Details for: CDC42
Associated with
Other Information
Genular Protein ID: 91791884
Symbol: CDC42_HUMAN
Name: G25K GTP-binding protein
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2122236
Title: Molecular cloning and expression of a G25K cDNA, the human homolog of the yeast cell cycle gene CDC42.
PubMed ID: 2122236
PubMed ID: 2124704
Title: Molecular cloning of the gene for the human placental GTP-binding protein Gp (G25K): identification of this GTP-binding protein as the human homolog of the yeast cell-division-cycle protein CDC42.
PubMed ID: 2124704
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8504089
Title: Regulation of the human neutrophil NADPH oxidase by rho-related G-proteins.
PubMed ID: 8504089
DOI: 10.1021/bi00072a029
PubMed ID: 2496687
Title: Characterization of G25K, a GTP-binding protein containing a novel putative nucleotide binding domain.
PubMed ID: 2496687
PubMed ID: 7512369
Title: Identification of a novel protein with GDP dissociation inhibitor activity for the ras-like proteins CDC42Hs and rac I.
PubMed ID: 7512369
PubMed ID: 7777059
Title: Glucosylation of Rho proteins by Clostridium difficile toxin B.
PubMed ID: 7777059
DOI: 10.1038/375500a0
PubMed ID: 7775453
Title: The enterotoxin from Clostridium difficile (ToxA) monoglucosylates the Rho proteins.
PubMed ID: 7775453
PubMed ID: 8810274
Title: Clostridium novyi alpha-toxin-catalyzed incorporation of GlcNAc into Rho subfamily proteins.
PubMed ID: 8810274
PubMed ID: 10490598
Title: The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins.
PubMed ID: 10490598
PubMed ID: 10587647
Title: Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas.
PubMed ID: 10587647
DOI: 10.1038/70302
PubMed ID: 10816584
PubMed ID: 10954424
Title: The mammalian homologue of the Caenorhabditis elegans polarity protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and Rac1.
PubMed ID: 10954424
PubMed ID: 11130076
Title: IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling.
PubMed ID: 11130076
DOI: 10.1038/35047107
PubMed ID: 11260256
Title: Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C.
PubMed ID: 11260256
PubMed ID: 11807099
Title: The integrin cytoplasmic domain-associated protein ICAP-1 binds and regulates Rho family GTPases during cell spreading.
PubMed ID: 11807099
PubMed ID: 12172552
Title: Zizimin1, a novel Cdc42 activator, reveals a new GEF domain for Rho proteins.
PubMed ID: 12172552
DOI: 10.1038/ncb835
PubMed ID: 14506284
Title: Epidermal growth factor-dependent regulation of Cdc42 is mediated by the Src tyrosine kinase.
PubMed ID: 14506284
PubMed ID: 12612085
Title: The TRE17 oncogene encodes a component of a novel effector pathway for Rho GTPases Cdc42 and Rac1 and stimulates actin remodeling.
PubMed ID: 12612085
PubMed ID: 14978216
Title: Regulation of dendritic branching and filopodia formation in hippocampal neurons by specific acylated protein motifs.
PubMed ID: 14978216
PubMed ID: 15642749
Title: Ect2 and MgcRacGAP regulate the activation and function of Cdc42 in mitosis.
PubMed ID: 15642749
PubMed ID: 17038317
Title: Ack1 mediates Cdc42-dependent cell migration and signaling to p130Cas.
PubMed ID: 17038317
PubMed ID: 19029984
Title: Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease.
PubMed ID: 19029984
DOI: 10.1038/nm.1879
PubMed ID: 19362538
Title: The fic domain: regulation of cell signaling by adenylylation.
PubMed ID: 19362538
PubMed ID: 19798448
Title: Requirements for F-BAR proteins TOCA-1 and TOCA-2 in actin dynamics and membrane trafficking during Caenorhabditis elegans oocyte growth and embryonic epidermal morphogenesis.
PubMed ID: 19798448
PubMed ID: 19039103
Title: AMPylation of Rho GTPases by Vibrio VopS disrupts effector binding and downstream signaling.
