Details for: ABR

Gene ID: 29

Symbol: ABR

Ensembl ID: ENSG00000159842

Description: ABR activator of RhoGEF and GTPase

Associated with

  • Activation of gtpase activity
  • Axon
  • Cdc42 gtpase cycle
  • Cell death signalling via nrage, nrif and nade
  • Cytosol
  • Death receptor signaling
  • Dendritic spine
  • G alpha (12/13) signalling events
  • Glutamatergic synapse
  • Gpcr downstream signalling
  • Gtpase activator activity
  • Guanyl-nucleotide exchange factor activity
  • Membrane
  • Modulation of chemical synaptic transmission
  • Nrage signals death through jnk
  • P75 ntr receptor-mediated signalling
  • Protein binding
  • Rac1 gtpase cycle
  • Rac2 gtpase cycle
  • Rac3 gtpase cycle
  • Regulation of small gtpase mediated signal transduction
  • Rhoa gtpase cycle
  • Rhob gtpase cycle
  • Rhoc gtpase cycle
  • Rho gtpase cycle
  • Schaffer collateral - ca1 synapse
  • Signaling by gpcr
  • Signaling by rho gtpases
  • Signaling by rho gtpases, miro gtpases and rhobtb3
  • Signal transduction
  • Small gtpase-mediated signal transduction
**Summary:** The ABR gene encodes a protein called ABR, which is an activator of the RhoGEF and GTPase signaling pathways. It is significantly expressed in various cell types, including mature microglial cells, pigmented epithelial cells, central nervous system macrophages, astrocytes, and interneurons. **Key characteristics:** - The ABR gene is a member of the RhoGEF family of guanosine triphosphate (GTP)-binding proteins. - It is a key regulator of cell death signaling pathways, including the cdc42 gtpase, nrage, nrif, and nade pathways. - It is also involved in the G alpha (12/13) signaling events, Gpcr downstream signaling, Guanyl-nucleotide exchange factor activity, and Nrage signals death through jnk, P75 ntr receptor-mediated signaling, Rac1 gtpase cycle, Rac2 gtpase cycle, Rac3 gtpase cycle, Rhoa gtpase cycle, Rhob gtpase cycle, Rho gtpase cycle, and signaling by gpcr. **Pathways and functions:** - Activation of the ABR gene leads to the activation of the RhoGEF and GTPase signaling pathways. - These pathways are involved in cell cycle regulation, apoptosis, and inflammation. - In the context of cell death, ABR signaling promotes cell death through the cdc42 gtpase, nrage, nrif, and nade pathways. - It also plays a role in promoting cell death in response to various stimuli, including ischemia, oxidative stress, and neurotoxic agents. **Clinical significance:** - Aberrant expression of the ABR gene has been linked to various neurological diseases, including multiple sclerosis, Parkinson's disease, and Alzheimer's disease. - Targeting the ABR gene has been explored as a therapeutic strategy for these diseases. - However, the development of effective anti-ABR therapies has proven challenging due to the complex and multifaceted nature of the disease.


Only first 5 entries are kept for 'singleCellExpressions', 'mRNAExpressions' and other large data arrays.