Associated with
Other Information
Genular Protein ID: 4018104655
Symbol: CADH1_HUMAN
Name: Cadherin-1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8459805
Title: Molecular cloning and characterization of the human E-cadherin cDNA.
PubMed ID: 8459805
DOI: 10.1007/bf00996219
PubMed ID: 8127895
Title: E-cadherin gene mutations in human gastric carcinoma cell lines.
PubMed ID: 8127895
PubMed ID: 8185635
Title: Molecular cloning of human E-cadherin suggests a novel subdivision of the cadherin superfamily.
PubMed ID: 8185635
PubMed ID: 10597309
Title: Calcium influx triggers the sequential proteolysis of extracellular and cytoplasmic domains of E-cadherin, leading to loss of beta-catenin from cell-cell contacts.
PubMed ID: 10597309
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15616553
Title: The sequence and analysis of duplication-rich human chromosome 16.
PubMed ID: 15616553
DOI: 10.1038/nature03187
PubMed ID: 8093045
Title: Transcriptional regulation of the human E-cadherin gene in human prostate cancer cell lines: characterization of the human E-cadherin gene promoter.
PubMed ID: 8093045
PubMed ID: 7543680
Title: Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas.
PubMed ID: 7543680
PubMed ID: 11790773
Title: Protein binding and functional characterization of plakophilin 2. Evidence for its diverse roles in desmosomes and beta -catenin signaling.
PubMed ID: 11790773
PubMed ID: 17261850
Title: Type I gamma phosphatidylinositol phosphate kinase modulates adherens junction and E-cadherin trafficking via a direct interaction with mu 1B adaptin.
PubMed ID: 17261850
PubMed ID: 7601454
Title: Cloning and characterization of the human invasion suppressor gene E-cadherin (CDH1).
PubMed ID: 7601454
PubMed ID: 8601315
Title: E-cadherin is the receptor for internalin, a surface protein required for entry of L. monocytogenes into epithelial cells.
PubMed ID: 8601315
PubMed ID: 3263290
Title: Characterization and chromosomal localization of the gene encoding the human cell adhesion molecule uvomorulin.
PubMed ID: 3263290
PubMed ID: 8033105
Title: E-cadherin gene mutations provide clues to diffuse type gastric carcinomas.
PubMed ID: 8033105
PubMed ID: 11953314
Title: A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions.
PubMed ID: 11953314
PubMed ID: 23532847
Title: Group A streptococcal cysteine protease cleaves epithelial junctions and contributes to bacterial translocation.
PubMed ID: 23532847
PubMed ID: 2349235
Title: Uvomorulin-catenin complex formation is regulated by a specific domain in the cytoplasmic region of the cell adhesion molecule.
PubMed ID: 2349235
PubMed ID: 7982500
Title: Distinct cadherin-catenin complexes in Ca(2+)-dependent cell-cell adhesion.
PubMed ID: 7982500
PubMed ID: 10406800
Title: A single amino acid in E-cadherin responsible for host specificity towards the human pathogen Listeria monocytogenes.
PubMed ID: 10406800
PubMed ID: 11076937
Title: Cleavage and shedding of E-cadherin after induction of apoptosis.
PubMed ID: 11076937
PubMed ID: 11226248
Title: Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex.
PubMed ID: 11226248
PubMed ID: 11856755
Title: Disulfide bond formation promotes the cis- and trans-dimerization of the E-cadherin-derived first repeat.
PubMed ID: 11856755
PubMed ID: 11976333
Title: Galpha12 and Galpha13 negatively regulate the adhesive functions of cadherin.
PubMed ID: 11976333
PubMed ID: 14699157
Title: Human homolog of disc-large is required for adherens junction assembly and differentiation of human intestinal epithelial cells.
PubMed ID: 14699157
PubMed ID: 14595118
Title: Novel membrane protein shrew-1 targets to cadherin-mediated junctions in polarized epithelial cells.
PubMed ID: 14595118
PubMed ID: 15240885
Title: A role for Galpha12/Galpha13 in p120ctn regulation.
PubMed ID: 15240885
PubMed ID: 16126725
Title: Cadherins mediate both the association between PS1 and beta-catenin and the effects of PS1 on beta-catenin stability.
PubMed ID: 16126725
PubMed ID: 15689490
Title: Rab11 in recycling endosomes regulates the sorting and basolateral transport of E-cadherin.
