Details for: ABAT

Gene ID: 18

Symbol: ABAT

Ensembl ID: ENSG00000183044

Description: 4-aminobutyrate aminotransferase

Associated with

  • (s)-3-amino-2-methylpropionate transaminase activity
  • 4-aminobutyrate:2-oxoglutarate transaminase activity
  • 4-aminobutyrate transaminase activity
  • 4-aminobutyrate transaminase complex
  • Behavioral response to cocaine
  • Cerebellum development
  • Copulation
  • Degradation of gaba
  • Exploration behavior
  • Gaba synthesis, release, reuptake and degradation
  • Gamma-aminobutyric acid biosynthetic process
  • Gamma-aminobutyric acid catabolic process
  • Gamma-aminobutyric acid metabolic process
  • Identical protein binding
  • Iron-sulfur cluster binding
  • Locomotory behavior
  • Metal ion binding
  • Mitochondrial matrix
  • Mitochondrion
  • Negative regulation of blood pressure
  • Negative regulation of dopamine secretion
  • Negative regulation of gamma-aminobutyric acid secretion
  • Neuronal system
  • Neurotransmitter release cycle
  • Positive regulation of aspartate secretion
  • Positive regulation of dopamine metabolic process
  • Positive regulation of heat generation
  • Positive regulation of inhibitory postsynaptic potential
  • Positive regulation of insulin secretion
  • Positive regulation of prolactin secretion
  • Positive regulation of uterine smooth muscle contraction
  • Pyridoxal phosphate binding
  • Response to ethanol
  • Response to hypoxia
  • Response to iron ion
  • Response to nicotine
  • Response to xenobiotic stimulus
  • Succinate-semialdehyde dehydrogenase binding
  • Transmission across chemical synapses
**Summary:** The ABAT gene encodes a protein that is involved in the metabolism of gamma-aminobutyric acid (GABA). GABA is an inhibitory neurotransmitter in the central nervous system (CNS). The ABAT gene is significantly expressed in neurons of the cerebral cortex, particularly in interneurons. **Key characteristics:** - It is a protein of the cytochrome P450 family. - It is expressed in a wide range of brain regions, including the cerebral cortex, hippocampus, and cerebellum. - It is a key enzyme in the degradation of GABA. - It is also involved in the synthesis of gaba and the reuptake of GABA into neurons. **Pathways and functions:** - The ABAT gene is involved in the (-)-3-amino-2-methylpropionate transaminase (AMPA) pathway, which is responsible for the synthesis of GABA from glutamate. - It is also involved in the degradation of gaba through the gamma-aminobutyric acid (GABA) catabolism pathway. - It is also involved in the regulation of synaptic plasticity and learning and memory. **Clinical significance:** - Mutations in the ABAT gene have been linked to autism, schizophrenia, and other neurodevelopmental disorders. - ABAT inhibitors are being investigated as potential treatments for these disorders. **Additional information:** - The ABAT gene is also involved in the regulation of blood pressure and blood sugar levels. - It is a highly conserved protein, with a similar sequence in mammals and humans. - It is a well-characterized protein that has been extensively studied in models of neurodegenerative diseases.


Only first 5 entries are kept for 'singleCellExpressions', 'mRNAExpressions' and other large data arrays.