Details for: CDC42

Gene ID: 998

Symbol: CDC42

Ensembl ID: ENSG00000070831

Description: cell division cycle 42

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 679.9630
    Cell Significance Index: -105.7700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 419.5260
    Cell Significance Index: -106.4100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 315.7440
    Cell Significance Index: -130.0700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 269.9276
    Cell Significance Index: -109.6600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 267.4941
    Cell Significance Index: -126.2900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 245.5358
    Cell Significance Index: -126.3000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 189.2337
    Cell Significance Index: -126.9800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 117.5919
    Cell Significance Index: -112.2700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 96.1308
    Cell Significance Index: -118.5300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 37.4114
    Cell Significance Index: -100.2200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 32.4451
    Cell Significance Index: -128.0300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 29.1002
    Cell Significance Index: -89.3800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 19.6656
    Cell Significance Index: -43.0400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.7282
    Cell Significance Index: 87.3900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 3.5637
    Cell Significance Index: 642.4200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 3.5434
    Cell Significance Index: 228.6100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 3.5134
    Cell Significance Index: 432.0000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 3.3869
    Cell Significance Index: 176.4200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.3368
    Cell Significance Index: 458.2400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.1833
    Cell Significance Index: 149.6100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.9865
    Cell Significance Index: 81.2900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.8213
    Cell Significance Index: 80.8800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.8193
    Cell Significance Index: 75.2800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.5021
    Cell Significance Index: 186.4800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.4586
    Cell Significance Index: 1342.6900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.3337
    Cell Significance Index: 21.4900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.1511
    Cell Significance Index: 951.0600
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 2.0994
    Cell Significance Index: 12.9200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.0962
    Cell Significance Index: 55.1200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.0343
    Cell Significance Index: 70.6900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.9745
    Cell Significance Index: 57.9900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.8169
    Cell Significance Index: 38.0300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.8100
    Cell Significance Index: 31.9900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.5684
    Cell Significance Index: 314.6200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.5466
    Cell Significance Index: 17.5700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.5391
    Cell Significance Index: 71.7600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.5182
    Cell Significance Index: 79.7100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.4512
    Cell Significance Index: 171.1400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.4033
    Cell Significance Index: 179.8900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.3897
    Cell Significance Index: 179.5500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.3482
    Cell Significance Index: 95.3500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1918
    Cell Significance Index: 61.9100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9289
    Cell Significance Index: 333.1900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7981
    Cell Significance Index: 158.3800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.7891
    Cell Significance Index: 48.5000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.5848
    Cell Significance Index: 13.5100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3303
    Cell Significance Index: 56.4000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1955
    Cell Significance Index: 37.2100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0946
    Cell Significance Index: 9.3600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0896
    Cell Significance Index: 67.8400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0108
    Cell Significance Index: 0.1800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0088
    Cell Significance Index: 16.5600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0043
    Cell Significance Index: -0.1200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0170
    Cell Significance Index: -12.4800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0430
    Cell Significance Index: -58.4700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0434
    Cell Significance Index: -79.9900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0458
    Cell Significance Index: -33.8900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0536
    Cell Significance Index: -82.5000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0966
    Cell Significance Index: -60.3500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1051
    Cell Significance Index: -66.7300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1090
    Cell Significance Index: -3.8300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1099
    Cell Significance Index: -3.1700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1116
    Cell Significance Index: -11.4000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1443
    Cell Significance Index: -81.4100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1470
    Cell Significance Index: -66.7200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2522
