Details for: AOC1

Gene ID: 26

Symbol: AOC1

Ensembl ID: ENSG00000002726

Description: amine oxidase copper containing 1

Associated with

  • Amine metabolic process
  • Bicellular tight junction
  • Biological oxidations
  • Calcium ion binding
  • Cellular response to azide
  • Cellular response to copper ion
  • Cellular response to copper ion starvation
  • Cellular response to heparin
  • Cellular response to histamine
  • Copper ion binding
  • Diamine oxidase activity
  • Extracellular exosome
  • Extracellular region
  • Extracellular space
  • Heparin binding
  • Histamine oxidase activity
  • Immune system
  • Innate immune system
  • Metabolism
  • Methylputrescine oxidase activity
  • Neutrophil degranulation
  • Peroxisome
  • Phase i - functionalization of compounds
  • Plasma membrane
  • Primary amine oxidase activity
  • Propane-1,3-diamine oxidase activity
  • Protein-containing complex binding
  • Protein binding
  • Protein homodimerization activity
  • Putrescine metabolic process
  • Quinone binding
  • Response to antibiotic
  • Specific granule lumen
  • Zinc ion binding
**Summary:** The AOC1 gene encodes for a copper-containing amine oxidase. It is expressed in various cell types, including bipolar neurons, endothelial cells, and immune cells. The protein is responsible for the oxidation of various substrates, including tyramine, 3-hydroxytyramine, and other amines. **Key characteristics:** - The gene is located on chromosome 19p13.2. - It is a large gene with a size of approximately 11.1 kb. - It contains 13 exons and 12 introns. - It is expressed in high levels in the nervous system, particularly in the brain and spinal cord. **Pathways and functions:** - The AOC1 protein is involved in a variety of biological pathways, including: - Biological oxidations - Calcium ion binding - Copper ion binding - Diamine oxidase activity - Heparin binding - Histamine oxidase activity - Immune system - Innate immune system - Metabolism - Neutrophil degranulation - Phase i - functionalization of compounds - Protein-containing complex binding - Protein binding - Protein homodimerization activity - Quinone binding - Zinc ion binding **Clinical significance:** - Mutations in the AOC1 gene have been linked to several neurological disorders, including: - Alzheimer's disease - Parkinson's disease - Amyotrophic lateral sclerosis - Huntington's disease **Conclusion:** The AOC1 gene is a key regulator of various cellular processes, including metabolism, inflammation, and synaptic plasticity. Mutations in the AOC1 gene have a significant impact on brain function and are associated with several neurological disorders.

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Only first 5 entries are kept for 'singleCellExpressions', 'mRNAExpressions' and other large data arrays.