Details for: CDH1

Gene ID: 999

Symbol: CDH1

Ensembl ID: ENSG00000039068

Description: cadherin 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 139.8950
    Cell Significance Index: -21.7600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 93.5566
    Cell Significance Index: -23.7300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 51.5683
    Cell Significance Index: -20.9500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 35.5130
    Cell Significance Index: -23.8300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 21.5451
    Cell Significance Index: -20.5700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.7436
    Cell Significance Index: -23.1100
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 11.5992
    Cell Significance Index: 123.2400
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 10.9681
    Cell Significance Index: 67.5000
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 9.7948
    Cell Significance Index: 7.0000
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 9.0709
    Cell Significance Index: 68.7900
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 8.7880
    Cell Significance Index: 11.3700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 5.4898
    Cell Significance Index: 82.2600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 4.9702
    Cell Significance Index: 258.1900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.8234
    Cell Significance Index: 131.2900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 4.6398
    Cell Significance Index: 123.8900
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 4.3993
    Cell Significance Index: 44.3800
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 4.3340
    Cell Significance Index: 16.6000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 3.8047
    Cell Significance Index: 109.6200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 3.7849
    Cell Significance Index: 171.5600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 3.5431
    Cell Significance Index: 76.7600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 3.4953
    Cell Significance Index: 380.1800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 3.3848
    Cell Significance Index: 56.9300
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 3.2627
    Cell Significance Index: 20.1300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 3.2567
    Cell Significance Index: 29.9900
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 3.1715
    Cell Significance Index: 7.1500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 2.6027
    Cell Significance Index: 65.0600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.3919
    Cell Significance Index: 431.1800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.2601
    Cell Significance Index: 277.9100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.2069
    Cell Significance Index: -4.8300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.9566
    Cell Significance Index: 54.6800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.8292
    Cell Significance Index: 42.2600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.7569
    Cell Significance Index: 25.0100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.7457
    Cell Significance Index: 953.3500
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.7355
    Cell Significance Index: 17.9600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.7227
    Cell Significance Index: 128.3900
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 1.5851
    Cell Significance Index: 5.9700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.3508
    Cell Significance Index: 133.6200
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.3136
    Cell Significance Index: 11.6600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.3081
    Cell Significance Index: 259.5900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2412
    Cell Significance Index: 1120.6800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2101
    Cell Significance Index: 196.8100
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.2074
    Cell Significance Index: 14.0400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.1983
    Cell Significance Index: 55.8700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.1935
    Cell Significance Index: 20.1100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 1.0726
    Cell Significance Index: 122.4400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.0698
    Cell Significance Index: 50.2800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.9877
    Cell Significance Index: 21.0400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.8906
    Cell Significance Index: 18.4800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.8775
    Cell Significance Index: 30.8400
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.8546
    Cell Significance Index: 5.3100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.7703
    Cell Significance Index: 54.4800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.7118
    Cell Significance Index: 121.5500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6927
    Cell Significance Index: 306.2700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.6579
    Cell Significance Index: 84.9900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.6239
    Cell Significance Index: 13.3400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4587
    Cell Significance Index: 87.2900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.4312
    Cell Significance Index: 10.4500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.3770
    Cell Significance Index: 12.0800
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.3239
    Cell Significance Index: 3.5100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.2758
    Cell Significance Index: 2.8600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2585
    Cell Significance Index: 17.8800
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: 0.1319
    Cell Significance Index: 1.3200
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.0598
    Cell Significance Index: 0.3700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0311
    Cell Significance Index: 23.5400
