Details for: CL0000065

Cell ID: CL0000065

Cell Name: ependymal cell

Marker Score Threshold: 349
(Derived using integrated single-cell and genomic data)

Description: A neuroepithelial glial cell, derived from a radial glial cell originating from the neuroectoderm, lines the ventricles of the brain and the central canal of the spinal cord. This cell is characterized by the presence of cilia on its apical surface, which can be motile or non-motile.

Synonyms: ependymocyte

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 4.01
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.59
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.42
    Ensembl ID: ENSG00000184009
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 3.33
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.79
    Ensembl ID: ENSG00000135390
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.73
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.67
    Ensembl ID: ENSG00000124172
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.49
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.41
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.26
    Ensembl ID: ENSG00000169020
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.26
    Ensembl ID: ENSG00000179218
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 2.25
    Ensembl ID: ENSG00000084234
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.19
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.17
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.16
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.16
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.14
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 2.13
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.13
    Ensembl ID: ENSG00000099624
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 2.11
    Ensembl ID: ENSG00000172270
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.1
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 2.03
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.02
    Ensembl ID: ENSG00000154518
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.99
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.99
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.96
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.94
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.88
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.88
    Ensembl ID: ENSG00000163399
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.85
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.77
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.75
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.74
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.73
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.71
    Ensembl ID: ENSG00000116459
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.63
    Ensembl ID: ENSG00000005022
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.62
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.61
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.6
    Ensembl ID: ENSG00000072778
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.6
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.6
    Ensembl ID: ENSG00000241837
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 1.59
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.57
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.57
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.53
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.51
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.49
    Ensembl ID: ENSG00000197043
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.47
    Ensembl ID: ENSG00000123505
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.47
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.46
    Ensembl ID: ENSG00000141522
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.43
    Ensembl ID: ENSG00000108561
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.43
    Ensembl ID: ENSG00000143799
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.42
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.42
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.41
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.41
    Ensembl ID: ENSG00000135046
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.41
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.4
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.4
    Ensembl ID: ENSG00000087274
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.34
    Ensembl ID: ENSG00000100300
  • Gene Symbol: CALU (ENSG00000128595)
    Fold Change: 1.34
    Ensembl ID: ENSG00000128595
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.32
    Ensembl ID: ENSG00000072110
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.3
    Ensembl ID: ENSG00000183255
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.3
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.29
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.29
    Ensembl ID: ENSG00000149311
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.28
    Ensembl ID: ENSG00000149823
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.26
    Ensembl ID: ENSG00000004059
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.23
    Ensembl ID: ENSG00000140299
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.22
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.22
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.21
    Ensembl ID: ENSG00000137845
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.21
    Ensembl ID: ENSG00000006125
  • Gene Symbol: BCL2L1 (ENSG00000171552)
    Fold Change: 1.2
    Ensembl ID: ENSG00000171552
  • Gene Symbol: AP2A2 (ENSG00000183020)
    Fold Change: 1.19
    Ensembl ID: ENSG00000183020
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.19
    Ensembl ID: ENSG00000115307
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.14
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.14
    Ensembl ID: ENSG00000165527
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.12
    Ensembl ID: ENSG00000004455
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.12
    Ensembl ID: ENSG00000197894
  • Gene Symbol: BIRC2 (ENSG00000110330)
    Fold Change: 1.11
    Ensembl ID: ENSG00000110330
  • Gene Symbol: ACAT1 (ENSG00000075239)
    Fold Change: 1.1
    Ensembl ID: ENSG00000075239
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.1
    Ensembl ID: ENSG00000155366
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.1
    Ensembl ID: ENSG00000100412
  • Gene Symbol: ADSS2 (ENSG00000035687)
    Fold Change: 1.1
    Ensembl ID: ENSG00000035687
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.1
    Ensembl ID: ENSG00000174437
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.09
    Ensembl ID: ENSG00000131100
  • Gene Symbol: BNIP3 (ENSG00000176171)
    Fold Change: 1.07
    Ensembl ID: ENSG00000176171
  • Gene Symbol: CAMK2D (ENSG00000145349)
    Fold Change: 1.05
    Ensembl ID: ENSG00000145349
  • Gene Symbol: ABCF1 (ENSG00000204574)
    Fold Change: 1.05
    Ensembl ID: ENSG00000204574
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.04
    Ensembl ID: ENSG00000087088
  • Gene Symbol: TMEM50B (ENSG00000142188)
    Fold Change: 1.04
    Ensembl ID: ENSG00000142188
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 1.04
    Ensembl ID: ENSG00000136717
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 1.04
    Ensembl ID: ENSG00000071553
  • Gene Symbol: ATP6V1B2 (ENSG00000147416)
    Fold Change: 1.04
    Ensembl ID: ENSG00000147416
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.03
    Ensembl ID: ENSG00000196975
  • Gene Symbol: ALCAM (ENSG00000170017)
    Fold Change: 1.03
    Ensembl ID: ENSG00000170017
  • Gene Symbol: XIAP (ENSG00000101966)
    Fold Change: 1.02
    Ensembl ID: ENSG00000101966
  • Gene Symbol: ATP6V1C1 (ENSG00000155097)
    Fold Change: 1.02
    Ensembl ID: ENSG00000155097
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: 1
    Ensembl ID: ENSG00000117054
Hovered Details

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Hovered Details

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**Key Characteristics** * Derived from radial glial cells originating from the neuroectoderm * Characterized by the presence of cilia on their apical surface, which can be motile or non-motile * Lines the ventricles of the brain and the central canal of the spinal cord * Plays a crucial role in maintaining the blood-brain barrier * Involved in the production and transport of cerebrospinal fluid * Has been implicated in various neurological disorders, including multiple sclerosis and neurodegenerative diseases **Clinical Significance** Ependymal cells have been implicated in various neurological disorders, including: * Multiple sclerosis: Ependymal cells have been shown to play a role in the pathogenesis of multiple sclerosis, a chronic autoimmune disease that affects the central nervous system. * Neurodegenerative diseases: Ependymal cells have been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. * Hydrocephalus: Ependymal cells play a crucial role in the production and transport of cerebrospinal fluid, which helps to maintain the homeostasis of the central nervous system. Dysfunction of ependymal cells can lead to hydrocephalus, a condition characterized by an accumulation of cerebrospinal fluid in the brain. * Cancer: Ependymal cells have been shown to play a role in the development and progression of certain types of cancer, including glioblastoma and medulloblastoma. In addition to their role in neurological disorders, ependymal cells have also been implicated in various other diseases, including: * Infectious diseases: Ependymal cells have been shown to play a role in the pathogenesis of certain infectious diseases, including HIV and tuberculosis. * Autoimmune diseases: Ependymal cells have been implicated in the pathogenesis of certain autoimmune diseases, including multiple sclerosis and rheumatoid arthritis. * Metabolic disorders: Ependymal cells have been shown to play a role in the regulation of metabolism and have been implicated in the pathogenesis of certain metabolic disorders, including diabetes and obesity. Overall, ependymal cells play a critical role in maintaining the homeostasis of the central nervous system and have been implicated in various neurological and non-neurological disorders.