Details for: VCP
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 384.8398
Cell Significance Index: -59.8600 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 247.2369
Cell Significance Index: -62.7100 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 187.5967
Cell Significance Index: -77.2800 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 157.4126
Cell Significance Index: -63.9500 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 155.7434
Cell Significance Index: -73.5300 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 139.0981
Cell Significance Index: -71.5500 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 110.2348
Cell Significance Index: -73.9700 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 67.3166
Cell Significance Index: -64.2700 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 56.1091
Cell Significance Index: -69.1800 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 19.7229
Cell Significance Index: -52.8400 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 18.3297
Cell Significance Index: -72.3300 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 16.7120
Cell Significance Index: -51.3300 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 12.8485
Cell Significance Index: -28.1200 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 2.3386
Cell Significance Index: 254.3700 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 2.0074
Cell Significance Index: 53.6000 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.7012
Cell Significance Index: 306.6800 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.6573
Cell Significance Index: 203.7900 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.6549
Cell Significance Index: 47.4400 - Cell Name: cell in vitro (CL0001034)
Fold Change: 1.5529
Cell Significance Index: 848.0500 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.5220
Cell Significance Index: 44.7000 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.3994
Cell Significance Index: 65.7700 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.3693
Cell Significance Index: 188.0400 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.3682
Cell Significance Index: 63.7900 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.2717
Cell Significance Index: 149.9700 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.2493
Cell Significance Index: 247.9200 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.1736
Cell Significance Index: 235.4200 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 1.1533
Cell Significance Index: 24.1400 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 1.1517
Cell Significance Index: 40.0200 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.1301
Cell Significance Index: 30.7600 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.1073
Cell Significance Index: 71.4400 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.0599
Cell Significance Index: 78.9900 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 1.0052
Cell Significance Index: 26.9400 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 1.0013
Cell Significance Index: 442.7200 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.9279
Cell Significance Index: 48.2000 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.8808
Cell Significance Index: 23.1600 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.8145
Cell Significance Index: 735.3900 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.7901
Cell Significance Index: 102.0800 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.7398
Cell Significance Index: 9.4700 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.7388
Cell Significance Index: 94.7100 - Cell Name: peg cell (CL4033014)
Fold Change: 0.6549
Cell Significance Index: 15.1300 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.6469
Cell Significance Index: 49.6500 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.6363
Cell Significance Index: 45.0000 - Cell Name: type I muscle cell (CL0002211)
Fold Change: 0.6189
Cell Significance Index: 15.1000 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.5869
Cell Significance Index: 210.5200 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.5721
Cell Significance Index: 30.0400 - Cell Name: germ cell (CL0000586)
Fold Change: 0.5562
Cell Significance Index: 4.2000 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.5443
Cell Significance Index: 15.2100 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.4760
Cell Significance Index: 13.7200 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.4672
Cell Significance Index: 88.9200 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.4537
Cell Significance Index: 23.6300 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.3795
Cell Significance Index: 17.2000 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.3241
Cell Significance Index: 55.3500 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1526
Cell Significance Index: 15.1000 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.1058
Cell Significance Index: 1.1500 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.0911
Cell Significance Index: 14.8200 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0843
Cell Significance Index: 58.3100 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0560
Cell Significance Index: 105.4700 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.0307
Cell Significance Index: 1.7200 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 0.0108
Cell Significance Index: 1.2300 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0093
Cell Significance Index: 7.0200 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0033
Cell Significance Index: -2.1000 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0118
Cell Significance Index: -18.2100 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0177
Cell Significance Index: -32.6700 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0217
Cell Significance Index: -29.5700 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0233
Cell Significance Index: -0.3900 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0243
Cell Significance Index: -17.8400 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0291
Cell Significance Index: -21.5600 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0535
Cell Significance Index: -5.4600 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0550
Cell Significance Index: -24.9500 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0610
Cell Significance Index: -38.0900 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.0780
Cell Significance Index: -0.9300 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0947
Cell Significance Index: -53.4300 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1522
Cell Significance Index: -32.0600 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1824
Cell Significance Index: -20.9000 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.2072
Cell Significance Index: -3.8300 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2170
Cell Significance Index: -62.4500 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2230
Cell Significance Index: -25.9900 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2479
Cell Significance Index: -36.0300 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.2606
Cell Significance Index: -2.4000 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.2679
Cell Significance Index: -8.5800 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.2828
Cell Significance Index: -17.3900 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.3798
Cell Significance Index: -25.5400 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.4331
Cell Significance Index: -27.3000 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.5094
Cell Significance Index: -6.9500 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.5306
Cell Significance Index: -13.5600 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.5720
Cell Significance Index: -15.3000 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.6035
Cell Significance Index: -8.9100 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.6314
Cell Significance Index: -65.7400 - Cell Name: kidney cell (CL1000497)
Fold Change: -0.6569
Cell Significance Index: -5.2500 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.6663
Cell Significance Index: -7.5700 - Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.6851
Cell Significance Index: -9.6100 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.7030
Cell Significance Index: -18.0700 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.7341
Cell Significance Index: -12.5800 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.7447
Cell Significance Index: -58.9800 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.9351
Cell Significance Index: -5.6500 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.9511
Cell Significance Index: -42.0700 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.9844
Cell Significance Index: -60.3600 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -1.0749
Cell Significance Index: -19.0000 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -1.1453
Cell Significance Index: -43.3700 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -1.2472
Cell Significance Index: -27.0200
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3939583105
Symbol: TERA_HUMAN
Name: Transitional endoplasmic reticulum ATPase
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10931946
Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.
