
Raf/map kinase cascade
(R-HSA-5673001)
Recognition of dna damage by pcna-containing replication complex
(R-HSA-110314)
Regulation of bach1 activity
(R-HSA-9708530)
Regulation of expression of slits and robos
(R-HSA-9010553)
Regulation of ras by gaps
(R-HSA-5658442)
Regulation of runx2 expression and activity
(R-HSA-8939902)
Respiratory syncytial virus infection pathway
(R-HSA-9820952)
Rna polymerase ii transcription
(R-HSA-73857)
Rsv-host interactions
(R-HSA-9833110)
Sars-cov infections
(R-HSA-9679506)
Signaling by alk fusions and activated point mutants
(R-HSA-9725370)
Signaling by alk in cancer
(R-HSA-9700206)
Signaling by hedgehog
(R-HSA-5358351)
Signaling by interleukins
(R-HSA-449147)
Signaling by notch
(R-HSA-157118)
Signaling by notch1
(R-HSA-1980143)
Signaling by notch1 hd+pest domain mutants in cancer
(R-HSA-2894858)
Signaling by notch1 in cancer
(R-HSA-2644603)
Signaling by notch1 pest domain mutants in cancer
(R-HSA-2644602)
Signaling by notch4
(R-HSA-9013694)
Signaling by robo receptors
(R-HSA-376176)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
S phase
(R-HSA-69242)
Switching of origins to a post-replicative state
(R-HSA-69052)
Synthesis of dna
(R-HSA-69239)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Transcription-coupled nucleotide excision repair (tc-ner)
(R-HSA-6781827)
Transcriptional regulation by runx2
(R-HSA-8878166)
Vif-mediated degradation of apobec3g
(R-HSA-180585)
Viral infection pathways
(R-HSA-9824446)
Nedd8 transferase activity
(GO:0019788)
Protein binding
(GO:0005515)
Ubiquitin-protein transferase activity
(GO:0004842)
Ubiquitin protein ligase binding
(GO:0031625)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

E3 ubiquitin-protein ligase RBX1

Genular Protein ID: 2264201498

Symbol: RBX1_HUMAN

Name: E3 ubiquitin-protein ligase RBX1

UniProtKB Accession Codes:

P62877 B2RDY1 Q8N6Z8 Q9D1S2 Q9WUK9 Q9Y254

Database IDs:

Citations:

PubMed ID: 10230407

Title: ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity.

PubMed ID: 10230407

DOI: 10.1016/s1097-2765(00)80482-7

PubMed ID: 10213691

Title: Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase.

PubMed ID: 10213691

DOI: 10.1126/science.284.5414.657

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10643962

Title: Genomic organization and expression of the ubiquitin-proteasome complex-associated protein Rbx1/ROC1/Hrt1.

PubMed ID: 10643962

PubMed ID: 10230406

Title: Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha.

PubMed ID: 10230406

DOI: 10.1016/s1097-2765(00)80481-5

PubMed ID: 10579999

Title: The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2.

PubMed ID: 10579999

DOI: 10.1101/gad.13.22.2928

PubMed ID: 11027288

Title: The CUL1 C-terminal sequence and ROC1 are required for efficient nuclear accumulation, NEDD8 modification, and ubiquitin ligase activity of CUL1.

PubMed ID: 11027288

DOI: 10.1128/mcb.20.21.8185-8197.2000

PubMed ID: 11384984

Title: Muf1, a novel elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase.

PubMed ID: 11384984

DOI: 10.1074/jbc.m103093200

PubMed ID: 11337588

Title: Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome.

PubMed ID: 11337588

DOI: 10.1126/science.1059780

PubMed ID: 12149480

Title: Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase.

PubMed ID: 12149480

DOI: 10.1073/pnas.162424199

PubMed ID: 12481031

Title: CUL7: a DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex.

PubMed ID: 12481031

DOI: 10.1073/pnas.252646399

PubMed ID: 12732143

Title: The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage.

PubMed ID: 12732143

DOI: 10.1016/s0092-8674(03)00316-7

PubMed ID: 14739464

Title: Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase.

