Details for: COX2
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 977.8709
Cell Significance Index: -461.6800 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 951.3298
Cell Significance Index: -489.3500 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 100.1695
Cell Significance Index: -268.3400 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 66.6886
Cell Significance Index: 2448.0900 - Cell Name: Sertoli cell (CL0000216)
Fold Change: 58.2278
Cell Significance Index: 816.7300 - Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 54.0779
Cell Significance Index: 430.2700 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 45.5829
Cell Significance Index: 33421.2500 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: 45.4689
Cell Significance Index: 3601.1400 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 44.4130
Cell Significance Index: 12778.9300 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 26.3752
Cell Significance Index: 389.3000 - Cell Name: abnormal cell (CL0001061)
Fold Change: 16.3755
Cell Significance Index: 1672.7600 - Cell Name: cell in vitro (CL0001034)
Fold Change: 12.9719
Cell Significance Index: 7084.2900 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 12.9252
Cell Significance Index: 678.6200 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 12.5312
Cell Significance Index: 341.0900 - Cell Name: pro-T cell (CL0000827)
Fold Change: 11.5745
Cell Significance Index: 295.6900 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 11.5144
Cell Significance Index: 521.9100 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 11.3636
Cell Significance Index: 210.0300 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 10.9473
Cell Significance Index: 100.8100 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 10.1165
Cell Significance Index: 152.4500 - Cell Name: seromucus secreting cell (CL0000159)
Fold Change: 9.8769
Cell Significance Index: 205.9900 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 9.4985
Cell Significance Index: 273.6700 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 9.0600
Cell Significance Index: 242.3500 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 8.9560
Cell Significance Index: 1101.2300 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 8.5275
Cell Significance Index: 1171.0600 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 8.5015
Cell Significance Index: 396.3800 - Cell Name: enterocyte (CL0000584)
Fold Change: 7.7741
Cell Significance Index: 48.2300 - Cell Name: hepatic pit cell (CL2000054)
Fold Change: 7.6506
Cell Significance Index: 20.4900 - Cell Name: granulosa cell (CL0000501)
Fold Change: 7.5294
Cell Significance Index: 197.9900 - Cell Name: peg cell (CL4033014)
Fold Change: 7.4930
Cell Significance Index: 173.1200 - Cell Name: lactocyte (CL0002325)
Fold Change: 7.3015
Cell Significance Index: 943.3000 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 6.9339
Cell Significance Index: 1249.9600 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 6.8168
Cell Significance Index: 439.7900 - Cell Name: odontoblast (CL0000060)
Fold Change: 6.6665
Cell Significance Index: 854.6100 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 5.7276
Cell Significance Index: 4335.3100 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 5.5865
Cell Significance Index: 552.6300 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 5.5216
Cell Significance Index: 259.5100 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 5.2879
Cell Significance Index: 394.1000 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 5.2363
Cell Significance Index: 4728.0200 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 4.7437
Cell Significance Index: 515.9800 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 4.4363
Cell Significance Index: 130.2900 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 3.8620
Cell Significance Index: 628.1200 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 3.5568
Cell Significance Index: 213.5300 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 3.3805
Cell Significance Index: 117.4700 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 3.1170
Cell Significance Index: 1118.0000 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 2.2538
Cell Significance Index: 447.2800 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.4679
Cell Significance Index: 294.4700 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.4160
Cell Significance Index: 40.5900 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.3849
Cell Significance Index: 263.5600 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 1.2350
Cell Significance Index: 43.4000 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.9331
Cell Significance Index: 10.6000 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.5314
Cell Significance Index: 6.8100 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.5188
Cell Significance Index: 26.9500 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.4517
Cell Significance Index: 12.0600 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.2128
Cell Significance Index: -400.7400 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.3368
Cell Significance Index: -621.1400 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.4050
Cell Significance Index: -623.4500 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.4627
Cell Significance Index: -629.2000 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.5020
Cell Significance Index: -85.7200 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.5700
Cell Significance Index: -422.2100 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.6406
Cell Significance Index: -406.8400 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.7881
Cell Significance Index: -444.4800 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.9337
Cell Significance Index: -423.7700 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.9440
Cell Significance Index: -52.9700 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -1.0264
Cell Significance Index: -640.9400 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -1.1835
Cell Significance Index: -79.5800 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -1.3565
Cell Significance Index: -22.8500 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -1.8185
Cell Significance Index: -208.3400 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -1.9543
Cell Significance Index: -34.5400 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -2.0054
Cell Significance Index: -138.6900 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -2.5063
Cell Significance Index: -527.8900 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -3.0951
Cell Significance Index: -99.1300 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -3.1015
Cell Significance Index: -77.5300 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -3.2149
Cell Significance Index: -467.3200 - Cell Name: preadipocyte (CL0002334)
Fold Change: -3.2674
Cell Significance Index: -63.7700 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -4.1027
Cell Significance Index: -68.6600 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -4.1459
Cell Significance Index: -89.8200 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -4.2017
Cell Significance Index: -437.5000 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -4.7903
Cell Significance Index: -136.7000 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -4.8232
Cell Significance Index: -303.9900 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -5.0315
Cell Significance Index: -386.1100 - Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: -5.5696
Cell Significance Index: -42.9300 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -5.5763
Cell Significance Index: -116.7200 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -6.0332
Cell Significance Index: -370.8300 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -6.3317
Cell Significance Index: -388.1900 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -6.4702
Cell Significance Index: -96.9500 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -6.5589
Cell Significance Index: -331.4700 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -6.7779
Cell Significance Index: -277.7300 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -7.4959
Cell Significance Index: -129.2200 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -8.3349
Cell Significance Index: -177.5100 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -9.0080
Cell Significance Index: -93.2500 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -10.0199
Cell Significance Index: -295.1300 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -10.3049
Cell Significance Index: -455.8100 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -11.3423
Cell Significance Index: -154.7500 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -12.4711
Cell Significance Index: -472.2500 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -12.4780
Cell Significance Index: -258.8500 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -12.9797
Cell Significance Index: -454.7000 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -13.5094
Cell Significance Index: -161.0400 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -13.7361
Cell Significance Index: -449.7200 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -14.1211
Cell Significance Index: -449.7400 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -14.3499
Cell Significance Index: -368.8600
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3358810535
Symbol: COX2_HUMAN
Name: Cytochrome c oxidase subunit 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7219534
Title: Sequence and organization of the human mitochondrial genome.