    Cell Significance Index: -53.1200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2896
    Cell Significance Index: -4.3400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3682
    Cell Significance Index: -105.9300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4436
    Cell Significance Index: -2.6800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5225
    Cell Significance Index: -59.8700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.5607
    Cell Significance Index: -43.0300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.5617
    Cell Significance Index: -65.4600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.5705
    Cell Significance Index: -82.9300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.6308
    Cell Significance Index: -10.8100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.6658
    Cell Significance Index: -72.4200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.7982
    Cell Significance Index: -10.8900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.8250
    Cell Significance Index: -52.0000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.8548
    Cell Significance Index: -97.5800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.9331
    Cell Significance Index: -42.3000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.9745
    Cell Significance Index: -24.9000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.9793
    Cell Significance Index: -54.9600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.1464
    Cell Significance Index: -119.3700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.1480
    Cell Significance Index: -77.1900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.1529
    Cell Significance Index: -91.3100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.2425
    Cell Significance Index: -33.2400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.5514
    Cell Significance Index: -33.6100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.6048
    Cell Significance Index: -41.2500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.8654
    Cell Significance Index: -59.7500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -2.0062
    Cell Significance Index: -88.7400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -2.0535
    Cell Significance Index: -125.9000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -2.1140
    Cell Significance Index: -50.7000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -2.1933
    Cell Significance Index: -26.1500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -2.2086
    Cell Significance Index: -59.1800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -2.4114
    Cell Significance Index: -91.3200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -2.4560
    Cell Significance Index: -72.3400
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -2.6121
    Cell Significance Index: -16.2300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -2.7260
    Cell Significance Index: -89.2500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -2.7686
    Cell Significance Index: -101.6400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -2.8215
    Cell Significance Index: -60.0900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -2.8488
    Cell Significance Index: -90.7300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **GTP-binding protein**: CDC42 is a GTP-binding protein that cycles between an active GTP-bound state and an inactive GDP-bound state, regulating its activity and interactions with other proteins. 2. **Actin dynamics regulation**: CDC42 regulates actin dynamics by interacting with actin-binding proteins, such as WASP and Arp2/3, to promote actin polymerization and reorganization. 3. **Cell migration and polarity**: CDC42 is involved in regulating cell migration, polarity, and morphology, particularly in immune cells, such as T cells and macrophages. 4. **Immune system regulation**: CDC42 is expressed in various immune cells and is involved in regulating immune responses, including adaptive and innate immunity. 5. **Signaling pathways**: CDC42 interacts with multiple signaling pathways, including those involved in cell signaling, cytokine signaling, and receptor tyrosine kinase signaling. **Pathways and Functions** 1. **Actin cytoskeleton organization**: CDC42 regulates actin dynamics by interacting with actin-binding proteins, such as WASP and Arp2/3. 2. **Adaptive immune system**: CDC42 is involved in regulating T cell activation, proliferation, and differentiation. 3. **Innate immune system**: CDC42 is expressed in various innate immune cells, such as macrophages and neutrophils, and is involved in regulating phagocytosis and cytokine production. 4. **Cytokine signaling**: CDC42 interacts with cytokine receptors, such as IL-12R, to regulate cytokine signaling. 5. **Cell polarity and migration**: CDC42 regulates cell polarity and migration, particularly in immune cells, such as T cells and macrophages. 6. **Signaling by receptor tyrosine kinases**: CDC42 interacts with receptor tyrosine kinases, such as EGFR, to regulate signaling pathways. 7. **G-protein signaling**: CDC42 interacts with G-proteins to regulate signaling pathways. **Clinical Significance** 1. **Cancer**: CDC42 is overexpressed in various cancers, including breast and lung cancer, and is associated with poor prognosis. 2. **Autoimmune diseases**: CDC42 is involved in regulating immune responses and is implicated in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 3. **Neurological disorders**: CDC42 is involved in regulating neural development and function and is implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Infectious diseases**: CDC42 is involved in regulating immune responses and is implicated in infectious diseases, such as Leishmaniasis and tuberculosis. 5. **Therapeutic targeting**: CDC42 is a potential therapeutic target for various diseases, including cancer and autoimmune diseases. In conclusion, the CDC42 gene plays a crucial role in regulating various cellular processes, including cell signaling, cytoskeleton organization, and immune responses. Its dysregulation is implicated in various diseases, including cancer, autoimmune diseases, and neurological disorders, making it a potential therapeutic target for various diseases.

