Details for: FGFBP1

Gene ID: 9982

Symbol: FGFBP1

Ensembl ID: ENSG00000137440

Description: fibroblast growth factor binding protein 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 15.99
    Marker Score: 162,070
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.68
    Marker Score: 8,266
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.72
    Marker Score: 921
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.6
    Marker Score: 20,288
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 2.45
    Marker Score: 2,047
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.36
    Marker Score: 2,489
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 2.19
    Marker Score: 1,215
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.16
    Marker Score: 18,608
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.76
    Marker Score: 1,384
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.51
    Marker Score: 1,768
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.23
    Marker Score: 609
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 1.23
    Marker Score: 701
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.21
    Marker Score: 1,333
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1
    Marker Score: 1,095
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.07
    Marker Score: 308
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.05
    Marker Score: 3,304
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,819
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,044
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1
    Marker Score: 2,431
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 510
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 463
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.98
    Marker Score: 1,784
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.98
    Marker Score: 1,259
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,411
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.92
    Marker Score: 266
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5,240
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 327
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.88
    Marker Score: 11,840
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,294
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.86
    Marker Score: 1,631
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.84
    Marker Score: 28,924
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.83
    Marker Score: 333
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,267
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 698
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2,909
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.68
    Marker Score: 1,382
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.63
    Marker Score: 928
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.62
    Marker Score: 646
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.61
    Marker Score: 489
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.61
    Marker Score: 1,503
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.58
    Marker Score: 306
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.58
    Marker Score: 407
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.54
    Marker Score: 3,547
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.54
    Marker Score: 8,446
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.52
    Marker Score: 3,154
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.5
    Marker Score: 1,191
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.49
    Marker Score: 118
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.49
    Marker Score: 177
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.48
    Marker Score: 178
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.48
    Marker Score: 425
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.47
    Marker Score: 758
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 279
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.46
    Marker Score: 309
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.46
    Marker Score: 439
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.46
    Marker Score: 274
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.43
    Marker Score: 339
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.42
    Marker Score: 199
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.41
    Marker Score: 263
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4
    Marker Score: 273
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.4
    Marker Score: 2,560
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.39
    Marker Score: 123
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.39
    Marker Score: 169
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.37
    Marker Score: 1,051
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.37
    Marker Score: 159
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.35
    Marker Score: 87
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.34
    Marker Score: 385
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.33
    Marker Score: 137
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.31
    Marker Score: 205
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.3
    Marker Score: 140
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.29
    Marker Score: 2,156
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.28
    Marker Score: 145
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.27
    Marker Score: 86
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.27
    Marker Score: 1,291
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.27
    Marker Score: 260
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 91
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.25
    Marker Score: 67
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.25
    Marker Score: 357
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.24
    Marker Score: 61
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.23
    Marker Score: 801
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.22
    Marker Score: 98
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.21
    Marker Score: 343
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.21
    Marker Score: 98
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.21
    Marker Score: 338
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.21
    Marker Score: 386
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.21
    Marker Score: 63
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.21
    Marker Score: 99
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.21
    Marker Score: 94
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.2
    Marker Score: 59
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.2
    Marker Score: 1,759
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.19
    Marker Score: 188
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.18
    Marker Score: 44
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.18
    Marker Score: 64
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.18
    Marker Score: 1,197
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.17
    Marker Score: 118
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.17
    Marker Score: 47