PubMed ID: 14739464

DOI: 10.1126/science.1093549

PubMed ID: 15983046

Title: Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway.

PubMed ID: 15983046

DOI: 10.1074/jbc.m501279200

PubMed ID: 16751180

Title: CSA-dependent degradation of CSB by the ubiquitin-proteasome pathway establishes a link between complementation factors of the Cockayne syndrome.

PubMed ID: 16751180

DOI: 10.1101/gad.378206

PubMed ID: 16678110

Title: Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage.

PubMed ID: 16678110

DOI: 10.1016/j.molcel.2006.03.035

PubMed ID: 18397884

Title: Regulation of TIP60 by ATF2 modulates ATM activation.

PubMed ID: 18397884

DOI: 10.1074/jbc.m802030200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18809579

Title: PML activates transcription by protecting HIPK2 and p300 from SCFFbx3-mediated degradation.

PubMed ID: 18809579

DOI: 10.1128/mcb.00897-08

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19112177

Title: Histidine triad nucleotide-binding protein 1 up-regulates cellular levels of p27KIP1 by targeting ScfSKP2 ubiquitin ligase and Src.

PubMed ID: 19112177

DOI: 10.1074/jbc.m804531200

PubMed ID: 19250909

Title: E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification.

PubMed ID: 19250909

DOI: 10.1016/j.molcel.2009.01.011

PubMed ID: 19679664

Title: Adenovirus E1A inhibits SCF(Fbw7) ubiquitin ligase.

PubMed ID: 19679664

DOI: 10.1074/jbc.m109.006809

PubMed ID: 19920177

Title: Distinct ubiquitin ligases act sequentially for RNA polymerase II polyubiquitylation.

PubMed ID: 19920177

DOI: 10.1073/pnas.0907052106

PubMed ID: 20596027

Title: SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation.

PubMed ID: 20596027

DOI: 10.1038/nature09140

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23274085

Title: Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage.

PubMed ID: 23274085

DOI: 10.1016/j.cmet.2012.12.002

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23455478

Title: Ubiquitylation-dependent localization of PLK1 in mitosis.

PubMed ID: 23455478

DOI: 10.1038/ncb2695

PubMed ID: 24192928

Title: Oncogenic function of SCCRO5/DCUN1D5 requires its Neddylation E3 activity and nuclear localization.

PubMed ID: 24192928

DOI: 10.1158/1078-0432.ccr-13-1252

PubMed ID: 25349211

Title: SCCRO3 (DCUN1D3) antagonizes the neddylation and oncogenic activity of SCCRO (DCUN1D1).

PubMed ID: 25349211

DOI: 10.1074/jbc.m114.585505

PubMed ID: 25684205

Title: CUL3-KBTBD6/KBTBD7 ubiquitin ligase cooperates with GABARAP proteins to spatially restrict TIAM1-RAC1 signaling.

PubMed ID: 25684205

DOI: 10.1016/j.molcel.2014.12.040

PubMed ID: 27565346

Title: Two distinct types of E3 ligases work in unison to regulate substrate ubiquitylation.

PubMed ID: 27565346

DOI: 10.1016/j.cell.2016.07.027

PubMed ID: 26906416

Title: Characterization of the mammalian family of DCN-type NEDD8 E3 ligases.

PubMed ID: 26906416

DOI: 10.1242/jcs.181784

PubMed ID: 29149593

Title: NOTCH2 Hajdu-Cheney mutations escape SCFFBW7-dependent proteolysis to promote osteoporosis.

PubMed ID: 29149593

DOI: 10.1016/j.molcel.2017.10.018

PubMed ID: 29769719

Title: KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing.

PubMed ID: 29769719

DOI: 10.1038/s41586-018-0128-9

PubMed ID: 11961546

Title: Structure of the Cul1-Rbx1-Skp1-F box Skp2 SCF ubiquitin ligase complex.

PubMed ID: 11961546

DOI: 10.1038/416703a

PubMed ID: 22748924

Title: Structure of a glomulin-RBX1-CUL1 complex: inhibition of a RING E3 ligase through masking of its E2-binding surface.