Genular Protein ID: 91791884

Symbol: CDC42_HUMAN

Name: G25K GTP-binding protein

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2122236

Title: Molecular cloning and expression of a G25K cDNA, the human homolog of the yeast cell cycle gene CDC42.

PubMed ID: 2122236

DOI: 10.1128/mcb.10.11.5977-5982.1990

PubMed ID: 2124704

Title: Molecular cloning of the gene for the human placental GTP-binding protein Gp (G25K): identification of this GTP-binding protein as the human homolog of the yeast cell-division-cycle protein CDC42.

PubMed ID: 2124704

DOI: 10.1073/pnas.87.24.9853

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8504089

Title: Regulation of the human neutrophil NADPH oxidase by rho-related G-proteins.

PubMed ID: 8504089

DOI: 10.1021/bi00072a029

PubMed ID: 2496687

Title: Characterization of G25K, a GTP-binding protein containing a novel putative nucleotide binding domain.

PubMed ID: 2496687

DOI: 10.1016/0006-291x(89)91615-x

PubMed ID: 7512369

Title: Identification of a novel protein with GDP dissociation inhibitor activity for the ras-like proteins CDC42Hs and rac I.

PubMed ID: 7512369

DOI: 10.1002/gcc.2870080408

PubMed ID: 7777059

Title: Glucosylation of Rho proteins by Clostridium difficile toxin B.

PubMed ID: 7777059

DOI: 10.1038/375500a0

PubMed ID: 7775453

Title: The enterotoxin from Clostridium difficile (ToxA) monoglucosylates the Rho proteins.

PubMed ID: 7775453

DOI: 10.1074/jbc.270.23.13932

PubMed ID: 8810274

Title: Clostridium novyi alpha-toxin-catalyzed incorporation of GlcNAc into Rho subfamily proteins.

PubMed ID: 8810274

DOI: 10.1074/jbc.271.41.25173

PubMed ID: 10490598

Title: The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins.

PubMed ID: 10490598

DOI: 10.1128/mcb.19.10.6585

PubMed ID: 10587647

Title: Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas.

PubMed ID: 10587647

DOI: 10.1038/70302

PubMed ID: 10816584

Title: SPECs, small binding proteins for Cdc42.

PubMed ID: 10816584

DOI: 10.1074/jbc.m002832200

PubMed ID: 10954424

Title: The mammalian homologue of the Caenorhabditis elegans polarity protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and Rac1.

PubMed ID: 10954424

DOI: 10.1242/jcs.113.18.3267

PubMed ID: 11130076

Title: IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling.

PubMed ID: 11130076

DOI: 10.1038/35047107

PubMed ID: 11260256

Title: Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C.

PubMed ID: 11260256

DOI: 10.1046/j.1365-2443.2001.00404.x

PubMed ID: 11807099

Title: The integrin cytoplasmic domain-associated protein ICAP-1 binds and regulates Rho family GTPases during cell spreading.

PubMed ID: 11807099

DOI: 10.1083/jcb.200108030

PubMed ID: 12172552

Title: Zizimin1, a novel Cdc42 activator, reveals a new GEF domain for Rho proteins.

PubMed ID: 12172552

DOI: 10.1038/ncb835

PubMed ID: 14506284

Title: Epidermal growth factor-dependent regulation of Cdc42 is mediated by the Src tyrosine kinase.

PubMed ID: 14506284

DOI: 10.1074/jbc.m307021200

PubMed ID: 12612085

Title: The TRE17 oncogene encodes a component of a novel effector pathway for Rho GTPases Cdc42 and Rac1 and stimulates actin remodeling.

PubMed ID: 12612085

DOI: 10.1128/mcb.23.6.2151-2161.2003

PubMed ID: 14978216

Title: Regulation of dendritic branching and filopodia formation in hippocampal neurons by specific acylated protein motifs.

PubMed ID: 14978216

DOI: 10.1091/mbc.e03-07-0493

PubMed ID: 15642749

Title: Ect2 and MgcRacGAP regulate the activation and function of Cdc42 in mitosis.

PubMed ID: 15642749

DOI: 10.1083/jcb.200408085

PubMed ID: 17038317

Title: Ack1 mediates Cdc42-dependent cell migration and signaling to p130Cas.

PubMed ID: 17038317

DOI: 10.1074/jbc.m604342200

PubMed ID: 19029984

Title: Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease.

PubMed ID: 19029984

DOI: 10.1038/nm.1879

PubMed ID: 19362538

Title: The fic domain: regulation of cell signaling by adenylylation.

PubMed ID: 19362538

DOI: 10.1016/j.molcel.2009.03.008

PubMed ID: 19798448

Title: Requirements for F-BAR proteins TOCA-1 and TOCA-2 in actin dynamics and membrane trafficking during Caenorhabditis elegans oocyte growth and embryonic epidermal morphogenesis.

PubMed ID: 19798448

DOI: 10.1371/journal.pgen.1000675

PubMed ID: 19039103

Title: AMPylation of Rho GTPases by Vibrio VopS disrupts effector binding and downstream signaling.

PubMed ID: 19039103

DOI: 10.1126/science.1166382

PubMed ID: 20873783

Title: Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome.

PubMed ID: 20873783

DOI: 10.1021/pr100562w

PubMed ID: 21565175

Title: ARHGAP30 is a Wrch-1-interacting protein involved in actin dynamics and cell adhesion.

PubMed ID: 21565175

DOI: 10.1016/j.bbrc.2011.04.116

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21139582

Title: The HPV16 E6 binding protein Tip-1 interacts with ARHGEF16, which activates Cdc42.

