Details for: CDC42
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 679.9630
Cell Significance Index: -105.7700 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 419.5260
Cell Significance Index: -106.4100 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 315.7440
Cell Significance Index: -130.0700 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 269.9276
Cell Significance Index: -109.6600 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 267.4941
Cell Significance Index: -126.2900 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 245.5358
Cell Significance Index: -126.3000 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 189.2337
Cell Significance Index: -126.9800 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 117.5919
Cell Significance Index: -112.2700 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 96.1308
Cell Significance Index: -118.5300 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 37.4114
Cell Significance Index: -100.2200 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 32.4451
Cell Significance Index: -128.0300 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 29.1002
Cell Significance Index: -89.3800 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 19.6656
Cell Significance Index: -43.0400 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 4.7282
Cell Significance Index: 87.3900 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 3.5637
Cell Significance Index: 642.4200 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 3.5434
Cell Significance Index: 228.6100 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 3.5134
Cell Significance Index: 432.0000 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 3.3869
Cell Significance Index: 176.4200 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 3.3368
Cell Significance Index: 458.2400 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 3.1833
Cell Significance Index: 149.6100 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.9865
Cell Significance Index: 81.2900 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.8213
Cell Significance Index: 80.8800 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 2.8193
Cell Significance Index: 75.2800 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.5021
Cell Significance Index: 186.4800 - Cell Name: cell in vitro (CL0001034)
Fold Change: 2.4586
Cell Significance Index: 1342.6900 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 2.3337
Cell Significance Index: 21.4900 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 2.1511
Cell Significance Index: 951.0600 - Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 2.0994
Cell Significance Index: 12.9200 - Cell Name: granulosa cell (CL0000501)
Fold Change: 2.0962
Cell Significance Index: 55.1200 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 2.0343
Cell Significance Index: 70.6900 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.9745
Cell Significance Index: 57.9900 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 1.8169
Cell Significance Index: 38.0300 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 1.8100
Cell Significance Index: 31.9900 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.5684
Cell Significance Index: 314.6200 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 1.5466
Cell Significance Index: 17.5700 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.5391
Cell Significance Index: 71.7600 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.5182
Cell Significance Index: 79.7100 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.4512
Cell Significance Index: 171.1400 - Cell Name: odontoblast (CL0000060)
Fold Change: 1.4033
Cell Significance Index: 179.8900 - Cell Name: lactocyte (CL0002325)
Fold Change: 1.3897
Cell Significance Index: 179.5500 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 1.3482
Cell Significance Index: 95.3500 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.1918
Cell Significance Index: 61.9100 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.9289
Cell Significance Index: 333.1900 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.7981
Cell Significance Index: 158.3800 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.7891
Cell Significance Index: 48.5000 - Cell Name: peg cell (CL4033014)
Fold Change: 0.5848
Cell Significance Index: 13.5100 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.3303
Cell Significance Index: 56.4000 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1955
Cell Significance Index: 37.2100 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0946
Cell Significance Index: 9.3600 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0896
Cell Significance Index: 67.8400 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0108
Cell Significance Index: 0.1800 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0088
Cell Significance Index: 16.5600 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0043
Cell Significance Index: -0.1200 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0170
Cell Significance Index: -12.4800 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0430
Cell Significance Index: -58.4700 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0434
Cell Significance Index: -79.9900 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0458
Cell Significance Index: -33.8900 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0536
Cell Significance Index: -82.5000 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0966
Cell Significance Index: -60.3500 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.1051
Cell Significance Index: -66.7300 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.1090
Cell Significance Index: -3.8300 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.1099
Cell Significance Index: -3.1700 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1116
Cell Significance Index: -11.4000 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1443
Cell Significance Index: -81.4100 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.1470
Cell Significance Index: -66.7200 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2522
Cell Significance Index: -53.1200 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.2896
Cell Significance Index: -4.3400 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.3682
Cell Significance Index: -105.9300 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.4436
Cell Significance Index: -2.6800 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.5225
Cell Significance Index: -59.8700 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.5607
Cell Significance Index: -43.0300 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.5617
Cell Significance Index: -65.4600 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.5705
Cell Significance Index: -82.9300 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.6308
Cell Significance Index: -10.8100 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.6658
Cell Significance Index: -72.4200 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.7982
Cell Significance Index: -10.8900 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.8250
Cell Significance Index: -52.0000 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.8548
Cell Significance Index: -97.5800 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.9331
Cell Significance Index: -42.3000 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.9745
Cell Significance Index: -24.9000 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.9793
Cell Significance Index: -54.9600 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -1.1464
Cell Significance Index: -119.3700 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -1.1480
Cell Significance Index: -77.1900 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -1.1529
Cell Significance Index: -91.3100 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -1.2425
Cell Significance Index: -33.2400 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -1.5514
Cell Significance Index: -33.6100 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -1.6048
Cell Significance Index: -41.2500 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.8654
Cell Significance Index: -59.7500 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -2.0062
Cell Significance Index: -88.7400 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -2.0535
Cell Significance Index: -125.9000 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -2.1140
Cell Significance Index: -50.7000 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -2.1933
Cell Significance Index: -26.1500 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -2.2086
Cell Significance Index: -59.1800 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -2.4114
Cell Significance Index: -91.3200 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -2.4560
Cell Significance Index: -72.3400 - Cell Name: extravillous trophoblast (CL0008036)
Fold Change: -2.6121
Cell Significance Index: -16.2300 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -2.7260
Cell Significance Index: -89.2500 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -2.7686
Cell Significance Index: -101.6400 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -2.8215
Cell Significance Index: -60.0900 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -2.8488
Cell Significance Index: -90.7300
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 91791884
Symbol: CDC42_HUMAN
Name: G25K GTP-binding protein
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2122236
Title: Molecular cloning and expression of a G25K cDNA, the human homolog of the yeast cell cycle gene CDC42.
