Details for: COX2

Gene ID: 4513

Symbol: COX2

Ensembl ID: ENSG00000198712

Description: cytochrome c oxidase subunit II

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 8.25
    Marker Score: 5520
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 7.73
    Marker Score: 14083
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 7.62
    Marker Score: 6554.5
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 7.03
    Marker Score: 93467
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 6.48
    Marker Score: 1901
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 6.43
    Marker Score: 6681
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 6.22
    Marker Score: 30562.5
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 5.99
    Marker Score: 35511
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 5.9
    Marker Score: 46100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 5.85
    Marker Score: 12355
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 5.78
    Marker Score: 12114.5
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 5.68
    Marker Score: 14428.5
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 5.56
    Marker Score: 3797
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 5.52
    Marker Score: 4705
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 5.52
    Marker Score: 16111.5
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 5.47
    Marker Score: 7125.5
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 5.45
    Marker Score: 3954
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 5.24
    Marker Score: 3701
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 5.2
    Marker Score: 51529
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 5.12
    Marker Score: 18191
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 5.12
    Marker Score: 2631.5
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 5.1
    Marker Score: 8754
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 5.04
    Marker Score: 12386
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.99
    Marker Score: 169682
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 4.97
    Marker Score: 3201
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 4.91
    Marker Score: 3717
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 4.9
    Marker Score: 1845.5
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 4.87
    Marker Score: 15366
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 4.84
    Marker Score: 5713
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 4.83
    Marker Score: 255264
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 4.79
    Marker Score: 30581
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 4.77
    Marker Score: 8071
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 4.76
    Marker Score: 2888
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 4.73
    Marker Score: 21864
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 4.69
    Marker Score: 3117
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 4.68
    Marker Score: 3190
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 4.65
    Marker Score: 11344
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 4.64
    Marker Score: 1995
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.64
    Marker Score: 259349
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 4.58
    Marker Score: 5090.5
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 4.58
    Marker Score: 5531
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 4.53
    Marker Score: 3711
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 4.47
    Marker Score: 58960
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 4.46
    Marker Score: 5360.5
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 4.45
    Marker Score: 27054
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 4.44
    Marker Score: 3159
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 4.41
    Marker Score: 11827
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 4.41
    Marker Score: 6384
  • Cell Name: blood cell (CL0000081)
    Fold Change: 4.41
    Marker Score: 51261
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 4.41
    Marker Score: 3935
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 4.4
    Marker Score: 1621
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 4.37
    Marker Score: 1421
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 4.37
    Marker Score: 1995
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 4.36
    Marker Score: 3420.5
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 4.35
    Marker Score: 3693
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 4.31
    Marker Score: 1030
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 4.3
    Marker Score: 4059.5
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 4.26
    Marker Score: 11963
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 4.24
    Marker Score: 855
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 4.23
    Marker Score: 4092
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.23
    Marker Score: 10329.5
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 4.21
    Marker Score: 2562
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 4.19
    Marker Score: 2756
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 4.15
    Marker Score: 30891.5
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.14
    Marker Score: 9427
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 4.11
    Marker Score: 3177.5
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 4.1
    Marker Score: 17595
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 4.07
    Marker Score: 2624
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 4.07
    Marker Score: 4344.5
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 4.06
    Marker Score: 5981
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 4.05
    Marker Score: 7616
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 4.04
    Marker Score: 2295
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 4.04
    Marker Score: 3560.5
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 4.03
    Marker Score: 3433.5
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 4.02
    Marker Score: 21607
  • Cell Name: theca cell (CL0000503)
    Fold Change: 3.99
    Marker Score: 2859
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 3.99
    Marker Score: 1440.5
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 3.98
    Marker Score: 4658
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.97
    Marker Score: 3913
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 3.95
    Marker Score: 2432
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 3.94
    Marker Score: 2635.5
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 3.92
    Marker Score: 3483
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 3.9
    Marker Score: 3958
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 3.87
    Marker Score: 2134
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 3.85
    Marker Score: 2681
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 3.85
    Marker Score: 1235
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 3.79
    Marker Score: 1963
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 3.78
    Marker Score: 1519
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 3.78
    Marker Score: 1032
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 3.78
    Marker Score: 1412
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 3.77
    Marker Score: 2500
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 3.77
    Marker Score: 3547
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 3.77
    Marker Score: 957
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 3.77
    Marker Score: 1689
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.77
    Marker Score: 4308.5
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 3.76
    Marker Score: 862
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 3.76
    Marker Score: 1296
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 3.75
    Marker Score: 3440
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 3.74
    Marker Score: 1022
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 3.74
    Marker Score: 3103

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Other Information

**Key characteristics:** * Gene name: COX2 * Ensembl ID: ENSG00000198712 * Protein: Cytochrome c oxidase subunit 2 * Protein length: 145 amino acids * Expression: Significantly expressed in skeletal muscle satellite cell, microglial cell, pulmonary artery endothelial cell, cardiac muscle cell, tracheobronchial smooth muscle cell, pancreatic ductal cell, myoepithelial cell of mammary gland, Sertoli cell, stratified epithelial cell, pancreatic acinar cell **Pathways and functions:** * Cytochrome c oxidase activity: The COX2 protein is responsible for the transfer of electrons from NADH and FADH2 to oxygen, which is necessary for the production of energy in the form of ATP through oxidative phosphorylation. * Cellular responses to stimuli: COX2 is also involved in cellular responses to stimuli, such as muscle contraction and inflammation. * Cellular response to chemical stress: COX2 is a stress sensor that is activated by various chemical stresses, such as hydrogen peroxide and ammonia. * Copper ion binding: COX2 is a copper-dependent enzyme, which means that it requires copper ions for its activity. * Mitochondrial protein degradation: COX2 is involved in the degradation of mitochondrial proteins. **Clinical significance:** * Mutations in the COX2 gene have been linked to various human diseases, including heart disease, stroke, and cancer. * COX2 inhibitors are being investigated as potential treatments for these diseases.

