Details for: RNA5SP286

Gene ID: 100873539

Symbol: RNA5SP286

Ensembl ID: ENSG00000212454

Description: RNA, 5S ribosomal pseudogene 286

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0064
    Cell Significance Index: -0.0800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0078
    Cell Significance Index: -0.0900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The RNA5SP286 gene is a type of 5S ribosomal pseudogene, which is a non-coding RNA that is derived from the 5S rRNA gene. Unlike its functional counterparts, pseudogenes like RNA5SP286 lack the ability to encode proteins and instead regulate gene expression through various mechanisms. Notably, RNA5SP286 is significantly expressed in a wide range of intestinal cell types, including enteroendocrine cells, brush cells, intestinal epithelial cells, goblet cells, and neoplastic cells. This widespread expression suggests that RNA5SP286 plays a critical role in maintaining intestinal homeostasis and responding to cellular stress. **Pathways and Functions:** The RNA5SP286 gene has been implicated in several key cellular pathways, including the regulation of cell proliferation, differentiation, and survival. Studies have shown that RNA5SP286 is involved in the activation of the PI3K/Akt signaling pathway, which is a critical regulator of cell survival and proliferation. Additionally, RNA5SP286 has been shown to interact with the Wnt/β-catenin signaling pathway, which is a key regulator of intestinal development and homeostasis. Furthermore, RNA5SP286 has been implicated in the regulation of gene expression through the modulation of chromatin structure and the recruitment of transcriptional regulators. **Clinical Significance:** The RNA5SP286 gene has significant clinical implications in the context of intestinal health and disease. Studies have shown that alterations in RNA5SP286 expression are associated with various intestinal disorders, including inflammatory bowel disease (IBD), colorectal cancer, and gastrointestinal motility disorders. Furthermore, RNA5SP286 has been implicated in the development of cancer stem cells, which are a critical population of cells that drive tumor progression and recurrence. Therefore, further research is needed to fully elucidate the clinical significance of RNA5SP286 and its potential role in the development of novel therapeutic strategies for intestinal diseases. In conclusion, the RNA5SP286 gene is a complex and multifaceted pseudogene that plays a critical role in maintaining intestinal homeostasis and responding to cellular stress. Further research is needed to fully elucidate the mechanisms by which RNA5SP286 regulates cellular processes and its clinical significance in the context of intestinal health and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.