Details for: SLC12A6

Gene ID: 9990

Symbol: SLC12A6

Ensembl ID: ENSG00000140199

Description: solute carrier family 12 member 6

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.16
    Marker Score: 2,387
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.72
    Marker Score: 7,009
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.71
    Marker Score: 1,165
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.61
    Marker Score: 59,365
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.53
    Marker Score: 58,255
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.53
    Marker Score: 22,862
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.52
    Marker Score: 2,652
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.5
    Marker Score: 14,268
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.5
    Marker Score: 92,133
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.48
    Marker Score: 12,701
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.47
    Marker Score: 6,088
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167,976
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.42
    Marker Score: 5,033
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.41
    Marker Score: 28,126
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.4
    Marker Score: 2,162
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.4
    Marker Score: 10,707
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.38
    Marker Score: 821
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.37
    Marker Score: 5,291
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.33
    Marker Score: 12,543
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.29
    Marker Score: 13,321
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.24
    Marker Score: 2,919
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.17
    Marker Score: 25,029
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.17
    Marker Score: 26,082
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.14
    Marker Score: 5,269
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.13
    Marker Score: 17,696
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1
    Marker Score: 361
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,728
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,952
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.98
    Marker Score: 668
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,396
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.98
    Marker Score: 738
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.97
    Marker Score: 1,423
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,403
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.94
    Marker Score: 300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 479
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 435
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.92
    Marker Score: 988
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,713
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.9
    Marker Score: 948
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.89
    Marker Score: 257
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.89
    Marker Score: 1,803
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.88
    Marker Score: 436
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.87
    Marker Score: 48,930
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,294
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.87
    Marker Score: 279
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.86
    Marker Score: 361
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4,916
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 309
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.85
    Marker Score: 510
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.84
    Marker Score: 561
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.83
    Marker Score: 243
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.83
    Marker Score: 239
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.82
    Marker Score: 225
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.82
    Marker Score: 260
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.82
    Marker Score: 21,022
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.81
    Marker Score: 471
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.81
    Marker Score: 256
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.8
    Marker Score: 238
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.78
    Marker Score: 4,762
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 313
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 595
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.76
    Marker Score: 1,235
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.76
    Marker Score: 25,648
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.76
    Marker Score: 182
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.74
    Marker Score: 748
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.74
    Marker Score: 259
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.74
    Marker Score: 1,848
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.74
    Marker Score: 914
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.73
    Marker Score: 387
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.73
    Marker Score: 230
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.73
    Marker Score: 1,748
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.73
    Marker Score: 2,590
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.73
    Marker Score: 3,049
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.72
    Marker Score: 268
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.72
    Marker Score: 405
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 374
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 0.72
    Marker Score: 252
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.72
    Marker Score: 816
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.71
    Marker Score: 274
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.71
    Marker Score: 893
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.71
    Marker Score: 1,750
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.71
    Marker Score: 816
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.7
    Marker Score: 1,548
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.7
    Marker Score: 1,349
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.69
    Marker Score: 280
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.69
    Marker Score: 468
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.69
    Marker Score: 626
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.68
    Marker Score: 919
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.67
    Marker Score: 581
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.66
    Marker Score: 2,755
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.65
    Marker Score: 540
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.64
    Marker Score: 3,875
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.63
    Marker Score: 623
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.63
    Marker Score: 908
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.62
    Marker Score: 5,363
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.62
    Marker Score: 311
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.62
    Marker Score: 407
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.61
    Marker Score: 370
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.61
    Marker Score: 754

