Details for: SERPINA3

Gene ID: 12

Symbol: SERPINA3

Ensembl ID: ENSG00000196136

Description: serpin family A member 3

Associated with

  • Acute-phase response
  • Azurophil granule lumen
  • Blood microparticle
  • Collagen-containing extracellular matrix
  • Dna binding
  • Extracellular exosome
  • Extracellular region
  • Extracellular space
  • Hemostasis
  • Immune system
  • Inflammatory response
  • Innate immune system
  • Maintenance of gastrointestinal epithelium
  • Negative regulation of endopeptidase activity
  • Neutrophil degranulation
  • Nucleus
  • Platelet activation, signaling and aggregation
  • Platelet alpha granule lumen
  • Platelet degranulation
  • Protein binding
  • Regulation of lipid metabolic process
  • Response to elevated platelet cytosolic ca2+
  • Secretory granule lumen
  • Serine-type endopeptidase inhibitor activity
## Summary SERPINA3 is a serpin family A member with a diverse expression pattern across different cell types. It is significantly expressed in progenitor cells, prostate gland microvascular endothelial cells, hematopoietic cells, myoepithelial cells of the mammary gland, mammary gland epithelial cells, fibroblasts of connective tissue of the nonglandular part of the prostate, luminal epithelial cells of the mammary gland, and fibroblasts of connective tissue of the glandular part of the prostate. ## Key characteristics * Serpin family A member * Ensembl ID: ENSG00000196136 * Protein: AACT_HUMAN (Alpha-1-antichymotrypsin) * Expression pattern: Progenitor cells, prostate gland microvascular endothelial cells, hematopoietic cells, myoepithelial cells of the mammary gland, mammary gland epithelial cells, fibroblasts of connective tissue of the nonglandular part of the prostate, luminal epithelial cells of the mammary gland, and fibroblasts of connective tissue of the glandular part of the prostate ## Pathways and functions * Acute-phase response * DNA binding * Extracellular region * Extracellular space * Hemostasis * Immune system * Inflammatory response * Innate immune system * Maintenance of gastrointestinal epithelium * Negative regulation of endopeptidase activity * Neutrophil degranulation * Platelet activation * Signaling and aggregation * Platelet degranulation * Protein binding * Regulation of lipid metabolic process * Response to elevated platelet cytosolic ca2+ ## Clinical significance SERPINA3 is a potential therapeutic target for various diseases. It has been implicated in a variety of conditions, including prostate cancer, breast cancer, and heart failure. By targeting SERPINA3, it may be possible to inhibit the activity of platelet-activating factor (PAF), a protein that is involved in platelet activation. This could lead to a reduction in platelet aggregation and inflammation, which may be beneficial in the treatment of these diseases.

Document:

Only first 5 entries are kept for 'singleCellExpressions', 'mRNAExpressions' and other large data arrays.