Details for: THOC1
Associated with
Other Information
Genular Protein ID: 2989202898
Symbol: THOC1_HUMAN
Name: THO complex subunit 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7525595
Title: The amino-terminal region of the retinoblastoma gene product binds a novel nuclear matrix protein that co-localizes to centers for RNA processing.
PubMed ID: 7525595
PubMed ID: 15358532
Title: The death domain protein p84N5, but not the short isoform p84N5s, is cell cycle-regulated and shuttles between the nucleus and the cytoplasm.
PubMed ID: 15358532
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16177791
Title: DNA sequence and analysis of human chromosome 18.
PubMed ID: 16177791
DOI: 10.1038/nature03983
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10512864
Title: Apoptosis induced by the nuclear death domain protein p84N5 is inhibited by association with Rb protein.
PubMed ID: 10512864
PubMed ID: 10840029
Title: Apoptosis induced by the nuclear death domain protein p84N5 is associated with caspase-6 and NF-kappa B activation.
PubMed ID: 10840029
PubMed ID: 11050087
Title: The nuclear death domain protein p84N5 activates a G2/M cell cycle checkpoint prior to the onset of apoptosis.
PubMed ID: 11050087
PubMed ID: 11979277
Title: TREX is a conserved complex coupling transcription with messenger RNA export.
PubMed ID: 11979277
DOI: 10.1038/nature746
PubMed ID: 12096345
Title: Nuclear localization is required for induction of apoptotic cell death by the Rb-associated p84N5 death domain protein.
PubMed ID: 12096345
PubMed ID: 15833825
Title: Linking transcriptional elongation and messenger RNA export to metastatic breast cancers.
PubMed ID: 15833825
PubMed ID: 15998806
Title: Recruitment of the human TREX complex to mRNA during splicing.
PubMed ID: 15998806
DOI: 10.1101/gad.1302205
PubMed ID: 15870275
Title: Human hHpr1/p84/Thoc1 regulates transcriptional elongation and physically links RNA polymerase II and RNA processing factors.
PubMed ID: 15870275
PubMed ID: 17190602
Title: Human mRNA export machinery recruited to the 5' end of mRNA.
PubMed ID: 17190602
PubMed ID: 18220336
Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
PubMed ID: 18220336
DOI: 10.1021/pr0705441
PubMed ID: 18974867
Title: Recruitment of the complete hTREX complex is required for Kaposi's sarcoma-associated herpesvirus intronless mRNA nuclear export and virus replication.
PubMed ID: 18974867
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22144908
Title: Genome instability and transcription elongation impairment in human cells depleted of THO/TREX.
PubMed ID: 22144908
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 23222130
Title: Aly and THO are required for assembly of the human TREX complex and association of TREX components with the spliced mRNA.
PubMed ID: 23222130
DOI: 10.1093/nar/gks1188
PubMed ID: 23460917
Title: The Thoc1 encoded ribonucleoprotein is a substrate for the NEDD4-1 E3 ubiquitin protein ligase.
PubMed ID: 23460917
PubMed ID: 25218447
Title: Uncovering global SUMOylation signaling networks in a site-specific manner.
PubMed ID: 25218447
DOI: 10.1038/nsmb.2890
PubMed ID: 25114211
Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.
PubMed ID: 25114211
PubMed ID: 25772364
Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.
PubMed ID: 25772364
PubMed ID: 25755297
Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.
PubMed ID: 25755297
PubMed ID: 25662211
Title: Luzp4 defines a new mRNA export pathway in cancer cells.
PubMed ID: 25662211
DOI: 10.1093/nar/gkv070
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 32776944
Title: THOC1 deficiency leads to late-onset nonsyndromic hearing loss through p53-mediated hair cell apoptosis.
PubMed ID: 32776944
Sequence Information:
- Length: 657
- Mass: 75666
- Checksum: DB7980BD0F252DAB
- Sequence:
MSPTPPLFSL PEARTRFTKS TREALNNKNI KPLLSTFSQV PGSENEKKCT LDQAFRGILE EEIINHSSCE NVLAIISLAI GGVTEGICTA STPFVLLGDV LDCLPLDQCD TIFTFVEKNV ATWKSNTFYS AGKNYLLRMC NDLLRRLSKS QNTVFCGRIQ LFLARLFPLS EKSGLNLQSQ FNLENVTVFN TNEQESTLGQ KHTEDREEGM DVEEGEMGDE EAPTTCSIPI DYNLYRKFWS LQDYFRNPVQ CYEKISWKTF LKYSEEVLAV FKSYKLDDTQ ASRKKMEELK TGGEHVYFAK FLTSEKLMDL QLSDSNFRRH ILLQYLILFQ YLKGQVKFKS SNYVLTDEQS LWIEDTTKSV YQLLSENPPD GERFSKMVEH ILNTEENWNS WKNEGCPSFV KERTSDTKPT RIIRKRTAPE DFLGKGPTKK ILMGNEELTR LWNLCPDNME ACKSETREHM PTLEEFFEEA IEQADPENMV ENEYKAVNNS NYGWRALRLL ARRSPHFFQP TNQQFKSLPE YLENMVIKLA KELPPPSEEI KTGEDEDEED NDALLKENES PDVRRDKPVT GEQIEVFANK LGEQWKILAP YLEMKDSEIR QIECDSEDMK MRAKQLLVAW QDQEGVHATP ENLINALNKS GLSDLAESLT NDNETNS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.