PubMed ID: 10931946
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15164053
Title: DNA sequence and analysis of human chromosome 9.
PubMed ID: 15164053
DOI: 10.1038/nature02465
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12665801
Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
PubMed ID: 12665801
DOI: 10.1038/nbt810
PubMed ID: 8413590
Title: Valosin-containing protein, VCP, is a ubiquitous clathrin-binding protein.
PubMed ID: 8413590
DOI: 10.1038/365459a0
PubMed ID: 23349634
Title: A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity.
PubMed ID: 23349634
PubMed ID: 15362974
Title: A novel UBA and UBX domain protein that binds polyubiquitin and VCP and is a substrate for SAPKs.
PubMed ID: 15362974
DOI: 10.1042/bj20041498
PubMed ID: 15456787
Title: Physical and functional interaction between dorfin and valosin-containing protein that are colocalized in ubiquitylated inclusions in neurodegenerative disorders.
PubMed ID: 15456787
PubMed ID: 15215856
Title: A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol.
PubMed ID: 15215856
DOI: 10.1038/nature02656
PubMed ID: 16139798
Title: Proteomic identification of proteins conjugated to ISG15 in mouse and human cells.
PubMed ID: 16139798
PubMed ID: 16289116
Title: The ubiquitin-domain protein HERP forms a complex with components of the endoplasmic reticulum associated degradation pathway.
PubMed ID: 16289116
PubMed ID: 16168377
Title: Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase.
PubMed ID: 16168377
PubMed ID: 16186510
Title: Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane.
PubMed ID: 16186510
PubMed ID: 16186509
Title: Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane.
PubMed ID: 16186509
PubMed ID: 16513638
Title: Calcium-sensing receptor ubiquitination and degradation mediated by the E3 ubiquitin ligase dorfin.
PubMed ID: 16513638
PubMed ID: 16449189
Title: Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation.
PubMed ID: 16449189
PubMed ID: 16968747
Title: Characterization of erasin (UBXD2): a new ER protein that promotes ER-associated protein degradation.
PubMed ID: 16968747
DOI: 10.1242/jcs.03163
PubMed ID: 17314412
Title: The RBCC gene RFP2 (Leu5) encodes a novel transmembrane E3 ubiquitin ligase involved in ERAD.
PubMed ID: 17314412
PubMed ID: 17525332
Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
PubMed ID: 17525332
PubMed ID: 18675248
Title: Ubiquitin ligase Kf-1 is involved in the endoplasmic reticulum-associated degradation pathway.
PubMed ID: 18675248
PubMed ID: 18656546
Title: Ubxd1 is a novel co-factor of the human p97 ATPase.
PubMed ID: 18656546
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18022694
Title: Ro52 functionally interacts with IgG1 and regulates its quality control via the ERAD system.
PubMed ID: 18022694
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19174149
Title: UBXD1 binds p97 through two independent binding sites.
PubMed ID: 19174149
PubMed ID: 19275885
Title: UBXD1 is a VCP-interacting protein that is involved in ER-associated degradation.
PubMed ID: 19275885
PubMed ID: 19822669
Title: Ubiquilin and p97/VCP bind erasin, forming a complex involved in ERAD.
PubMed ID: 19822669
PubMed ID: 19818707
Title: The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER.
PubMed ID: 19818707
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20833645
Title: Strumpellin is a novel valosin-containing protein binding partner linking hereditary spastic paraplegia to protein aggregation diseases.
PubMed ID: 20833645
DOI: 10.1093/brain/awq222
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21118995
Title: The AAA-ATPase p97 is essential for outer mitochondrial membrane protein turnover.
PubMed ID: 21118995
PubMed ID: 21636303
Title: A ubiquitin ligase-associated chaperone holdase maintains polypeptides in soluble states for proteasome degradation.
