Details for: ABCA1

Gene ID: 19

Symbol: ABCA1

Ensembl ID: ENSG00000165029

Description: ATP binding cassette subfamily A member 1

Associated with

  • Abc-type transporter activity
  • Abc transporter disorders
  • Adenylate cyclase-activating g protein-coupled receptor signaling pathway
  • Apolipoprotein a-i-mediated signaling pathway
  • Apolipoprotein a-i binding
  • Apolipoprotein a-i receptor activity
  • Apolipoprotein binding
  • Atpase-coupled transmembrane transporter activity
  • Atpase binding
  • Atp binding
  • Atp hydrolysis activity
  • Basolateral plasma membrane
  • Cellular response to cholesterol
  • Cellular response to cytokine stimulus
  • Cellular response to lipopolysaccharide
  • Cellular response to low-density lipoprotein particle stimulus
  • Cellular response to retinoic acid
  • Cellular response to xenobiotic stimulus
  • Cholesterol binding
  • Cholesterol efflux
  • Cholesterol homeostasis
  • Cholesterol metabolic process
  • Cholesterol transfer activity
  • Defective abca1 causes tgd
  • Disease
  • Disorders of transmembrane transporters
  • Endocytic vesicle
  • Endoplasmic reticulum membrane
  • Endosomal transport
  • Endosome
  • Export across plasma membrane
  • External side of plasma membrane
  • Floppase activity
  • Golgi apparatus
  • G protein-coupled receptor signaling pathway
  • Hdl assembly
  • High-density lipoprotein particle assembly
  • High-density lipoprotein particle binding
  • Intermembrane lipid transfer
  • Intracellular cholesterol transport
  • Intracellular membrane-bounded organelle
  • Intracellular vesicle
  • Lipoprotein biosynthetic process
  • Lysosome organization
  • Membrane raft
  • Metabolism
  • Metabolism of lipids
  • Negative regulation of cholesterol storage
  • Negative regulation of macrophage derived foam cell differentiation
  • Nr1h2 and nr1h3-mediated signaling
  • Nr1h3 & nr1h2 regulate gene expression linked to cholesterol transport and efflux
  • Peptide secretion
  • Perinuclear region of cytoplasm
  • Phagocytic vesicle
  • Phagocytosis, engulfment
  • Phosphatidylcholine binding
  • Phosphatidylcholine floppase activity
  • Phosphatidylserine floppase activity
  • Phospholipid efflux
  • Phospholipid homeostasis
  • Phospholipid translocation
  • Phospholipid transporter activity
  • Plasma lipoprotein assembly
  • Plasma lipoprotein assembly, remodeling, and clearance
  • Plasma membrane
  • Platelet dense granule organization
  • Positive regulation of cholesterol efflux
  • Positive regulation of high-density lipoprotein particle assembly
  • Ppara activates gene expression
  • Protein binding
  • Protein secretion
  • Protein transmembrane transport
  • Protein transmembrane transporter activity
  • Regulation of cdc42 protein signal transduction
  • Regulation of high-density lipoprotein particle assembly
  • Regulation of lipid metabolism by pparalpha
  • Response to laminar fluid shear stress
  • Response to vitamin b3
  • Reverse cholesterol transport
  • Signaling by nuclear receptors
  • Signaling receptor binding
  • Signal release
  • Signal transduction
  • Small gtpase binding
  • Sphingolipid floppase activity
  • Sphingolipid translocation
  • Syntaxin binding
  • Transport of small molecules
## Summary ABCA1 is a protein that is involved in the assembly and trafficking of proteins involved in cholesterol transport and efflux. It is expressed in a variety of cell types, including endothelial cells, hepatocytes, and fibroblasts. ## Key characteristics * ABCA1 is a transmembrane protein that is expressed in the plasma membrane of cells. * It is a member of the ATP-binding cassette subfamily A (ABC) of proteins. * It is a key regulator of cholesterol transport and efflux in cells. * It is involved in the assembly and trafficking of proteins involved in cholesterol transport and efflux. * It is also involved in the regulation of lipid metabolism. ## Pathways and functions * ABCA1 is involved in the assembly and trafficking of proteins involved in cholesterol transport and efflux. * It is responsible for the sorting and transport of proteins to the cell surface. * It is also involved in the regulation of cholesterol efflux from cells. * It is involved in the metabolism of lipids. * It is also involved in the regulation of inflammation. ## Clinical significance ABCA1 is a gene that is linked to a number of human diseases. Mutations in ABCA1 have been linked to a number of diseases, including familial hypercholesterolemia, atherosclerosis, and diabetes. These diseases are characterized by high levels of cholesterol in the blood. ABCA1 is a potential target for the treatment of these diseases. By blocking ABCA1, it is possible to lower cholesterol levels and reduce the risk of developing these diseases.

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Only first 5 entries are kept for 'singleCellExpressions', 'mRNAExpressions' and other large data arrays.