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Binding Protein for FGFs:** FGFBP1 is a binding protein for FGFs, which allows it to modulate the activity of these growth factors. 2. **High Expression in Various Cell Types:** FGFBP1 is highly expressed in various cell types, including glutamatergic neurons, oligodendrocyte precursor cells, stem cells of the epidermis, and stratified epithelial cells. 3. **Regulation of Cell Signaling:** FGFBP1 modulates the activity of FGFs, which are essential for the regulation of cell growth, differentiation, and angiogenesis. 4. **Negative Regulation of Cell Population Proliferation:** FGFBP1 has been shown to negatively regulate cell population proliferation, which is essential for maintaining tissue homeostasis. **Pathways and Functions:** 1. **Fibroblast Growth Factor Receptor Signaling Pathway:** FGFBP1 is involved in the regulation of the fibroblast growth factor receptor (FGFR) signaling pathway, which is essential for the regulation of cell growth, differentiation, and angiogenesis. 2. **Angiogenesis:** FGFBP1 is involved in the regulation of angiogenesis, which is the formation of new blood vessels from pre-existing vessels. 3. **Myoblast Proliferation:** FGFBP1 regulates myoblast proliferation, which is essential for the development and growth of skeletal muscle. 4. **Negative Regulation of Cell Migration:** FGFBP1 has been shown to negatively regulate cell migration, which is essential for maintaining tissue homeostasis. **Clinical Significance:** 1. **Cancer:** FGFBP1 is overexpressed in various types of cancer, including breast cancer, lung cancer, and colon cancer. The dysregulation of FGFBP1 has been shown to contribute to tumorigenesis and cancer progression. 2. **Cardiovascular Disorders:** FGFBP1 is involved in the regulation of angiogenesis, which is essential for the development of cardiovascular disorders, including atherosclerosis and coronary artery disease. 3. **Neurological Disorders:** FGFBP1 is involved in the regulation of myoblast proliferation, which is essential for the development and growth of skeletal muscle. Dysregulation of FGFBP1 has been shown to contribute to neurological disorders, including muscular dystrophy. 4. **Wound Healing:** FGFBP1 is involved in the regulation of angiogenesis, which is essential for the healing of wounds. In conclusion, FGFBP1 is a key regulator of cell signaling and angiogenesis, and its dysregulation has significant implications for the pathogenesis of various diseases, including cancer, cardiovascular disorders, and neurological disorders. Further research is needed to fully understand the complex interplay between FGFBP1 and FGFs, and to explore the therapeutic potential of targeting FGFBP1 in the treatment of these diseases.

Genular Protein ID: 2067006127

Symbol: FGFP1_HUMAN

Name: Fibroblast growth factor-binding protein 1

UniProtKB Accession Codes:

Q14512 A8K5J2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EPD 1 Ensembl 1 GO 16 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1885605

Title: Characterization and molecular cloning of a putative binding protein for heparin-binding growth factors.

PubMed ID: 1885605

DOI: 10.1016/s0021-9258(18)55368-0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9334727

Title: A secreted FGF-binding protein can serve as the angiogenic switch in human cancer.

PubMed ID: 9334727

DOI: 10.1038/nm1097-1137

PubMed ID: 11148217

Title: Fibroblast growth factor-binding protein is a novel partner for perlecan protein core.

PubMed ID: 11148217

DOI: 10.1074/jbc.m011493200

PubMed ID: 11509569

Title: Enhancement of fibroblast growth factor (FGF) activity by an FGF-binding protein.

PubMed ID: 11509569

DOI: 10.1074/jbc.m104933200

PubMed ID: 15806171

Title: The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair.

PubMed ID: 15806171

DOI: 10.1038/sj.onc.1208560

PubMed ID: 16257968

Title: Identification of the fibroblast growth factor (FGF)-interacting domain in a secreted FGF-binding protein by phage display.

PubMed ID: 16257968

DOI: 10.1074/jbc.m510754200

Sequence Information:

  • Length: 234
  • Mass: 26264
  • Checksum: AAF4209F29F2D058
  • Sequence:
    • MKICSLTLLS FLLLAAQVLL VEGKKKVKNG LHSKVVSEQK DTLGNTQIKQ KSRPGNKGKF 
VTKDQANCRW AATEQEEGIS LKVECTQLDH EFSCVFAGNP TSCLKLKDER VYWKQVARNL 
RSQKDICRYS KTAVKTRVCR KDFPESSLKL VSSTLFGNTK PRKEKTEMSP REHIKGKETT 
PSSLAVTQTM ATKAPECVED PDMANQRKTA LEFCGETWSS LCTFFLSIVQ DTSC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.