Details for: OR2G1P

Gene ID: 26717

Symbol: OR2G1P

Ensembl ID: ENSG00000213911

Description: olfactory receptor family 2 subfamily G member 1 pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0034
    Cell Significance Index: -0.0400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** OR2G1P is a pseudogene, which means it has undergone a process of genetic degeneration, resulting in a non-functional gene. Despite its pseudogenic status, OR2G1P is significantly expressed in ependymal cells and neurons, suggesting a potential role in these cell types. The gene's expression in ependymal cells, in particular, is noteworthy, as these cells are involved in the production of cerebrospinal fluid and play a crucial role in maintaining the central nervous system's health. **Pathways and Functions:** The OR2G1P gene is part of the olfactory receptor family, which is responsible for detecting odorant molecules in the air. While OR2G1P itself is a pseudogene, its presence in ependymal cells and neurons may indicate a conserved genetic pathway related to olfaction. The gene's expression in neurons could also suggest a role in neuronal development, plasticity, or function. Furthermore, the OR2G1P gene may be involved in the regulation of the blood-brain barrier, given its expression in ependymal cells, which are involved in the production of cerebrospinal fluid. **Clinical Significance:** The OR2G1P gene's expression in ependymal cells and neurons raises several potential clinical implications. Firstly, the gene's presence in these cell types may be associated with neurological disorders, such as multiple sclerosis, where ependymal cells are affected. Secondly, the OR2G1P gene's role in regulating the blood-brain barrier may be relevant in the context of neuroinflammatory diseases, such as Alzheimer's disease or Parkinson's disease. Finally, the gene's expression in neurons may be linked to neurodevelopmental disorders, such as autism spectrum disorder or schizophrenia. In conclusion, while the OR2G1P gene is a pseudogene, its expression in ependymal cells and neurons suggests a potential role in neuroimmunology and neurological disorders. Further research is necessary to fully understand the clinical significance of this gene and its implications for human health. **Future Directions:** To further explore the OR2G1P gene's potential, future studies should focus on: 1. Investigating the gene's expression patterns in various neurological disorders. 2. Examining the gene's role in regulating the blood-brain barrier and its potential implications for neuroinflammatory diseases. 3. Exploring the gene's involvement in neurodevelopmental disorders, such as autism spectrum disorder or schizophrenia. 4. Investigating the gene's potential as a biomarker for neurological disorders. By addressing these research gaps, we may uncover new insights into the OR2G1P gene's role in human health and disease, ultimately leading to the development of novel therapeutic strategies for neurological disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.