PubMed ID: 21139582

DOI: 10.1038/sj.bjc.6606026

PubMed ID: 22843693

Title: Tetraspanin CD151 stimulates adhesion-dependent activation of Ras, Rac, and Cdc42 by facilitating molecular association between beta1 integrins and small GTPases.

PubMed ID: 22843693

DOI: 10.1074/jbc.m111.314443

PubMed ID: 23940119

Title: The GEF Bcr activates RhoA/MAL signaling to promote keratinocyte differentiation via desmoglein-1.

PubMed ID: 23940119

DOI: 10.1083/jcb.201304133

PubMed ID: 23434736

Title: ARHGDIA: a novel gene implicated in nephrotic syndrome.

PubMed ID: 23434736

DOI: 10.1136/jmedgenet-2012-101442

PubMed ID: 24141704

Title: A bacterial toxin catalyzing tyrosine glycosylation of Rho and deamidation of Gq and Gi proteins.

PubMed ID: 24141704

DOI: 10.1038/nsmb.2688

PubMed ID: 24905543

Title: Haemorrhagic toxin and lethal toxin from Clostridium sordellii strain vpi9048: molecular characterization and comparative analysis of substrate specificity of the large clostridial glucosylating toxins.

PubMed ID: 24905543

DOI: 10.1111/cmi.12321

PubMed ID: 26465210

Title: Phosphoinositide 3-kinase enables phagocytosis of large particles by terminating actin assembly through Rac/Cdc42 GTPase-activating proteins.

PubMed ID: 26465210

DOI: 10.1038/ncomms9623

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 33310911

Title: PLEKHG4B enables actin cytoskeletal remodeling during epithelial cell-cell junction formation.

PubMed ID: 33310911

DOI: 10.1242/jcs.249078

PubMed ID: 33523862

Title: Recessive NOS1AP variants impair actin remodeling and cause glomerulopathy in humans and mice.

PubMed ID: 33523862

DOI: 10.1126/sciadv.abe1386

PubMed ID: 9220962

Title: Definition of the switch surface in the solution structure of Cdc42Hs.

PubMed ID: 9220962

DOI: 10.1021/bi970694x

PubMed ID: 9760238

Title: Identification of the binding surface on Cdc42Hs for p21-activated kinase.

PubMed ID: 9760238

DOI: 10.1021/bi981352+

PubMed ID: 9262406

Title: Crystal structure of a small G protein in complex with the GTPase-activating protein rhoGAP.

PubMed ID: 9262406

DOI: 10.1038/41805

PubMed ID: 10211824

Title: Nucleotide binding to the G12V-mutant of Cdc42 investigated by X-ray diffraction and fluorescence spectroscopy: two different nucleotide states in one crystal.

PubMed ID: 10211824

DOI: 10.1110/ps.8.4.778

PubMed ID: 10676816

Title: Structure of the Rho family GTP-binding protein Cdc42 in complex with the multifunctional regulator RhoGDI.

PubMed ID: 10676816

DOI: 10.1016/s0092-8674(00)80670-4

PubMed ID: 19745154

Title: Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor.

PubMed ID: 19745154

DOI: 10.1126/science.1174468

PubMed ID: 20622875

Title: Structural basis of Fic-mediated adenylylation.

PubMed ID: 20622875

DOI: 10.1038/nsmb.1867

PubMed ID: 22461490

Title: DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses.

PubMed ID: 22461490

DOI: 10.1182/blood-2012-01-407098

PubMed ID: 26386261

Title: Macrothrombocytopenia and developmental delay with a de novo CDC42 mutation: Yet another locus for thrombocytopenia and developmental delay.

PubMed ID: 26386261

DOI: 10.1002/ajmg.a.37275

PubMed ID: 26708094

Title: Further evidence of a mutation in CDC42 as a cause of a recognizable syndromic form of thrombocytopenia.

PubMed ID: 26708094

DOI: 10.1002/ajmg.a.37526

Sequence Information:

  • Length: 191
  • Mass: 21259
  • Checksum: 51A437E22A4D8FFF
  • Sequence:
  • MQTIKCVVVG DGAVGKTCLL ISYTTNKFPS EYVPTVFDNY AVTVMIGGEP YTLGLFDTAG 
    QEDYDRLRPL SYPQTDVFLV CFSVVSPSSF ENVKEKWVPE ITHHCPKTPF LLVGTQIDLR 
    DDPSTIEKLA KNKQKPITPE TAEKLARDLK AVKYVECSAL TQKGLKNVFD EAILAALEPP 
    EPKKSRRCVL L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.