PubMed ID: 22748924

DOI: 10.1016/j.molcel.2012.05.044

PubMed ID: 34700328

Title: A conserved mechanism for regulating replisome disassembly in eukaryotes.

PubMed ID: 34700328

DOI: 10.1038/s41586-021-04145-3

Sequence Information:

Length: 108
Mass: 12274
Checksum: 30FC5ADF66096C0E
Sequence:

MAAAMDVDTP SGTNSGAGKK RFEVKKWNAV ALWAWDIVVD NCAICRNHIM DLCIECQANQ 
ASATSEECTV AWGVCNHAFH FHCISRWLKT RQVCPLDNRE WEFQKYGH

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: RBX1

Associated with

Other Information

ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity. PubMed ID: 10230407

Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase. PubMed ID: 10213691

A genome annotation-driven approach to cloning the human ORFeome. PubMed ID: 15461802

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence of human chromosome 22. PubMed ID: 10591208

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Genomic organization and expression of the ubiquitin-proteasome complex-associated protein Rbx1/ROC1/Hrt1. PubMed ID: 10643962

Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha. PubMed ID: 10230406

The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2. PubMed ID: 10579999

The CUL1 C-terminal sequence and ROC1 are required for efficient nuclear accumulation, NEDD8 modification, and ubiquitin ligase activity of CUL1. PubMed ID: 11027288

Muf1, a novel elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase. PubMed ID: 11384984

Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome. PubMed ID: 11337588

Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase. PubMed ID: 12149480

CUL7: a DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex. PubMed ID: 12481031

The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage. PubMed ID: 12732143

Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase. PubMed ID: 14739464

Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway. PubMed ID: 15983046

CSA-dependent degradation of CSB by the ubiquitin-proteasome pathway establishes a link between complementation factors of the Cockayne syndrome. PubMed ID: 16751180

Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage. PubMed ID: 16678110

Regulation of TIP60 by ATF2 modulates ATM activation. PubMed ID: 18397884

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

PML activates transcription by protecting HIPK2 and p300 from SCFFbx3-mediated degradation. PubMed ID: 18809579

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Histidine triad nucleotide-binding protein 1 up-regulates cellular levels of p27KIP1 by targeting ScfSKP2 ubiquitin ligase and Src. PubMed ID: 19112177

E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification. PubMed ID: 19250909

Adenovirus E1A inhibits SCF(Fbw7) ubiquitin ligase. PubMed ID: 19679664

Distinct ubiquitin ligases act sequentially for RNA polymerase II polyubiquitylation. PubMed ID: 19920177

SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation. PubMed ID: 20596027

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage. PubMed ID: 23274085

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Ubiquitylation-dependent localization of PLK1 in mitosis. PubMed ID: 23455478

Oncogenic function of SCCRO5/DCUN1D5 requires its Neddylation E3 activity and nuclear localization. PubMed ID: 24192928

SCCRO3 (DCUN1D3) antagonizes the neddylation and oncogenic activity of SCCRO (DCUN1D1). PubMed ID: 25349211

CUL3-KBTBD6/KBTBD7 ubiquitin ligase cooperates with GABARAP proteins to spatially restrict TIAM1-RAC1 signaling. PubMed ID: 25684205

Two distinct types of E3 ligases work in unison to regulate substrate ubiquitylation. PubMed ID: 27565346

Characterization of the mammalian family of DCN-type NEDD8 E3 ligases. PubMed ID: 26906416

NOTCH2 Hajdu-Cheney mutations escape SCFFBW7-dependent proteolysis to promote osteoporosis. PubMed ID: 29149593

KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing. PubMed ID: 29769719

Structure of the Cul1-Rbx1-Skp1-F box Skp2 SCF ubiquitin ligase complex. PubMed ID: 11961546

Structure of a glomulin-RBX1-CUL1 complex: inhibition of a RING E3 ligase through masking of its E2-binding surface. PubMed ID: 22748924

A conserved mechanism for regulating replisome disassembly in eukaryotes. PubMed ID: 34700328