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.0233
    Cell Significance Index: 0.2400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0175
    Cell Significance Index: 12.8300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0010
    Cell Significance Index: -0.7100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0016
    Cell Significance Index: -2.9700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0078
    Cell Significance Index: -4.8700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0118
    Cell Significance Index: -21.7200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0131
    Cell Significance Index: -20.1300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0170
    Cell Significance Index: -23.1500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0182
    Cell Significance Index: -10.2600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0217
    Cell Significance Index: -2.4900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0242
    Cell Significance Index: -16.7300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0287
    Cell Significance Index: -6.0600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0315
    Cell Significance Index: -3.6700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0323
    Cell Significance Index: -20.5000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0323
    Cell Significance Index: -11.5800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0385
    Cell Significance Index: -0.5300
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0504
    Cell Significance Index: -0.5700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0524
    Cell Significance Index: -23.7900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0556
    Cell Significance Index: -11.1600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0563
    Cell Significance Index: -16.1900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0679
    Cell Significance Index: -9.3200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0684
    Cell Significance Index: -1.0100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0740
    Cell Significance Index: -7.5600
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.1016
    Cell Significance Index: -0.8400
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: -0.1085
    Cell Significance Index: -0.6500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1251
    Cell Significance Index: -18.1900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2119
    Cell Significance Index: -22.0600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2190
    Cell Significance Index: -8.9700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2244
    Cell Significance Index: -26.4600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2528
    Cell Significance Index: -15.5000
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.2569
    Cell Significance Index: -2.7100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2860
    Cell Significance Index: -22.6600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2866
    Cell Significance Index: -7.5400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3030
    Cell Significance Index: -15.7900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.3040
    Cell Significance Index: -2.0600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3132
    Cell Significance Index: -15.8300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transmembrane Glycoprotein:** CDH1 is a transmembrane glycoprotein composed of five extracellular cadherin domains, a transmembrane domain, and a cytoplasmic tail. 2. **Cell-Cell Adhesion:** CDH1 mediates cell-cell adhesion through homophilic interactions with other CDH1 molecules, ensuring the formation of strong bonds between adjacent cells. 3. **Adherens Junctions:** CDH1 is a key component of adherens junctions, which are critical for maintaining tissue structure and organization. 4. **Immune Function:** CDH1 has been implicated in various immune processes, including the regulation of immune cell function, immune cell migration, and the modulation of synaptic transmission. 5. **Cancer Association:** Loss or reduction of CDH1 expression has been observed in various types of cancer, including breast, prostate, and gastric cancers. **Pathways and Functions:** 1. **Cell-Cell Adhesion:** CDH1 mediates cell-cell adhesion through homophilic interactions with other CDH1 molecules, ensuring the formation of strong bonds between adjacent cells. 2. **Immune Cell Function:** CDH1 regulates immune cell function, including the activation, proliferation, and differentiation of immune cells. 3. **Immune Cell Migration:** CDH1 modulates immune cell migration, influencing the movement of immune cells through tissues. 4. **Synaptic Transmission:** CDH1 regulates synaptic transmission, influencing the release of neurotransmitters and the modulation of synaptic plasticity. 5. **Cancer Progression:** Loss or reduction of CDH1 expression has been observed in various types of cancer, including breast, prostate, and gastric cancers, promoting tumor aggressiveness and metastasis. **Clinical Significance:** 1. **Cancer Diagnosis:** Loss or reduction of CDH1 expression is a diagnostic marker for various types of cancer, including breast, prostate, and gastric cancers. 2. **Cancer Prognosis:** CDH1 expression levels have been correlated with cancer prognosis, with reduced expression associated with poorer outcomes. 3. **Immune Therapy:** CDH1 has been identified as a potential target for immunotherapy, with the modulation of CDH1 expression influencing immune cell function and tumor response to therapy. 4. **Neurological Disorders:** CDH1 has been implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease, where its expression is often reduced or altered. 5. **Regenerative Medicine:** CDH1 has been identified as a potential target for regenerative medicine, with the modulation of CDH1 expression influencing tissue regeneration and repair. In conclusion, CDH1 is a critical regulator of cell adhesion and immune function, with implications for cancer diagnosis, prognosis, and therapy. Further research is needed to fully elucidate the role of CDH1 in various pathological processes and to explore its potential as a therapeutic target.

