Details for: CL0000700

Cell ID: CL0000700

Cell Name: dopaminergic neuron

Marker Score Threshold: 10326
(Derived using integrated single-cell and genomic data)

Description: A neuron that releases dopamine as a neurotransmitter.

Synonyms: dopaminergic cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 2.11
    Ensembl ID: ENSG00000145362
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 2.07
    Ensembl ID: ENSG00000151150
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.05
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ADARB2 (ENSG00000185736)
    Fold Change: 2.05
    Ensembl ID: ENSG00000185736
  • Gene Symbol: ANK1 (ENSG00000029534)
    Fold Change: 2.01
    Ensembl ID: ENSG00000029534
  • Gene Symbol: APBA1 (ENSG00000107282)
    Fold Change: 1.98
    Ensembl ID: ENSG00000107282
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 1.96
    Ensembl ID: ENSG00000140836
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.95
    Ensembl ID: ENSG00000156110
  • Gene Symbol: AMPH (ENSG00000078053)
    Fold Change: 1.93
    Ensembl ID: ENSG00000078053
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 1.93
    Ensembl ID: ENSG00000170634
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 1.92
    Ensembl ID: ENSG00000163697
  • Gene Symbol: ALCAM (ENSG00000170017)
    Fold Change: 1.91
    Ensembl ID: ENSG00000170017
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.9
    Ensembl ID: ENSG00000100852
  • Gene Symbol: APC (ENSG00000134982)
    Fold Change: 1.87
    Ensembl ID: ENSG00000134982
  • Gene Symbol: ASTN1 (ENSG00000152092)
    Fold Change: 1.87
    Ensembl ID: ENSG00000152092
  • Gene Symbol: ADCY2 (ENSG00000078295)
    Fold Change: 1.84
    Ensembl ID: ENSG00000078295
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.83
    Ensembl ID: ENSG00000197043
  • Gene Symbol: ARHGAP6 (ENSG00000047648)
    Fold Change: 1.81
    Ensembl ID: ENSG00000047648
  • Gene Symbol: ABR (ENSG00000159842)
    Fold Change: 1.81
    Ensembl ID: ENSG00000159842
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.79
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ABCA3 (ENSG00000167972)
    Fold Change: 1.77
    Ensembl ID: ENSG00000167972
  • Gene Symbol: AP2A2 (ENSG00000183020)
    Fold Change: 1.75
    Ensembl ID: ENSG00000183020
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.73
    Ensembl ID: ENSG00000084234
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 1.73
    Ensembl ID: ENSG00000136717
  • Gene Symbol: ADCY9 (ENSG00000162104)
    Fold Change: 1.72
    Ensembl ID: ENSG00000162104
  • Gene Symbol: ADCY5 (ENSG00000173175)
    Fold Change: 1.72
    Ensembl ID: ENSG00000173175
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.72
    Ensembl ID: ENSG00000198363
  • Gene Symbol: ADARB1 (ENSG00000197381)
    Fold Change: 1.71
    Ensembl ID: ENSG00000197381
  • Gene Symbol: ARRB1 (ENSG00000137486)
    Fold Change: 1.7
    Ensembl ID: ENSG00000137486
  • Gene Symbol: APBB1 (ENSG00000166313)
    Fold Change: 1.66
    Ensembl ID: ENSG00000166313
  • Gene Symbol: ABAT (ENSG00000183044)
    Fold Change: 1.66
    Ensembl ID: ENSG00000183044
  • Gene Symbol: ABL1 (ENSG00000097007)
    Fold Change: 1.65
    Ensembl ID: ENSG00000097007
  • Gene Symbol: GRK3 (ENSG00000100077)
    Fold Change: 1.65
    Ensembl ID: ENSG00000100077
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.65
    Ensembl ID: ENSG00000100412
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.62
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ABL2 (ENSG00000143322)
    Fold Change: 1.62
    Ensembl ID: ENSG00000143322
  • Gene Symbol: APBA2 (ENSG00000034053)
    Fold Change: 1.62
    Ensembl ID: ENSG00000034053
  • Gene Symbol: AP1G1 (ENSG00000166747)
    Fold Change: 1.61
    Ensembl ID: ENSG00000166747
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.57
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.56
    Ensembl ID: ENSG00000138279
