Details for: ABL2

Gene ID: 27

Symbol: ABL2

Ensembl ID: ENSG00000143322

Description: ABL proto-oncogene 2, non-receptor tyrosine kinase

Associated with

  • Actin cytoskeleton
  • Actin filament binding
  • Actin monomer binding
  • Atp binding
  • Axon guidance
  • Cell adhesion
  • Cellular response to retinoic acid
  • Cytokine signaling in immune system
  • Cytosol
  • Developmental biology
  • Epidermal growth factor receptor signaling pathway
  • Exploration behavior
  • Flt3 signaling
  • Immune system
  • Magnesium ion binding
  • Manganese ion binding
  • Negative regulation of flt3
  • Negative regulation of rho protein signal transduction
  • Nervous system development
  • Non-membrane spanning protein tyrosine kinase activity
  • Peptidyl-tyrosine phosphorylation
  • Phosphotyrosine residue binding
  • Positive regulation of cytosolic calcium ion concentration
  • Positive regulation of establishment of t cell polarity
  • Positive regulation of neuron projection development
  • Positive regulation of oxidoreductase activity
  • Positive regulation of phospholipase c activity
  • Positive regulation of t cell migration
  • Protein binding
  • Protein kinase activity
  • Protein modification process
  • Protein phosphorylation
  • Protein tyrosine kinase activity
  • Rac1 gtpase cycle
  • Rac3 gtpase cycle
  • Regulation of actin cytoskeleton organization
  • Regulation of autophagy
  • Regulation of cell adhesion
  • Regulation of cell motility
  • Regulation of endocytosis
  • Rho gtpase cycle
  • Role of abl in robo-slit signaling
  • Signaling by rho gtpases
  • Signaling by rho gtpases, miro gtpases and rhobtb3
  • Signaling by robo receptors
  • Signal transduction
**Summary:** ABL2 is a non-receptor tyrosine kinase that plays a crucial role in various cellular processes, including cell migration, proliferation, and survival. It is highly expressed in different cell types, including fibroblasts, ciliary muscle cells, and neurons. **Key characteristics:** - ABL2 is a large protein (135 kDa) with seven immunoglobulin domains. - It is a member of the Src family of tyrosine kinases. - It is activated by various growth factors and cytokines. - It phosphorylates various substrates involved in cell cycle regulation, cell survival, and migration. **Pathways and functions:** - ABL2 is involved in various cellular processes, including cell migration, proliferation, and survival. - It is essential for the development and survival of mammary gland epithelial cells. - It is involved in the regulation of ciliary muscle cells, promoting cell cycle arrest and migration. - It plays a role in the development of the nervous system and the growth and survival of neurons. - It is involved in the regulation of vascular endothelial cells, promoting angiogenesis and tumor growth. **Clinical significance:** - Mutations in ABL2 have been linked to various human cancers, including breast cancer, lung cancer, and colon cancer. - Targeting ABL2 has emerged as a promising therapeutic strategy for these cancers. - ABL2 inhibitors are currently being investigated in clinical trials for the treatment of cancer and other diseases. **Additional information:** - ABL2 is a highly conserved protein, with similar sequences found in mammals and birds. - It is a substrate for various phosphatases, including PI3K, MAPK, and Src. - It is a key regulator of cell growth, proliferation, and survival.


Only first 5 entries are kept for 'singleCellExpressions', 'mRNAExpressions' and other large data arrays.