PubMed ID: 2122236
PubMed ID: 2124704
Title: Molecular cloning of the gene for the human placental GTP-binding protein Gp (G25K): identification of this GTP-binding protein as the human homolog of the yeast cell-division-cycle protein CDC42.
PubMed ID: 2124704
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8504089
Title: Regulation of the human neutrophil NADPH oxidase by rho-related G-proteins.
PubMed ID: 8504089
DOI: 10.1021/bi00072a029
PubMed ID: 2496687
Title: Characterization of G25K, a GTP-binding protein containing a novel putative nucleotide binding domain.
PubMed ID: 2496687
PubMed ID: 7512369
Title: Identification of a novel protein with GDP dissociation inhibitor activity for the ras-like proteins CDC42Hs and rac I.
PubMed ID: 7512369
PubMed ID: 7777059
Title: Glucosylation of Rho proteins by Clostridium difficile toxin B.
PubMed ID: 7777059
DOI: 10.1038/375500a0
PubMed ID: 7775453
Title: The enterotoxin from Clostridium difficile (ToxA) monoglucosylates the Rho proteins.
PubMed ID: 7775453
PubMed ID: 8810274
Title: Clostridium novyi alpha-toxin-catalyzed incorporation of GlcNAc into Rho subfamily proteins.
PubMed ID: 8810274
PubMed ID: 10490598
Title: The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins.
PubMed ID: 10490598
PubMed ID: 10587647
Title: Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas.
PubMed ID: 10587647
DOI: 10.1038/70302
PubMed ID: 10816584
PubMed ID: 10954424
Title: The mammalian homologue of the Caenorhabditis elegans polarity protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and Rac1.
PubMed ID: 10954424
PubMed ID: 11130076
Title: IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling.
PubMed ID: 11130076
DOI: 10.1038/35047107
PubMed ID: 11260256
Title: Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C.
PubMed ID: 11260256
PubMed ID: 11807099
Title: The integrin cytoplasmic domain-associated protein ICAP-1 binds and regulates Rho family GTPases during cell spreading.
PubMed ID: 11807099
PubMed ID: 12172552
Title: Zizimin1, a novel Cdc42 activator, reveals a new GEF domain for Rho proteins.
PubMed ID: 12172552
DOI: 10.1038/ncb835
PubMed ID: 14506284
Title: Epidermal growth factor-dependent regulation of Cdc42 is mediated by the Src tyrosine kinase.
PubMed ID: 14506284
PubMed ID: 12612085
Title: The TRE17 oncogene encodes a component of a novel effector pathway for Rho GTPases Cdc42 and Rac1 and stimulates actin remodeling.
PubMed ID: 12612085
PubMed ID: 14978216
Title: Regulation of dendritic branching and filopodia formation in hippocampal neurons by specific acylated protein motifs.
PubMed ID: 14978216
PubMed ID: 15642749
Title: Ect2 and MgcRacGAP regulate the activation and function of Cdc42 in mitosis.
PubMed ID: 15642749
PubMed ID: 17038317
Title: Ack1 mediates Cdc42-dependent cell migration and signaling to p130Cas.
PubMed ID: 17038317
PubMed ID: 19029984
Title: Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease.
PubMed ID: 19029984
DOI: 10.1038/nm.1879
PubMed ID: 19362538
Title: The fic domain: regulation of cell signaling by adenylylation.
PubMed ID: 19362538
PubMed ID: 19798448
Title: Requirements for F-BAR proteins TOCA-1 and TOCA-2 in actin dynamics and membrane trafficking during Caenorhabditis elegans oocyte growth and embryonic epidermal morphogenesis.
