Details for: ABCB7

Gene ID: 22

Symbol: ABCB7

Ensembl ID: ENSG00000131269

Description: ATP binding cassette subfamily B member 7

Associated with

  • Abc-family proteins mediated transport
  • Abc-type iron-sulfur cluster transporter activity
  • Atpase-coupled transmembrane transporter activity
  • Atp binding
  • Atp hydrolysis activity
  • Cytosolic iron-sulfur cluster assembly
  • Heme transmembrane transporter activity
  • Heme transport
  • Identical protein binding
  • Intracellular iron ion homeostasis
  • Iron-sulfur cluster assembly
  • Iron-sulfur cluster export from the mitochondrion
  • Iron ion transmembrane transport
  • Metabolism
  • Mitochondrial abc transporters
  • Mitochondrial inner membrane
  • Mitochondrion
  • Negative regulation of reactive oxygen species biosynthetic process
  • Positive regulation of heme biosynthetic process
  • Positive regulation of iron-sulfur cluster assembly
  • Protein binding
  • Protein homodimerization activity
  • Transmembrane transport
  • Transport of small molecules
**Summary**: The ABCB7 gene encodes a protein that is a member of the ATP-binding cassette (ABC) family of proteins. ABCB7 is involved in a variety of cellular processes, including the transport of small molecules and ions. **Key characteristics:** - ABCB7 is a type of ATP-binding cassette protein, which are a family of proteins that are involved in the transport of molecules between the cytosol and the extracellular environment. - ABCB7 is expressed in a variety of cell types, including cardiac myocytes, lens epithelial cells, and immune cells. - ABCB7 is a key regulator of heme biosynthetic process, as it is involved in the transport of iron ions between the cytosol and the mitochondria. - ABCB7 is also involved in the transport of small molecules between the cytosol and the extracellular environment. **Pathways and functions:** - ABCB7 is involved in the Abc-family proteins mediated transport pathway, which is responsible for the transport of molecules between the cytosol and the extracellular environment. - ABCB7 is also involved in the Abc-type iron-sulfur cluster transporter activity, which is responsible for the transport of iron ions between the cytosol and the mitochondria. - ABCB7 is also involved in the ATP-coupled transmembrane transporter activity, which is responsible for the transport of molecules between the cytosol and the extracellular environment. **Clinical significance:** - ABCB7 gene mutations have been linked to a number of human diseases, including sickle cell disease, beta-thalassemia, and hereditary spherocytosis. - Targeting ABCB7 has been shown to be a potential therapeutic strategy for these diseases.

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Only first 5 entries are kept for 'singleCellExpressions', 'mRNAExpressions' and other large data arrays.