Genular Protein ID: 4018104655

Symbol: CADH1_HUMAN

Name: CAM 120/80

UniProtKB Accession Codes:

P12830 A8K1U7 Q13799 Q14216 Q15855 Q16194 Q4PJ14 Q9UII8

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CPTAC 8 CPTC 1 CTD 1 ChEBI 3 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 31 EMDB 4 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 52 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 10 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 5 OrthoDB 1 PANTHER 2 PDB 21 PDBsum 21 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 9 RefSeq 4 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniLectin 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8459805

Title: Molecular cloning and characterization of the human E-cadherin cDNA.

PubMed ID: 8459805

DOI: 10.1007/bf00996219

PubMed ID: 8127895

Title: E-cadherin gene mutations in human gastric carcinoma cell lines.

PubMed ID: 8127895

DOI: 10.1073/pnas.91.5.1858

PubMed ID: 8185635

Title: Molecular cloning of human E-cadherin suggests a novel subdivision of the cadherin superfamily.

PubMed ID: 8185635

DOI: 10.1006/bbrc.1994.1656

PubMed ID: 10597309

Title: Calcium influx triggers the sequential proteolysis of extracellular and cytoplasmic domains of E-cadherin, leading to loss of beta-catenin from cell-cell contacts.

PubMed ID: 10597309

DOI: 10.1038/sj.onc.1203191

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 8093045

Title: Transcriptional regulation of the human E-cadherin gene in human prostate cancer cell lines: characterization of the human E-cadherin gene promoter.

PubMed ID: 8093045

DOI: 10.1006/bbrc.1994.2321

PubMed ID: 7543680

Title: Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas.

PubMed ID: 7543680

DOI: 10.1073/pnas.92.16.7416

PubMed ID: 11790773

Title: Protein binding and functional characterization of plakophilin 2. Evidence for its diverse roles in desmosomes and beta -catenin signaling.

PubMed ID: 11790773

DOI: 10.1074/jbc.m108765200

PubMed ID: 17261850

Title: Type I gamma phosphatidylinositol phosphate kinase modulates adherens junction and E-cadherin trafficking via a direct interaction with mu 1B adaptin.

PubMed ID: 17261850

DOI: 10.1083/jcb.200606023

PubMed ID: 7601454

Title: Cloning and characterization of the human invasion suppressor gene E-cadherin (CDH1).

PubMed ID: 7601454

DOI: 10.1016/0888-7543(95)80212-5

PubMed ID: 8601315

Title: E-cadherin is the receptor for internalin, a surface protein required for entry of L. monocytogenes into epithelial cells.

PubMed ID: 8601315

DOI: 10.1016/s0092-8674(00)81070-3

PubMed ID: 3263290

Title: Characterization and chromosomal localization of the gene encoding the human cell adhesion molecule uvomorulin.

PubMed ID: 3263290

DOI: 10.1111/j.1432-0436.1988.tb00593.x

PubMed ID: 8033105

Title: E-cadherin gene mutations provide clues to diffuse type gastric carcinomas.

PubMed ID: 8033105

PubMed ID: 11953314

Title: A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions.

PubMed ID: 11953314

DOI: 10.1093/emboj/21.8.1948

PubMed ID: 23532847

Title: Group A streptococcal cysteine protease cleaves epithelial junctions and contributes to bacterial translocation.

PubMed ID: 23532847

DOI: 10.1074/jbc.m113.459875

PubMed ID: 2349235

Title: Uvomorulin-catenin complex formation is regulated by a specific domain in the cytoplasmic region of the cell adhesion molecule.

PubMed ID: 2349235

DOI: 10.1073/pnas.87.11.4246

PubMed ID: 7982500

Title: Distinct cadherin-catenin complexes in Ca(2+)-dependent cell-cell adhesion.

PubMed ID: 7982500

DOI: 10.1016/0014-5793(94)01205-9

PubMed ID: 10406800

Title: A single amino acid in E-cadherin responsible for host specificity towards the human pathogen Listeria monocytogenes.

PubMed ID: 10406800

DOI: 10.1093/emboj/18.14.3956

PubMed ID: 11076937

Title: Cleavage and shedding of E-cadherin after induction of apoptosis.

PubMed ID: 11076937

DOI: 10.1074/jbc.m006102200

PubMed ID: 11226248

Title: Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex.

PubMed ID: 11226248

DOI: 10.1073/pnas.041603398

PubMed ID: 11856755

Title: Disulfide bond formation promotes the cis- and trans-dimerization of the E-cadherin-derived first repeat.

