Details for: NAT1

Gene ID: 9

Symbol: NAT1

Ensembl ID: ENSG00000171428

Description: N-acetyltransferase 1

Associated with

  • Acetylation
  • Arylamine n-acetyltransferase activity
  • Biological oxidations
  • Cytosol
  • Drug adme
  • Metabolism
  • Paracetamol adme
  • Phase ii - conjugation of compounds
  • Xenobiotic metabolic process
**Summary:** The NAT1 gene encodes for a protein called N-acetyltransferase 1, which is involved in the acetylation of various substrates in the body. It is highly expressed in cells of the respiratory tract, heart, brain, and liver. **Key characteristics:** - It is a protein of the cytochrome P450 family. - It is responsible for the acetylation of various substrates, including proteins, lipids, and carbohydrates. - It is involved in a variety of cellular processes, including cell cycle regulation, inflammation, and metabolism. **Pathways and functions:** - Nat1 is involved in the acetylation of proteins involved in cell cycle regulation, such as p53 and p21 proteins. - It is also involved in the acetylation of inflammatory mediators, such as IL-1 beta and TNF-alpha. - It is involved in the metabolism of drugs, such as paracetamol. - It is involved in the detoxification of xenobiotics. **Clinical significance:** - Mutations in the NAT1 gene have been linked to a number of human diseases, including liver cancer, heart disease, and inflammation. - Overexpression of NAT1 has been linked to the development of liver cancer. - Inhibition of NAT1 has been shown to reduce cancer cell growth.


Only first 5 entries are kept for 'singleCellExpressions', 'mRNAExpressions' and other large data arrays.