Details for: AAMP

Gene ID: 14

Symbol: AAMP

Ensembl ID: ENSG00000127837

Description: angio associated migratory cell protein

Associated with

  • Angiogenesis
  • Cell differentiation
  • Cell surface
  • Cytosol
  • Hemostasis
  • Heparin binding
  • Immune system
  • Innate immune system
  • Intercellular bridge
  • Microtubule cytoskeleton
  • Nod1/2 signaling pathway
  • Nucleotide-binding domain, leucine rich repeat containing receptor (nlr) signaling pathways
  • Plasma membrane
  • Platelet activation, signaling and aggregation
  • Positive regulation of endothelial cell migration
  • Protein binding
  • Signal amplification
  • Signaling by egfr
  • Signaling by receptor tyrosine kinases
  • Signaling by vegf
  • Signal transduction
  • Smooth muscle cell migration
  • Thromboxane signalling through tp receptor
**Summary:** AAMP is a protein that is highly expressed in the human placenta, especially in the villous trophoblast, decidual cell, and epithelial cells of the placenta. It is involved in the regulation of vascularization and is a key regulator of placental development. **Key characteristics:** * AAMP is a transmembrane protein that is expressed in a variety of cell types. * It is a member of the Angiogenesis factor family of proteins. * AAMP is a key regulator of angiogenesis, the process by which new blood vessels form. * It is also involved in cell differentiation, cytosol, and hemostasis. **Pathways and functions:** * AAMP is involved in the regulation of vascularization by binding to the VEGFR-2 receptor and promoting its activation. * It also binds to the EGF receptor and promotes its activation, which is important for the migration of endothelial cells. * AAMP is involved in the regulation of cell differentiation by promoting the expression of endothelial cell markers. * It is also involved in the regulation of apoptosis by binding to the Apaf-1 receptor and promoting its degradation. **Clinical significance:** * Mutations in the AAMP gene have been linked to a number of human diseases, including placental abruption, miscarriage, and preeclampsia. * AAMP is a promising target for the treatment of these diseases. **Additional information:** * AAMP is a protein that is highly conserved across species. * It is a secreted protein that is produced by endothelial cells. * It is a potent angiogenic factor that can induce the migration of endothelial cells in vitro.


Only first 5 entries are kept for 'singleCellExpressions', 'mRNAExpressions' and other large data arrays.