Details for: AANAT

Gene ID: 15

Symbol: AANAT

Ensembl ID: ENSG00000129673

Description: aralkylamine N-acetyltransferase

Associated with

  • 14-3-3 protein binding
  • Aralkylamine n-acetyltransferase activity
  • Arylamine n-acetyltransferase activity
  • Cellular response to camp
  • Circadian rhythm
  • Cytoplasm
  • Cytosol
  • Indolalkylamine biosynthetic process
  • Melatonin biosynthetic process
  • Metabolism
  • Metabolism of amine-derived hormones
  • Metabolism of amino acids and derivatives
  • N-terminal protein amino acid acetylation
  • Perinuclear region of cytoplasm
  • Photoperiodism
  • Protein binding
  • Response to calcium ion
  • Response to copper ion
  • Response to corticosterone
  • Response to cytokine
  • Response to insulin
  • Response to light stimulus
  • Response to prostaglandin e
  • Response to zinc ion
  • Serotonin and melatonin biosynthesis
**Summary:** AANAT is a multifunctional enzyme that plays crucial roles in various physiological processes. It is involved in multiple pathways, including the regulation of circadian rhythm, the synthesis of melatonin, and the metabolism of amino acids and derivatives. **Key characteristics:** - AANAT is a transmembrane protein with a molecular weight of approximately 60 kDa. - It is expressed in a variety of cell types, including endothelial cells, epithelial cells, and immune cells. - It is a highly conserved enzyme with a similar sequence found in organisms from yeast to humans. **Pathways and functions:** - AANAT is involved in the regulation of circadian rhythm through its interaction with the clock protein periodin 2 (PER2). - It also plays a role in the synthesis of melatonin, a hormone that regulates the sleep-wake cycle. - AANAT is involved in the metabolism of amino acids and derivatives, including the synthesis of neurotransmitters and the degradation of damaged proteins. - It is also involved in the regulation of the immune response and inflammation. **Clinical significance:** - Mutations in AANAT have been linked to several human diseases, including circadian disorders, sleep apnea, and obesity. - AANAT inhibitors have been investigated as potential therapeutic agents for these diseases. **Additional notes:** - AANAT is a highly active enzyme that is regulated by various hormones and signaling molecules. - It is a key regulator of the body's circadian rhythm and the synthesis of melatonin. - It is also involved in the metabolism of amino acids and derivatives, which is essential for maintaining homeostasis in the body.


Only first 5 entries are kept for 'singleCellExpressions', 'mRNAExpressions' and other large data arrays.