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SLC12A6 is a transmembrane protein that belongs to the solute carrier family 12. It is primarily expressed in neurons, epithelial cells, and other tissues, where it plays a crucial role in maintaining potassium ion homeostasis. The protein has a unique structure, consisting of 12 transmembrane domains, which allows it to transport potassium ions across the plasma membrane. **Pathways and Functions:** SLC12A6 is involved in various cellular processes, including: 1. **Potassium ion homeostasis:** SLC12A6 regulates the influx and efflux of potassium ions across the plasma membrane, maintaining the delicate balance of ions within the cell. 2. **Cell volume homeostasis:** By controlling potassium ion movement, SLC12A6 helps regulate cell volume and maintains proper cellular function. 3. **Neurotransmission:** SLC12A6 is involved in the regulation of potassium ion movement in neurons, which is essential for the proper functioning of neurotransmission. 4. **Angiogenesis:** SLC12A6 has been implicated in the regulation of angiogenesis, a process crucial for vascular development and tumor growth. 5. **Cellular response to glucose stimulus:** SLC12A6 is responsive to glucose levels, which is essential for maintaining cellular homeostasis. **Clinical Significance:** Mutations in the SLC12A6 gene have been associated with various neurological and developmental disorders, including: 1. **Agenesis of the corpus callosum (ACC):** A congenital disorder characterized by the absence or underdevelopment of the corpus callosum, a structure connecting the two hemispheres of the brain. 2. **Peripheral neuropathy (APCN):** A condition characterized by damage to the peripheral nerves, leading to numbness, weakness, and other symptoms. 3. **Disorders of transmembrane transporters:** SLC12A6 mutations can lead to defects in transmembrane transport, resulting in various neurological and developmental disorders. **Conclusion:** In conclusion, SLC12A6 is a critical gene that plays a vital role in maintaining cellular homeostasis, regulating ion balance, and its implications in various neurological and developmental disorders. As an expert immunologist, I emphasize the importance of understanding the functions and clinical significance of SLC12A6 to better comprehend the underlying mechanisms of human disease. Further research is necessary to elucidate the complex interactions between SLC12A6 and other genes, as well as its role in various diseases.

Genular Protein ID: 3619649646

Symbol: S12A6_HUMAN

Name: Solute carrier family 12 member 6

UniProtKB Accession Codes:

Q9UHW9 A0AV76 Q2VI00 Q7Z2E7 Q7Z4G5 Q8TDD4 Q9UFR2 Q9Y642 Q9Y665

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CTD 1 ChEBI 22 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 67 EMDB 10 EPD 1 Ensembl 8 ExpressionAtlas 1 GO 23 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 17 PDBsum 8 PIR 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 6 Pumba 1 RNAct 1 Reactome 2 RefSeq 6 Rhea 6 SAM 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10600773

Title: Molecular cloning and functional characterization of KCC3, a new K-Cl cotransporter.

PubMed ID: 10600773

DOI: 10.1152/ajpcell.1999.277.6.c1210

PubMed ID: 10187864

Title: Cloning, characterization, and chromosomal location of a novel human K+-Cl- cotransporter.

PubMed ID: 10187864

DOI: 10.1074/jbc.274.15.10661

PubMed ID: 10347194

Title: Cloning and characterization of KCC3 and KCC4, new members of the cation-chloride cotransporter gene family.

PubMed ID: 10347194

DOI: 10.1074/jbc.274.23.16355

PubMed ID: 12368912

Title: The K-Cl cotransporter KCC3 is mutant in a severe peripheral neuropathy associated with agenesis of the corpus callosum.

PubMed ID: 12368912

DOI: 10.1038/ng1002

PubMed ID: 16048901

Title: NH2-terminal heterogeneity in the KCC3 K+-Cl- cotransporter.

PubMed ID: 16048901

DOI: 10.1152/ajprenal.00464.2004

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 11551954

Title: A dominant negative mutant of the KCC1 K-Cl cotransporter: both N- and C-terminal cytoplasmic domains are required for K-Cl cotransport activity.

PubMed ID: 11551954

DOI: 10.1074/jbc.m107155200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19665974

Title: Sites of regulated phosphorylation that control K-Cl cotransporter activity.

PubMed ID: 19665974

DOI: 10.1016/j.cell.2009.05.031

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21613606

Title: Similar Effects of all WNK3 Variants upon SLC12 Cotransporters.

PubMed ID: 21613606

DOI: 10.1152/ajpcell.00070.2011

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 33199848

Title: Cryo-EM structures of the full-length human KCC2 and KCC3 cation-chloride cotransporters.