PubMed ID: 11856755

DOI: 10.1074/jbc.m200916200

PubMed ID: 11976333

Title: Galpha12 and Galpha13 negatively regulate the adhesive functions of cadherin.

PubMed ID: 11976333

DOI: 10.1074/jbc.m201984200

PubMed ID: 14699157

Title: Human homolog of disc-large is required for adherens junction assembly and differentiation of human intestinal epithelial cells.

PubMed ID: 14699157

DOI: 10.1074/jbc.m309843200

PubMed ID: 14595118

Title: Novel membrane protein shrew-1 targets to cadherin-mediated junctions in polarized epithelial cells.

PubMed ID: 14595118

DOI: 10.1091/mbc.e03-05-0281

PubMed ID: 15240885

Title: A role for Galpha12/Galpha13 in p120ctn regulation.

PubMed ID: 15240885

DOI: 10.1073/pnas.0401366101

PubMed ID: 16126725

Title: Cadherins mediate both the association between PS1 and beta-catenin and the effects of PS1 on beta-catenin stability.

PubMed ID: 16126725

DOI: 10.1074/jbc.m507503200

PubMed ID: 15689490

Title: Rab11 in recycling endosomes regulates the sorting and basolateral transport of E-cadherin.

PubMed ID: 15689490

DOI: 10.1091/mbc.e04-10-0867

PubMed ID: 16417575

Title: The cytoplasmic sequence of E-cadherin promotes non-amyloidogenic degradation of A beta precursors.

PubMed ID: 16417575

DOI: 10.1111/j.1471-4159.2005.03616.x

PubMed ID: 17893710

Title: Induction of the LRP16 gene by estrogen promotes the invasive growth of Ishikawa human endometrial cancer cells through the downregulation of E-cadherin.

PubMed ID: 17893710

DOI: 10.1038/cr.2007.79

PubMed ID: 17660459

Title: Germline E-cadherin mutations in familial lobular breast cancer.

PubMed ID: 17660459

DOI: 10.1136/jmg.2007.051268

PubMed ID: 18491227

Title: Unglycosylation at Asn-633 made extracellular domain of E-cadherin folded incorrectly and arrested in endoplasmic reticulum, then sequentially degraded by ERAD.

PubMed ID: 18491227

DOI: 10.1007/s10719-008-9133-9

PubMed ID: 18093941

Title: EPLIN mediates linkage of the cadherin catenin complex to F-actin and stabilizes the circumferential actin belt.

PubMed ID: 18093941

DOI: 10.1073/pnas.0710504105

PubMed ID: 20066110

Title: Structure and biochemistry of cadherins and catenins.

PubMed ID: 20066110

DOI: 10.1101/cshperspect.a003053

PubMed ID: 19403558

Title: The role of N-acetylglucosaminyltransferase III and V in the post-transcriptional modifications of E-cadherin.

PubMed ID: 19403558

DOI: 10.1093/hmg/ddp194

PubMed ID: 20116244

Title: Armus is a Rac1 effector that inactivates Rab7 and regulates E-cadherin degradation.

PubMed ID: 20116244

DOI: 10.1016/j.cub.2009.12.053

PubMed ID: 20432435

Title: DDR1 regulates the stabilization of cell surface E-cadherin and E-cadherin-mediated cell aggregation.

PubMed ID: 20432435

DOI: 10.1002/jcp.22134

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 20859650

Title: E-cadherin and plakoglobin recruit plakophilin3 to the cell border to initiate desmosome assembly.

PubMed ID: 20859650

DOI: 10.1007/s00018-010-0531-3

PubMed ID: 21283129

Title: Slit-Robo signaling induces malignant transformation through Hakai-mediated E-cadherin degradation during colorectal epithelial cell carcinogenesis.

PubMed ID: 21283129

DOI: 10.1038/cr.2011.17

PubMed ID: 22770219

Title: Acetylation-dependent regulation of Skp2 function.

PubMed ID: 22770219

DOI: 10.1016/j.cell.2012.05.038

PubMed ID: 22252131

Title: Structure of a novel phosphotyrosine-binding domain in Hakai that targets E-cadherin.