PubMed ID: 19039103
PubMed ID: 20873783
Title: Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome.
PubMed ID: 20873783
DOI: 10.1021/pr100562w
PubMed ID: 21565175
Title: ARHGAP30 is a Wrch-1-interacting protein involved in actin dynamics and cell adhesion.
PubMed ID: 21565175
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21139582
Title: The HPV16 E6 binding protein Tip-1 interacts with ARHGEF16, which activates Cdc42.
PubMed ID: 21139582
PubMed ID: 23940119
Title: The GEF Bcr activates RhoA/MAL signaling to promote keratinocyte differentiation via desmoglein-1.
PubMed ID: 23940119
PubMed ID: 23434736
Title: ARHGDIA: a novel gene implicated in nephrotic syndrome.
PubMed ID: 23434736
PubMed ID: 24141704
Title: A bacterial toxin catalyzing tyrosine glycosylation of Rho and deamidation of Gq and Gi proteins.
PubMed ID: 24141704
DOI: 10.1038/nsmb.2688
PubMed ID: 24905543
Title: Haemorrhagic toxin and lethal toxin from Clostridium sordellii strain vpi9048: molecular characterization and comparative analysis of substrate specificity of the large clostridial glucosylating toxins.
PubMed ID: 24905543
DOI: 10.1111/cmi.12321
PubMed ID: 26465210
Title: Phosphoinositide 3-kinase enables phagocytosis of large particles by terminating actin assembly through Rac/Cdc42 GTPase-activating proteins.
PubMed ID: 26465210
DOI: 10.1038/ncomms9623
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 33523862
Title: Recessive NOS1AP variants impair actin remodeling and cause glomerulopathy in humans and mice.
PubMed ID: 33523862
PubMed ID: 9220962
Title: Definition of the switch surface in the solution structure of Cdc42Hs.
PubMed ID: 9220962
DOI: 10.1021/bi970694x
PubMed ID: 9760238
Title: Identification of the binding surface on Cdc42Hs for p21-activated kinase.
PubMed ID: 9760238
DOI: 10.1021/bi981352+
PubMed ID: 9262406
Title: Crystal structure of a small G protein in complex with the GTPase-activating protein rhoGAP.
PubMed ID: 9262406
DOI: 10.1038/41805
PubMed ID: 10211824
Title: Nucleotide binding to the G12V-mutant of Cdc42 investigated by X-ray diffraction and fluorescence spectroscopy: two different nucleotide states in one crystal.
PubMed ID: 10211824
DOI: 10.1110/ps.8.4.778
PubMed ID: 10676816
Title: Structure of the Rho family GTP-binding protein Cdc42 in complex with the multifunctional regulator RhoGDI.
PubMed ID: 10676816
PubMed ID: 19745154
Title: Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor.
PubMed ID: 19745154
PubMed ID: 20622875
PubMed ID: 22461490
Title: DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses.
PubMed ID: 22461490
PubMed ID: 26386261
Title: Macrothrombocytopenia and developmental delay with a de novo CDC42 mutation: Yet another locus for thrombocytopenia and developmental delay.
PubMed ID: 26386261
DOI: 10.1002/ajmg.a.37275
PubMed ID: 26708094
Title: Further evidence of a mutation in CDC42 as a cause of a recognizable syndromic form of thrombocytopenia.
PubMed ID: 26708094
DOI: 10.1002/ajmg.a.37526
Sequence Information:
- Length: 191
- Mass: 21259
- Checksum: 51A437E22A4D8FFF
- Sequence:
MQTIKCVVVG DGAVGKTCLL ISYTTNKFPS EYVPTVFDNY AVTVMIGGEP YTLGLFDTAG QEDYDRLRPL SYPQTDVFLV CFSVVSPSSF ENVKEKWVPE ITHHCPKTPF LLVGTQIDLR DDPSTIEKLA KNKQKPITPE TAEKLARDLK AVKYVECSAL TQKGLKNVFD EAILAALEPP EPKKSRRCVL L
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.