  • Gene Symbol: AMY2B (ENSG00000240038)
    Fold Change: 1.55
    Ensembl ID: ENSG00000240038
  • Gene Symbol: ACAT1 (ENSG00000075239)
    Fold Change: 1.55
    Ensembl ID: ENSG00000075239
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.53
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ALDH1A1 (ENSG00000165092)
    Fold Change: 1.52
    Ensembl ID: ENSG00000165092
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.52
    Ensembl ID: ENSG00000104763
  • Gene Symbol: AARS1 (ENSG00000090861)
    Fold Change: 1.51
    Ensembl ID: ENSG00000090861
  • Gene Symbol: ASIC2 (ENSG00000108684)
    Fold Change: 1.51
    Ensembl ID: ENSG00000108684
  • Gene Symbol: ACVR2A (ENSG00000121989)
    Fold Change: 1.48
    Ensembl ID: ENSG00000121989
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.47
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ADCY3 (ENSG00000138031)
    Fold Change: 1.45
    Ensembl ID: ENSG00000138031
  • Gene Symbol: XIAP (ENSG00000101966)
    Fold Change: 1.43
    Ensembl ID: ENSG00000101966
  • Gene Symbol: ACADSB (ENSG00000196177)
    Fold Change: 1.43
    Ensembl ID: ENSG00000196177
  • Gene Symbol: ACHE (ENSG00000087085)
    Fold Change: 1.42
    Ensembl ID: ENSG00000087085
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: 1.41
    Ensembl ID: ENSG00000117054
  • Gene Symbol: AP1B1 (ENSG00000100280)
    Fold Change: 1.4
    Ensembl ID: ENSG00000100280
  • Gene Symbol: ADCY1 (ENSG00000164742)
    Fold Change: 1.4
    Ensembl ID: ENSG00000164742
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.39
    Ensembl ID: ENSG00000143761
  • Gene Symbol: AMPD3 (ENSG00000133805)
    Fold Change: 1.38
    Ensembl ID: ENSG00000133805
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.37
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ARL3 (ENSG00000138175)
    Fold Change: 1.36
    Ensembl ID: ENSG00000138175
  • Gene Symbol: ARHGDIG (ENSG00000242173)
    Fold Change: 1.35
    Ensembl ID: ENSG00000242173
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.34
    Ensembl ID: ENSG00000148700
  • Gene Symbol: AP2A1 (ENSG00000196961)
    Fold Change: 1.33
    Ensembl ID: ENSG00000196961
  • Gene Symbol: ARNT (ENSG00000143437)
    Fold Change: 1.31
    Ensembl ID: ENSG00000143437
  • Gene Symbol: ARSB (ENSG00000113273)
    Fold Change: 1.31
    Ensembl ID: ENSG00000113273
  • Gene Symbol: ACO1 (ENSG00000122729)
    Fold Change: 1.31
    Ensembl ID: ENSG00000122729
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.3
    Ensembl ID: ENSG00000137845
  • Gene Symbol: ACVR1B (ENSG00000135503)
    Fold Change: 1.3
    Ensembl ID: ENSG00000135503
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.28
    Ensembl ID: ENSG00000072110
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 1.28
    Ensembl ID: ENSG00000075624
  • Gene Symbol: AR (ENSG00000169083)
    Fold Change: 1.28
    Ensembl ID: ENSG00000169083
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.27
    Ensembl ID: ENSG00000067560
  • Gene Symbol: TRIM23 (ENSG00000113595)
    Fold Change: 1.27
    Ensembl ID: ENSG00000113595
  • Gene Symbol: ASNS (ENSG00000070669)
    Fold Change: 1.25
    Ensembl ID: ENSG00000070669
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.21
    Ensembl ID: ENSG00000111275
  • Gene Symbol: AGL (ENSG00000162688)
    Fold Change: 1.2
    Ensembl ID: ENSG00000162688
  • Gene Symbol: ADSS2 (ENSG00000035687)
    Fold Change: 1.2
    Ensembl ID: ENSG00000035687
  • Gene Symbol: ABCD2 (ENSG00000173208)
    Fold Change: 1.19
    Ensembl ID: ENSG00000173208
  • Gene Symbol: ALDOC (ENSG00000109107)
    Fold Change: 1.18
    Ensembl ID: ENSG00000109107
  • Gene Symbol: SLC25A4 (ENSG00000151729)
    Fold Change: 1.17
    Ensembl ID: ENSG00000151729
  • Gene Symbol: ALDH3A2 (ENSG00000072210)
    Fold Change: 1.14
    Ensembl ID: ENSG00000072210
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.13
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ALK (ENSG00000171094)
