Details for: ABL1

Gene ID: 25

Symbol: ABL1

Ensembl ID: ENSG00000097007

Description: ABL proto-oncogene 1, non-receptor tyrosine kinase

Associated with

  • Actin cytoskeleton
  • Actin cytoskeleton organization
  • Actin filament binding
  • Actin filament polymerization
  • Actin monomer binding
  • Activated t cell proliferation
  • Activation of protein kinase c activity
  • Alpha-beta t cell differentiation
  • Associative learning
  • Atp binding
  • Autophagy
  • Axon guidance
  • B-1 b cell homeostasis
  • B cell proliferation involved in immune response
  • B cell receptor signaling pathway
  • Bergmann glial cell differentiation
  • Bmp signaling pathway
  • Bubble dna binding
  • Canonical nf-kappab signal transduction
  • Cardiac muscle cell proliferation
  • Cell-cell adhesion
  • Cell cycle
  • Cell cycle, mitotic
  • Cellular response to dopamine
  • Cellular response to hydrogen peroxide
  • Cellular response to lipopolysaccharide
  • Cellular response to oxidative stress
  • Cellular response to transforming growth factor beta stimulus
  • Cellular senescence
  • Cerebellum morphogenesis
  • Cyclin d associated events in g1
  • Cytoplasm
  • Cytosol
  • Delta-catenin binding
  • Dendrite
  • Developmental biology
  • Disease
  • Dn4 thymocyte differentiation
  • Dna binding
  • Dna conformation change
  • Dna damage response
  • Dna double-strand break repair
  • Dna double strand break response
  • Dna repair
  • Endothelial cell migration
  • Ephrin receptor binding
  • Epidermal growth factor receptor signaling pathway
  • Erk1 and erk2 cascade
  • Establishment of localization in cell
  • Factors involved in megakaryocyte development and platelet production
  • Fc-gamma receptor signaling pathway involved in phagocytosis
  • Fcgamma receptor (fcgr) dependent phagocytosis
  • Fcgr3a-mediated phagocytosis
  • Four-way junction dna binding
  • G1 phase
  • Gene expression (transcription)
  • Generic transcription pathway
  • Growth cone
  • Hdr through homologous recombination (hrr) or single strand annealing (ssa)
  • Hdr through single strand annealing (ssa)
  • Hemostasis
  • Homology directed repair
  • Immune system
  • Infectious disease
  • Innate immune system
  • Integrin-mediated signaling pathway
  • Intrinsic apoptotic signaling pathway in response to dna damage
  • Kinase activity
  • Leishmania infection
  • Leishmania phagocytosis
  • Magnesium ion binding
  • Manganese ion binding
  • Microspike assembly
  • Mismatch repair
  • Mitochondrial depolarization
  • Mitochondrion
  • Mitogen-activated protein kinase binding
  • Mitotic cell cycle
  • Mitotic g1 phase and g1/s transition
  • Myoblast proliferation
  • Myogenesis
  • Negative regulation of bmp signaling pathway
  • Negative regulation of cell-cell adhesion
  • Negative regulation of cellular senescence
  • Negative regulation of double-strand break repair via homologous recombination
  • Negative regulation of endothelial cell apoptotic process
  • Negative regulation of erk1 and erk2 cascade
  • Negative regulation of long-term synaptic potentiation
  • Negative regulation of mitotic cell cycle
  • Negative regulation of phospholipase c activity
  • Negative regulation of protein serine/threonine kinase activity
  • Negative regulation of ubiquitin-protein transferase activity
  • Nervous system development
  • Neural tube closure
  • Neuroepithelial cell differentiation
  • Neuromuscular process controlling balance
  • Neuronal cell body
  • Neuron apoptotic process
  • Neuron differentiation
  • Neuropilin binding
  • Neuropilin signaling pathway
  • Nicotinate-nucleotide adenylyltransferase activity
  • Non-membrane spanning protein tyrosine kinase activity
  • Nuclear body
  • Nuclear membrane
  • Nucleolus
  • Nucleoplasm
  • Nucleus
  • Parasite infection
  • Parasitic infection pathways
  • Peptidyl-tyrosine autophosphorylation
  • Peptidyl-tyrosine phosphorylation
  • Perinuclear region of cytoplasm
  • Phosphotyrosine residue binding
  • Platelet-derived growth factor receptor-beta signaling pathway
  • Podocyte apoptotic process
  • Positive regulation of actin filament binding
  • Positive regulation of apoptotic process
  • Positive regulation of blood vessel branching
  • Positive regulation of canonical nf-kappab signal transduction
  • Positive regulation of cell migration involved in sprouting angiogenesis
  • Positive regulation of cytosolic calcium ion concentration
  • Positive regulation of dendrite development
  • Positive regulation of endothelial cell migration
  • Positive regulation of erk1 and erk2 cascade
  • Positive regulation of establishment of t cell polarity
  • Positive regulation of extracellular matrix organization
  • Positive regulation of fibroblast proliferation
  • Positive regulation of focal adhesion assembly
  • Positive regulation of interleukin-2 production
  • Positive regulation of microtubule binding