PubMed ID: 21636303
PubMed ID: 21822278
Title: Endolysosomal sorting of ubiquitylated caveolin-1 is regulated by VCP and UBXD1 and impaired by VCP disease mutations.
PubMed ID: 21822278
DOI: 10.1038/ncb2301
PubMed ID: 22020440
Title: The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks.
PubMed ID: 22020440
DOI: 10.1038/ncb2367
PubMed ID: 22120668
Title: The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaks.
PubMed ID: 22120668
DOI: 10.1038/nsmb.2188
PubMed ID: 21949850
Title: The tissue-specific Rep8/UBXD6 tethers p97 to the endoplasmic reticulum membrane for degradation of misfolded proteins.
PubMed ID: 21949850
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22537386
Title: UBXN7 docks on neddylated cullin complexes using its UIM motif and causes HIF1alpha accumulation.
PubMed ID: 22537386
PubMed ID: 22795130
Title: Ubiquitin-dependent intramembrane rhomboid protease promotes ERAD of membrane proteins.
PubMed ID: 22795130
PubMed ID: 22902628
Title: Proliferating cell nuclear antigen (PCNA)-binding protein C1orf124 is a regulator of translesion synthesis.
PubMed ID: 22902628
PubMed ID: 22607976
Title: STT3B-dependent posttranslational N-glycosylation as a surveillance system for secretory protein.
PubMed ID: 22607976
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 22948820
Title: Lysine methylation of VCP by a member of a novel human protein methyltransferase family.
PubMed ID: 22948820
DOI: 10.1038/ncomms2041
PubMed ID: 23042607
Title: DVC1 (C1orf124) recruits the p97 protein segregase to sites of DNA damage.
PubMed ID: 23042607
DOI: 10.1038/nsmb.2394
PubMed ID: 23042605
Title: DVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks.
PubMed ID: 23042605
DOI: 10.1038/nsmb.2395
PubMed ID: 23335559
Title: Ubiquitination of the N-terminal region of caveolin-1 regulates endosomal sorting by the VCP/p97 AAA-ATPase.
PubMed ID: 23335559
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24160817
Title: Signal-peptide-mediated translocation is regulated by a p97-AIRAPL complex.
PubMed ID: 24160817
DOI: 10.1042/bj20130710
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24726327
Title: Binding of OTULIN to the PUB domain of HOIP controls NF-kappaB signaling.
PubMed ID: 24726327
PubMed ID: 26265139
Title: UBXN2A regulates nicotinic receptor degradation by modulating the E3 ligase activity of CHIP.
PubMed ID: 26265139
PubMed ID: 26565908
Title: Pre-emptive quality control protects the ER from protein overload via the proximity of ERAD components and SRP.
PubMed ID: 26565908
PubMed ID: 26471729
Title: A non-canonical role of the p97 complex in RIG-I antiviral signaling.
PubMed ID: 26471729
PubMed ID: 26337389
Title: Proteasomal degradation of preemptive quality control (pQC) substrates is mediated by an AIRAPL-p97 complex.
PubMed ID: 26337389
PubMed ID: 26389662
Title: Systematic proteomics of the VCP-UBXD adaptor network identifies a role for UBXN10 in regulating ciliogenesis.
PubMed ID: 26389662
DOI: 10.1038/ncb3238
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 26842564
Title: Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression.
PubMed ID: 26842564
DOI: 10.1038/ncomms10612
PubMed ID: 26692333
Title: Loss of the proteostasis factor AIRAPL causes myeloid transformation by deregulating IGF-1 signaling.
PubMed ID: 26692333
DOI: 10.1038/nm.4013
PubMed ID: 28302725
Title: Ankyrin repeat and zinc-finger domain-containing 1 mutations are associated with infantile-onset inflammatory bowel disease.
PubMed ID: 28302725
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 30455355
Title: Physiological and pathophysiological characteristics of ataxin-3 isoforms.
PubMed ID: 30455355
PubMed ID: 31073040
Title: LMBR1L regulates lymphopoiesis through Wnt/beta-catenin signaling.
PubMed ID: 31073040
PubMed ID: 32152270
Title: TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts.
PubMed ID: 32152270
PubMed ID: 34739333
Title: Ubiquitination of G3BP1 mediates stress granule disassembly in a context-specific manner.
PubMed ID: 34739333
PubMed ID: 35013556
Title: The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.
PubMed ID: 35013556
PubMed ID: 20512113
Title: A novel ATP-dependent conformation in p97 N-D1 fragment revealed by crystal structures of disease-related mutants.
PubMed ID: 20512113
PubMed ID: 19887378
Title: Structure and function of the PLAA/Ufd3-p97/Cdc48 complex.
