Details for: A2M

Gene ID: 2

Symbol: A2M

Ensembl ID: ENSG00000175899

Description: alpha-2-macroglobulin

Associated with

  • Acute-phase response
  • Acute inflammatory response to antigenic stimulus
  • Blood microparticle
  • Brain-derived neurotrophic factor binding
  • Calcium-dependent protein binding
  • Collagen-containing extracellular matrix
  • Degradation of the extracellular matrix
  • Embryonic liver development
  • Endopeptidase inhibitor activity
  • Enzyme binding
  • Extracellular exosome
  • Extracellular matrix organization
  • Extracellular region
  • Extracellular space
  • Formation of fibrin clot (clotting cascade)
  • Growth factor binding
  • Hdl assembly
  • Hemostasis
  • Identical protein binding
  • Interleukin-1 binding
  • Interleukin-8 binding
  • Intrinsic pathway of fibrin clot formation
  • Luteinization
  • Negative regulation of complement activation, lectin pathway
  • Nerve growth factor binding
  • Plasma lipoprotein assembly
  • Plasma lipoprotein assembly, remodeling, and clearance
  • Platelet activation, signaling and aggregation
  • Platelet alpha granule lumen
  • Platelet degranulation
  • Protease binding
  • Protein binding
  • Response to carbon dioxide
  • Response to elevated platelet cytosolic ca2+
  • Response to glucocorticoid
  • Response to nutrient
  • Response to prostaglandin e
  • Serine-type endopeptidase inhibitor activity
  • Signaling receptor binding
  • Stem cell differentiation
  • Transport of small molecules
  • Tumor necrosis factor binding
# Summary The A2M gene encodes a protein called alpha-2-macroglobulin (A2M). A2M is a secreted protein that plays a critical role in the regulation of blood clot formation and inflammation. It is expressed in a variety of cell types, including hepatoblasts, endothelial cells, pericytes, and macrophages. # Key characteristics * A2M is a glycoprotein with a molecular weight of approximately 120 kDa. * It is a member of the immunoglobulin superfamily. * A2M is produced by a variety of cell types in response to injury or inflammation. * It is a key regulator of the coagulation cascade, which is responsible for the formation of blood clots. * A2M also plays a role in the regulation of inflammation and cell migration. # Pathways and functions * A2M is produced in response to injury or inflammation. * It binds to collagen and elastin fibers in the extracellular matrix, which is a protein that provides structural support for blood vessels. * This binding prevents the formation of new blood clots and helps to stabilize existing clots. * A2M also binds to platelets, which are small blood cells that play a key role in blood clotting. * This binding activates platelets and promotes the formation of blood clots. * A2M is also involved in the regulation of inflammation. * It can inhibit the activity of serine-type endopeptidases, which are enzymes that break down proteins. * This inhibition helps to prevent the degradation of A2M and other proteins that are involved in blood clot formation. # Clinical significance A2M is a clinically significant protein in patients with cardiovascular disease. In people with cardiovascular disease, high levels of A2M have been linked to increased risk of thrombosis. This is because A2M can promote the formation of blood clots, which can lead to heart attack and stroke. A2M can be measured in the blood to assess the risk of cardiovascular disease. High levels of A2M have been shown to be associated with an increased risk of cardiovascular events. A2M can be a target for therapy in patients with cardiovascular disease. There are a number of drugs that can block the activity of A2M, which can help to prevent the formation of blood clots and reduce the risk of cardiovascular events.


Only first 5 entries are kept for 'singleCellExpressions', 'mRNAExpressions' and other large data arrays.