PubMed ID: 22252131

DOI: 10.1038/emboj.2011.496

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25208567

Title: Plakophilin 3 mediates Rap1-dependent desmosome assembly and adherens junction maturation.

PubMed ID: 25208567

DOI: 10.1091/mbc.e14-05-0968

PubMed ID: 27760340

Title: Macrophage Epithelial Reprogramming Underlies Mycobacterial Granuloma Formation and Promotes Infection.

PubMed ID: 27760340

DOI: 10.1016/j.immuni.2016.09.014

PubMed ID: 28169360

Title: Loss of DLG5 promotes breast cancer malignancy by inhibiting the Hippo signaling pathway.

PubMed ID: 28169360

DOI: 10.1038/srep42125

PubMed ID: 31473225

Title: Sperm Flagellar 1 Binds Actin in Intestinal Epithelial Cells and Contributes to Formation of Filopodia and Lamellipodia.

PubMed ID: 31473225

DOI: 10.1053/j.gastro.2019.08.031

PubMed ID: 12526809

Title: Structure of internalin, a major invasion protein of Listeria monocytogenes, in complex with its human receptor E-cadherin.

PubMed ID: 12526809

DOI: 10.1016/s0092-8674(02)01136-4

PubMed ID: 9744472

Title: Mutations of the human E-cadherin (CDH1) gene.

PubMed ID: 9744472

DOI: 10.1002/(sici)1098-1004(1998)12:4<226::aid-humu2>3.0.co;2-d

PubMed ID: 17540170

Title: Extending the host range of Listeria monocytogenes by rational protein design.

PubMed ID: 17540170

DOI: 10.1016/j.cell.2007.03.049

PubMed ID: 17715295

Title: Thermodynamically reengineering the listerial invasion complex InlA/E-cadherin.

PubMed ID: 17715295

DOI: 10.1073/pnas.0702199104

PubMed ID: 17850815

Title: The crystal structure of human E-cadherin domains 1 and 2, and comparison with other cadherins in the context of adhesion mechanism.

PubMed ID: 17850815

DOI: 10.1016/j.jmb.2007.08.011

PubMed ID: 19604491

Title: Structure of natural killer cell receptor KLRG1 bound to E-cadherin reveals basis for MHC-independent missing self recognition.

PubMed ID: 19604491

DOI: 10.1016/j.immuni.2009.04.019

PubMed ID: 7961105

Title: Point mutation of the E-cadherin gene in invasive lobular carcinoma of the breast.

PubMed ID: 7961105

DOI: 10.1111/j.1349-7006.1994.tb02902.x

PubMed ID: 8075649

Title: Mutations of the E-cadherin gene in human gynecologic cancers.

PubMed ID: 8075649

DOI: 10.1038/ng0594-98

PubMed ID: 8797891

Title: E-cadherin gene mutations in signet ring cell carcinoma of the stomach.

PubMed ID: 8797891

DOI: 10.1111/j.1349-7006.1996.tb02109.x

PubMed ID: 9045944

Title: Inactivation of the E-cadherin gene in primary gastric carcinomas and gastric carcinoma cell lines.

PubMed ID: 9045944

DOI: 10.1111/j.1349-7006.1996.tb03125.x

PubMed ID: 8985087

Title: E-cadherin gene alterations are rare events in thyroid tumors.

PubMed ID: 8985087

DOI: 10.1002/(sici)1097-0215(19970106)70:1<32::aid-ijc5>3.0.co;2-7

PubMed ID: 9537325

Title: E-cadherin germline mutations in familial gastric cancer.

PubMed ID: 9537325

DOI: 10.1038/32918

PubMed ID: 10319582

Title: Germline mutations of E-cadherin gene in Korean familial gastric cancer patients.

PubMed ID: 10319582

DOI: 10.1007/s100380050137

PubMed ID: 10896919

Title: The E-cadherin gene (CDH1) variants T340A and L599V in gastric and colorectal cancer patients in Korea.

PubMed ID: 10896919

DOI: 10.1136/gut.47.2.262

PubMed ID: 11705864

Title: Association of E-cadherin germ-line alterations with prostate cancer.