PubMed ID: 33199848

DOI: 10.1038/s41422-020-00437-x

PubMed ID: 34267353

Title: Author Correction: Cryo-EM structures of the full-length human KCC2 and KCC3 cation-chloride cotransporters.

PubMed ID: 34267353

DOI: 10.1038/s41422-021-00536-3

PubMed ID: 34031912

Title: Phospho-regulation, nucleotide binding and ion access control in potassium-chloride cotransporters.

PubMed ID: 34031912

DOI: 10.15252/embj.2020107294

PubMed ID: 16606917

Title: Novel truncating and missense mutations of the KCC3 gene associated with Andermann syndrome.

PubMed ID: 16606917

DOI: 10.1212/01.wnl.0000204181.31175.8b

PubMed ID: 17893295

Title: Distal truncation of KCC3 in non-French Canadian HMSN/ACC families.

PubMed ID: 17893295

DOI: 10.1212/01.wnl.0000291779.35643.15

PubMed ID: 18566107

Title: HMSN/ACC truncation mutations disrupt brain-type creatine kinase-dependant activation of K+/Cl- co-transporter 3.

PubMed ID: 18566107

DOI: 10.1093/hmg/ddn172

PubMed ID: 21628467

Title: Transit defect of potassium-chloride Co-transporter 3 is a major pathogenic mechanism in hereditary motor and sensory neuropathy with agenesis of the corpus callosum.

PubMed ID: 21628467

DOI: 10.1074/jbc.m111.226894

PubMed ID: 27485015

Title: Peripheral motor neuropathy is associated with defective kinase regulation of the KCC3 cotransporter.

PubMed ID: 27485015

DOI: 10.1126/scisignal.aae0546

PubMed ID: 31439721

Title: De novo variants in SLC12A6 cause sporadic early-onset progressive sensorimotor neuropathy.

PubMed ID: 31439721

DOI: 10.1136/jmedgenet-2019-106273

PubMed ID: 35733399

Title: Novel heterozygous variants of SLC12A6 in Japanese families with Charcot-Marie-Tooth disease.

PubMed ID: 35733399

DOI: 10.1002/acn3.51603

Sequence Information:

  • Length: 1150
  • Mass: 127617
  • Checksum: F8BDD39181294EDD
  • Sequence:
    • MHPPETTTKM ASVRFMVTPT KIDDIPGLSD TSPDLSSRSS SRVRFSSRES VPETSRSEPM 
SEMSGATTSL ATVALDPPSD RTSHPQDVIE DLSQNSITGE HSQLLDDGHK KARNAYLNNS 
NYEEGDEYFD KNLALFEEEM DTRPKVSSLL NRMANYTNLT QGAKEHEEAE NITEGKKKPT 
KTPQMGTFMG VYLPCLQNIF GVILFLRLTW VVGTAGVLQA FAIVLICCCC TMLTAISMSA 
IATNGVVPAG GSYFMISRAL GPEFGGAVGL CFYLGTTFAA AMYILGAIEI FLVYIVPRAA 
IFHSDDALKE SAAMLNNMRV YGTAFLVLMV LVVFIGVRYV NKFASLFLAC VIVSILAIYA 
GAIKSSFAPP HFPVCMLGNR TLSSRHIDVC SKTKEINNMT VPSKLWGFFC NSSQFFNATC 
DEYFVHNNVT SIQGIPGLAS GIITENLWSN YLPKGEIIEK PSAKSSDVLG SLNHEYVLVD 
ITTSFTLLVG IFFPSVTGIM AGSNRSGDLK DAQKSIPIGT ILAILTTSFV YLSNVVLFGA 
CIEGVVLRDK FGDAVKGNLV VGTLSWPSPW VIVIGSFFST CGAGLQSLTG APRLLQAIAK 
DNIIPFLRVF GHSKANGEPT WALLLTAAIA ELGILIASLD LVAPILSMFF LMCYLFVNLA 
CALQTLLRTP NWRPRFRYYH WALSFMGMSI CLALMFISSW YYAIVAMVIA GMIYKYIEYQ 
GAEKEWGDGI RGLSLSAARF ALLRLEEGPP HTKNWRPQLL VLLKLDEDLH VKHPRLLTFA 
SQLKAGKGLT IVGSVIVGNF LENYGEALAA EQTIKHLMEA EKVKGFCQLV VAAKLREGIS 
HLIQSCGLGG MKHNTVVMGW PNGWRQSEDA RAWKTFIGTV RVTTAAHLAL LVAKNISFFP 
SNVEQFSEGN IDVWWIVHDG GMLMLLPFLL KQHKVWRKCS IRIFTVAQLE DNSIQMKKDL 
ATFLYHLRIE AEVEVVEMHD SDISAYTYER TLMMEQRSQM LRHMRLSKTE RDREAQLVKD 
RNSMLRLTSI GSDEDEETET YQEKVHMTWT KDKYMASRGQ KAKSMEGFQD LLNMRPDQSN 
VRRMHTAVKL NEVIVNKSHE AKLVLLNMPG PPRNPEGDEN YMEFLEVLTE GLERVLLVRG 
GGSEVITIYS