PubMed ID: 7219534
DOI: 10.1038/290457a0
PubMed ID: 2550900
Title: Nucleotide sequence of human mitochondrial cytochrome c oxidase II cDNA.
PubMed ID: 2550900
PubMed ID: 226894
PubMed ID: 7530363
Title: Recent African origin of modern humans revealed by complete sequences of hominoid mitochondrial DNAs.
PubMed ID: 7530363
PubMed ID: 8277847
Title: Mitochondrial COII sequences and modern human origins.
PubMed ID: 8277847
PubMed ID: 12949126
Title: Lineage-specific selection in human mtDNA: lack of polymorphisms in a segment of MTND5 gene in haplogroup J.
PubMed ID: 12949126
PubMed ID: 11130070
Title: Mitochondrial genome variation and the origin of modern humans.
PubMed ID: 11130070
DOI: 10.1038/35047064
PubMed ID: 12840039
Title: Mitochondrial genome variation and evolutionary history of Australian and New Guinean aborigines.
PubMed ID: 12840039
DOI: 10.1101/gr.686603
PubMed ID: 14760490
Title: Single nucleotide polymorphisms over the entire mtDNA genome that increase the power of forensic testing in Caucasians.
PubMed ID: 14760490
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23125284
Title: A mutation in the FAM36A gene, the human ortholog of COX20, impairs cytochrome c oxidase assembly and is associated with ataxia and muscle hypotonia.
PubMed ID: 23125284
DOI: 10.1093/hmg/dds473
PubMed ID: 24403053
Title: Human COX20 cooperates with SCO1 and SCO2 to mature COX2 and promote the assembly of cytochrome c oxidase.
PubMed ID: 24403053
DOI: 10.1093/hmg/ddu003
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 29154948
Title: The mitochondrial TMEM177 associates with COX20 during COX2 biogenesis.
PubMed ID: 29154948
PubMed ID: 28330871
Title: Human mitochondrial cytochrome c oxidase assembly factor COX18 acts transiently as a membrane insertase within the subunit 2 maturation module.
PubMed ID: 28330871
PubMed ID: 29355485
Title: COX16 is required for assembly of cytochrome c oxidase in human cells and is involved in copper delivery to COX2.
PubMed ID: 29355485
PubMed ID: 29381136
Title: COX16 promotes COX2 metallation and assembly during respiratory complex IV biogenesis.
PubMed ID: 29381136
DOI: 10.7554/elife.32572
PubMed ID: 28844695
Title: Architecture of human mitochondrial respiratory megacomplex I2III2IV2.
PubMed ID: 28844695
PubMed ID: 30030519
Title: Structure of the intact 14-subunit human cytochrome c oxidase.
PubMed ID: 30030519
PubMed ID: 1757091
Title: Normal variants of human mitochondrial DNA and translation products: the building of a reference data base.
PubMed ID: 1757091
DOI: 10.1007/bf00206061
PubMed ID: 9806551
Title: Somatic mutations of the mitochondrial genome in human colorectal tumours.
PubMed ID: 9806551
DOI: 10.1038/3108
PubMed ID: 10486321
Title: A missense mutation of cytochrome oxidase subunit II causes defective assembly and myopathy.
PubMed ID: 10486321
DOI: 10.1086/302590
Sequence Information:
- Length: 227
- Mass: 25565
- Checksum: 402A3145241DDEE6
- Sequence:
MAHAAQVGLQ DATSPIMEEL ITFHDHALMI IFLICFLVLY ALFLTLTTKL TNTNISDAQE METVWTILPA IILVLIALPS LRILYMTDEV NDPSLTIKSI GHQWYWTYEY TDYGGLIFNS YMLPPLFLEP GDLRLLDVDN RVVLPIEAPI RMMITSQDVL HSWAVPTLGL KTDAIPGRLN QTTFTATRPG VYYGQCSEIC GANHSFMPIV LELIPLKIFE MGPVFTL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.