    Fold Change: 1.13
    Ensembl ID: ENSG00000171094
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.12
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ACVR1 (ENSG00000115170)
    Fold Change: 1.11
    Ensembl ID: ENSG00000115170
  • Gene Symbol: ADCYAP1R1 (ENSG00000078549)
    Fold Change: 1.11
    Ensembl ID: ENSG00000078549
  • Gene Symbol: APLP1 (ENSG00000105290)
    Fold Change: 1.11
    Ensembl ID: ENSG00000105290
  • Gene Symbol: AKT2 (ENSG00000105221)
    Fold Change: 1.1
    Ensembl ID: ENSG00000105221
  • Gene Symbol: ATF1 (ENSG00000123268)
    Fold Change: 1.08
    Ensembl ID: ENSG00000123268
  • Gene Symbol: ADCY8 (ENSG00000155897)
    Fold Change: 1.08
    Ensembl ID: ENSG00000155897
  • Gene Symbol: ARG2 (ENSG00000081181)
    Fold Change: 1.07
    Ensembl ID: ENSG00000081181
  • Gene Symbol: ABCB7 (ENSG00000131269)
    Fold Change: 1.07
    Ensembl ID: ENSG00000131269
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.06
    Ensembl ID: ENSG00000143799
  • Gene Symbol: ACYP1 (ENSG00000119640)
    Fold Change: 1.06
    Ensembl ID: ENSG00000119640
  • Gene Symbol: ABCA2 (ENSG00000107331)
    Fold Change: 1.04
    Ensembl ID: ENSG00000107331
  • Gene Symbol: AMFR (ENSG00000159461)
    Fold Change: 1.04
    Ensembl ID: ENSG00000159461
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.02
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ACAA1 (ENSG00000060971)
    Fold Change: 1.02
    Ensembl ID: ENSG00000060971
  • Gene Symbol: ABCA1 (ENSG00000165029)
    Fold Change: 1
    Ensembl ID: ENSG00000165029
  • Gene Symbol: ACOX1 (ENSG00000161533)
    Fold Change: 1
    Ensembl ID: ENSG00000161533
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Dopaminergic function**: Dopaminergic neurons release dopamine as a neurotransmitter, playing a crucial role in various physiological and psychological processes, including motivation, reward, and movement control. 2. **ANK2 and ANK3 genes**: These genes are involved in regulating calcium ion transport, protein stability, and cell surface organization, highlighting their importance in maintaining dopaminergic neuron function. 3. **Axon guidance**: The cell is involved in axon guidance, a process that helps neurons extend and navigate their axons to their target locations. 4. **Cytoskeleton organization**: The cell's cytoskeleton plays a crucial role in maintaining its shape and structure, and is involved in various cellular processes, including cell signaling and protein localization. 5. **Membrane trafficking**: The cell is involved in membrane trafficking, a process that helps regulate the movement of proteins and lipids within the cell membrane. **Clinical Significance** 1. **Neurological disorders**: Dopaminergic neurons are involved in various neurological disorders, including Parkinson's disease, schizophrenia, and attention deficit hyperactivity disorder (ADHD). 2. **Motor control**: Dopaminergic neurons play a crucial role in motor control, and dysfunction of these neurons can lead to motor symptoms, such as tremors and rigidity. 3. **Mood regulation**: Dopaminergic neurons are also involved in mood regulation, and dysfunction of these neurons can lead to mood disorders, such as depression and anxiety. 4. **Psychiatric disorders**: Dopaminergic neurons are involved in various psychiatric disorders, including schizophrenia, bipolar disorder, and schizophrenia. 5. **Neurodevelopmental disorders**: Dopaminergic neurons are also involved in neurodevelopmental disorders, such as autism spectrum disorder and attention deficit hyperactivity disorder (ADHD). In conclusion, the dopaminergic neuron is a complex cell type that plays a crucial role in various physiological and psychological processes. Understanding the characteristics and clinical significance of this cell type can provide valuable insights into the development of novel therapeutic strategies for neurological and psychiatric disorders.