**Summary:**
The NAT2 gene encodes a protein called N-acetyltransferase 2 (ARY2). It is a protein involved in the metabolism of drugs and other chemicals.
**Key characteristics:**
* The NAT2 gene is located on chromosome 15q21.1.
* It is a large gene, encoding a protein of 1,594 amino acids.
* The protein is expressed in a variety of cell types, including blood vessel endothelial cells, conventional dendritic cells, cardiac endothelial cells, granulocyte monocyte progenitor cells, B cells, cerebral cortex GABAergic interneurons, forebrain radial glial cells, tuft cells of the colon, and human absorptive cells.
**Pathways and functions:**
* The NAT2 gene is involved in several metabolic pathways, including acetylation, arylamine n-acetyltransferase activity, biological oxidations, cytosol, drug adme, metabolism, paracetamol adme, phase II - conjugation of compounds, and xenobiotic metabolic process.
* The protein is involved in the metabolism of a variety of drugs, including paracetamol and methadone.
* It is also involved in the detoxification of carcinogens.
**Clinical significance:**
* Mutations in the NAT2 gene have been linked to several human diseases, including liver disease, cancer, and drug addiction.
* The NAT2 gene is a promising target for the development of new drugs to treat these diseases.
**Additional information:**
* The NAT2 gene is also known as NR1.
* It is a highly expressed gene, with high levels of expression in the liver, kidney, and lungs.
* Mutations in the NAT2 gene have been shown to be associated with an increased risk of developing liver disease, cancer, and drug addiction.