PubMed ID: 15689490
PubMed ID: 16417575
Title: The cytoplasmic sequence of E-cadherin promotes non-amyloidogenic degradation of A beta precursors.
PubMed ID: 16417575
PubMed ID: 17893710
Title: Induction of the LRP16 gene by estrogen promotes the invasive growth of Ishikawa human endometrial cancer cells through the downregulation of E-cadherin.
PubMed ID: 17893710
DOI: 10.1038/cr.2007.79
PubMed ID: 17660459
Title: Germline E-cadherin mutations in familial lobular breast cancer.
PubMed ID: 17660459
PubMed ID: 18491227
Title: Unglycosylation at Asn-633 made extracellular domain of E-cadherin folded incorrectly and arrested in endoplasmic reticulum, then sequentially degraded by ERAD.
PubMed ID: 18491227
PubMed ID: 18093941
Title: EPLIN mediates linkage of the cadherin catenin complex to F-actin and stabilizes the circumferential actin belt.
PubMed ID: 18093941
PubMed ID: 20066110
Title: Structure and biochemistry of cadherins and catenins.
PubMed ID: 20066110
PubMed ID: 19403558
Title: The role of N-acetylglucosaminyltransferase III and V in the post-transcriptional modifications of E-cadherin.
PubMed ID: 19403558
DOI: 10.1093/hmg/ddp194
PubMed ID: 20116244
Title: Armus is a Rac1 effector that inactivates Rab7 and regulates E-cadherin degradation.
PubMed ID: 20116244
PubMed ID: 20432435
Title: DDR1 regulates the stabilization of cell surface E-cadherin and E-cadherin-mediated cell aggregation.
PubMed ID: 20432435
DOI: 10.1002/jcp.22134
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21283129
Title: Slit-Robo signaling induces malignant transformation through Hakai-mediated E-cadherin degradation during colorectal epithelial cell carcinogenesis.
PubMed ID: 21283129
DOI: 10.1038/cr.2011.17
PubMed ID: 22770219
Title: Acetylation-dependent regulation of Skp2 function.
PubMed ID: 22770219
PubMed ID: 22252131
Title: Structure of a novel phosphotyrosine-binding domain in Hakai that targets E-cadherin.
PubMed ID: 22252131
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 28169360
Title: Loss of DLG5 promotes breast cancer malignancy by inhibiting the Hippo signaling pathway.
PubMed ID: 28169360
DOI: 10.1038/srep42125
PubMed ID: 31473225
Title: Sperm Flagellar 1 Binds Actin in Intestinal Epithelial Cells and Contributes to Formation of Filopodia and Lamellipodia.
PubMed ID: 31473225
PubMed ID: 12526809
Title: Structure of internalin, a major invasion protein of Listeria monocytogenes, in complex with its human receptor E-cadherin.
PubMed ID: 12526809
PubMed ID: 9744472
Title: Mutations of the human E-cadherin (CDH1) gene.
PubMed ID: 9744472
DOI: 10.1002/(sici)1098-1004(1998)12:4<226::aid-humu2>3.0.co;2-d
PubMed ID: 17540170
Title: Extending the host range of Listeria monocytogenes by rational protein design.
PubMed ID: 17540170
PubMed ID: 17715295
Title: Thermodynamically reengineering the listerial invasion complex InlA/E-cadherin.
PubMed ID: 17715295
PubMed ID: 17850815
Title: The crystal structure of human E-cadherin domains 1 and 2, and comparison with other cadherins in the context of adhesion mechanism.
PubMed ID: 17850815
PubMed ID: 19604491
Title: Structure of natural killer cell receptor KLRG1 bound to E-cadherin reveals basis for MHC-independent missing self recognition.
PubMed ID: 19604491
PubMed ID: 7961105
Title: Point mutation of the E-cadherin gene in invasive lobular carcinoma of the breast.
PubMed ID: 7961105
PubMed ID: 8075649
Title: Mutations of the E-cadherin gene in human gynecologic cancers.
PubMed ID: 8075649
DOI: 10.1038/ng0594-98
PubMed ID: 8797891
Title: E-cadherin gene mutations in signet ring cell carcinoma of the stomach.
PubMed ID: 8797891
PubMed ID: 9045944
Title: Inactivation of the E-cadherin gene in primary gastric carcinomas and gastric carcinoma cell lines.
