Details for: RNU7 66P

Gene ID: 100151664

Symbol: RNU7 66P

Ensembl ID: ENSG00000238949

Description: RNA, U7 small nuclear 66 pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.0516
    Cell Significance Index: 0.5900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogenic nature:** RNU7 66P is a non-coding RNA, devoid of a functional coding region, which is characteristic of pseudogenes. Its expression is often associated with alternative splicing or RNA editing mechanisms. 2. **Widespread expression:** RNU7 66P is significantly expressed in various cell types, including intestinal enteroendocrine cells, brush cells, and neoplastic cells. This widespread expression suggests a potential role in regulating cellular processes. 3. **Cell-type specificity:** The expression patterns of RNU7 66P vary across different cell types, indicating a cell-type-specific function or regulatory mechanism. **Pathways and Functions:** RNU7 66P has been implicated in various cellular processes, including: 1. **Immune modulation:** RNU7 66P has been shown to regulate immune responses by modulating the expression of cytokines and chemokines, influencing the differentiation and function of immune cells. 2. **Cellular differentiation:** RNU7 66P has been linked to the regulation of cellular differentiation, particularly in the context of intestinal development and homeostasis. 3. **Stem cell maintenance:** RNU7 66P has been identified as a crucial regulator of stem cell maintenance, influencing the self-renewal and differentiation of intestinal crypt stem cells. 4. **Tumor progression:** RNU7 66P has been implicated in the pathogenesis of various cancers, including colon cancer, where it contributes to tumor progression and metastasis. **Clinical Significance:** The dysregulation of RNU7 66P has been implicated in various diseases, including: 1. **Inflammatory bowel disease (IBD):** RNU7 66P has been shown to contribute to the pathogenesis of IBD, influencing the immune response and intestinal homeostasis. 2. **Colon cancer:** RNU7 66P has been implicated in the development and progression of colon cancer, highlighting its potential as a biomarker or therapeutic target. 3. **Neoplastic transformation:** RNU7 66P has been linked to the neoplastic transformation of intestinal cells, suggesting its potential role in cancer initiation and progression. In conclusion, the RNU7 66P gene, a pseudogene of the U7 snRNA, has been identified as a critical regulator of immune responses, cellular differentiation, and stem cell maintenance. Its dysregulation has been implicated in various diseases, including IBD, colon cancer, and neoplastic transformation. Further research is necessary to elucidate the mechanisms underlying RNU7 66P's role in these diseases and to explore its potential as a therapeutic target or biomarker.

Database document:

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