PubMed ID: 19887378
PubMed ID: 21914798
Title: The structural and functional basis of the p97/valosin-containing protein (VCP)-interacting motif (VIM): mutually exclusive binding of cofactors to the N-terminal domain of p97.
PubMed ID: 21914798
PubMed ID: 27714797
Title: Structural insights into the interaction of human p97 N-terminal domain and SHP motif in Derlin-1 rhomboid pseudoprotease.
PubMed ID: 27714797
PubMed ID: 15034582
Title: Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein.
PubMed ID: 15034582
DOI: 10.1038/ng1332
PubMed ID: 15732117
Title: Mutant valosin-containing protein causes a novel type of frontotemporal dementia.
PubMed ID: 15732117
DOI: 10.1002/ana.20407
PubMed ID: 16247064
Title: Inclusion body myopathy and Paget disease is linked to a novel mutation in the VCP gene.
PubMed ID: 16247064
PubMed ID: 16321991
Title: Inclusion body myopathy-associated mutations in p97/VCP impair endoplasmic reticulum-associated degradation.
PubMed ID: 16321991
DOI: 10.1093/hmg/ddi426
PubMed ID: 17935506
Title: Novel VCP mutations in inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia.
PubMed ID: 17935506
PubMed ID: 20104022
Title: VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD.
PubMed ID: 20104022
PubMed ID: 29804830
Title: ZFAND1 recruits p97 and the 26S proteasome to promote the clearance of arsenite-induced stress granules.
PubMed ID: 29804830
PubMed ID: 20335036
Title: Two Australian families with inclusion-body myopathy, Paget's disease of bone and frontotemporal dementia: novel clinical and genetic findings.
PubMed ID: 20335036
PubMed ID: 21145000
Title: Exome sequencing reveals VCP mutations as a cause of familial ALS.
PubMed ID: 21145000
PubMed ID: 25125609
Title: A novel mutation in VCP causes Charcot-Marie-Tooth Type 2 disease.
PubMed ID: 25125609
DOI: 10.1093/brain/awu224
PubMed ID: 25878907
Title: Rare Manifestation of a c.290 C>T, p.Gly97Glu VCP Mutation.
PubMed ID: 25878907
DOI: 10.1155/2015/239167
PubMed ID: 27209344
Title: Nuclear inclusions mimicking poly(A)-binding protein nuclear 1 inclusions in a case of inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia with a novel mutation in the valosin-containing protein gene.
PubMed ID: 27209344
PubMed ID: 27753622
Title: VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy.
PubMed ID: 27753622
PubMed ID: 36980948
Title: Novel Variants in the VCP Gene Causing Multisystem Proteinopathy 1.
PubMed ID: 36980948
Sequence Information:
- Length: 806
- Mass: 89322
- Checksum: 501B721D3A77BA8A
- Sequence:
MASGADSKGD DLSTAILKQK NRPNRLIVDE AINEDNSVVS LSQPKMDELQ LFRGDTVLLK GKKRREAVCI VLSDDTCSDE KIRMNRVVRN NLRVRLGDVI SIQPCPDVKY GKRIHVLPID DTVEGITGNL FEVYLKPYFL EAYRPIRKGD IFLVRGGMRA VEFKVVETDP SPYCIVAPDT VIHCEGEPIK REDEEESLNE VGYDDIGGCR KQLAQIKEMV ELPLRHPALF KAIGVKPPRG ILLYGPPGTG KTLIARAVAN ETGAFFFLIN GPEIMSKLAG ESESNLRKAF EEAEKNAPAI IFIDELDAIA PKREKTHGEV ERRIVSQLLT LMDGLKQRAH VIVMAATNRP NSIDPALRRF GRFDREVDIG IPDATGRLEI LQIHTKNMKL ADDVDLEQVA NETHGHVGAD LAALCSEAAL QAIRKKMDLI DLEDETIDAE VMNSLAVTMD DFRWALSQSN PSALRETVVE VPQVTWEDIG GLEDVKRELQ ELVQYPVEHP DKFLKFGMTP SKGVLFYGPP GCGKTLLAKA IANECQANFI SIKGPELLTM WFGESEANVR EIFDKARQAA PCVLFFDELD SIAKARGGNI GDGGGAADRV INQILTEMDG MSTKKNVFII GATNRPDIID PAILRPGRLD QLIYIPLPDE KSRVAILKAN LRKSPVAKDV DLEFLAKMTN GFSGADLTEI CQRACKLAIR ESIESEIRRE RERQTNPSAM EVEEDDPVPE IRRDHFEEAM RFARRSVSDN DIRKYEMFAQ TLQQSRGFGS FRFPSGNQGG AGPSQGSGGG TGGSVYTEDN DDDLYG
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.