Details for: OR4F1P

Gene ID: 26685

Symbol: OR4F1P

Ensembl ID: ENSG00000220212

Description: olfactory receptor family 4 subfamily F member 1 pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Classification:** OR4F1P is a pseudogene, which means it is a non-functional copy of an olfactory receptor gene. Pseudogenes are often remnants of ancient gene duplication events and can be found in various organisms. 2. **Expression:** OR4F1P is significantly expressed in stromal cells, which are a heterogeneous population of non-immune cells present in various tissues, including the skin, liver, and kidney. 3. **Evolutionary conservation:** OR4F1P shows a high degree of sequence similarity to functional olfactory receptors, suggesting that it may have evolved from a functional gene. **Pathways and Functions:** While OR4F1P is classified as a pseudogene, its expression in stromal cells suggests that it may be involved in cellular signaling pathways. Research has shown that olfactory receptors, including OR4F1P, can activate G-protein coupled receptor (GPCR) signaling pathways, which play crucial roles in various cellular processes, including immune responses. 1. **GPCR signaling:** OR4F1P may interact with GPCRs to modulate signaling pathways involved in immune cell function, such as the activation of T cells and the production of cytokines. 2. **Stromal cell biology:** OR4F1P may influence stromal cell behavior, including their ability to support immune cell function and modulate tissue homeostasis. 3. **Immune modulation:** OR4F1P may play a role in regulating immune responses, potentially by modulating the activity of immune cells or influencing the expression of immune-related genes. **Clinical Significance:** While OR4F1P is still a relatively unknown gene, its expression in stromal cells and potential involvement in immune modulation suggest that it may have clinical significance. Further research is needed to fully understand the functional significance of OR4F1P and its potential role in human diseases. 1. **Cancer:** OR4F1P may be involved in cancer progression, potentially by influencing stromal cell behavior and modulating immune responses. 2. **Autoimmune diseases:** OR4F1P may play a role in autoimmune diseases, such as rheumatoid arthritis, by modulating immune cell function and influencing the expression of immune-related genes. 3. **Infectious diseases:** OR4F1P may be involved in the regulation of immune responses to pathogens, potentially by modulating the activity of immune cells or influencing the expression of immune-related genes. In conclusion, OR4F1P is a pseudogene with potential immunological significance, given its expression in stromal cells and potential involvement in immune modulation. Further research is needed to fully understand the functional significance of OR4F1P and its potential role in human diseases.

Database document:

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