  • Positive regulation of mitotic cell cycle
  • Positive regulation of neuron apoptotic process
  • Positive regulation of osteoblast proliferation
  • Positive regulation of oxidoreductase activity
  • Positive regulation of peptidyl-tyrosine phosphorylation
  • Positive regulation of protein phosphorylation
  • Positive regulation of release of sequestered calcium ion into cytosol
  • Positive regulation of stress fiber assembly
  • Positive regulation of substrate adhesion-dependent cell spreading
  • Positive regulation of t cell migration
  • Positive regulation of transcription by rna polymerase ii
  • Positive regulation of type ii interferon production
  • Positive regulation of vasoconstriction
  • Positive regulation of wnt signaling pathway, planar cell polarity pathway
  • Post-embryonic development
  • Postsynapse
  • Proline-rich region binding
  • Protein-containing complex
  • Protein autophosphorylation
  • Protein binding
  • Protein kinase activity
  • Protein kinase c binding
  • Protein localization to cytoplasmic microtubule plus-end
  • Protein modification process
  • Protein phosphorylation
  • Protein self-association
  • Protein tyrosine kinase activity
  • Recruitment and atm-mediated phosphorylation of repair and signaling proteins at dna double strand breaks
  • Regulation of actin cytoskeleton organization
  • Regulation of actin dynamics for phagocytic cup formation
  • Regulation of autophagy
  • Regulation of axon extension
  • Regulation of cdc42 protein signal transduction
  • Regulation of cell adhesion
  • Regulation of cell cycle
  • Regulation of cell motility
  • Regulation of dna-templated transcription
  • Regulation of endocytosis
  • Regulation of hematopoietic stem cell differentiation
  • Regulation of microtubule polymerization
  • Regulation of modification of synaptic structure
  • Regulation of t cell differentiation
  • Response to endoplasmic reticulum stress
  • Response to epinephrine
  • Response to oxidative stress
  • Response to xenobiotic stimulus
  • Rho gtpase effectors
  • Rho gtpases activate wasps and waves
  • Rna polymerase ii transcription
  • Role of abl in robo-slit signaling
  • Ruffle
  • Runx1 regulates transcription of genes involved in differentiation of hscs
  • Runx2 regulates bone development
  • Runx2 regulates osteoblast differentiation
  • Sequence-specific double-stranded dna binding
  • Sh2 domain binding
  • Sh3 domain binding
  • Signaling by rho gtpases
  • Signaling by rho gtpases, miro gtpases and rhobtb3
  • Signaling by robo receptors
  • Signal transduction
  • Signal transduction in response to dna damage
  • Spleen development
  • Substrate adhesion-dependent cell spreading
  • Supercoiled dna binding
  • Syntaxin binding
  • T cell receptor signaling pathway
  • Thymus development
  • Transcriptional regulation by runx1
  • Transcriptional regulation by runx2
  • Transcription coactivator activity
  • Transitional one stage b cell differentiation
**Summary:** ABL1 is a proto-oncogene that plays a crucial role in the regulation of cell cycle progression and cell growth. It is a non-receptor tyrosine kinase that is highly expressed in various cell types, including hematopoietic cells, endothelial cells, and cancer cells. **Key characteristics:** * ABL1 is a member of the Tyrosine kinase family of receptors. * It is a highly conserved gene with a similar sequence in mammals. * It is involved in multiple cellular processes, including cell cycle regulation, cell growth, and angiogenesis. **Pathways and functions:** * ABL1 is involved in various cellular processes, including cell cycle regulation, cell growth, and angiogenesis. * It is a key regulator of cell cycle progression, ensuring that cells enter and exit the cell cycle at the appropriate times. * It also plays a role in regulating cell growth and differentiation. * ABL1 is involved in the regulation of angiogenesis, the formation of new blood vessels. * It is also involved in the regulation of inflammation and cell migration. **Clinical significance:** * Mutations in the ABL1 gene have been linked to the development of various human cancers, including leukemia, breast cancer, and colon cancer. * Targeting ABL1 has emerged as a promising therapeutic strategy for cancer treatment. * The development of antibodies and other therapeutic agents targeting ABL1 has shown promising results in clinical trials. **Additional notes:** * ABL1 is a highly conserved gene, with a similar sequence in humans and other mammals. * It is a key regulator of cell cycle progression and cell growth. * It is involved in various cellular processes, including cell cycle regulation, cell growth, and angiogenesis. * Mutations in the ABL1 gene have been linked to the development of various human cancers.

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Only first 5 entries are kept for 'singleCellExpressions', 'mRNAExpressions' and other large data arrays.