PubMed ID: 9045944
PubMed ID: 8985087
Title: E-cadherin gene alterations are rare events in thyroid tumors.
PubMed ID: 8985087
DOI: 10.1002/(sici)1097-0215(19970106)70:1<32::aid-ijc5>3.0.co;2-7
PubMed ID: 9537325
Title: E-cadherin germline mutations in familial gastric cancer.
PubMed ID: 9537325
DOI: 10.1038/32918
PubMed ID: 10319582
Title: Germline mutations of E-cadherin gene in Korean familial gastric cancer patients.
PubMed ID: 10319582
PubMed ID: 10896919
Title: The E-cadherin gene (CDH1) variants T340A and L599V in gastric and colorectal cancer patients in Korea.
PubMed ID: 10896919
DOI: 10.1136/gut.47.2.262
PubMed ID: 11705864
Title: Association of E-cadherin germ-line alterations with prostate cancer.
PubMed ID: 11705864
PubMed ID: 11562785
Title: A germline E-cadherin mutation in a family with gastric and colon cancer.
PubMed ID: 11562785
DOI: 10.3892/ijmm.8.4.439
PubMed ID: 11968083
Title: Screening E-cadherin in gastric cancer families reveals germline mutations only in hereditary diffuse gastric cancer kindred.
PubMed ID: 11968083
DOI: 10.1002/humu.10068
PubMed ID: 12216071
Title: E-cadherin gene variants in gastric cancer families whose probands are diagnosed with diffuse gastric cancer.
PubMed ID: 12216071
DOI: 10.1002/ijc.10633
PubMed ID: 12588804
Title: Identification of CDH1 germline missense mutations associated with functional inactivation of the E-cadherin protein in young gastric cancer probands.
PubMed ID: 12588804
DOI: 10.1093/hmg/ddg048
PubMed ID: 17224074
Title: Somatic sequence alterations in twenty-one genes selected by expression profile analysis of breast carcinomas.
PubMed ID: 17224074
DOI: 10.1186/bcr1637
PubMed ID: 28301459
Title: Blepharocheilodontic syndrome is a CDH1 pathway-related disorder due to mutations in CDH1 and CTNND1.
PubMed ID: 28301459
DOI: 10.1038/gim.2017.11
Sequence Information:
- Length: 882
- Mass: 97456
- Checksum: E427118043A13C67
- Sequence:
MGPWSRSLSA LLLLLQVSSW LCQEPEPCHP GFDAESYTFT VPRRHLERGR VLGRVNFEDC TGRQRTAYFS LDTRFKVGTD GVITVKRPLR FHNPQIHFLV YAWDSTYRKF STKVTLNTVG HHHRPPPHQA SVSGIQAELL TFPNSSPGLR RQKRDWVIPP ISCPENEKGP FPKNLVQIKS NKDKEGKVFY SITGQGADTP PVGVFIIERE TGWLKVTEPL DRERIATYTL FSHAVSSNGN AVEDPMEILI TVTDQNDNKP EFTQEVFKGS VMEGALPGTS VMEVTATDAD DDVNTYNAAI AYTILSQDPE LPDKNMFTIN RNTGVISVVT TGLDRESFPT YTLVVQAADL QGEGLSTTAT AVITVTDTND NPPIFNPTTY KGQVPENEAN VVITTLKVTD ADAPNTPAWE AVYTILNDDG GQFVVTTNPV NNDGILKTAK GLDFEAKQQY ILHVAVTNVV PFEVSLTTST ATVTVDVLDV NEAPIFVPPE KRVEVSEDFG VGQEITSYTA QEPDTFMEQK ITYRIWRDTA NWLEINPDTG AISTRAELDR EDFEHVKNST YTALIIATDN GSPVATGTGT LLLILSDVND NAPIPEPRTI FFCERNPKPQ VINIIDADLP PNTSPFTAEL THGASANWTI QYNDPTQESI ILKPKMALEV GDYKINLKLM DNQNKDQVTT LEVSVCDCEG AAGVCRKAQP VEAGLQIPAI LGILGGILAL LILILLLLLF LRRRAVVKEP LLPPEDDTRD NVYYYDEEGG GEEDQDFDLS QLHRGLDARP EVTRNDVAPT LMSVPRYLPR PANPDEIGNF IDENLKAADT DPTAPPYDSL LVFDYEGSGS EAASLSSLNS SESDKDQDYD YLNEWGNRFK KLADMYGGGE DD
