Details for: ABCA2

Gene ID: 20

Symbol: ABCA2

Ensembl ID: ENSG00000107331

Description: ATP binding cassette subfamily A member 2

Associated with

  • Abc-family proteins mediated transport
  • Abc-type transporter activity
  • Abc transporters in lipid homeostasis
  • Atp-binding cassette (abc) transporter complex
  • Atpase-coupled transmembrane transporter activity
  • Atp binding
  • Atp hydrolysis activity
  • Central nervous system myelin formation
  • Ceramide floppase activity
  • Cholesterol homeostasis
  • Cytoplasmic vesicle
  • Endopeptidase regulator activity
  • Endosome
  • Endosome membrane
  • Ganglioside metabolic process
  • Glycosphingolipid metabolic process
  • Intracellular membrane-bounded organelle
  • Intracellular sphingolipid homeostasis
  • Lipid metabolic process
  • Lipid transport
  • Lipid transporter activity
  • Locomotory behavior
  • Lysosomal membrane
  • Lysosome
  • Membrane
  • Microtubule organizing center
  • Negative regulation of cholesterol efflux
  • Negative regulation of intracellular cholesterol transport
  • Negative regulation of low-density lipoprotein receptor activity
  • Negative regulation of receptor-mediated endocytosis involved in cholesterol transport
  • Negative regulation of steroid metabolic process
  • Nucleotide binding
  • Plasma membrane
  • Positive regulation of amyloid-beta formation
  • Positive regulation of amyloid precursor protein biosynthetic process
  • Positive regulation of amyloid precursor protein catabolic process
  • Positive regulation of low-density lipoprotein particle receptor catabolic process
  • Regulation of cholesterol biosynthetic process
  • Regulation of intracellular cholesterol transport
  • Regulation of post-translational protein modification
  • Regulation of protein glycosylation
  • Regulation of protein localization to cell periphery
  • Regulation of protein localization to cell surface
  • Regulation of steroid metabolic process
  • Response to cholesterol
  • Response to steroid hormone
  • Response to xenobiotic stimulus
  • Sphingomyelin metabolic process
  • Sphingosine biosynthetic process
  • Transmembrane transport
  • Transport across blood-brain barrier
  • Transport of small molecules
**Summary:** ABCA2 is a protein that belongs to the ATP-binding cassette subfamily A (ABC) of ATP-binding cassette proteins. ABC proteins are responsible for the transport of molecules between the cell and the extracellular environment. ABCA2 is expressed in a variety of cell types, including oligodendrocytes, pyramidal neurons, L6b glutamatergic cortical neurons, corticothalamic-projecting glutamatergic cortical neurons, kidney loop of Henle thick ascending limb epithelial cells, L2/3-6 intratelencephalic projecting glutamatergic neuron, near-projecting glutamatergic cortical neuron, L5 extratelencephalic projecting glutamatergic cortical neuron, endocrine cells, dopaminergic neurons. **Key characteristics:** * ABCA2 is a type of ATP-binding cassette protein. * It is expressed in a variety of cell types. * It is involved in the transport of molecules between the cell and the extracellular environment. * It is a significant protein in the brain. **Pathways and functions:** * ABCA2 is involved in a variety of cellular processes, including: * Lipid metabolism * Sphingomyelin metabolic process * Transport of small molecules * Immune response * It is involved in the regulation of neuronal function and development. **Clinical significance:** * Mutations in ABCA2 have been linked to a number of neurological disorders, including: * Cerebrovascular disease * Neurodegenerative diseases * Diabetes * ABCA2 is a promising target for the treatment of neurological disorders.


Only first 5 entries are kept for 'singleCellExpressions', 'mRNAExpressions' and other large data arrays.