Details for: KCNE2

Gene ID: 9992

Symbol: KCNE2

Ensembl ID: ENSG00000159197

Description: potassium voltage-gated channel subfamily E regulatory subunit 2

Associated with

  • Cardiac conduction
    (R-HSA-5576891)
  • Muscle contraction
    (R-HSA-397014)
  • Phase 2 - plateau phase
    (R-HSA-5576893)
  • Phase 3 - rapid repolarisation
    (R-HSA-5576890)
  • Apical plasma membrane
    (GO:0016324)
  • Cardiac muscle cell action potential involved in contraction
    (GO:0086002)
  • Cell surface
    (GO:0009986)
  • Cellular response to xenobiotic stimulus
    (GO:0071466)
  • Delayed rectifier potassium channel activity
    (GO:0005251)
  • Identical protein binding
    (GO:0042802)
  • Inward rectifier potassium channel activity
    (GO:0005242)
  • Lysosome
    (GO:0005764)
  • Membrane repolarization
    (GO:0086009)
  • Membrane repolarization during action potential
    (GO:0086011)
  • Membrane repolarization during ventricular cardiac muscle cell action potential
    (GO:0098915)
  • Negative regulation of delayed rectifier potassium channel activity
    (GO:1902260)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of proteasomal protein catabolic process
    (GO:1901800)
  • Potassium channel regulator activity
    (GO:0015459)
  • Potassium ion export across plasma membrane
    (GO:0097623)
  • Potassium ion import across plasma membrane
    (GO:1990573)
  • Potassium ion transmembrane transport
    (GO:0071805)
  • Protein binding
    (GO:0005515)
  • Regulation of delayed rectifier potassium channel activity
    (GO:1902259)
  • Regulation of heart rate by cardiac conduction
    (GO:0086091)
  • Regulation of inward rectifier potassium channel activity
    (GO:1901979)
  • Regulation of membrane repolarization
    (GO:0060306)
  • Regulation of potassium ion transmembrane transport
    (GO:1901379)
  • Regulation of ventricular cardiac muscle cell membrane repolarization
    (GO:0060307)
  • Tongue development
    (GO:0043586)
  • Transmembrane transporter binding
    (GO:0044325)
  • Ventricular cardiac muscle cell action potential
    (GO:0086005)
  • Voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
    (GO:1902282)
  • Voltage-gated potassium channel complex
    (GO:0008076)

Other Information

Genular Protein ID: 3099752340

Symbol: KCNE2_HUMAN

Name: Potassium voltage-gated channel subfamily E member 2

UniProtKB Accession Codes:

Q9Y6J6 A5H1P3 D3DSF8 Q52LJ5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EMBL 6 Ensembl 1 GO 29 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10219239

Title: MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia.

PubMed ID: 10219239

DOI: 10.1016/s0092-8674(00)80728-x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11034315

Title: M-type KCNQ2-KCNQ3 potassium channels are modulated by the KCNE2 subunit.

PubMed ID: 11034315

DOI: 10.1016/s0014-5793(00)01918-9

PubMed ID: 11101505

Title: KCNE2 confers background current characteristics to the cardiac KCNQ1 potassium channel.

PubMed ID: 11101505

DOI: 10.1093/emboj/19.23.6326

PubMed ID: 11874988

Title: Disease-associated mutations in KCNE potassium channel subunits (MiRPs) reveal promiscuous disruption of multiple currents and conservation of mechanism.

PubMed ID: 11874988

DOI: 10.1096/fj.01-0520hyp

PubMed ID: 20533308

Title: Impact of KCNE subunits on KCNQ1 (Kv7.1) channel membrane surface targeting.

PubMed ID: 20533308

DOI: 10.1002/jcp.22265

PubMed ID: 12185453

Title: Identification and functional characterization of a novel KCNE2 (MiRP1) mutation that alters HERG channel kinetics.

PubMed ID: 12185453

DOI: 10.1007/s00109-002-0364-0

PubMed ID: 15368194

Title: Identification of a KCNE2 gain-of-function mutation in patients with familial atrial fibrillation.

PubMed ID: 15368194

DOI: 10.1086/425342

PubMed ID: 16922724

Title: Spectrum of pathogenic mutations and associated polymorphisms in a cohort of 44 unrelated patients with long QT syndrome.

PubMed ID: 16922724

DOI: 10.1111/j.1399-0004.2006.00671.x

PubMed ID: 19716085

Title: Spectrum and prevalence of mutations from the first 2,500 consecutive unrelated patients referred for the FAMILION long QT syndrome genetic test.

PubMed ID: 19716085

DOI: 10.1016/j.hrthm.2009.05.021

Sequence Information:

  • Length: 123
  • Mass: 14472
  • Checksum: C3016415E1B44890
  • Sequence:
    • MSTLSNFTQT LEDVFRRIFI TYMDNWRQNT TAEQEALQAK VDAENFYYVI LYLMVMIGMF 
SFIIVAILVS TVKSKRREHS NDPYHQYIVE DWQEKYKSQI LNLEESKATI HENIGAAGFK 
MSP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.