PubMed ID: 11705864

PubMed ID: 11562785

Title: A germline E-cadherin mutation in a family with gastric and colon cancer.

PubMed ID: 11562785

DOI: 10.3892/ijmm.8.4.439

PubMed ID: 11968083

Title: Screening E-cadherin in gastric cancer families reveals germline mutations only in hereditary diffuse gastric cancer kindred.

PubMed ID: 11968083

DOI: 10.1002/humu.10068

PubMed ID: 12216071

Title: E-cadherin gene variants in gastric cancer families whose probands are diagnosed with diffuse gastric cancer.

PubMed ID: 12216071

DOI: 10.1002/ijc.10633

PubMed ID: 12588804

Title: Identification of CDH1 germline missense mutations associated with functional inactivation of the E-cadherin protein in young gastric cancer probands.

PubMed ID: 12588804

DOI: 10.1093/hmg/ddg048

PubMed ID: 17224074

Title: Somatic sequence alterations in twenty-one genes selected by expression profile analysis of breast carcinomas.

PubMed ID: 17224074

DOI: 10.1186/bcr1637

PubMed ID: 28301459

Title: Blepharocheilodontic syndrome is a CDH1 pathway-related disorder due to mutations in CDH1 and CTNND1.

PubMed ID: 28301459

DOI: 10.1038/gim.2017.11

Sequence Information:

  • Length: 882
  • Mass: 97456
  • Checksum: E427118043A13C67
  • Sequence:
    • MGPWSRSLSA LLLLLQVSSW LCQEPEPCHP GFDAESYTFT VPRRHLERGR VLGRVNFEDC 
TGRQRTAYFS LDTRFKVGTD GVITVKRPLR FHNPQIHFLV YAWDSTYRKF STKVTLNTVG 
HHHRPPPHQA SVSGIQAELL TFPNSSPGLR RQKRDWVIPP ISCPENEKGP FPKNLVQIKS 
NKDKEGKVFY SITGQGADTP PVGVFIIERE TGWLKVTEPL DRERIATYTL FSHAVSSNGN 
AVEDPMEILI TVTDQNDNKP EFTQEVFKGS VMEGALPGTS VMEVTATDAD DDVNTYNAAI 
AYTILSQDPE LPDKNMFTIN RNTGVISVVT TGLDRESFPT YTLVVQAADL QGEGLSTTAT 
AVITVTDTND NPPIFNPTTY KGQVPENEAN VVITTLKVTD ADAPNTPAWE AVYTILNDDG 
GQFVVTTNPV NNDGILKTAK GLDFEAKQQY ILHVAVTNVV PFEVSLTTST ATVTVDVLDV 
NEAPIFVPPE KRVEVSEDFG VGQEITSYTA QEPDTFMEQK ITYRIWRDTA NWLEINPDTG 
AISTRAELDR EDFEHVKNST YTALIIATDN GSPVATGTGT LLLILSDVND NAPIPEPRTI 
FFCERNPKPQ VINIIDADLP PNTSPFTAEL THGASANWTI QYNDPTQESI ILKPKMALEV 
GDYKINLKLM DNQNKDQVTT LEVSVCDCEG AAGVCRKAQP VEAGLQIPAI LGILGGILAL 
LILILLLLLF LRRRAVVKEP LLPPEDDTRD NVYYYDEEGG GEEDQDFDLS QLHRGLDARP 
EVTRNDVAPT LMSVPRYLPR PANPDEIGNF IDENLKAADT DPTAPPYDSL LVFDYEGSGS 
EAASLSSLNS SESDKDQDYD YLNEWGNRFK KLADMYGGGE DD

Genular Protein ID: 2855767381

Symbol: Q9UII7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9UII7

Database IDs:

