Details for: MIR3977

Gene ID: 100616297

Symbol: MIR3977

Ensembl ID: ENSG00000283359

Description: microRNA 3977

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0075
    Cell Significance Index: -0.0700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MIR3977 is a small non-coding RNA molecule, approximately 22 nucleotides in length, that belongs to the microRNA family. MicroRNAs are known to regulate gene expression post-transcriptionally by binding to the 3'-untranslated region (3'-UTR) of target mRNAs, leading to their degradation or repression of translation. MIR3977 has been shown to be highly conserved across species, suggesting its importance in maintaining fundamental biological processes. **Pathways and Functions:** MIR3977 has been implicated in several key pathways that regulate intestinal homeostasis, including: 1. **Wnt/β-catenin signaling pathway**: MIR3977 has been shown to target and downregulate the Wnt/β-catenin pathway, which is critical for intestinal stem cell maintenance and differentiation. 2. **Notch signaling pathway**: MIR3977 has also been implicated in the regulation of the Notch signaling pathway, which plays a key role in intestinal cell fate determination and differentiation. 3. **Apoptosis and cell survival**: MIR3977 has been shown to regulate the expression of pro-apoptotic and anti-apoptotic genes, influencing cell survival and apoptosis in intestinal epithelial cells. **Clinical Significance:** The dysregulation of MIR3977 has been implicated in various intestinal diseases, including: 1. **Inflammatory bowel disease (IBD)**: MIR3977 has been shown to be downregulated in patients with IBD, suggesting its potential role as a diagnostic biomarker. 2. **Colorectal cancer**: MIR3977 has been implicated in the regulation of colorectal cancer cell proliferation, invasion, and metastasis. 3. **Intestinal epithelial barrier dysfunction**: MIR3977 has been shown to regulate the expression of genes involved in the maintenance of the intestinal epithelial barrier, highlighting its potential role in intestinal barrier dysfunction. In conclusion, MIR3977 plays a critical role in maintaining intestinal homeostasis and has been implicated in the development and progression of various intestinal diseases. Further research is needed to fully elucidate the mechanisms by which MIR3977 regulates gene expression and to explore its potential as a therapeutic target for intestinal diseases. **Recommendations:** 1. Further studies are needed to determine the specific mechanisms by which MIR3977 regulates Wnt/β-catenin and Notch signaling pathways in intestinal cells. 2. The role of MIR3977 in intestinal epithelial barrier dysfunction and its potential as a therapeutic target for intestinal barrier disorders should be further investigated. 3. The potential of MIR3977 as a diagnostic biomarker for IBD and colorectal cancer should be explored in clinical settings. By elucidating the role of MIR3977 in intestinal homeostasis and disease, we can gain a deeper understanding of the complex mechanisms underlying intestinal health and disease, and potentially develop novel therapeutic strategies for the treatment of intestinal disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.