Details for: OR4G3P

Gene ID: 26679

Symbol: OR4G3P

Ensembl ID: ENSG00000282137

Description: olfactory receptor family 4 subfamily G member 3 pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0152
    Cell Significance Index: -0.1700
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0538
    Cell Significance Index: -0.4700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** OR4G3P is a pseudogene, which implies that it does not encode a functional protein. Despite its non-coding nature, it is significantly expressed in stromal cells and glutamatergic neurons, two cell types with distinct functions in the immune system. The expression of OR4G3P in these cells suggests that it may play a role in modulating immune responses or influencing neuronal activity. **Pathways and Functions:** The OR4G3P gene is part of the olfactory receptor family, which is primarily involved in the detection of odorant molecules. However, recent studies have suggested that olfactory receptors, including OR4G3P, may also be involved in other cellular processes, such as: 1. **Immune modulation:** OR4G3P expression in stromal cells may contribute to the regulation of immune responses, potentially influencing the activity of immune cells, such as T cells and dendritic cells. 2. **Neurotransmission:** The expression of OR4G3P in glutamatergic neurons may modulate neurotransmitter release and synaptic transmission, which could have implications for neuronal function and behavior. 3. **Cell signaling:** OR4G3P may interact with other signaling molecules to regulate cellular processes, such as cell proliferation, differentiation, and survival. **Clinical Significance:** While OR4G3P is a pseudogene, its expression in specific cell types suggests that it may have implications for various diseases and disorders. Some potential clinical applications of OR4G3P include: 1. **Immune system disorders:** OR4G3P expression in stromal cells may be involved in the pathogenesis of autoimmune diseases, such as multiple sclerosis or rheumatoid arthritis. 2. **Neurological disorders:** OR4G3P expression in glutamatergic neurons may contribute to the development of neurological disorders, such as epilepsy or Alzheimer's disease. 3. **Cancer:** OR4G3P may play a role in cancer progression, potentially influencing tumor growth, metastasis, or immune evasion. In conclusion, while OR4G3P is a pseudogene, its expression in specific cell types suggests that it may have significant immunological and clinical implications. Further research is needed to fully understand the role of OR4G3P in these processes and to explore its potential applications in disease diagnosis and treatment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.