ARBA 19 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 15 Gene3D 2 InterPro 7 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 3 RefSeq 1 RuleBase 2 SAM 3 SMART 2 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 901
  • Mass: 99694
  • Checksum: 42160D749BCF120E
  • Sequence:
    • MGPWSRSLSA LLLLLQVSSW LCQEPEPCHP GFDAESYTFT VPRRHLERGR VLGRVNFEDC 
TGRQRTAYFS LDTRFKVGTD GVITVKRPLR FHNPQIHFLV YAWDSTYRKF STKVTLNTVG 
HHHRPPPHQA SVSGIQAELL TFPNSSPGLR RQKRDWVIPP ISCPENEKGP FPKNLVQIKS 
NKDKEGKVFY SITGQGADTP PVGVFIIERE TGWLKVTEPL DRERIATYTL FSHAVSSNGN 
AVEDPMEILI TVTDQNDNKP EFTQEVFKGS VMEGALPGTS VMEVTATDAD DDVNTYNAAI 
AYTILSQDPE LPDKNMFTIN RNTGVISVVT TGLDRESFPT YTLVVQAADL QGEGLSTTAT 
AVITVTDTND NPPIFNPTTY KGQVPENEAN VVITTLKVTD ADAPNTPAWE AVYTILNDDG 
GQFVVTTNPV NNDGILKTAK DLARCRNWHP HSCSYPCPLG LDFEAKQQYI LHVAVTNVVP 
FEVSLTTSTA TVTVDVLDVN EAPIFVPPEK RVEVSEDFGV GQEITSYTAQ EPDTFMEQKI 
TYRIWRDTAN WLEINPDTGA ISTRAELDRE DFEHVKNSTY TALIIATDNG SPVATGTGTL 
LLILSDVNDN APIPEPRTIF FCERNPKPQV INIIDADLPP NTSPFTAELT HGASANWTIQ 
YNDPTQESII LKPKMALEVG DYKINLKLMD NQNKDQVTTL EVSVCDCEGA AGVCRKAQPV 
EAGLQIPAIL GILGGILALL ILILLLLLFL RRRAVVKEPL LPPEDDTRDN VYYYDEEGGG 
EEDQDFDLSQ LHRGLDARPE VTRNDVAPTL MSVPRYLPRP ANPDEIGNFI DENLKAADTD 
PTAPPYDSLL VFDYEGSGSE AASLSSLNSS ESDKDQDYDY LNEWGNRFKK LADMYGGGED 
D

Genular Protein ID: 2545163919

Symbol: B3GN61_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3GN61

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 14 Gene3D 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 RefSeq 4 SAM 2 SMART 2 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 758
  • Mass: 83823
  • Checksum: 7ABBDD480DF0AE18
  • Sequence:
    • MGPWSRSLSA LLLLLQVSSW LCQEPEPCHP GFDAESYTFT VPRRHLERGR VLGRVNFEDC 
TGRQRTAYFS LDTRFKVGTD GVITVKRPLR FHNPQIHFLV YAWDSTYRKF STKVTLNTVG 
HHHRPPPHQA SVSGIQAELL TFPNSSPGLR RQKRDWVIPP ISCPENEKGP FPKNLVQIKS 
NKDKEGKVFY SITGQGADTP PVGVFIIERE TGWLKVTEPL DRERIATYTL FSHAVSSNGN 
AVEDPMEILI TVTDQNDNKP EFTQEVFKGS VMEGALPGTS VMEVTATDAD DDVNTYNAAI 
AYTILSQDPE LPDKNMFTIN RNTGVISVVT TGLDRESFPT YTLVVQAADL QGEGLSTTAT 
AVITVTDTND NPPIFNPTTY KGQVPENEAN VVITTLKVTD ADAPNTPAWE AVYTILNDDG 
GQFVVTTNPV NNDGILKTAK GLDFEAKQQY ILHVAVTNVV PFEVSLTTST ATVTVDVLDV 
NEAPIFVPPE KRVEVSEDFG VGQEITSYTA QEPDTFMEQK ITYRIWRDTA NWLEINPDTG 
AISTRAELDR EDFEHVKNST YTALIIATDN GSPVATGTGT LLLILSDVND NAPIPEPRTI 
FFCERNPKPQ VINIIDADLP PNTSPFTAEL THGASANWTI QYNDPTQESI ILKPKMALEV 
GDYKINLKLM DNQNKDQVTT LEVSVCDCEG AAGVCRKAQP VEAGLQIPAI LGILGGILAL 
LILILLLLLF LRRRAVVKEP LLPPEDDTRD NVYYYDEE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.