Details for: ABO

Gene ID: 28

Symbol: ABO

Ensembl ID: ENSG00000175164

Description: ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase

Associated with

  • Antigen binding
  • Carbohydrate metabolic process
  • Extracellular region
  • Fucosylgalactoside 3-alpha-galactosyltransferase activity
  • Glycoprotein-fucosylgalactoside alpha-n-acetylgalactosaminyltransferase activity
  • Golgi apparatus
  • Golgi cisterna membrane
  • Golgi membrane
  • Lipid glycosylation
  • Manganese ion binding
  • Nucleotide binding
  • Protein glycosylation
  • Vesicle
**Summary:** The ABO gene encodes for two proteins, alpha 1-3-N-acetylgalactosaminyltransferase (BGAT) and alpha 1-3-galactosyltransferase. These proteins are involved in the synthesis of glycoproteins that are expressed on the surface of red blood cells. The ABO blood group system is determined by the presence or absence of two sugar molecules on the surface of red blood cells. **Key characteristics:** - The ABO system is a complex network of antigens and antibodies that helps the body to recognize and respond to foreign pathogens. - The ABO genes are located on chromosome 1. - There are four different alleles of the ABO genes: A, B, AB, and O. - People with blood group A have antigen A on their red blood cells, people with blood group B have antigen B on their red blood cells, people with blood group AB have both antigens A and B on their red blood cells, and people with blood group O have neither antigen A nor B on their red blood cells. **Pathways and functions:** - The ABO system is involved in the processing and presentation of antigens on the surface of red blood cells. - This process is essential for the immune system to recognize and respond to foreign pathogens. - The ABO system is also involved in the regulation of inflammation. **Clinical significance:** - The ABO system is a major factor in blood transfusions. - People with incompatible blood types can develop a condition called ABO incompatibility, which can lead to hemolytic disease of the newborn (HDN). - HDN is a condition in which the immune system mistakenly attacks red blood cells, causing them to clump together and form blood clots. - ABO incompatibility can be prevented by matching blood types during a blood transfusion.

Document:

Only first 5 entries are kept for 'singleCellExpressions', 'mRNAExpressions' and other large data arrays.