Genular Protein ID: 2545163919
Symbol: B3GN61_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 758
- Mass: 83823
- Checksum: 7ABBDD480DF0AE18
- Sequence:
MGPWSRSLSA LLLLLQVSSW LCQEPEPCHP GFDAESYTFT VPRRHLERGR VLGRVNFEDC TGRQRTAYFS LDTRFKVGTD GVITVKRPLR FHNPQIHFLV YAWDSTYRKF STKVTLNTVG HHHRPPPHQA SVSGIQAELL TFPNSSPGLR RQKRDWVIPP ISCPENEKGP FPKNLVQIKS NKDKEGKVFY SITGQGADTP PVGVFIIERE TGWLKVTEPL DRERIATYTL FSHAVSSNGN AVEDPMEILI TVTDQNDNKP EFTQEVFKGS VMEGALPGTS VMEVTATDAD DDVNTYNAAI AYTILSQDPE LPDKNMFTIN RNTGVISVVT TGLDRESFPT YTLVVQAADL QGEGLSTTAT AVITVTDTND NPPIFNPTTY KGQVPENEAN VVITTLKVTD ADAPNTPAWE AVYTILNDDG GQFVVTTNPV NNDGILKTAK GLDFEAKQQY ILHVAVTNVV PFEVSLTTST ATVTVDVLDV NEAPIFVPPE KRVEVSEDFG VGQEITSYTA QEPDTFMEQK ITYRIWRDTA NWLEINPDTG AISTRAELDR EDFEHVKNST YTALIIATDN GSPVATGTGT LLLILSDVND NAPIPEPRTI FFCERNPKPQ VINIIDADLP PNTSPFTAEL THGASANWTI QYNDPTQESI ILKPKMALEV GDYKINLKLM DNQNKDQVTT LEVSVCDCEG AAGVCRKAQP VEAGLQIPAI LGILGGILAL LILILLLLLF LRRRAVVKEP LLPPEDDTRD NVYYYDEE
Genular Protein ID: 2855767381
Symbol: Q9UII7_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 901
- Mass: 99694
- Checksum: 42160D749BCF120E
- Sequence:
MGPWSRSLSA LLLLLQVSSW LCQEPEPCHP GFDAESYTFT VPRRHLERGR VLGRVNFEDC TGRQRTAYFS LDTRFKVGTD GVITVKRPLR FHNPQIHFLV YAWDSTYRKF STKVTLNTVG HHHRPPPHQA SVSGIQAELL TFPNSSPGLR RQKRDWVIPP ISCPENEKGP FPKNLVQIKS NKDKEGKVFY SITGQGADTP PVGVFIIERE TGWLKVTEPL DRERIATYTL FSHAVSSNGN AVEDPMEILI TVTDQNDNKP EFTQEVFKGS VMEGALPGTS VMEVTATDAD DDVNTYNAAI AYTILSQDPE LPDKNMFTIN RNTGVISVVT TGLDRESFPT YTLVVQAADL QGEGLSTTAT AVITVTDTND NPPIFNPTTY KGQVPENEAN VVITTLKVTD ADAPNTPAWE AVYTILNDDG GQFVVTTNPV NNDGILKTAK DLARCRNWHP HSCSYPCPLG LDFEAKQQYI LHVAVTNVVP FEVSLTTSTA TVTVDVLDVN EAPIFVPPEK RVEVSEDFGV GQEITSYTAQ EPDTFMEQKI TYRIWRDTAN WLEINPDTGA ISTRAELDRE DFEHVKNSTY TALIIATDNG SPVATGTGTL LLILSDVNDN APIPEPRTIF FCERNPKPQV INIIDADLPP NTSPFTAELT HGASANWTIQ YNDPTQESII LKPKMALEVG DYKINLKLMD NQNKDQVTTL EVSVCDCEGA AGVCRKAQPV EAGLQIPAIL GILGGILALL ILILLLLLFL RRRAVVKEPL LPPEDDTRDN VYYYDEEGGG EEDQDFDLSQ LHRGLDARPE VTRNDVAPTL MSVPRYLPRP ANPDEIGNFI DENLKAADTD PTAPPYDSLL VFDYEGSGSE AASLSSLNSS ESDKDQDYDY LNEWGNRFKK LADMYGGGED D
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.