Genular Protein ID: 3358810535

Symbol: COX2_HUMAN

Name: Cytochrome c oxidase subunit 2

UniProtKB Accession Codes:

P00403 Q37526

Database IDs:

AGR 2 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CDD 1 CORUM 1 CTD 1 ChEBI 15 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EC 2 EMBL 100 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 13 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 2 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 Rhea 4 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7219534

Title: Sequence and organization of the human mitochondrial genome.

PubMed ID: 7219534

DOI: 10.1038/290457a0

PubMed ID: 2550900

Title: Nucleotide sequence of human mitochondrial cytochrome c oxidase II cDNA.

PubMed ID: 2550900

DOI: 10.1093/nar/17.16.6734

PubMed ID: 226894

Title: A different genetic code in human mitochondria.

PubMed ID: 226894

DOI: 10.1038/282189a0

PubMed ID: 7530363

Title: Recent African origin of modern humans revealed by complete sequences of hominoid mitochondrial DNAs.

PubMed ID: 7530363

DOI: 10.1073/pnas.92.2.532

PubMed ID: 8277847

Title: Mitochondrial COII sequences and modern human origins.

PubMed ID: 8277847

DOI: 10.1093/oxfordjournals.molbev.a040068

PubMed ID: 12949126

Title: Lineage-specific selection in human mtDNA: lack of polymorphisms in a segment of MTND5 gene in haplogroup J.

PubMed ID: 12949126

DOI: 10.1093/molbev/msg230

PubMed ID: 11130070

Title: Mitochondrial genome variation and the origin of modern humans.

PubMed ID: 11130070

DOI: 10.1038/35047064

PubMed ID: 12840039

Title: Mitochondrial genome variation and evolutionary history of Australian and New Guinean aborigines.

PubMed ID: 12840039

DOI: 10.1101/gr.686603

PubMed ID: 14760490

Title: Single nucleotide polymorphisms over the entire mtDNA genome that increase the power of forensic testing in Caucasians.

PubMed ID: 14760490

DOI: 10.1007/s00414-004-0427-6

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23125284

Title: A mutation in the FAM36A gene, the human ortholog of COX20, impairs cytochrome c oxidase assembly and is associated with ataxia and muscle hypotonia.

PubMed ID: 23125284

DOI: 10.1093/hmg/dds473

PubMed ID: 24403053

Title: Human COX20 cooperates with SCO1 and SCO2 to mature COX2 and promote the assembly of cytochrome c oxidase.

PubMed ID: 24403053

DOI: 10.1093/hmg/ddu003

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29154948

Title: The mitochondrial TMEM177 associates with COX20 during COX2 biogenesis.

PubMed ID: 29154948

DOI: 10.1016/j.bbamcr.2017.11.010

PubMed ID: 28330871

Title: Human mitochondrial cytochrome c oxidase assembly factor COX18 acts transiently as a membrane insertase within the subunit 2 maturation module.

PubMed ID: 28330871

DOI: 10.1074/jbc.m117.778514

PubMed ID: 29355485

Title: COX16 is required for assembly of cytochrome c oxidase in human cells and is involved in copper delivery to COX2.

PubMed ID: 29355485

DOI: 10.1016/j.bbabio.2018.01.004

PubMed ID: 29381136

Title: COX16 promotes COX2 metallation and assembly during respiratory complex IV biogenesis.

PubMed ID: 29381136

DOI: 10.7554/elife.32572

PubMed ID: 28844695

Title: Architecture of human mitochondrial respiratory megacomplex I2III2IV2.

PubMed ID: 28844695

DOI: 10.1016/j.cell.2017.07.050

PubMed ID: 30030519

Title: Structure of the intact 14-subunit human cytochrome c oxidase.

PubMed ID: 30030519

DOI: 10.1038/s41422-018-0071-1

PubMed ID: 1757091

Title: Normal variants of human mitochondrial DNA and translation products: the building of a reference data base.

PubMed ID: 1757091

DOI: 10.1007/bf00206061

PubMed ID: 9806551

Title: Somatic mutations of the mitochondrial genome in human colorectal tumours.

PubMed ID: 9806551

DOI: 10.1038/3108

PubMed ID: 10486321

Title: A missense mutation of cytochrome oxidase subunit II causes defective assembly and myopathy.

PubMed ID: 10486321

DOI: 10.1086/302590

Sequence Information:

  • Length: 227
  • Mass: 25565
  • Checksum: 402A3145241DDEE6
  • Sequence:
    • MAHAAQVGLQ DATSPIMEEL ITFHDHALMI IFLICFLVLY ALFLTLTTKL TNTNISDAQE 
METVWTILPA IILVLIALPS LRILYMTDEV NDPSLTIKSI GHQWYWTYEY TDYGGLIFNS 
YMLPPLFLEP GDLRLLDVDN RVVLPIEAPI RMMITSQDVL HSWAVPTLGL KTDAIPGRLN 
QTTFTATRPG VYYGQCSEIC GANHSFMPIV LELIPLKIFE MGPVFTL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.