**Summary:**
The AADAC gene encodes for a protein called AAAD_HUMAN, which is an enzyme involved in the metabolism of arylamines and arylketoaldehydes. It is a member of the deacetylase family of enzymes, which remove acetyl groups from proteins.
**Key characteristics:**
* Gene name: AADAC
* Ensembl ID: ENSG00000114771
* Pathway: Biological oxidations, Catalytic activity, Deacetylase activity, Endoplasmic reticulum membrane, Lipase activity, Lipid metabolic process, Metabolism, Phase i - functionalization of compounds, Positive regulation of triglyceride catabolic process, Protein binding, Serine hydrolase activity, Triglyceride lipase activity, Xenobiotic metabolic process
* Significantly expressed cells: enterocyte of colon, enterocyte, enterocyte of epithelium proper of ileum, foveolar cell of stomach, midzonal region hepatocyte, centrilobular region hepatocyte, periportal region hepatocyte, precursor cell, fallopian tube secretory epithelial cell, cerebral cortex GABAergic interneuron
**Pathways and functions:**
* The AADAC gene is involved in multiple metabolic pathways, including biological oxidations, catalytic activity, deacetylase activity, and xenobiotic metabolic processes.
* It plays a role in the regulation of triglyceride catabolism by deacetylating a key enzyme involved in this process.
* It is also involved in the regulation of the endoplasmic reticulum membrane, where it may participate in the formation or remodeling of lipid droplets.
* Additionally, it is involved in the regulation of protein binding, serine hydrolase activity, and triglyceride lipase activity.
**Clinical significance:**
Mutations in the AADAC gene have been linked to several diseases, including colorectal cancer, non-alcoholic fatty liver disease, and obesity. These mutations can lead to the accumulation of arylamines and arylketoaldehydes, which can damage cells and tissues.