PubMed ID: 19798448
PubMed ID: 19039103
Title: AMPylation of Rho GTPases by Vibrio VopS disrupts effector binding and downstream signaling.
PubMed ID: 19039103
PubMed ID: 20873783
Title: Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome.
PubMed ID: 20873783
DOI: 10.1021/pr100562w
PubMed ID: 21565175
Title: ARHGAP30 is a Wrch-1-interacting protein involved in actin dynamics and cell adhesion.
PubMed ID: 21565175
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21139582
Title: The HPV16 E6 binding protein Tip-1 interacts with ARHGEF16, which activates Cdc42.
PubMed ID: 21139582
PubMed ID: 22843693
Title: Tetraspanin CD151 stimulates adhesion-dependent activation of Ras, Rac, and Cdc42 by facilitating molecular association between beta1 integrins and small GTPases.
PubMed ID: 22843693
PubMed ID: 23940119
Title: The GEF Bcr activates RhoA/MAL signaling to promote keratinocyte differentiation via desmoglein-1.
PubMed ID: 23940119
PubMed ID: 23434736
Title: ARHGDIA: a novel gene implicated in nephrotic syndrome.
PubMed ID: 23434736
PubMed ID: 24141704
Title: A bacterial toxin catalyzing tyrosine glycosylation of Rho and deamidation of Gq and Gi proteins.
PubMed ID: 24141704
DOI: 10.1038/nsmb.2688
PubMed ID: 24905543
Title: Haemorrhagic toxin and lethal toxin from Clostridium sordellii strain vpi9048: molecular characterization and comparative analysis of substrate specificity of the large clostridial glucosylating toxins.
PubMed ID: 24905543
DOI: 10.1111/cmi.12321
PubMed ID: 26465210
Title: Phosphoinositide 3-kinase enables phagocytosis of large particles by terminating actin assembly through Rac/Cdc42 GTPase-activating proteins.
PubMed ID: 26465210
DOI: 10.1038/ncomms9623
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 33310911
Title: PLEKHG4B enables actin cytoskeletal remodeling during epithelial cell-cell junction formation.
PubMed ID: 33310911
DOI: 10.1242/jcs.249078
PubMed ID: 33523862
Title: Recessive NOS1AP variants impair actin remodeling and cause glomerulopathy in humans and mice.
PubMed ID: 33523862
PubMed ID: 9220962
Title: Definition of the switch surface in the solution structure of Cdc42Hs.
PubMed ID: 9220962
DOI: 10.1021/bi970694x
PubMed ID: 9760238
Title: Identification of the binding surface on Cdc42Hs for p21-activated kinase.
PubMed ID: 9760238
DOI: 10.1021/bi981352+
PubMed ID: 9262406
Title: Crystal structure of a small G protein in complex with the GTPase-activating protein rhoGAP.
PubMed ID: 9262406
DOI: 10.1038/41805
PubMed ID: 10211824
Title: Nucleotide binding to the G12V-mutant of Cdc42 investigated by X-ray diffraction and fluorescence spectroscopy: two different nucleotide states in one crystal.
PubMed ID: 10211824
DOI: 10.1110/ps.8.4.778
PubMed ID: 10676816
Title: Structure of the Rho family GTP-binding protein Cdc42 in complex with the multifunctional regulator RhoGDI.
PubMed ID: 10676816
PubMed ID: 19745154
Title: Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor.
PubMed ID: 19745154
PubMed ID: 20622875
PubMed ID: 22461490
Title: DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses.
PubMed ID: 22461490
PubMed ID: 26386261
Title: Macrothrombocytopenia and developmental delay with a de novo CDC42 mutation: Yet another locus for thrombocytopenia and developmental delay.
PubMed ID: 26386261
DOI: 10.1002/ajmg.a.37275
PubMed ID: 26708094
Title: Further evidence of a mutation in CDC42 as a cause of a recognizable syndromic form of thrombocytopenia.
PubMed ID: 26708094
DOI: 10.1002/ajmg.a.37526
Sequence Information:
- Length: 191
- Mass: 21259
- Checksum: 51A437E22A4D8FFF
- Sequence:
MQTIKCVVVG DGAVGKTCLL ISYTTNKFPS EYVPTVFDNY AVTVMIGGEP YTLGLFDTAG QEDYDRLRPL SYPQTDVFLV CFSVVSPSSF ENVKEKWVPE ITHHCPKTPF LLVGTQIDLR DDPSTIEKLA KNKQKPITPE TAEKLARDLK AVKYVECSAL TQKGLKNVFD EAILAALEPP EPKKSRRCVL L
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.