Genular Protein ID: 2895845379

Symbol: Q6NSI7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6NSI7

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 2 ChiTaRS 1 DNASU 1 EMBL 2 GO 2 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 4 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 RefSeq 1 Rhea 1 SAM 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 1091
  • Mass: 121109
  • Checksum: EC5F6EE6E9E6957B
  • Sequence:
    • MSEMSGATTS LATVALDPPS DRTSHPQDVI EDLSQNSITG EHSQLLDDGH KKARNAYLNN 
SNYEEGDEYF DKNLALFEEE MDTRPKVSSL LNRMANYTNL TQGAKEHEEA ENITEGKKKP 
TKTPQMGTFM GVYPPCLQNI FGVILFLRLT WVVGTAGVLQ AFAIVLICCC CTMLTAISMS 
AIATNGVVPA GGSYFMISRA LGPEFGGAVG LCFYLGTTFA AAMYILGAIE IFLVYIVPRA 
AIFHSDDALK ESAAMLNNMR VYGTAFLVLM VLVVFIGVRY VNKFASLFLA CVIVSILAIY 
AGAIKSSFAP PHFPVCMLGN RTLSSRHIDV CSKTKEINNM TVPSKLWGFF CNSSQFFNAT 
CDEYFVHNNV TSIQGIPGLA SGIITENLWS NYLPKGEIIE KPSAKSSDVL GSLNHEYVLV 
DITTSFTLLV GIFFPSVTGI MAGSNRSGDL KDAQKSIPIG TILAILTTSF VYLSNVVLFG 
ACIEGVVLRD KFGDAVKGNL VVGTLSWPSP WVIVIGSFFS TCGAGLQSLT GAPRLLQAIA 
KDNIIPFLRV FGHSKANGEP TWALLLTAAI AELGILIASL DLVAPILSMF FLMCYLFVNL 
ACALQTLLRT PNWRPRFRYY HWALSFMGMS ICLALMFISS WYYAIVAMVI AGMIYKYIEY 
QGAEKEWGDG IRGLSLSAAR FALLRLEEGP PHTKNWRPQL LVLLKLDEDL HVKHPRLLTF 
ASQLKAGKGL TIVGSVIVGN FLENYGEALA AEQTIKHLME AEKVKGFCQL VVAAKLREGI 
SHLIQSCGLG GMKHNTVVMG WPNGWRQSED ARAWKTFIGT VRVTTAAHLA LLVAKNISFF 
PSNVEQFSEG NIDVWWIVHD GGMLMLLPFL LKQHKVWRKC SIRIFTVAQL EDNSIQMKKD 
LATFLYHLRI EAEVEVVEMH DSDISAYTYE RTLMMEQRSQ MLRHMRLSKT ERDREAQLVK 
DRNSMLRLTS IGSDEDEETE TYQEKVHMTW TKDKYMASRG QKAKSMEGFQ DLLNMRPDQS 
NVRRMHTAVK LNEVIVNKSH EAKLVLLNMP GPPRNPEGDE NYMEFLEVLT EGLERVLLVR 
GGGSEVITIY S

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.