Details for: A1BG

Gene ID: 1

Symbol: A1BG

Ensembl ID: ENSG00000121410

Description: alpha-1-B glycoprotein

Associated with

  • Biological_process
  • Blood microparticle
  • Collagen-containing extracellular matrix
  • Extracellular exosome
  • Extracellular region
  • Extracellular space
  • Ficolin-1-rich granule lumen
  • Hemostasis
  • Immune system
  • Innate immune system
  • Molecular_function
  • Neutrophil degranulation
  • Plasma membrane
  • Platelet activation, signaling and aggregation
  • Platelet alpha granule lumen
  • Platelet degranulation
  • Response to elevated platelet cytosolic ca2+
  • Secretory granule lumen
**Summary:** The A1BG gene encodes a glycoprotein called alpha-1-B glycoprotein (A1BG). A1BG is a transmembrane protein that is expressed in various cell types, including thymocytes, hepatocytes, dendritic cells, and retinal ganglion cells. **Key characteristics:** - A1BG is a type I glycoprotein, which are characterized by the presence of a single extracellular domain. - It is expressed in high levels in hematopoietic cells, where it is involved in cell adhesion and signaling. - A1BG is also expressed in various tissues, including the skin, lungs, and brain. - It is a key component of the platelet alpha granule lumen, a specialized structure involved in platelet aggregation. **Pathways and functions:** - A1BG is involved in several biological processes, including cell adhesion, signaling, and aggregation. - It is a key regulator of platelet aggregation, a process that is essential for blood clotting. - A1BG also plays a role in the regulation of inflammation and immune responses. **Clinical significance:** - Mutations in the A1BG gene have been linked to several human diseases, including platelet disorders such as von Willebrand disease and thrombocytopenia. - A1BG is a potential therapeutic target for these disorders, as it can inhibit platelet aggregation and improve blood clotting.


Only first 5 entries are kept for 'singleCellExpressions', 'mRNAExpressions' and other large data arrays.